Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AVV0_LEIMU

TriTrypDb:

LmxM.22.1180

Length:

505

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 4
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AVV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVV0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	227	229	PF00675	0.373
CLV_NRD_NRD_1	256	258	PF00675	0.341
CLV_NRD_NRD_1	269	271	PF00675	0.551
CLV_NRD_NRD_1	313	315	PF00675	0.423
CLV_NRD_NRD_1	420	422	PF00675	0.490
CLV_NRD_NRD_1	89	91	PF00675	0.417
CLV_PCSK_FUR_1	256	260	PF00082	0.439
CLV_PCSK_KEX2_1	218	220	PF00082	0.373
CLV_PCSK_KEX2_1	226	228	PF00082	0.345
CLV_PCSK_KEX2_1	256	258	PF00082	0.429
CLV_PCSK_KEX2_1	269	271	PF00082	0.482
CLV_PCSK_KEX2_1	313	315	PF00082	0.423
CLV_PCSK_KEX2_1	420	422	PF00082	0.495
CLV_PCSK_KEX2_1	89	91	PF00082	0.417
CLV_PCSK_PC1ET2_1	218	220	PF00082	0.387
CLV_PCSK_PC1ET2_1	258	260	PF00082	0.421
CLV_PCSK_PC7_1	252	258	PF00082	0.318
CLV_PCSK_SKI1_1	147	151	PF00082	0.347
CLV_PCSK_SKI1_1	158	162	PF00082	0.351
CLV_PCSK_SKI1_1	236	240	PF00082	0.498
CLV_PCSK_SKI1_1	313	317	PF00082	0.482
CLV_PCSK_SKI1_1	420	424	PF00082	0.486
DEG_SPOP_SBC_1	345	349	PF00917	0.640
DOC_ANK_TNKS_1	269	276	PF00023	0.701
DOC_MAPK_gen_1	89	96	PF00069	0.598
DOC_MAPK_RevD_3	76	90	PF00069	0.435
DOC_PP2B_LxvP_1	220	223	PF13499	0.562
DOC_PP2B_LxvP_1	321	324	PF13499	0.615
DOC_PP4_FxxP_1	9	12	PF00568	0.334
DOC_SPAK_OSR1_1	421	425	PF12202	0.724
DOC_USP7_MATH_1	168	172	PF00917	0.362
DOC_USP7_MATH_1	192	196	PF00917	0.362
DOC_USP7_MATH_1	23	27	PF00917	0.356
DOC_USP7_MATH_1	279	283	PF00917	0.643
DOC_USP7_MATH_1	345	349	PF00917	0.704
DOC_USP7_MATH_1	355	359	PF00917	0.682
DOC_USP7_MATH_1	394	398	PF00917	0.669
DOC_USP7_MATH_1	474	478	PF00917	0.730
DOC_USP7_UBL2_3	464	468	PF12436	0.736
DOC_WW_Pin1_4	138	143	PF00397	0.366
DOC_WW_Pin1_4	289	294	PF00397	0.657
DOC_WW_Pin1_4	328	333	PF00397	0.735
DOC_WW_Pin1_4	382	387	PF00397	0.630
DOC_WW_Pin1_4	424	429	PF00397	0.792
DOC_WW_Pin1_4	454	459	PF00397	0.713
DOC_WW_Pin1_4	476	481	PF00397	0.813
DOC_WW_Pin1_4	7	12	PF00397	0.342
LIG_14-3-3_CanoR_1	147	157	PF00244	0.362
LIG_14-3-3_CanoR_1	230	238	PF00244	0.537
LIG_14-3-3_CanoR_1	25	34	PF00244	0.331
LIG_14-3-3_CanoR_1	313	321	PF00244	0.684
LIG_14-3-3_CanoR_1	357	361	PF00244	0.636
LIG_14-3-3_CanoR_1	405	410	PF00244	0.790
LIG_14-3-3_CanoR_1	89	95	PF00244	0.651
LIG_BIR_II_1	1	5	PF00653	0.372
LIG_CtBP_PxDLS_1	406	410	PF00389	0.727
LIG_deltaCOP1_diTrp_1	173	177	PF00928	0.208
LIG_EH1_1	63	71	PF00400	0.199
LIG_FHA_1	120	126	PF00498	0.336
LIG_FHA_1	131	137	PF00498	0.272
LIG_FHA_1	14	20	PF00498	0.321
LIG_FHA_1	242	248	PF00498	0.514
LIG_FHA_1	393	399	PF00498	0.729
LIG_FHA_1	455	461	PF00498	0.718
LIG_FHA_1	477	483	PF00498	0.678
LIG_FHA_2	314	320	PF00498	0.809
LIG_GBD_Chelix_1	108	116	PF00786	0.362
LIG_HCF-1_HBM_1	443	446	PF13415	0.698
LIG_Integrin_isoDGR_2	311	313	PF01839	0.428
LIG_LIR_Apic_2	7	12	PF02991	0.342
LIG_LIR_Gen_1	151	161	PF02991	0.490
LIG_LIR_Gen_1	62	71	PF02991	0.265
LIG_LIR_Gen_1	74	83	PF02991	0.299
LIG_LIR_Gen_1	88	99	PF02991	0.504
LIG_LIR_Nem_3	151	156	PF02991	0.432
LIG_LIR_Nem_3	172	178	PF02991	0.499
LIG_LIR_Nem_3	282	286	PF02991	0.731
LIG_LIR_Nem_3	62	66	PF02991	0.265
LIG_LIR_Nem_3	74	78	PF02991	0.299
LIG_LIR_Nem_3	88	94	PF02991	0.502
LIG_LYPXL_yS_3	283	286	PF13949	0.703
LIG_NRBOX	66	72	PF00104	0.208
LIG_Pex14_2	140	144	PF04695	0.299
LIG_Pex14_2	149	153	PF04695	0.299
LIG_SH2_CRK	190	194	PF00017	0.265
LIG_SH2_CRK	63	67	PF00017	0.268
LIG_SH2_CRK	91	95	PF00017	0.599
LIG_SH2_NCK_1	446	450	PF00017	0.718
LIG_SH2_STAP1	98	102	PF00017	0.362
LIG_SH2_STAT5	123	126	PF00017	0.378
LIG_SH2_STAT5	205	208	PF00017	0.372
LIG_SH2_STAT5	210	213	PF00017	0.322
LIG_SH2_STAT5	214	217	PF00017	0.384
LIG_SH2_STAT5	221	224	PF00017	0.552
LIG_SH2_STAT5	446	449	PF00017	0.736
LIG_SH3_1	455	461	PF00018	0.680
LIG_SH3_3	17	23	PF00018	0.332
LIG_SH3_3	278	284	PF00018	0.694
LIG_SH3_3	367	373	PF00018	0.628
LIG_SH3_3	455	461	PF00018	0.740
LIG_SUMO_SIM_anti_2	111	117	PF11976	0.362
LIG_SUMO_SIM_anti_2	16	21	PF11976	0.314
LIG_SUMO_SIM_anti_2	68	74	PF11976	0.309
LIG_SUMO_SIM_anti_2	77	82	PF11976	0.294
LIG_SUMO_SIM_par_1	192	197	PF11976	0.299
LIG_SUMO_SIM_par_1	405	411	PF11976	0.672
LIG_SUMO_SIM_par_1	68	74	PF11976	0.309
LIG_SUMO_SIM_par_1	77	82	PF11976	0.294
LIG_TRAF2_1	102	105	PF00917	0.362
LIG_TRAF2_1	427	430	PF00917	0.666
LIG_TYR_ITIM	155	160	PF00017	0.426
LIG_TYR_ITIM	281	286	PF00017	0.699
LIG_TYR_ITIM	61	66	PF00017	0.373
LIG_ULM_U2AF65_1	256	261	PF00076	0.530
LIG_WRC_WIRS_1	146	151	PF05994	0.358
LIG_WRC_WIRS_1	6	11	PF05994	0.350
LIG_WRC_WIRS_1	72	77	PF05994	0.362
LIG_WW_3	322	326	PF00397	0.617
MOD_CDK_SPK_2	382	387	PF00069	0.630
MOD_CDK_SPxxK_3	289	296	PF00069	0.669
MOD_CDK_SPxxK_3	328	335	PF00069	0.734
MOD_CK1_1	179	185	PF00069	0.477
MOD_CK1_1	2	8	PF00069	0.452
MOD_CK1_1	26	32	PF00069	0.326
MOD_CK1_1	282	288	PF00069	0.746
MOD_CK1_1	336	342	PF00069	0.816
MOD_CK1_1	397	403	PF00069	0.630
MOD_CK1_1	408	414	PF00069	0.620
MOD_CK1_1	448	454	PF00069	0.694
MOD_CK1_1	462	468	PF00069	0.702
MOD_CK1_1	82	88	PF00069	0.475
MOD_CK2_1	355	361	PF00069	0.746
MOD_CK2_1	424	430	PF00069	0.687
MOD_CK2_1	478	484	PF00069	0.730
MOD_Cter_Amidation	311	314	PF01082	0.412
MOD_GlcNHglycan	1	4	PF01048	0.573
MOD_GlcNHglycan	166	169	PF01048	0.362
MOD_GlcNHglycan	206	209	PF01048	0.362
MOD_GlcNHglycan	352	355	PF01048	0.608
MOD_GlcNHglycan	447	450	PF01048	0.410
MOD_GlcNHglycan	476	479	PF01048	0.507
MOD_GSK3_1	119	126	PF00069	0.333
MOD_GSK3_1	164	171	PF00069	0.510
MOD_GSK3_1	285	292	PF00069	0.647
MOD_GSK3_1	333	340	PF00069	0.817
MOD_GSK3_1	346	353	PF00069	0.705
MOD_GSK3_1	356	363	PF00069	0.681
MOD_GSK3_1	388	395	PF00069	0.723
MOD_GSK3_1	420	427	PF00069	0.786
MOD_GSK3_1	44	51	PF00069	0.403
MOD_GSK3_1	444	451	PF00069	0.681
MOD_GSK3_1	474	481	PF00069	0.766
MOD_NEK2_1	13	18	PF00069	0.412
MOD_NEK2_1	145	150	PF00069	0.405
MOD_NEK2_1	287	292	PF00069	0.582
MOD_NEK2_1	337	342	PF00069	0.758
MOD_NEK2_1	360	365	PF00069	0.632
MOD_NEK2_1	422	427	PF00069	0.746
MOD_NEK2_1	44	49	PF00069	0.346
MOD_NEK2_1	59	64	PF00069	0.340
MOD_NEK2_1	71	76	PF00069	0.299
MOD_PIKK_1	231	237	PF00454	0.500
MOD_PIKK_1	346	352	PF00454	0.744
MOD_PIKK_1	448	454	PF00454	0.735
MOD_PKA_1	313	319	PF00069	0.623
MOD_PKA_1	420	426	PF00069	0.681
MOD_PKA_2	163	169	PF00069	0.465
MOD_PKA_2	313	319	PF00069	0.623
MOD_PKA_2	356	362	PF00069	0.676
MOD_PKA_2	420	426	PF00069	0.792
MOD_Plk_1	333	339	PF00069	0.732
MOD_Plk_4	103	109	PF00069	0.473
MOD_Plk_4	119	125	PF00069	0.388
MOD_Plk_4	132	138	PF00069	0.248
MOD_Plk_4	15	21	PF00069	0.334
MOD_Plk_4	282	288	PF00069	0.659
MOD_Plk_4	405	411	PF00069	0.762
MOD_Plk_4	65	71	PF00069	0.287
MOD_ProDKin_1	138	144	PF00069	0.366
MOD_ProDKin_1	289	295	PF00069	0.655
MOD_ProDKin_1	328	334	PF00069	0.737
MOD_ProDKin_1	382	388	PF00069	0.631
MOD_ProDKin_1	424	430	PF00069	0.787
MOD_ProDKin_1	454	460	PF00069	0.713
MOD_ProDKin_1	476	482	PF00069	0.813
MOD_ProDKin_1	7	13	PF00069	0.340
TRG_DiLeu_BaEn_2	172	178	PF01217	0.208
TRG_DiLeu_BaEn_4	429	435	PF01217	0.671
TRG_ENDOCYTIC_2	157	160	PF00928	0.522
TRG_ENDOCYTIC_2	190	193	PF00928	0.318
TRG_ENDOCYTIC_2	283	286	PF00928	0.703
TRG_ENDOCYTIC_2	63	66	PF00928	0.268
TRG_ENDOCYTIC_2	91	94	PF00928	0.587
TRG_ENDOCYTIC_2	98	101	PF00928	0.262
TRG_ER_diArg_1	226	228	PF00400	0.603
TRG_ER_diArg_1	256	259	PF00400	0.600
TRG_ER_diArg_1	313	315	PF00400	0.645
TRG_ER_diArg_1	420	422	PF00400	0.693
TRG_ER_diArg_1	89	91	PF00400	0.617
TRG_NES_CRM1_1	105	118	PF08389	0.362
TRG_NLS_MonoExtC_3	256	261	PF00514	0.537
TRG_NLS_MonoExtN_4	256	261	PF00514	0.534
TRG_Pf-PMV_PEXEL_1	230	235	PF00026	0.305
TRG_Pf-PMV_PEXEL_1	432	436	PF00026	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8E2	Leptomonas seymouri	39%	77%
A0A3S7WX94	Leishmania donovani	79%	100%
A4HZY9	Leishmania infantum	79%	100%
Q4QBM9	Leishmania major	71%	100%