Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AVW0_LEIMU

TriTrypDb:

LmxM.22.1280

Length:

389

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVW0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVW0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	271	275	PF00656	0.633
CLV_C14_Caspase3-7	325	329	PF00656	0.472
CLV_NRD_NRD_1	326	328	PF00675	0.480
CLV_PCSK_KEX2_1	326	328	PF00082	0.480
CLV_PCSK_KEX2_1	64	66	PF00082	0.627
CLV_PCSK_PC1ET2_1	64	66	PF00082	0.627
CLV_PCSK_SKI1_1	11	15	PF00082	0.557
CLV_PCSK_SKI1_1	343	347	PF00082	0.618
CLV_PCSK_SKI1_1	92	96	PF00082	0.641
CLV_PCSK_SKI1_1	99	103	PF00082	0.580
CLV_Separin_Metazoa	20	24	PF03568	0.446
DEG_Nend_UBRbox_2	1	3	PF02207	0.695
DOC_CKS1_1	257	262	PF01111	0.611
DOC_CYCLIN_RxL_1	8	16	PF00134	0.569
DOC_CYCLIN_yCln2_LP_2	282	288	PF00134	0.638
DOC_CYCLIN_yCln2_LP_2	348	354	PF00134	0.612
DOC_MAPK_gen_1	342	350	PF00069	0.612
DOC_PP2B_LxvP_1	133	136	PF13499	0.724
DOC_PP2B_LxvP_1	348	351	PF13499	0.610
DOC_PP2B_PxIxI_1	109	115	PF00149	0.579
DOC_PP4_FxxP_1	50	53	PF00568	0.638
DOC_USP7_MATH_1	170	174	PF00917	0.521
DOC_USP7_MATH_1	242	246	PF00917	0.711
DOC_USP7_MATH_1	250	254	PF00917	0.620
DOC_USP7_MATH_1	299	303	PF00917	0.680
DOC_USP7_MATH_1	376	380	PF00917	0.596
DOC_USP7_UBL2_3	98	102	PF12436	0.647
DOC_WW_Pin1_4	256	261	PF00397	0.613
DOC_WW_Pin1_4	281	286	PF00397	0.636
DOC_WW_Pin1_4	360	365	PF00397	0.646
DOC_WW_Pin1_4	42	47	PF00397	0.731
DOC_WW_Pin1_4	80	85	PF00397	0.538
LIG_14-3-3_CanoR_1	3	13	PF00244	0.568
LIG_EH1_1	7	15	PF00400	0.622
LIG_eIF4E_1	73	79	PF01652	0.653
LIG_EVH1_1	133	137	PF00568	0.544
LIG_FHA_1	145	151	PF00498	0.569
LIG_FHA_1	229	235	PF00498	0.547
LIG_FHA_1	257	263	PF00498	0.693
LIG_FHA_1	5	11	PF00498	0.593
LIG_FHA_2	269	275	PF00498	0.668
LIG_FHA_2	296	302	PF00498	0.708
LIG_FHA_2	46	52	PF00498	0.516
LIG_GBD_Chelix_1	380	388	PF00786	0.612
LIG_LIR_Apic_2	47	53	PF02991	0.633
LIG_MYND_1	137	141	PF01753	0.684
LIG_MYND_1	187	191	PF01753	0.563
LIG_NRP_CendR_1	386	389	PF00754	0.594
LIG_RPA_C_Fungi	322	334	PF08784	0.465
LIG_SH2_NCK_1	251	255	PF00017	0.651
LIG_SH2_NCK_1	270	274	PF00017	0.481
LIG_SH2_PTP2	111	114	PF00017	0.627
LIG_SH2_SRC	71	74	PF00017	0.664
LIG_SH2_STAP1	251	255	PF00017	0.648
LIG_SH2_STAP1	71	75	PF00017	0.661
LIG_SH2_STAT5	111	114	PF00017	0.655
LIG_SH2_STAT5	270	273	PF00017	0.642
LIG_SH3_3	131	137	PF00018	0.585
LIG_SH3_3	254	260	PF00018	0.484
LIG_SUMO_SIM_anti_2	259	266	PF11976	0.608
LIG_SUMO_SIM_par_1	111	117	PF11976	0.640
LIG_SUMO_SIM_par_1	259	266	PF11976	0.631
LIG_SUMO_SIM_par_1	284	290	PF11976	0.646
LIG_TRAF2_1	298	301	PF00917	0.670
MOD_CK1_1	129	135	PF00069	0.750
MOD_CK2_1	289	295	PF00069	0.687
MOD_CK2_1	376	382	PF00069	0.597
MOD_CK2_1	45	51	PF00069	0.522
MOD_Cter_Amidation	96	99	PF01082	0.600
MOD_GlcNHglycan	106	109	PF01048	0.643
MOD_GlcNHglycan	156	159	PF01048	0.680
MOD_GlcNHglycan	163	166	PF01048	0.532
MOD_GlcNHglycan	244	247	PF01048	0.699
MOD_GlcNHglycan	252	255	PF01048	0.795
MOD_GlcNHglycan	27	30	PF01048	0.635
MOD_GlcNHglycan	300	305	PF01048	0.712
MOD_GlcNHglycan	317	320	PF01048	0.523
MOD_GlcNHglycan	328	332	PF01048	0.471
MOD_GlcNHglycan	42	45	PF01048	0.599
MOD_GlcNHglycan	54	57	PF01048	0.578
MOD_GSK3_1	100	107	PF00069	0.464
MOD_GSK3_1	150	157	PF00069	0.708
MOD_GSK3_1	295	302	PF00069	0.700
MOD_GSK3_1	322	329	PF00069	0.517
MOD_GSK3_1	346	353	PF00069	0.570
MOD_GSK3_1	80	87	PF00069	0.655
MOD_N-GLC_2	307	309	PF02516	0.606
MOD_NEK2_1	150	155	PF00069	0.683
MOD_NEK2_1	181	186	PF00069	0.641
MOD_OFUCOSY	309	314	PF10250	0.572
MOD_PK_1	126	132	PF00069	0.546
MOD_PKA_1	326	332	PF00069	0.488
MOD_PKA_1	343	349	PF00069	0.595
MOD_PKA_2	326	332	PF00069	0.510
MOD_ProDKin_1	256	262	PF00069	0.612
MOD_ProDKin_1	281	287	PF00069	0.635
MOD_ProDKin_1	360	366	PF00069	0.646
MOD_ProDKin_1	42	48	PF00069	0.731
MOD_ProDKin_1	80	86	PF00069	0.535
MOD_SUMO_rev_2	290	298	PF00179	0.573
TRG_ENDOCYTIC_2	111	114	PF00928	0.627
TRG_ENDOCYTIC_2	59	62	PF00928	0.705
TRG_NLS_Bipartite_1	326	346	PF00514	0.437
TRG_Pf-PMV_PEXEL_1	11	15	PF00026	0.607
TRG_Pf-PMV_PEXEL_1	202	206	PF00026	0.685

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ICA2	Leishmania donovani	83%	100%
A4HCG5	Leishmania braziliensis	66%	100%
E9AGZ8	Leishmania infantum	83%	100%
Q4QBL9	Leishmania major	82%	100%