Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVV5_LEIMU

TriTrypDb:

LmxM.22.1230

Length:

919

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVV5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVV5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	267	271	PF00656	0.809
CLV_C14_Caspase3-7	372	376	PF00656	0.613
CLV_C14_Caspase3-7	71	75	PF00656	0.706
CLV_NRD_NRD_1	153	155	PF00675	0.692
CLV_NRD_NRD_1	25	27	PF00675	0.749
CLV_NRD_NRD_1	302	304	PF00675	0.723
CLV_NRD_NRD_1	488	490	PF00675	0.487
CLV_NRD_NRD_1	501	503	PF00675	0.425
CLV_NRD_NRD_1	519	521	PF00675	0.431
CLV_NRD_NRD_1	610	612	PF00675	0.543
CLV_NRD_NRD_1	631	633	PF00675	0.492
CLV_NRD_NRD_1	808	810	PF00675	0.494
CLV_NRD_NRD_1	816	818	PF00675	0.665
CLV_PCSK_KEX2_1	152	154	PF00082	0.709
CLV_PCSK_KEX2_1	232	234	PF00082	0.758
CLV_PCSK_KEX2_1	25	27	PF00082	0.753
CLV_PCSK_KEX2_1	302	304	PF00082	0.755
CLV_PCSK_KEX2_1	363	365	PF00082	0.696
CLV_PCSK_KEX2_1	487	489	PF00082	0.499
CLV_PCSK_KEX2_1	501	503	PF00082	0.413
CLV_PCSK_KEX2_1	519	521	PF00082	0.431
CLV_PCSK_KEX2_1	610	612	PF00082	0.546
CLV_PCSK_KEX2_1	630	632	PF00082	0.261
CLV_PCSK_KEX2_1	816	818	PF00082	0.704
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.758
CLV_PCSK_PC1ET2_1	363	365	PF00082	0.696
CLV_PCSK_PC1ET2_1	487	489	PF00082	0.506
CLV_PCSK_PC7_1	21	27	PF00082	0.527
CLV_PCSK_PC7_1	359	365	PF00082	0.695
CLV_PCSK_SKI1_1	285	289	PF00082	0.622
CLV_PCSK_SKI1_1	29	33	PF00082	0.514
CLV_PCSK_SKI1_1	359	363	PF00082	0.697
CLV_PCSK_SKI1_1	422	426	PF00082	0.435
CLV_PCSK_SKI1_1	54	58	PF00082	0.646
CLV_PCSK_SKI1_1	571	575	PF00082	0.509
CLV_PCSK_SKI1_1	594	598	PF00082	0.667
CLV_PCSK_SKI1_1	656	660	PF00082	0.534
CLV_PCSK_SKI1_1	778	782	PF00082	0.488
CLV_PCSK_SKI1_1	784	788	PF00082	0.473
CLV_PCSK_SKI1_1	809	813	PF00082	0.530
CLV_PCSK_SKI1_1	90	94	PF00082	0.620
CLV_PCSK_SKI1_1	906	910	PF00082	0.522
DEG_APCC_DBOX_1	151	159	PF00400	0.641
DEG_APCC_DBOX_1	358	366	PF00400	0.697
DEG_APCC_DBOX_1	53	61	PF00400	0.407
DEG_Nend_UBRbox_1	1	4	PF02207	0.511
DEG_SCF_FBW7_1	258	265	PF00400	0.706
DEG_SPOP_SBC_1	335	339	PF00917	0.734
DOC_CKS1_1	1	6	PF01111	0.507
DOC_CKS1_1	259	264	PF01111	0.833
DOC_CKS1_1	33	38	PF01111	0.704
DOC_CKS1_1	353	358	PF01111	0.716
DOC_CYCLIN_yCln2_LP_2	600	606	PF00134	0.598
DOC_MAPK_DCC_7	29	39	PF00069	0.718
DOC_MAPK_FxFP_2	93	96	PF00069	0.587
DOC_MAPK_gen_1	25	33	PF00069	0.520
DOC_MAPK_gen_1	487	498	PF00069	0.450
DOC_MAPK_MEF2A_6	492	500	PF00069	0.370
DOC_MAPK_MEF2A_6	671	679	PF00069	0.424
DOC_PP1_RVXF_1	88	94	PF00149	0.615
DOC_PP2B_LxvP_1	480	483	PF13499	0.552
DOC_PP4_FxxP_1	93	96	PF00568	0.587
DOC_USP7_MATH_1	262	266	PF00917	0.641
DOC_USP7_MATH_1	399	403	PF00917	0.520
DOC_USP7_MATH_1	714	718	PF00917	0.520
DOC_USP7_MATH_1	72	76	PF00917	0.590
DOC_USP7_MATH_1	78	82	PF00917	0.697
DOC_USP7_MATH_1	879	883	PF00917	0.579
DOC_USP7_UBL2_3	136	140	PF12436	0.678
DOC_USP7_UBL2_3	914	918	PF12436	0.541
DOC_WW_Pin1_4	140	145	PF00397	0.705
DOC_WW_Pin1_4	239	244	PF00397	0.739
DOC_WW_Pin1_4	258	263	PF00397	0.577
DOC_WW_Pin1_4	32	37	PF00397	0.710
DOC_WW_Pin1_4	352	357	PF00397	0.719
DOC_WW_Pin1_4	425	430	PF00397	0.729
DOC_WW_Pin1_4	677	682	PF00397	0.516
DOC_WW_Pin1_4	743	748	PF00397	0.611
DOC_WW_Pin1_4	771	776	PF00397	0.455
DOC_WW_Pin1_4	799	804	PF00397	0.547
LIG_14-3-3_CanoR_1	2	8	PF00244	0.501
LIG_14-3-3_CanoR_1	210	214	PF00244	0.601
LIG_14-3-3_CanoR_1	26	32	PF00244	0.737
LIG_14-3-3_CanoR_1	305	313	PF00244	0.732
LIG_14-3-3_CanoR_1	319	327	PF00244	0.712
LIG_14-3-3_CanoR_1	364	374	PF00244	0.607
LIG_14-3-3_CanoR_1	422	430	PF00244	0.538
LIG_14-3-3_CanoR_1	438	442	PF00244	0.721
LIG_14-3-3_CanoR_1	489	499	PF00244	0.489
LIG_14-3-3_CanoR_1	622	629	PF00244	0.525
LIG_14-3-3_CanoR_1	639	648	PF00244	0.519
LIG_Actin_WH2_2	550	565	PF00022	0.688
LIG_APCC_ABBA_1	522	527	PF00400	0.504
LIG_BIR_III_2	426	430	PF00653	0.636
LIG_eIF4E_1	623	629	PF01652	0.519
LIG_FHA_1	174	180	PF00498	0.418
LIG_FHA_1	28	34	PF00498	0.733
LIG_FHA_1	572	578	PF00498	0.530
LIG_FHA_1	911	917	PF00498	0.509
LIG_FHA_2	144	150	PF00498	0.700
LIG_FHA_2	259	265	PF00498	0.765
LIG_FHA_2	343	349	PF00498	0.670
LIG_FHA_2	457	463	PF00498	0.469
LIG_FHA_2	530	536	PF00498	0.606
LIG_FHA_2	680	686	PF00498	0.592
LIG_FHA_2	69	75	PF00498	0.734
LIG_FHA_2	81	87	PF00498	0.513
LIG_FHA_2	851	857	PF00498	0.591
LIG_IBAR_NPY_1	742	744	PF08397	0.491
LIG_LIR_Apic_2	583	587	PF02991	0.478
LIG_LIR_Apic_2	741	747	PF02991	0.623
LIG_LIR_Apic_2	771	775	PF02991	0.297
LIG_LIR_Gen_1	324	335	PF02991	0.699
LIG_LIR_Gen_1	417	424	PF02991	0.635
LIG_LIR_Gen_1	462	472	PF02991	0.450
LIG_LIR_Gen_1	534	545	PF02991	0.682
LIG_LIR_Gen_1	615	623	PF02991	0.459
LIG_LIR_Gen_1	673	681	PF02991	0.488
LIG_LIR_Gen_1	86	96	PF02991	0.598
LIG_LIR_Nem_3	324	330	PF02991	0.612
LIG_LIR_Nem_3	417	421	PF02991	0.688
LIG_LIR_Nem_3	462	467	PF02991	0.438
LIG_LIR_Nem_3	534	540	PF02991	0.679
LIG_LIR_Nem_3	583	588	PF02991	0.478
LIG_LIR_Nem_3	615	619	PF02991	0.443
LIG_LIR_Nem_3	620	626	PF02991	0.485
LIG_LIR_Nem_3	673	679	PF02991	0.460
LIG_LIR_Nem_3	86	91	PF02991	0.577
LIG_LIR_Nem_3	889	894	PF02991	0.490
LIG_LYPXL_yS_3	397	400	PF13949	0.682
LIG_Pex14_1	640	644	PF04695	0.469
LIG_Pex14_2	608	612	PF04695	0.590
LIG_Pex14_2	792	796	PF04695	0.475
LIG_Pex14_2	88	92	PF04695	0.532
LIG_SH2_CRK	203	207	PF00017	0.671
LIG_SH2_CRK	327	331	PF00017	0.655
LIG_SH2_CRK	744	748	PF00017	0.613
LIG_SH2_CRK	772	776	PF00017	0.281
LIG_SH2_NCK_1	623	627	PF00017	0.606
LIG_SH2_NCK_1	772	776	PF00017	0.281
LIG_SH2_PTP2	434	437	PF00017	0.664
LIG_SH2_PTP2	469	472	PF00017	0.512
LIG_SH2_PTP2	674	677	PF00017	0.425
LIG_SH2_PTP2	756	759	PF00017	0.450
LIG_SH2_SRC	469	472	PF00017	0.512
LIG_SH2_SRC	674	677	PF00017	0.474
LIG_SH2_STAT5	320	323	PF00017	0.641
LIG_SH2_STAT5	360	363	PF00017	0.696
LIG_SH2_STAT5	434	437	PF00017	0.664
LIG_SH2_STAT5	469	472	PF00017	0.459
LIG_SH2_STAT5	506	509	PF00017	0.435
LIG_SH2_STAT5	584	587	PF00017	0.403
LIG_SH2_STAT5	595	598	PF00017	0.482
LIG_SH2_STAT5	674	677	PF00017	0.417
LIG_SH2_STAT5	756	759	PF00017	0.450
LIG_SH2_STAT5	768	771	PF00017	0.476
LIG_SH2_STAT5	890	893	PF00017	0.544
LIG_SH3_1	713	719	PF00018	0.537
LIG_SH3_2	131	136	PF14604	0.394
LIG_SH3_3	128	134	PF00018	0.479
LIG_SH3_3	252	258	PF00018	0.808
LIG_SH3_3	30	36	PF00018	0.722
LIG_SH3_3	312	318	PF00018	0.799
LIG_SH3_3	520	526	PF00018	0.541
LIG_SH3_3	558	564	PF00018	0.710
LIG_SH3_3	713	719	PF00018	0.537
LIG_SH3_3	777	783	PF00018	0.529
LIG_SH3_3	808	814	PF00018	0.660
LIG_SH3_3	867	873	PF00018	0.611
LIG_SUMO_SIM_anti_2	749	754	PF11976	0.480
LIG_SxIP_EBH_1	619	632	PF03271	0.590
LIG_TRAF2_1	532	535	PF00917	0.617
LIG_TRAF2_1	682	685	PF00917	0.529
LIG_TRAF2_1	84	87	PF00917	0.662
LIG_TRAF2_1	853	856	PF00917	0.557
LIG_TYR_ITIM	467	472	PF00017	0.511
LIG_TYR_ITSM	323	330	PF00017	0.634
LIG_WRC_WIRS_1	605	610	PF05994	0.456
LIG_WW_3	26	30	PF00397	0.753
LIG_WW_3	428	432	PF00397	0.615
LIG_WW_3	781	785	PF00397	0.558
MOD_CDC14_SPxK_1	428	431	PF00782	0.739
MOD_CDK_SPK_2	743	748	PF00069	0.611
MOD_CDK_SPxK_1	425	431	PF00069	0.734
MOD_CDK_SPxxK_3	140	147	PF00069	0.709
MOD_CDK_SPxxK_3	352	359	PF00069	0.719
MOD_CDK_SPxxK_3	771	778	PF00069	0.454
MOD_CK1_1	143	149	PF00069	0.490
MOD_CK1_1	17	23	PF00069	0.655
MOD_CK1_1	241	247	PF00069	0.707
MOD_CK1_1	253	259	PF00069	0.551
MOD_CK1_1	308	314	PF00069	0.737
MOD_CK1_1	6	12	PF00069	0.790
MOD_CK1_1	621	627	PF00069	0.604
MOD_CK1_1	81	87	PF00069	0.749
MOD_CK1_1	830	836	PF00069	0.665
MOD_CK2_1	190	196	PF00069	0.674
MOD_CK2_1	224	230	PF00069	0.687
MOD_CK2_1	258	264	PF00069	0.767
MOD_CK2_1	273	279	PF00069	0.499
MOD_CK2_1	342	348	PF00069	0.747
MOD_CK2_1	365	371	PF00069	0.639
MOD_CK2_1	529	535	PF00069	0.553
MOD_CK2_1	677	683	PF00069	0.453
MOD_CK2_1	743	749	PF00069	0.607
MOD_CK2_1	80	86	PF00069	0.658
MOD_CK2_1	829	835	PF00069	0.495
MOD_CK2_1	850	856	PF00069	0.614
MOD_CK2_1	865	871	PF00069	0.485
MOD_GlcNHglycan	243	246	PF01048	0.756
MOD_GlcNHglycan	252	255	PF01048	0.804
MOD_GlcNHglycan	307	310	PF01048	0.807
MOD_GlcNHglycan	338	341	PF01048	0.761
MOD_GlcNHglycan	387	390	PF01048	0.772
MOD_GlcNHglycan	636	639	PF01048	0.635
MOD_GlcNHglycan	76	79	PF01048	0.718
MOD_GlcNHglycan	80	83	PF01048	0.687
MOD_GlcNHglycan	831	835	PF01048	0.638
MOD_GlcNHglycan	867	870	PF01048	0.539
MOD_GSK3_1	114	121	PF00069	0.652
MOD_GSK3_1	17	24	PF00069	0.714
MOD_GSK3_1	224	231	PF00069	0.643
MOD_GSK3_1	258	265	PF00069	0.644
MOD_GSK3_1	318	325	PF00069	0.675
MOD_GSK3_1	334	341	PF00069	0.523
MOD_GSK3_1	365	372	PF00069	0.636
MOD_GSK3_1	379	386	PF00069	0.622
MOD_GSK3_1	452	459	PF00069	0.536
MOD_GSK3_1	5	12	PF00069	0.722
MOD_GSK3_1	617	624	PF00069	0.513
MOD_GSK3_1	66	73	PF00069	0.725
MOD_GSK3_1	74	81	PF00069	0.537
MOD_GSK3_1	906	913	PF00069	0.586
MOD_LATS_1	490	496	PF00433	0.481
MOD_N-GLC_1	384	389	PF02516	0.508
MOD_N-GLC_1	512	517	PF02516	0.631
MOD_N-GLC_1	598	603	PF02516	0.503
MOD_NEK2_1	126	131	PF00069	0.552
MOD_NEK2_1	238	243	PF00069	0.800
MOD_NEK2_1	365	370	PF00069	0.636
MOD_NEK2_1	518	523	PF00069	0.531
MOD_NEK2_1	569	574	PF00069	0.550
MOD_NEK2_1	604	609	PF00069	0.348
MOD_NEK2_1	661	666	PF00069	0.440
MOD_NEK2_1	877	882	PF00069	0.536
MOD_NEK2_2	173	178	PF00069	0.425
MOD_NEK2_2	804	809	PF00069	0.642
MOD_PIKK_1	190	196	PF00454	0.777
MOD_PKA_2	20	26	PF00069	0.684
MOD_PKA_2	209	215	PF00069	0.608
MOD_PKA_2	279	285	PF00069	0.517
MOD_PKA_2	318	324	PF00069	0.681
MOD_PKA_2	365	371	PF00069	0.606
MOD_PKA_2	408	414	PF00069	0.635
MOD_PKA_2	437	443	PF00069	0.642
MOD_PKA_2	491	497	PF00069	0.607
MOD_PKA_2	518	524	PF00069	0.474
MOD_PKA_2	562	568	PF00069	0.705
MOD_PKA_2	621	627	PF00069	0.533
MOD_PKB_1	303	311	PF00069	0.721
MOD_PKB_1	364	372	PF00069	0.674
MOD_Plk_1	569	575	PF00069	0.549
MOD_Plk_1	730	736	PF00069	0.634
MOD_Plk_4	279	285	PF00069	0.517
MOD_Plk_4	29	35	PF00069	0.779
MOD_Plk_4	322	328	PF00069	0.599
MOD_Plk_4	369	375	PF00069	0.658
MOD_Plk_4	414	420	PF00069	0.668
MOD_Plk_4	452	458	PF00069	0.628
MOD_Plk_4	492	498	PF00069	0.551
MOD_Plk_4	548	554	PF00069	0.580
MOD_Plk_4	580	586	PF00069	0.515
MOD_Plk_4	604	610	PF00069	0.586
MOD_Plk_4	784	790	PF00069	0.525
MOD_Plk_4	9	15	PF00069	0.507
MOD_ProDKin_1	140	146	PF00069	0.704
MOD_ProDKin_1	239	245	PF00069	0.739
MOD_ProDKin_1	258	264	PF00069	0.577
MOD_ProDKin_1	32	38	PF00069	0.707
MOD_ProDKin_1	352	358	PF00069	0.713
MOD_ProDKin_1	425	431	PF00069	0.737
MOD_ProDKin_1	677	683	PF00069	0.516
MOD_ProDKin_1	743	749	PF00069	0.606
MOD_ProDKin_1	771	777	PF00069	0.451
MOD_ProDKin_1	799	805	PF00069	0.546
MOD_SUMO_rev_2	159	167	PF00179	0.549
MOD_SUMO_rev_2	226	234	PF00179	0.728
TRG_DiLeu_BaEn_1	548	553	PF01217	0.629
TRG_DiLeu_BaEn_1	871	876	PF01217	0.481
TRG_ENDOCYTIC_2	132	135	PF00928	0.583
TRG_ENDOCYTIC_2	203	206	PF00928	0.681
TRG_ENDOCYTIC_2	320	323	PF00928	0.587
TRG_ENDOCYTIC_2	327	330	PF00928	0.571
TRG_ENDOCYTIC_2	397	400	PF00928	0.682
TRG_ENDOCYTIC_2	464	467	PF00928	0.444
TRG_ENDOCYTIC_2	469	472	PF00928	0.459
TRG_ENDOCYTIC_2	506	509	PF00928	0.409
TRG_ENDOCYTIC_2	623	626	PF00928	0.613
TRG_ENDOCYTIC_2	674	677	PF00928	0.423
TRG_ENDOCYTIC_2	690	693	PF00928	0.351
TRG_ER_diArg_1	151	154	PF00400	0.707
TRG_ER_diArg_1	25	27	PF00400	0.753
TRG_ER_diArg_1	364	367	PF00400	0.690
TRG_ER_diArg_1	500	502	PF00400	0.426
TRG_ER_diArg_1	518	520	PF00400	0.425
TRG_ER_diArg_1	609	611	PF00400	0.480
TRG_ER_diArg_1	629	632	PF00400	0.250
TRG_ER_diArg_1	815	817	PF00400	0.690
TRG_NLS_MonoExtN_4	484	491	PF00514	0.625
TRG_Pf-PMV_PEXEL_1	598	602	PF00026	0.567
TRG_Pf-PMV_PEXEL_1	639	643	PF00026	0.450
TRG_Pf-PMV_PEXEL_1	862	867	PF00026	0.567

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMB4	Leptomonas seymouri	47%	96%
A0A1X0NTF9	Trypanosomatidae	37%	100%
A0A3S7WXE8	Leishmania donovani	91%	95%
A4HCG3	Leishmania braziliensis	82%	99%
A4HZZ4	Leishmania infantum	91%	95%
Q4QBM4	Leishmania major	90%	100%