Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVV4_LEIMU

TriTrypDb:

LmxM.22.1220

Length:

163

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AVV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVV4

PDB structure(s): 7ane_az

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	161	163	PF00675	0.448
CLV_NRD_NRD_1	56	58	PF00675	0.361
CLV_NRD_NRD_1	96	98	PF00675	0.389
CLV_PCSK_KEX2_1	161	163	PF00082	0.448
CLV_PCSK_KEX2_1	56	58	PF00082	0.361
CLV_PCSK_KEX2_1	66	68	PF00082	0.415
CLV_PCSK_KEX2_1	84	86	PF00082	0.302
CLV_PCSK_KEX2_1	96	98	PF00082	0.374
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.603
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.302
CLV_PCSK_SKI1_1	37	41	PF00082	0.486
DEG_Nend_Nbox_1	1	3	PF02207	0.536
DEG_SCF_FBW7_1	17	23	PF00400	0.447
DOC_CKS1_1	17	22	PF01111	0.449
DOC_MAPK_gen_1	145	153	PF00069	0.405
DOC_MAPK_gen_1	37	46	PF00069	0.351
DOC_MAPK_MEF2A_6	15	24	PF00069	0.478
DOC_USP7_UBL2_3	126	130	PF12436	0.397
DOC_WW_Pin1_4	146	151	PF00397	0.424
DOC_WW_Pin1_4	16	21	PF00397	0.445
LIG_14-3-3_CanoR_1	3	9	PF00244	0.567
LIG_Actin_WH2_2	41	58	PF00022	0.356
LIG_BRCT_BRCA1_1	139	143	PF00533	0.467
LIG_eIF4E_1	103	109	PF01652	0.333
LIG_FHA_1	12	18	PF00498	0.423
LIG_FHA_1	122	128	PF00498	0.465
LIG_FHA_1	45	51	PF00498	0.371
LIG_FHA_1	56	62	PF00498	0.357
LIG_LIR_Nem_3	132	138	PF02991	0.369
LIG_LIR_Nem_3	140	146	PF02991	0.390
LIG_LIR_Nem_3	92	98	PF02991	0.369
LIG_SH2_CRK	138	142	PF00017	0.384
LIG_SH2_CRK	95	99	PF00017	0.349
LIG_SH2_STAT3	103	106	PF00017	0.328
LIG_SH2_STAT5	12	15	PF00017	0.544
LIG_SH2_STAT5	135	138	PF00017	0.369
LIG_SH2_STAT5	45	48	PF00017	0.365
LIG_SH3_3	14	20	PF00018	0.480
LIG_TYR_ITIM	136	141	PF00017	0.379
LIG_TYR_ITSM	91	98	PF00017	0.369
LIG_WW_3	73	77	PF00397	0.541
MOD_CK1_1	16	22	PF00069	0.413
MOD_GSK3_1	16	23	PF00069	0.424
MOD_N-GLC_1	122	127	PF02516	0.351
MOD_N-GLC_1	146	151	PF02516	0.424
MOD_NEK2_1	13	18	PF00069	0.422
MOD_NEK2_1	2	7	PF00069	0.503
MOD_NEK2_1	44	49	PF00069	0.364
MOD_NEK2_1	55	60	PF00069	0.359
MOD_NEK2_2	137	142	PF00069	0.473
MOD_PKA_2	2	8	PF00069	0.545
MOD_PKA_2	55	61	PF00069	0.364
MOD_Plk_4	8	14	PF00069	0.421
MOD_Plk_4	90	96	PF00069	0.376
MOD_ProDKin_1	146	152	PF00069	0.426
MOD_ProDKin_1	16	22	PF00069	0.439
TRG_ENDOCYTIC_2	138	141	PF00928	0.378
TRG_ENDOCYTIC_2	45	48	PF00928	0.368
TRG_ENDOCYTIC_2	95	98	PF00928	0.359
TRG_ER_diArg_1	55	57	PF00400	0.365
TRG_ER_diArg_1	95	97	PF00400	0.387
TRG_NLS_Bipartite_1	66	88	PF00514	0.529
TRG_Pf-PMV_PEXEL_1	156	160	PF00026	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAL0	Leptomonas seymouri	91%	100%
A0A0S4JSD9	Bodo saltans	69%	100%
A0A1X0NTE5	Trypanosomatidae	85%	100%
A0A3S7WX92	Leishmania donovani	99%	100%
A0A422NHS4	Trypanosoma rangeli	80%	100%
A4HCG1	Leishmania braziliensis	99%	100%
A4HZZ3	Leishmania infantum	99%	100%
C9ZSN3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	85%	100%
Q4QBM5	Leishmania major	98%	100%
V5B627	Trypanosoma cruzi	83%	100%