Gamma-glutamylcyclotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ChaC-like protein, putative

Species:

Leishmania mexicana

UniProt:

E9AVV1_LEIMU

TriTrypDb:

LmxM.22.1190

Length:

230

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AVV1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVV1

Function

Biological processes
Term	Name	Level	Count
GO:0006518	peptide metabolic process	4	14
GO:0006575	cellular modified amino acid metabolic process	3	14
GO:0006749	glutathione metabolic process	4	14
GO:0006751	glutathione catabolic process	5	14
GO:0006790	sulfur compound metabolic process	3	14
GO:0006807	nitrogen compound metabolic process	2	14
GO:0008152	metabolic process	1	14
GO:0009056	catabolic process	2	14
GO:0009987	cellular process	1	14
GO:0042219	cellular modified amino acid catabolic process	4	14
GO:0043171	peptide catabolic process	4	14
GO:0043603	amide metabolic process	3	14
GO:0044237	cellular metabolic process	2	14
GO:0044248	cellular catabolic process	3	14
GO:0044273	sulfur compound catabolic process	4	14
GO:0071704	organic substance metabolic process	2	14
GO:1901564	organonitrogen compound metabolic process	3	14
GO:1901565	organonitrogen compound catabolic process	4	14
GO:1901575	organic substance catabolic process	3	14

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0003839	gamma-glutamylcyclotransferase activity	5	14
GO:0016829	lyase activity	2	14
GO:0016840	carbon-nitrogen lyase activity	3	14
GO:0016842	amidine-lyase activity	4	14
GO:0061928	glutathione specific gamma-glutamylcyclotransferase activity	5	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	9	11	PF00675	0.335
CLV_PCSK_KEX2_1	56	58	PF00082	0.258
CLV_PCSK_KEX2_1	9	11	PF00082	0.335
CLV_PCSK_PC1ET2_1	56	58	PF00082	0.292
CLV_PCSK_SKI1_1	140	144	PF00082	0.211
CLV_PCSK_SKI1_1	181	185	PF00082	0.279
CLV_PCSK_SKI1_1	56	60	PF00082	0.249
CLV_PCSK_SKI1_1	75	79	PF00082	0.258
DEG_APCC_DBOX_1	193	201	PF00400	0.528
DOC_CKS1_1	149	154	PF01111	0.374
DOC_PP4_FxxP_1	18	21	PF00568	0.477
DOC_USP7_MATH_1	128	132	PF00917	0.420
DOC_USP7_UBL2_3	143	147	PF12436	0.352
DOC_WW_Pin1_4	148	153	PF00397	0.412
LIG_14-3-3_CanoR_1	75	80	PF00244	0.452
LIG_Actin_WH2_2	128	145	PF00022	0.352
LIG_BIR_II_1	1	5	PF00653	0.575
LIG_BIR_III_2	127	131	PF00653	0.420
LIG_FHA_2	122	128	PF00498	0.448
LIG_LIR_Apic_2	16	21	PF02991	0.497
LIG_LIR_Apic_2	169	173	PF02991	0.482
LIG_LIR_Gen_1	105	112	PF02991	0.551
LIG_LIR_Gen_1	119	130	PF02991	0.535
LIG_LIR_Gen_1	25	36	PF02991	0.435
LIG_LIR_Nem_3	105	110	PF02991	0.551
LIG_LIR_Nem_3	119	125	PF02991	0.540
LIG_LIR_Nem_3	25	31	PF02991	0.454
LIG_LIR_Nem_3	45	51	PF02991	0.498
LIG_Pex14_1	38	42	PF04695	0.449
LIG_SH2_CRK	33	37	PF00017	0.449
LIG_SH2_CRK	55	59	PF00017	0.449
LIG_SH2_CRK	94	98	PF00017	0.521
LIG_SH2_STAP1	118	122	PF00017	0.420
LIG_SH2_STAP1	48	52	PF00017	0.498
LIG_SH2_STAT3	14	17	PF00017	0.531
LIG_SH2_STAT5	170	173	PF00017	0.440
LIG_SH2_STAT5	196	199	PF00017	0.449
LIG_SH2_STAT5	51	54	PF00017	0.493
LIG_SH3_1	67	73	PF00018	0.467
LIG_SH3_1	94	100	PF00018	0.482
LIG_SH3_2	70	75	PF14604	0.467
LIG_SH3_2	97	102	PF14604	0.528
LIG_SH3_3	223	229	PF00018	0.369
LIG_SH3_3	67	73	PF00018	0.449
LIG_SH3_3	94	100	PF00018	0.492
LIG_UBA3_1	106	115	PF00899	0.420
LIG_WRC_WIRS_1	20	25	PF05994	0.457
MOD_CDK_SPxK_1	148	154	PF00069	0.412
MOD_GlcNHglycan	189	192	PF01048	0.253
MOD_GlcNHglycan	3	6	PF01048	0.580
MOD_GSK3_1	1	8	PF00069	0.649
MOD_GSK3_1	183	190	PF00069	0.432
MOD_GSK3_1	75	82	PF00069	0.467
MOD_N-GLC_1	161	166	PF02516	0.220
MOD_N-GLC_1	184	189	PF02516	0.182
MOD_NEK2_1	1	6	PF00069	0.411
MOD_NEK2_1	121	126	PF00069	0.420
MOD_NEK2_1	184	189	PF00069	0.495
MOD_PKA_1	9	15	PF00069	0.294
MOD_PKA_2	9	15	PF00069	0.513
MOD_Plk_4	102	108	PF00069	0.397
MOD_Plk_4	121	127	PF00069	0.492
MOD_Plk_4	32	38	PF00069	0.465
MOD_Plk_4	75	81	PF00069	0.449
MOD_ProDKin_1	148	154	PF00069	0.412
TRG_DiLeu_BaEn_1	216	221	PF01217	0.374
TRG_ENDOCYTIC_2	118	121	PF00928	0.467
TRG_ENDOCYTIC_2	33	36	PF00928	0.449
TRG_ENDOCYTIC_2	55	58	PF00928	0.449
TRG_NES_CRM1_1	101	114	PF08389	0.518
TRG_NES_CRM1_1	216	227	PF08389	0.420
TRG_NLS_MonoExtN_4	9	14	PF00514	0.303
TRG_Pf-PMV_PEXEL_1	202	206	PF00026	0.289
TRG_Pf-PMV_PEXEL_1	222	227	PF00026	0.204

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P815	Leptomonas seymouri	56%	85%
A0A1X0NTG7	Trypanosomatidae	51%	100%
A0A3Q8ILN3	Leishmania donovani	93%	100%
A0A3R7NMW8	Trypanosoma rangeli	52%	100%
A0A3S5H7B1	Leishmania donovani	61%	82%
A4HCF7	Leishmania braziliensis	61%	100%
A4HZZ0	Leishmania infantum	93%	100%
A4HZZ1	Leishmania infantum	61%	71%
B3STU3	Rattus norvegicus	37%	100%
C9ZSN1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9AVV2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	71%
P32656	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	99%
P87305	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
Q0IIH4	Bos taurus	38%	100%
Q4KMJ1	Danio rerio	44%	100%
Q4QBM7	Leishmania major	61%	100%
Q4QBM8	Leishmania major	91%	100%
Q5PPV4	Xenopus laevis	46%	100%
Q5SPB6	Danio rerio	37%	100%
Q5ZI66	Gallus gallus	43%	100%
Q641Z5	Rattus norvegicus	43%	100%
Q84MC1	Arabidopsis thaliana	38%	100%
Q84QC1	Arabidopsis thaliana	40%	100%
Q8GY54	Arabidopsis thaliana	36%	100%
Q8R3J5	Mus musculus	38%	100%
Q8WUX2	Homo sapiens	43%	100%
Q9BUX1	Homo sapiens	36%	100%
Q9CQG1	Mus musculus	43%	100%