Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVV8_LEIMU

TriTrypDb:

LmxM.22.1260

Length:

1083

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVV8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVV8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	309	313	PF00656	0.547
CLV_C14_Caspase3-7	35	39	PF00656	0.528
CLV_C14_Caspase3-7	558	562	PF00656	0.600
CLV_C14_Caspase3-7	892	896	PF00656	0.675
CLV_C14_Caspase3-7	999	1003	PF00656	0.625
CLV_NRD_NRD_1	1041	1043	PF00675	0.550
CLV_NRD_NRD_1	1047	1049	PF00675	0.463
CLV_NRD_NRD_1	144	146	PF00675	0.576
CLV_NRD_NRD_1	215	217	PF00675	0.666
CLV_NRD_NRD_1	241	243	PF00675	0.673
CLV_NRD_NRD_1	396	398	PF00675	0.695
CLV_NRD_NRD_1	486	488	PF00675	0.705
CLV_NRD_NRD_1	667	669	PF00675	0.650
CLV_NRD_NRD_1	711	713	PF00675	0.649
CLV_NRD_NRD_1	718	720	PF00675	0.703
CLV_NRD_NRD_1	740	742	PF00675	0.685
CLV_NRD_NRD_1	745	747	PF00675	0.608
CLV_NRD_NRD_1	76	78	PF00675	0.549
CLV_NRD_NRD_1	816	818	PF00675	0.695
CLV_NRD_NRD_1	979	981	PF00675	0.670
CLV_PCSK_FUR_1	1045	1049	PF00082	0.520
CLV_PCSK_FUR_1	716	720	PF00082	0.671
CLV_PCSK_FUR_1	738	742	PF00082	0.650
CLV_PCSK_KEX2_1	1047	1049	PF00082	0.519
CLV_PCSK_KEX2_1	144	146	PF00082	0.576
CLV_PCSK_KEX2_1	215	217	PF00082	0.666
CLV_PCSK_KEX2_1	241	243	PF00082	0.673
CLV_PCSK_KEX2_1	395	397	PF00082	0.698
CLV_PCSK_KEX2_1	486	488	PF00082	0.705
CLV_PCSK_KEX2_1	581	583	PF00082	0.567
CLV_PCSK_KEX2_1	667	669	PF00082	0.650
CLV_PCSK_KEX2_1	718	720	PF00082	0.715
CLV_PCSK_KEX2_1	740	742	PF00082	0.683
CLV_PCSK_KEX2_1	745	747	PF00082	0.606
CLV_PCSK_KEX2_1	76	78	PF00082	0.549
CLV_PCSK_KEX2_1	814	816	PF00082	0.700
CLV_PCSK_KEX2_1	979	981	PF00082	0.690
CLV_PCSK_PC1ET2_1	581	583	PF00082	0.524
CLV_PCSK_PC1ET2_1	814	816	PF00082	0.579
CLV_PCSK_PC7_1	72	78	PF00082	0.454
CLV_PCSK_PC7_1	741	747	PF00082	0.589
CLV_PCSK_SKI1_1	1047	1051	PF00082	0.524
CLV_PCSK_SKI1_1	1071	1075	PF00082	0.520
CLV_PCSK_SKI1_1	354	358	PF00082	0.549
CLV_PCSK_SKI1_1	532	536	PF00082	0.615
CLV_PCSK_SKI1_1	578	582	PF00082	0.524
CLV_PCSK_SKI1_1	702	706	PF00082	0.613
CLV_PCSK_SKI1_1	746	750	PF00082	0.576
CLV_Separin_Metazoa	529	533	PF03568	0.611
DEG_APCC_DBOX_1	1046	1054	PF00400	0.523
DEG_APCC_DBOX_1	1070	1078	PF00400	0.524
DEG_SPOP_SBC_1	599	603	PF00917	0.515
DOC_CKS1_1	355	360	PF01111	0.709
DOC_CKS1_1	871	876	PF01111	0.622
DOC_CYCLIN_RxL_1	1067	1079	PF00134	0.522
DOC_CYCLIN_RxL_1	699	709	PF00134	0.619
DOC_CYCLIN_yCln2_LP_2	792	798	PF00134	0.520
DOC_MAPK_gen_1	1045	1055	PF00069	0.522
DOC_MAPK_gen_1	144	154	PF00069	0.609
DOC_MAPK_gen_1	58	68	PF00069	0.503
DOC_MAPK_MEF2A_6	1071	1078	PF00069	0.523
DOC_MAPK_MEF2A_6	61	70	PF00069	0.494
DOC_MAPK_MEF2A_6	785	794	PF00069	0.639
DOC_MAPK_NFAT4_5	1071	1079	PF00069	0.526
DOC_PP1_RVXF_1	666	673	PF00149	0.650
DOC_PP2B_LxvP_1	264	267	PF13499	0.574
DOC_PP2B_LxvP_1	646	649	PF13499	0.765
DOC_PP2B_LxvP_1	68	71	PF13499	0.464
DOC_PP2B_LxvP_1	733	736	PF13499	0.520
DOC_PP2B_LxvP_1	792	795	PF13499	0.739
DOC_USP7_MATH_1	168	172	PF00917	0.678
DOC_USP7_MATH_1	247	251	PF00917	0.678
DOC_USP7_MATH_1	356	360	PF00917	0.706
DOC_USP7_MATH_1	431	435	PF00917	0.671
DOC_USP7_MATH_1	567	571	PF00917	0.623
DOC_USP7_MATH_1	636	640	PF00917	0.673
DOC_USP7_MATH_1	689	693	PF00917	0.652
DOC_USP7_MATH_1	726	730	PF00917	0.690
DOC_USP7_MATH_1	770	774	PF00917	0.581
DOC_USP7_MATH_1	796	800	PF00917	0.645
DOC_USP7_MATH_1	831	835	PF00917	0.752
DOC_USP7_MATH_1	839	843	PF00917	0.712
DOC_USP7_MATH_1	856	860	PF00917	0.600
DOC_USP7_MATH_1	907	911	PF00917	0.638
DOC_USP7_MATH_1	919	923	PF00917	0.555
DOC_USP7_UBL2_3	828	832	PF12436	0.653
DOC_WW_Pin1_4	176	181	PF00397	0.663
DOC_WW_Pin1_4	227	232	PF00397	0.705
DOC_WW_Pin1_4	344	349	PF00397	0.705
DOC_WW_Pin1_4	354	359	PF00397	0.618
DOC_WW_Pin1_4	42	47	PF00397	0.525
DOC_WW_Pin1_4	426	431	PF00397	0.510
DOC_WW_Pin1_4	550	555	PF00397	0.692
DOC_WW_Pin1_4	622	627	PF00397	0.695
DOC_WW_Pin1_4	786	791	PF00397	0.676
DOC_WW_Pin1_4	815	820	PF00397	0.671
DOC_WW_Pin1_4	870	875	PF00397	0.624
DOC_WW_Pin1_4	922	927	PF00397	0.514
LIG_14-3-3_CanoR_1	1006	1014	PF00244	0.518
LIG_14-3-3_CanoR_1	144	154	PF00244	0.609
LIG_14-3-3_CanoR_1	253	258	PF00244	0.525
LIG_14-3-3_CanoR_1	360	366	PF00244	0.590
LIG_14-3-3_CanoR_1	417	425	PF00244	0.688
LIG_14-3-3_CanoR_1	453	462	PF00244	0.517
LIG_14-3-3_CanoR_1	532	537	PF00244	0.523
LIG_14-3-3_CanoR_1	598	606	PF00244	0.582
LIG_14-3-3_CanoR_1	667	671	PF00244	0.679
LIG_14-3-3_CanoR_1	67	71	PF00244	0.470
LIG_14-3-3_CanoR_1	731	736	PF00244	0.650
LIG_14-3-3_CanoR_1	888	894	PF00244	0.674
LIG_14-3-3_CanoR_1	909	917	PF00244	0.636
LIG_Actin_WH2_2	895	911	PF00022	0.635
LIG_BIR_II_1	1	5	PF00653	0.510
LIG_BIR_III_2	914	918	PF00653	0.512
LIG_BIR_III_4	38	42	PF00653	0.574
LIG_BIR_III_4	897	901	PF00653	0.638
LIG_Clathr_ClatBox_1	1075	1079	PF01394	0.530
LIG_Clathr_ClatBox_1	704	708	PF01394	0.630
LIG_CtBP_PxDLS_1	492	496	PF00389	0.525
LIG_deltaCOP1_diTrp_1	585	594	PF00928	0.692
LIG_FHA_1	1007	1013	PF00498	0.736
LIG_FHA_1	1030	1036	PF00498	0.647
LIG_FHA_1	115	121	PF00498	0.512
LIG_FHA_1	153	159	PF00498	0.583
LIG_FHA_1	318	324	PF00498	0.688
LIG_FHA_1	42	48	PF00498	0.525
LIG_FHA_1	5	11	PF00498	0.631
LIG_FHA_1	554	560	PF00498	0.532
LIG_FHA_1	600	606	PF00498	0.551
LIG_FHA_1	677	683	PF00498	0.593
LIG_FHA_1	888	894	PF00498	0.552
LIG_FHA_1	985	991	PF00498	0.560
LIG_FHA_2	19	25	PF00498	0.607
LIG_FHA_2	232	238	PF00498	0.535
LIG_FHA_2	267	273	PF00498	0.684
LIG_FHA_2	28	34	PF00498	0.481
LIG_FHA_2	84	90	PF00498	0.552
LIG_Integrin_RGD_1	673	675	PF01839	0.602
LIG_LIR_Apic_2	585	590	PF02991	0.647
LIG_LIR_Gen_1	29	39	PF02991	0.510
LIG_LIR_Gen_1	50	59	PF02991	0.425
LIG_LIR_Gen_1	591	599	PF02991	0.725
LIG_LIR_Gen_1	6	15	PF02991	0.550
LIG_LIR_LC3C_4	987	991	PF02991	0.578
LIG_LIR_Nem_3	26	31	PF02991	0.506
LIG_LIR_Nem_3	50	54	PF02991	0.509
LIG_LIR_Nem_3	55	60	PF02991	0.540
LIG_LIR_Nem_3	591	597	PF02991	0.727
LIG_LIR_Nem_3	6	11	PF02991	0.553
LIG_LIR_Nem_3	89	94	PF02991	0.429
LIG_NRBOX	1069	1075	PF00104	0.520
LIG_PDZ_Class_3	1078	1083	PF00595	0.498
LIG_RPA_C_Fungi	140	152	PF08784	0.579
LIG_SH2_CRK	1052	1056	PF00017	0.517
LIG_SH2_CRK	161	165	PF00017	0.659
LIG_SH2_CRK	8	12	PF00017	0.533
LIG_SH2_GRB2like	1052	1055	PF00017	0.520
LIG_SH2_NCK_1	8	12	PF00017	0.489
LIG_SH2_NCK_1	936	940	PF00017	0.632
LIG_SH2_STAP1	28	32	PF00017	0.505
LIG_SH2_STAT3	214	217	PF00017	0.577
LIG_SH2_STAT5	1037	1040	PF00017	0.614
LIG_SH2_STAT5	700	703	PF00017	0.599
LIG_SH3_2	780	785	PF14604	0.625
LIG_SH3_3	151	157	PF00018	0.629
LIG_SH3_3	424	430	PF00018	0.510
LIG_SH3_3	649	655	PF00018	0.694
LIG_SH3_3	659	665	PF00018	0.653
LIG_SH3_3	678	684	PF00018	0.560
LIG_SH3_3	708	714	PF00018	0.785
LIG_SH3_3	777	783	PF00018	0.768
LIG_SH3_3	792	798	PF00018	0.631
LIG_SH3_3	871	877	PF00018	0.666
LIG_SH3_3	880	886	PF00018	0.604
LIG_SH3_3	899	905	PF00018	0.610
LIG_SH3_3	991	997	PF00018	0.560
LIG_SH3_4	713	720	PF00018	0.667
LIG_SUMO_SIM_anti_2	116	123	PF11976	0.437
LIG_SUMO_SIM_par_1	889	895	PF11976	0.631
LIG_TRAF2_1	189	192	PF00917	0.616
LIG_TRAF2_1	555	558	PF00917	0.649
LIG_TRAF2_1	706	709	PF00917	0.493
LIG_TRAF2_1	927	930	PF00917	0.624
LIG_TRAF2_1	938	941	PF00917	0.589
LIG_TYR_ITIM	1050	1055	PF00017	0.524
LIG_WW_2	780	783	PF00397	0.550
MOD_CDC14_SPxK_1	45	48	PF00782	0.510
MOD_CDK_SPK_2	176	181	PF00069	0.663
MOD_CDK_SPK_2	344	349	PF00069	0.705
MOD_CDK_SPxK_1	354	360	PF00069	0.710
MOD_CDK_SPxK_1	42	48	PF00069	0.525
MOD_CDK_SPxK_1	622	628	PF00069	0.698
MOD_CDK_SPxK_1	870	876	PF00069	0.503
MOD_CK1_1	1024	1030	PF00069	0.660
MOD_CK1_1	110	116	PF00069	0.519
MOD_CK1_1	150	156	PF00069	0.567
MOD_CK1_1	179	185	PF00069	0.648
MOD_CK1_1	186	192	PF00069	0.562
MOD_CK1_1	278	284	PF00069	0.661
MOD_CK1_1	318	324	PF00069	0.598
MOD_CK1_1	4	10	PF00069	0.567
MOD_CK1_1	416	422	PF00069	0.691
MOD_CK1_1	438	444	PF00069	0.677
MOD_CK1_1	520	526	PF00069	0.666
MOD_CK1_1	553	559	PF00069	0.577
MOD_CK1_1	630	636	PF00069	0.706
MOD_CK1_1	666	672	PF00069	0.646
MOD_CK1_1	842	848	PF00069	0.603
MOD_CK1_1	881	887	PF00069	0.685
MOD_CK1_1	910	916	PF00069	0.653
MOD_CK1_1	922	928	PF00069	0.645
MOD_CK2_1	1038	1044	PF00069	0.565
MOD_CK2_1	150	156	PF00069	0.624
MOD_CK2_1	18	24	PF00069	0.590
MOD_CK2_1	186	192	PF00069	0.687
MOD_CK2_1	266	272	PF00069	0.683
MOD_CK2_1	27	33	PF00069	0.418
MOD_CK2_1	385	391	PF00069	0.554
MOD_CK2_1	438	444	PF00069	0.668
MOD_CK2_1	654	660	PF00069	0.684
MOD_Cter_Amidation	201	204	PF01082	0.524
MOD_GlcNHglycan	109	112	PF01048	0.614
MOD_GlcNHglycan	147	150	PF01048	0.464
MOD_GlcNHglycan	15	18	PF01048	0.659
MOD_GlcNHglycan	186	189	PF01048	0.700
MOD_GlcNHglycan	21	24	PF01048	0.637
MOD_GlcNHglycan	245	248	PF01048	0.645
MOD_GlcNHglycan	279	283	PF01048	0.639
MOD_GlcNHglycan	298	301	PF01048	0.576
MOD_GlcNHglycan	457	460	PF01048	0.685
MOD_GlcNHglycan	509	512	PF01048	0.608
MOD_GlcNHglycan	569	572	PF01048	0.659
MOD_GlcNHglycan	633	636	PF01048	0.677
MOD_GlcNHglycan	656	659	PF01048	0.673
MOD_GlcNHglycan	691	694	PF01048	0.587
MOD_GlcNHglycan	733	736	PF01048	0.640
MOD_GlcNHglycan	802	805	PF01048	0.612
MOD_GlcNHglycan	858	861	PF01048	0.706
MOD_GlcNHglycan	880	883	PF01048	0.651
MOD_GlcNHglycan	909	912	PF01048	0.644
MOD_GlcNHglycan	921	924	PF01048	0.559
MOD_GSK3_1	1002	1009	PF00069	0.668
MOD_GSK3_1	1021	1028	PF00069	0.502
MOD_GSK3_1	107	114	PF00069	0.653
MOD_GSK3_1	175	182	PF00069	0.678
MOD_GSK3_1	183	190	PF00069	0.596
MOD_GSK3_1	19	26	PF00069	0.471
MOD_GSK3_1	223	230	PF00069	0.711
MOD_GSK3_1	243	250	PF00069	0.646
MOD_GSK3_1	313	320	PF00069	0.556
MOD_GSK3_1	327	334	PF00069	0.594
MOD_GSK3_1	350	357	PF00069	0.668
MOD_GSK3_1	431	438	PF00069	0.600
MOD_GSK3_1	600	607	PF00069	0.695
MOD_GSK3_1	620	627	PF00069	0.585
MOD_GSK3_1	631	638	PF00069	0.640
MOD_GSK3_1	722	729	PF00069	0.627
MOD_GSK3_1	748	755	PF00069	0.685
MOD_GSK3_1	786	793	PF00069	0.664
MOD_GSK3_1	796	803	PF00069	0.628
MOD_GSK3_1	850	857	PF00069	0.655
MOD_GSK3_1	962	969	PF00069	0.769
MOD_LATS_1	394	400	PF00433	0.694
MOD_N-GLC_1	41	46	PF02516	0.500
MOD_N-GLC_1	599	604	PF02516	0.514
MOD_N-GLC_1	800	805	PF02516	0.574
MOD_NEK2_1	132	137	PF00069	0.405
MOD_NEK2_1	183	188	PF00069	0.589
MOD_NEK2_1	27	32	PF00069	0.557
MOD_NEK2_1	298	303	PF00069	0.502
MOD_NEK2_1	327	332	PF00069	0.685
MOD_NEK2_1	66	71	PF00069	0.468
MOD_NEK2_1	984	989	PF00069	0.590
MOD_NEK2_2	23	28	PF00069	0.506
MOD_NEK2_2	636	641	PF00069	0.648
MOD_NEK2_2	726	731	PF00069	0.650
MOD_PIKK_1	1026	1032	PF00454	0.651
MOD_PIKK_1	1054	1060	PF00454	0.513
MOD_PIKK_1	187	193	PF00454	0.688
MOD_PIKK_1	315	321	PF00454	0.599
MOD_PIKK_1	542	548	PF00454	0.639
MOD_PIKK_1	589	595	PF00454	0.626
MOD_PIKK_1	83	89	PF00454	0.546
MOD_PIKK_1	979	985	PF00454	0.697
MOD_PKA_1	396	402	PF00069	0.642
MOD_PKA_1	712	718	PF00069	0.545
MOD_PKA_1	979	985	PF00069	0.653
MOD_PKA_2	1022	1028	PF00069	0.675
MOD_PKA_2	1038	1044	PF00069	0.397
MOD_PKA_2	150	156	PF00069	0.567
MOD_PKA_2	223	229	PF00069	0.709
MOD_PKA_2	252	258	PF00069	0.664
MOD_PKA_2	385	391	PF00069	0.707
MOD_PKA_2	396	402	PF00069	0.674
MOD_PKA_2	416	422	PF00069	0.549
MOD_PKA_2	485	491	PF00069	0.705
MOD_PKA_2	627	633	PF00069	0.713
MOD_PKA_2	66	72	PF00069	0.472
MOD_PKA_2	666	672	PF00069	0.665
MOD_PKA_2	689	695	PF00069	0.616
MOD_PKA_2	796	802	PF00069	0.571
MOD_PKA_2	808	814	PF00069	0.661
MOD_PKA_2	887	893	PF00069	0.632
MOD_PKA_2	979	985	PF00069	0.697
MOD_PKB_1	145	153	PF00069	0.617
MOD_PKB_1	815	823	PF00069	0.695
MOD_Plk_1	23	29	PF00069	0.614
MOD_Plk_1	520	526	PF00069	0.622
MOD_Plk_1	707	713	PF00069	0.708
MOD_Plk_1	770	776	PF00069	0.524
MOD_Plk_1	842	848	PF00069	0.633
MOD_Plk_1	850	856	PF00069	0.554
MOD_Plk_2-3	80	86	PF00069	0.372
MOD_Plk_2-3	850	856	PF00069	0.527
MOD_Plk_4	114	120	PF00069	0.531
MOD_Plk_4	6	12	PF00069	0.644
MOD_ProDKin_1	176	182	PF00069	0.666
MOD_ProDKin_1	227	233	PF00069	0.703
MOD_ProDKin_1	344	350	PF00069	0.706
MOD_ProDKin_1	354	360	PF00069	0.617
MOD_ProDKin_1	42	48	PF00069	0.525
MOD_ProDKin_1	426	432	PF00069	0.510
MOD_ProDKin_1	550	556	PF00069	0.693
MOD_ProDKin_1	622	628	PF00069	0.698
MOD_ProDKin_1	786	792	PF00069	0.678
MOD_ProDKin_1	815	821	PF00069	0.674
MOD_ProDKin_1	870	876	PF00069	0.624
MOD_ProDKin_1	922	928	PF00069	0.511
MOD_SUMO_for_1	875	878	PF00179	0.508
MOD_SUMO_rev_2	845	854	PF00179	0.536
MOD_SUMO_rev_2	910	917	PF00179	0.642
TRG_DiLeu_BaLyEn_6	1031	1036	PF01217	0.645
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.508
TRG_DiLeu_BaLyEn_6	787	792	PF01217	0.513
TRG_ENDOCYTIC_2	1052	1055	PF00928	0.520
TRG_ENDOCYTIC_2	31	34	PF00928	0.473
TRG_ENDOCYTIC_2	51	54	PF00928	0.558
TRG_ENDOCYTIC_2	8	11	PF00928	0.530
TRG_ENDOCYTIC_2	91	94	PF00928	0.434
TRG_ENDOCYTIC_2	936	939	PF00928	0.634
TRG_ER_diArg_1	1045	1048	PF00400	0.519
TRG_ER_diArg_1	144	147	PF00400	0.583
TRG_ER_diArg_1	214	216	PF00400	0.566
TRG_ER_diArg_1	395	397	PF00400	0.654
TRG_ER_diArg_1	716	719	PF00400	0.668
TRG_ER_diArg_1	738	741	PF00400	0.687
TRG_ER_diArg_1	75	77	PF00400	0.551
TRG_ER_diArg_1	815	817	PF00400	0.691
TRG_NES_CRM1_1	1068	1081	PF08389	0.523
TRG_NLS_MonoCore_2	813	818	PF00514	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ICE9	Leishmania donovani	80%	100%
A4HCG4	Leishmania braziliensis	66%	98%
E9AGZ6	Leishmania infantum	80%	100%
Q4QBM1	Leishmania major	82%	100%