Gamma-glutamylcyclotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ChaC-like protein, putative

Species:

Leishmania mexicana

UniProt:

E9AVV2_LEIMU

TriTrypDb:

LmxM.22.1200

Length:

323

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AVV2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVV2

Function

Biological processes
Term	Name	Level	Count
GO:0006518	peptide metabolic process	4	11
GO:0006575	cellular modified amino acid metabolic process	3	11
GO:0006749	glutathione metabolic process	4	11
GO:0006751	glutathione catabolic process	5	11
GO:0006790	sulfur compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	11
GO:0009987	cellular process	1	11
GO:0042219	cellular modified amino acid catabolic process	4	11
GO:0043171	peptide catabolic process	4	11
GO:0043603	amide metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044248	cellular catabolic process	3	11
GO:0044273	sulfur compound catabolic process	4	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901565	organonitrogen compound catabolic process	4	11
GO:1901575	organic substance catabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0003839	gamma-glutamylcyclotransferase activity	5	11
GO:0016829	lyase activity	2	11
GO:0016840	carbon-nitrogen lyase activity	3	11
GO:0016842	amidine-lyase activity	4	11
GO:0061928	glutathione specific gamma-glutamylcyclotransferase activity	5	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	211	215	PF00656	0.455
CLV_NRD_NRD_1	232	234	PF00675	0.233
CLV_PCSK_KEX2_1	302	304	PF00082	0.338
CLV_PCSK_KEX2_1	317	319	PF00082	0.436
CLV_PCSK_KEX2_1	99	101	PF00082	0.281
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.338
CLV_PCSK_PC1ET2_1	317	319	PF00082	0.436
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.281
CLV_PCSK_SKI1_1	118	122	PF00082	0.281
CLV_PCSK_SKI1_1	189	193	PF00082	0.275
CLV_PCSK_SKI1_1	302	306	PF00082	0.363
CLV_PCSK_SKI1_1	318	322	PF00082	0.458
CLV_PCSK_SKI1_1	36	40	PF00082	0.506
CLV_PCSK_SKI1_1	99	103	PF00082	0.281
DEG_APCC_DBOX_1	273	281	PF00400	0.481
DOC_MAPK_gen_1	233	239	PF00069	0.436
DOC_PP2B_LxvP_1	183	186	PF13499	0.421
DOC_PP4_FxxP_1	222	225	PF00568	0.433
DOC_PP4_FxxP_1	61	64	PF00568	0.413
DOC_USP7_MATH_1	21	25	PF00917	0.479
DOC_USP7_MATH_1	267	271	PF00917	0.498
DOC_USP7_MATH_1	46	50	PF00917	0.471
DOC_USP7_MATH_1	51	55	PF00917	0.390
DOC_WW_Pin1_4	177	182	PF00397	0.447
DOC_WW_Pin1_4	184	189	PF00397	0.461
DOC_WW_Pin1_4	204	209	PF00397	0.360
DOC_WW_Pin1_4	22	27	PF00397	0.572
LIG_14-3-3_CanoR_1	118	123	PF00244	0.481
LIG_14-3-3_CanoR_1	162	168	PF00244	0.449
LIG_BRCT_BRCA1_1	146	150	PF00533	0.377
LIG_FHA_1	172	178	PF00498	0.462
LIG_FHA_1	195	201	PF00498	0.583
LIG_FHA_1	259	265	PF00498	0.403
LIG_FHA_2	252	258	PF00498	0.377
LIG_HCF-1_HBM_1	11	14	PF13415	0.467
LIG_LIR_Apic_2	220	225	PF02991	0.433
LIG_LIR_Apic_2	59	64	PF02991	0.434
LIG_LIR_Gen_1	147	155	PF02991	0.487
LIG_LIR_Gen_1	157	168	PF02991	0.465
LIG_LIR_Gen_1	68	79	PF02991	0.448
LIG_LIR_Nem_3	147	153	PF02991	0.487
LIG_LIR_Nem_3	157	163	PF02991	0.465
LIG_LIR_Nem_3	68	74	PF02991	0.486
LIG_LIR_Nem_3	88	94	PF02991	0.360
LIG_MAD2	217	225	PF02301	0.421
LIG_MYND_1	42	46	PF01753	0.508
LIG_PDZ_Class_1	318	323	PF00595	0.467
LIG_Pex14_1	81	85	PF04695	0.481
LIG_SH2_CRK	137	141	PF00017	0.471
LIG_SH2_CRK	76	80	PF00017	0.481
LIG_SH2_CRK	98	102	PF00017	0.481
LIG_SH2_NCK_1	160	164	PF00017	0.449
LIG_SH2_STAP1	91	95	PF00017	0.481
LIG_SH2_STAT3	57	60	PF00017	0.610
LIG_SH2_STAT5	238	241	PF00017	0.459
LIG_SH2_STAT5	250	253	PF00017	0.515
LIG_SH2_STAT5	276	279	PF00017	0.481
LIG_SH2_STAT5	94	97	PF00017	0.507
LIG_SH3_1	110	116	PF00018	0.593
LIG_SH3_1	137	143	PF00018	0.471
LIG_SH3_2	113	118	PF14604	0.593
LIG_SH3_2	140	145	PF14604	0.481
LIG_SH3_3	110	116	PF00018	0.481
LIG_SH3_3	137	143	PF00018	0.481
LIG_SH3_3	178	184	PF00018	0.464
LIG_SH3_3	197	203	PF00018	0.365
LIG_SH3_3	222	228	PF00018	0.449
LIG_SH3_3	39	45	PF00018	0.554
LIG_SUMO_SIM_par_1	216	223	PF11976	0.464
LIG_WRC_WIRS_1	63	68	PF05994	0.391
LIG_WW_3	201	205	PF00397	0.464
MOD_CDK_SPK_2	184	189	PF00069	0.412
MOD_CK1_1	190	196	PF00069	0.462
MOD_CK1_1	49	55	PF00069	0.583
MOD_CK2_1	155	161	PF00069	0.380
MOD_CK2_1	251	257	PF00069	0.423
MOD_CK2_1	269	275	PF00069	0.412
MOD_GlcNHglycan	157	160	PF01048	0.177
MOD_GlcNHglycan	269	272	PF01048	0.281
MOD_GlcNHglycan	8	11	PF01048	0.554
MOD_GSK3_1	118	125	PF00069	0.481
MOD_GSK3_1	171	178	PF00069	0.449
MOD_GSK3_1	190	197	PF00069	0.449
MOD_GSK3_1	21	28	PF00069	0.562
MOD_GSK3_1	47	54	PF00069	0.586
MOD_N-GLC_1	175	180	PF02516	0.249
MOD_N-GLC_1	6	11	PF02516	0.474
MOD_PIKK_1	194	200	PF00454	0.464
MOD_PIKK_1	37	43	PF00454	0.507
MOD_PKA_2	155	161	PF00069	0.384
MOD_PKA_2	307	313	PF00069	0.308
MOD_Plk_1	252	258	PF00069	0.464
MOD_Plk_4	118	124	PF00069	0.481
MOD_Plk_4	145	151	PF00069	0.575
MOD_Plk_4	163	169	PF00069	0.460
MOD_Plk_4	75	81	PF00069	0.481
MOD_ProDKin_1	177	183	PF00069	0.447
MOD_ProDKin_1	184	190	PF00069	0.461
MOD_ProDKin_1	204	210	PF00069	0.360
MOD_ProDKin_1	22	28	PF00069	0.570
MOD_SUMO_for_1	191	194	PF00179	0.464
TRG_ENDOCYTIC_2	160	163	PF00928	0.481
TRG_ENDOCYTIC_2	76	79	PF00928	0.481
TRG_ENDOCYTIC_2	98	101	PF00928	0.481
TRG_ER_diArg_1	305	308	PF00400	0.442
TRG_NES_CRM1_1	144	157	PF08389	0.468

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P815	Leptomonas seymouri	67%	100%
A0A3Q8ILN3	Leishmania donovani	60%	100%
A0A3S5H7B1	Leishmania donovani	91%	100%
A4HCF7	Leishmania braziliensis	80%	100%
A4HZZ0	Leishmania infantum	60%	100%
A4HZZ1	Leishmania infantum	89%	100%
B3STU3	Rattus norvegicus	32%	100%
E9AVV1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	92%
P32656	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
Q4QBM7	Leishmania major	88%	100%
Q4QBM8	Leishmania major	60%	93%
Q8GY54	Arabidopsis thaliana	29%	100%
Q8R3J5	Mus musculus	31%	100%
Q9BUX1	Homo sapiens	32%	100%