Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVV7_LEIMU

TriTrypDb:

LmxM.22.1250

Length:

451

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	7
GO:0032991	protein-containing complex	1	7
GO:0043226	organelle	2	7
GO:0043228	non-membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043232	intracellular non-membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7
GO:1990904	ribonucleoprotein complex	2	7

Expansion

Sequence features

E9AVV7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVV7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	281	285	PF00656	0.621
CLV_NRD_NRD_1	324	326	PF00675	0.790
CLV_NRD_NRD_1	94	96	PF00675	0.432
CLV_PCSK_KEX2_1	324	326	PF00082	0.702
CLV_PCSK_KEX2_1	94	96	PF00082	0.432
CLV_PCSK_SKI1_1	324	328	PF00082	0.624
CLV_PCSK_SKI1_1	383	387	PF00082	0.438
CLV_PCSK_SKI1_1	405	409	PF00082	0.404
CLV_PCSK_SKI1_1	423	427	PF00082	0.501
DEG_Nend_Nbox_1	1	3	PF02207	0.416
DEG_SPOP_SBC_1	180	184	PF00917	0.379
DEG_SPOP_SBC_1	192	196	PF00917	0.425
DEG_SPOP_SBC_1	264	268	PF00917	0.591
DOC_CYCLIN_RxL_1	109	120	PF00134	0.390
DOC_CYCLIN_RxL_1	369	381	PF00134	0.390
DOC_CYCLIN_RxL_1	420	430	PF00134	0.381
DOC_PP1_RVXF_1	372	379	PF00149	0.367
DOC_PP2B_LxvP_1	114	117	PF13499	0.381
DOC_PP2B_LxvP_1	150	153	PF13499	0.410
DOC_PP2B_LxvP_1	251	254	PF13499	0.535
DOC_PP4_FxxP_1	237	240	PF00568	0.416
DOC_USP7_MATH_1	117	121	PF00917	0.530
DOC_USP7_MATH_1	128	132	PF00917	0.499
DOC_USP7_MATH_1	206	210	PF00917	0.354
DOC_USP7_MATH_1	254	258	PF00917	0.646
DOC_USP7_MATH_1	264	268	PF00917	0.607
DOC_USP7_MATH_1	286	290	PF00917	0.614
DOC_USP7_MATH_1	314	318	PF00917	0.636
DOC_USP7_MATH_1	341	345	PF00917	0.325
DOC_USP7_MATH_1	49	53	PF00917	0.541
DOC_WW_Pin1_4	16	21	PF00397	0.387
DOC_WW_Pin1_4	417	422	PF00397	0.385
LIG_14-3-3_CanoR_1	159	163	PF00244	0.474
LIG_14-3-3_CanoR_1	179	189	PF00244	0.371
LIG_14-3-3_CanoR_1	208	213	PF00244	0.393
LIG_14-3-3_CanoR_1	229	235	PF00244	0.487
LIG_14-3-3_CanoR_1	439	447	PF00244	0.345
LIG_BRCT_BRCA1_1	14	18	PF00533	0.372
LIG_BRCT_BRCA1_1	288	292	PF00533	0.541
LIG_CSL_BTD_1	114	117	PF09270	0.381
LIG_DLG_GKlike_1	208	216	PF00625	0.458
LIG_FHA_1	180	186	PF00498	0.420
LIG_FHA_1	193	199	PF00498	0.444
LIG_FHA_1	37	43	PF00498	0.372
LIG_FHA_1	399	405	PF00498	0.412
LIG_FHA_1	442	448	PF00498	0.535
LIG_FHA_1	8	14	PF00498	0.423
LIG_FHA_2	171	177	PF00498	0.472
LIG_FHA_2	182	188	PF00498	0.368
LIG_FHA_2	198	204	PF00498	0.352
LIG_FHA_2	22	28	PF00498	0.535
LIG_FHA_2	231	237	PF00498	0.616
LIG_FHA_2	32	38	PF00498	0.326
LIG_FHA_2	384	390	PF00498	0.365
LIG_FHA_2	426	432	PF00498	0.364
LIG_FHA_2	79	85	PF00498	0.469
LIG_LIR_Apic_2	235	240	PF02991	0.413
LIG_LIR_Gen_1	131	139	PF02991	0.351
LIG_LIR_Gen_1	74	82	PF02991	0.445
LIG_LIR_Nem_3	131	137	PF02991	0.371
LIG_LIR_Nem_3	74	80	PF02991	0.445
LIG_Pex14_1	438	442	PF04695	0.395
LIG_Pex14_2	348	352	PF04695	0.340
LIG_SH2_CRK	77	81	PF00017	0.477
LIG_SH2_SRC	146	149	PF00017	0.364
LIG_SH2_STAT5	146	149	PF00017	0.364
LIG_SH2_STAT5	372	375	PF00017	0.367
LIG_SH2_STAT5	77	80	PF00017	0.519
LIG_SH3_3	163	169	PF00018	0.462
LIG_SH3_3	186	192	PF00018	0.368
LIG_SH3_3	242	248	PF00018	0.423
LIG_SUMO_SIM_par_1	243	249	PF11976	0.423
LIG_SUMO_SIM_par_1	383	392	PF11976	0.360
MOD_CDC14_SPxK_1	420	423	PF00782	0.484
MOD_CDK_SPxK_1	417	423	PF00069	0.458
MOD_CK1_1	135	141	PF00069	0.346
MOD_CK1_1	181	187	PF00069	0.372
MOD_CK1_1	266	272	PF00069	0.707
MOD_CK1_1	388	394	PF00069	0.359
MOD_CK1_1	417	423	PF00069	0.393
MOD_CK2_1	152	158	PF00069	0.580
MOD_CK2_1	197	203	PF00069	0.351
MOD_CK2_1	21	27	PF00069	0.498
MOD_CK2_1	230	236	PF00069	0.594
MOD_CK2_1	389	395	PF00069	0.381
MOD_GlcNHglycan	103	106	PF01048	0.371
MOD_GlcNHglycan	130	133	PF01048	0.533
MOD_GlcNHglycan	137	140	PF01048	0.373
MOD_GlcNHglycan	154	157	PF01048	0.532
MOD_GlcNHglycan	248	251	PF01048	0.486
MOD_GlcNHglycan	316	319	PF01048	0.691
MOD_GlcNHglycan	34	37	PF01048	0.452
MOD_GlcNHglycan	416	419	PF01048	0.366
MOD_GSK3_1	12	19	PF00069	0.432
MOD_GSK3_1	123	130	PF00069	0.573
MOD_GSK3_1	154	161	PF00069	0.572
MOD_GSK3_1	193	200	PF00069	0.389
MOD_GSK3_1	3	10	PF00069	0.410
MOD_GSK3_1	309	316	PF00069	0.736
MOD_GSK3_1	32	39	PF00069	0.365
MOD_GSK3_1	385	392	PF00069	0.415
MOD_GSK3_1	413	420	PF00069	0.363
MOD_GSK3_1	71	78	PF00069	0.499
MOD_GSK3_1	80	87	PF00069	0.447
MOD_N-GLC_1	219	224	PF02516	0.537
MOD_N-GLC_2	121	123	PF02516	0.457
MOD_NEK2_1	178	183	PF00069	0.417
MOD_NEK2_1	218	223	PF00069	0.548
MOD_NEK2_1	30	35	PF00069	0.364
MOD_NEK2_1	413	418	PF00069	0.362
MOD_NEK2_1	425	430	PF00069	0.353
MOD_PIKK_1	49	55	PF00454	0.475
MOD_PKA_1	324	330	PF00069	0.605
MOD_PKA_2	158	164	PF00069	0.467
MOD_PKA_2	178	184	PF00069	0.382
MOD_PKA_2	324	330	PF00069	0.605
MOD_Plk_1	219	225	PF00069	0.534
MOD_Plk_1	37	43	PF00069	0.393
MOD_Plk_1	389	395	PF00069	0.361
MOD_Plk_1	84	90	PF00069	0.469
MOD_Plk_4	12	18	PF00069	0.367
MOD_Plk_4	170	176	PF00069	0.360
MOD_Plk_4	193	199	PF00069	0.368
MOD_Plk_4	75	81	PF00069	0.516
MOD_ProDKin_1	16	22	PF00069	0.392
MOD_ProDKin_1	417	423	PF00069	0.393
MOD_SUMO_rev_2	377	385	PF00179	0.465
TRG_DiLeu_BaLyEn_6	226	231	PF01217	0.460
TRG_ENDOCYTIC_2	77	80	PF00928	0.477
TRG_ER_diArg_1	323	325	PF00400	0.688
TRG_ER_diArg_1	93	95	PF00400	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM43	Leptomonas seymouri	68%	100%
A0A3S7WX82	Leishmania donovani	91%	100%
A4HCG2	Leishmania braziliensis	86%	100%
E9AGZ5	Leishmania infantum	91%	100%
Q4QBM2	Leishmania major	94%	100%