Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein kinase domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AVU9_LEIMU

TriTrypDb:

LmxM.22.1170

Length:

889

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0000922	spindle pole	2	1
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005813	centrosome	3	1
GO:0005815	microtubule organizing center	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AVU9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVU9

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016310	phosphorylation	5	6
GO:0019538	protein metabolic process	3	6
GO:0036211	protein modification process	4	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	6
GO:0000278	mitotic cell cycle	3	1
GO:0007049	cell cycle	2	1
GO:0010564	regulation of cell cycle process	5	1
GO:0032465	regulation of cytokinesis	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051302	regulation of cell division	4	1
GO:0051726	regulation of cell cycle	4	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0004672	protein kinase activity	3	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0140096	catalytic activity, acting on a protein	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	194	198	PF00656	0.556
CLV_C14_Caspase3-7	663	667	PF00656	0.499
CLV_C14_Caspase3-7	749	753	PF00656	0.638
CLV_NRD_NRD_1	156	158	PF00675	0.801
CLV_NRD_NRD_1	180	182	PF00675	0.525
CLV_NRD_NRD_1	526	528	PF00675	0.520
CLV_NRD_NRD_1	538	540	PF00675	0.497
CLV_NRD_NRD_1	788	790	PF00675	0.690
CLV_PCSK_KEX2_1	180	182	PF00082	0.558
CLV_PCSK_KEX2_1	517	519	PF00082	0.655
CLV_PCSK_KEX2_1	52	54	PF00082	0.497
CLV_PCSK_KEX2_1	538	540	PF00082	0.510
CLV_PCSK_KEX2_1	788	790	PF00082	0.690
CLV_PCSK_PC1ET2_1	517	519	PF00082	0.655
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.461
CLV_PCSK_PC7_1	48	54	PF00082	0.444
CLV_PCSK_SKI1_1	108	112	PF00082	0.459
CLV_PCSK_SKI1_1	180	184	PF00082	0.625
CLV_PCSK_SKI1_1	227	231	PF00082	0.385
CLV_PCSK_SKI1_1	235	239	PF00082	0.311
CLV_PCSK_SKI1_1	332	336	PF00082	0.456
CLV_PCSK_SKI1_1	37	41	PF00082	0.464
CLV_PCSK_SKI1_1	52	56	PF00082	0.321
CLV_PCSK_SKI1_1	566	570	PF00082	0.721
CLV_PCSK_SKI1_1	589	593	PF00082	0.547
CLV_PCSK_SKI1_1	680	684	PF00082	0.609
CLV_PCSK_SKI1_1	79	83	PF00082	0.458
CLV_PCSK_SKI1_1	882	886	PF00082	0.454
CLV_Separin_Metazoa	293	297	PF03568	0.385
DEG_APCC_DBOX_1	342	350	PF00400	0.385
DEG_SPOP_SBC_1	730	734	PF00917	0.539
DOC_CKS1_1	377	382	PF01111	0.322
DOC_CKS1_1	465	470	PF01111	0.556
DOC_CYCLIN_yCln2_LP_2	777	783	PF00134	0.702
DOC_MAPK_DCC_7	343	351	PF00069	0.385
DOC_MAPK_gen_1	655	664	PF00069	0.525
DOC_MAPK_gen_1	838	847	PF00069	0.633
DOC_MAPK_HePTP_8	652	664	PF00069	0.527
DOC_MAPK_MEF2A_6	343	351	PF00069	0.385
DOC_MAPK_MEF2A_6	655	664	PF00069	0.525
DOC_MAPK_MEF2A_6	778	785	PF00069	0.693
DOC_PP2B_LxvP_1	777	780	PF13499	0.702
DOC_PP4_FxxP_1	377	380	PF00568	0.444
DOC_PP4_FxxP_1	805	808	PF00568	0.631
DOC_USP7_MATH_1	130	134	PF00917	0.658
DOC_USP7_MATH_1	136	140	PF00917	0.613
DOC_USP7_MATH_1	205	209	PF00917	0.637
DOC_USP7_MATH_1	216	220	PF00917	0.425
DOC_USP7_MATH_1	510	514	PF00917	0.639
DOC_USP7_MATH_1	526	530	PF00917	0.553
DOC_USP7_MATH_1	618	622	PF00917	0.542
DOC_USP7_MATH_1	668	672	PF00917	0.694
DOC_USP7_MATH_1	730	734	PF00917	0.539
DOC_USP7_MATH_1	765	769	PF00917	0.606
DOC_USP7_MATH_1	773	777	PF00917	0.630
DOC_USP7_MATH_1	796	800	PF00917	0.624
DOC_WW_Pin1_4	170	175	PF00397	0.529
DOC_WW_Pin1_4	199	204	PF00397	0.592
DOC_WW_Pin1_4	358	363	PF00397	0.385
DOC_WW_Pin1_4	376	381	PF00397	0.304
DOC_WW_Pin1_4	441	446	PF00397	0.741
DOC_WW_Pin1_4	464	469	PF00397	0.611
DOC_WW_Pin1_4	476	481	PF00397	0.554
DOC_WW_Pin1_4	508	513	PF00397	0.639
DOC_WW_Pin1_4	522	527	PF00397	0.661
DOC_WW_Pin1_4	606	611	PF00397	0.520
DOC_WW_Pin1_4	629	634	PF00397	0.650
DOC_WW_Pin1_4	670	675	PF00397	0.655
DOC_WW_Pin1_4	705	710	PF00397	0.613
DOC_WW_Pin1_4	769	774	PF00397	0.587
DOC_WW_Pin1_4	871	876	PF00397	0.495
LIG_14-3-3_CanoR_1	157	165	PF00244	0.536
LIG_14-3-3_CanoR_1	287	291	PF00244	0.428
LIG_14-3-3_CanoR_1	37	46	PF00244	0.460
LIG_14-3-3_CanoR_1	439	445	PF00244	0.705
LIG_14-3-3_CanoR_1	497	505	PF00244	0.610
LIG_14-3-3_CanoR_1	527	531	PF00244	0.582
LIG_14-3-3_CanoR_1	617	624	PF00244	0.535
LIG_14-3-3_CanoR_1	70	76	PF00244	0.502
LIG_14-3-3_CanoR_1	789	795	PF00244	0.632
LIG_BIR_III_2	477	481	PF00653	0.549
LIG_BRCT_BRCA1_1	269	273	PF00533	0.385
LIG_BRCT_BRCA1_1	377	381	PF00533	0.372
LIG_CtBP_PxDLS_1	222	226	PF00389	0.274
LIG_deltaCOP1_diTrp_1	57	62	PF00928	0.470
LIG_EH_1	209	213	PF12763	0.479
LIG_eIF4E_1	95	101	PF01652	0.439
LIG_FHA_1	224	230	PF00498	0.356
LIG_FHA_1	38	44	PF00498	0.549
LIG_FHA_1	465	471	PF00498	0.556
LIG_FHA_1	500	506	PF00498	0.535
LIG_FHA_1	576	582	PF00498	0.693
LIG_FHA_1	607	613	PF00498	0.513
LIG_FHA_1	761	767	PF00498	0.686
LIG_FHA_1	872	878	PF00498	0.538
LIG_FHA_2	143	149	PF00498	0.849
LIG_FHA_2	381	387	PF00498	0.502
LIG_FHA_2	458	464	PF00498	0.696
LIG_FHA_2	770	776	PF00498	0.625
LIG_GBD_Chelix_1	349	357	PF00786	0.385
LIG_LIR_Apic_2	803	808	PF02991	0.628
LIG_LIR_Gen_1	444	453	PF02991	0.676
LIG_LIR_Gen_1	880	889	PF02991	0.546
LIG_LIR_Gen_1	92	102	PF02991	0.445
LIG_LIR_Nem_3	298	303	PF02991	0.385
LIG_LIR_Nem_3	378	384	PF02991	0.385
LIG_LIR_Nem_3	444	450	PF02991	0.677
LIG_LIR_Nem_3	699	704	PF02991	0.515
LIG_LIR_Nem_3	880	886	PF02991	0.494
LIG_MYND_1	344	348	PF01753	0.287
LIG_MYND_1	468	472	PF01753	0.553
LIG_MYND_1	544	548	PF01753	0.644
LIG_MYND_1	809	813	PF01753	0.573
LIG_PCNA_yPIPBox_3	12	24	PF02747	0.483
LIG_PDZ_Class_2	884	889	PF00595	0.473
LIG_Pex14_2	377	381	PF04695	0.372
LIG_SH2_CRK	243	247	PF00017	0.276
LIG_SH2_SRC	876	879	PF00017	0.582
LIG_SH2_STAP1	50	54	PF00017	0.449
LIG_SH2_STAT3	653	656	PF00017	0.476
LIG_SH2_STAT5	303	306	PF00017	0.499
LIG_SH2_STAT5	315	318	PF00017	0.302
LIG_SH2_STAT5	45	48	PF00017	0.568
LIG_SH2_STAT5	653	656	PF00017	0.596
LIG_SH2_STAT5	80	83	PF00017	0.417
LIG_SH2_STAT5	876	879	PF00017	0.582
LIG_SH3_1	338	344	PF00018	0.342
LIG_SH3_3	338	344	PF00018	0.385
LIG_SH3_3	462	468	PF00018	0.629
LIG_SH3_3	506	512	PF00018	0.550
LIG_SH3_3	531	537	PF00018	0.709
LIG_SH3_3	538	544	PF00018	0.679
LIG_SH3_3	778	784	PF00018	0.658
LIG_SH3_3	807	813	PF00018	0.661
LIG_SUMO_SIM_par_1	221	226	PF11976	0.274
LIG_SUMO_SIM_par_1	347	352	PF11976	0.287
LIG_SUMO_SIM_par_1	611	616	PF11976	0.646
LIG_TRAF2_1	361	364	PF00917	0.385
LIG_TRAF2_1	480	483	PF00917	0.545
LIG_TRAF2_1	593	596	PF00917	0.470
LIG_TRAF2_1	772	775	PF00917	0.581
LIG_TYR_ITIM	313	318	PF00017	0.342
LIG_UBA3_1	100	108	PF00899	0.455
LIG_WRC_WIRS_1	450	455	PF05994	0.677
LIG_WRC_WIRS_1	766	771	PF05994	0.530
LIG_WW_3	494	498	PF00397	0.638
MOD_CDC14_SPxK_1	525	528	PF00782	0.520
MOD_CDK_SPK_2	522	527	PF00069	0.530
MOD_CDK_SPK_2	629	634	PF00069	0.682
MOD_CDK_SPxK_1	522	528	PF00069	0.524
MOD_CDK_SPxxK_3	358	365	PF00069	0.385
MOD_CK1_1	415	421	PF00069	0.669
MOD_CK1_1	449	455	PF00069	0.759
MOD_CK1_1	673	679	PF00069	0.705
MOD_CK1_1	686	692	PF00069	0.582
MOD_CK1_1	708	714	PF00069	0.617
MOD_CK1_1	732	738	PF00069	0.705
MOD_CK1_1	746	752	PF00069	0.530
MOD_CK1_1	768	774	PF00069	0.684
MOD_CK1_1	790	796	PF00069	0.518
MOD_CK1_1	814	820	PF00069	0.680
MOD_CK1_1	90	96	PF00069	0.401
MOD_CK2_1	142	148	PF00069	0.818
MOD_CK2_1	169	175	PF00069	0.522
MOD_CK2_1	358	364	PF00069	0.385
MOD_CK2_1	380	386	PF00069	0.505
MOD_CK2_1	476	482	PF00069	0.590
MOD_CK2_1	769	775	PF00069	0.629
MOD_GlcNHglycan	133	136	PF01048	0.690
MOD_GlcNHglycan	138	141	PF01048	0.628
MOD_GlcNHglycan	165	168	PF01048	0.590
MOD_GlcNHglycan	413	417	PF01048	0.568
MOD_GlcNHglycan	454	457	PF01048	0.678
MOD_GlcNHglycan	505	508	PF01048	0.671
MOD_GlcNHglycan	512	515	PF01048	0.619
MOD_GlcNHglycan	534	537	PF01048	0.632
MOD_GlcNHglycan	595	601	PF01048	0.483
MOD_GlcNHglycan	625	628	PF01048	0.685
MOD_GlcNHglycan	675	678	PF01048	0.668
MOD_GlcNHglycan	718	721	PF01048	0.558
MOD_GlcNHglycan	789	792	PF01048	0.520
MOD_GlcNHglycan	798	801	PF01048	0.496
MOD_GlcNHglycan	816	819	PF01048	0.560
MOD_GSK3_1	100	107	PF00069	0.451
MOD_GSK3_1	118	125	PF00069	0.305
MOD_GSK3_1	131	138	PF00069	0.652
MOD_GSK3_1	142	149	PF00069	0.571
MOD_GSK3_1	165	172	PF00069	0.615
MOD_GSK3_1	187	194	PF00069	0.759
MOD_GSK3_1	2	9	PF00069	0.623
MOD_GSK3_1	263	270	PF00069	0.527
MOD_GSK3_1	376	383	PF00069	0.317
MOD_GSK3_1	485	492	PF00069	0.706
MOD_GSK3_1	499	506	PF00069	0.568
MOD_GSK3_1	508	515	PF00069	0.616
MOD_GSK3_1	522	529	PF00069	0.559
MOD_GSK3_1	613	620	PF00069	0.664
MOD_GSK3_1	623	630	PF00069	0.603
MOD_GSK3_1	668	675	PF00069	0.665
MOD_GSK3_1	708	715	PF00069	0.626
MOD_GSK3_1	71	78	PF00069	0.397
MOD_GSK3_1	716	723	PF00069	0.560
MOD_GSK3_1	725	732	PF00069	0.568
MOD_GSK3_1	742	749	PF00069	0.572
MOD_GSK3_1	765	772	PF00069	0.597
MOD_GSK3_1	796	803	PF00069	0.636
MOD_GSK3_1	814	821	PF00069	0.545
MOD_GSK3_1	828	835	PF00069	0.514
MOD_LATS_1	678	684	PF00433	0.552
MOD_N-GLC_1	104	109	PF02516	0.338
MOD_N-GLC_1	683	688	PF02516	0.672
MOD_N-GLC_1	90	95	PF02516	0.419
MOD_NEK2_1	1	6	PF00069	0.621
MOD_NEK2_1	104	109	PF00069	0.383
MOD_NEK2_1	263	268	PF00069	0.495
MOD_NEK2_1	283	288	PF00069	0.199
MOD_NEK2_1	446	451	PF00069	0.593
MOD_NEK2_1	485	490	PF00069	0.585
MOD_NEK2_1	660	665	PF00069	0.482
MOD_NEK2_1	828	833	PF00069	0.679
MOD_NEK2_2	327	332	PF00069	0.385
MOD_NEK2_2	512	517	PF00069	0.644
MOD_NEK2_2	773	778	PF00069	0.684
MOD_NEK2_2	800	805	PF00069	0.579
MOD_PIKK_1	582	588	PF00454	0.597
MOD_PIKK_1	668	674	PF00454	0.694
MOD_PK_1	655	661	PF00069	0.468
MOD_PKA_1	157	163	PF00069	0.656
MOD_PKA_2	156	162	PF00069	0.534
MOD_PKA_2	263	269	PF00069	0.492
MOD_PKA_2	283	289	PF00069	0.199
MOD_PKA_2	339	345	PF00069	0.385
MOD_PKA_2	402	408	PF00069	0.622
MOD_PKA_2	489	495	PF00069	0.666
MOD_PKA_2	526	532	PF00069	0.525
MOD_PKA_2	622	628	PF00069	0.528
MOD_PKA_2	787	793	PF00069	0.534
MOD_PKA_2	811	817	PF00069	0.643
MOD_PKB_1	161	169	PF00069	0.536
MOD_Plk_1	412	418	PF00069	0.533
MOD_Plk_1	683	689	PF00069	0.673
MOD_Plk_1	743	749	PF00069	0.684
MOD_Plk_1	90	96	PF00069	0.401
MOD_Plk_4	446	452	PF00069	0.755
MOD_Plk_4	601	607	PF00069	0.565
MOD_Plk_4	655	661	PF00069	0.496
MOD_Plk_4	708	714	PF00069	0.593
MOD_Plk_4	720	726	PF00069	0.573
MOD_Plk_4	743	749	PF00069	0.684
MOD_Plk_4	800	806	PF00069	0.636
MOD_Plk_4	90	96	PF00069	0.538
MOD_ProDKin_1	170	176	PF00069	0.530
MOD_ProDKin_1	199	205	PF00069	0.590
MOD_ProDKin_1	358	364	PF00069	0.385
MOD_ProDKin_1	376	382	PF00069	0.310
MOD_ProDKin_1	441	447	PF00069	0.742
MOD_ProDKin_1	464	470	PF00069	0.614
MOD_ProDKin_1	476	482	PF00069	0.555
MOD_ProDKin_1	508	514	PF00069	0.642
MOD_ProDKin_1	522	528	PF00069	0.663
MOD_ProDKin_1	606	612	PF00069	0.523
MOD_ProDKin_1	629	635	PF00069	0.648
MOD_ProDKin_1	670	676	PF00069	0.658
MOD_ProDKin_1	705	711	PF00069	0.615
MOD_ProDKin_1	769	775	PF00069	0.588
MOD_ProDKin_1	871	877	PF00069	0.492
TRG_DiLeu_BaEn_1	577	582	PF01217	0.615
TRG_DiLeu_BaLyEn_6	353	358	PF01217	0.385
TRG_ENDOCYTIC_2	243	246	PF00928	0.276
TRG_ENDOCYTIC_2	315	318	PF00928	0.385
TRG_ENDOCYTIC_2	565	568	PF00928	0.615
TRG_ENDOCYTIC_2	95	98	PF00928	0.419
TRG_ER_diArg_1	180	182	PF00400	0.525
TRG_ER_diArg_1	32	35	PF00400	0.557
TRG_ER_diArg_1	338	341	PF00400	0.238
TRG_ER_diArg_1	426	429	PF00400	0.650
TRG_ER_diArg_1	537	539	PF00400	0.512
TRG_ER_diArg_1	838	841	PF00400	0.638
TRG_Pf-PMV_PEXEL_1	227	231	PF00026	0.385
TRG_Pf-PMV_PEXEL_1	332	336	PF00026	0.221
TRG_Pf-PMV_PEXEL_1	53	57	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	617	622	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IBH5	Leishmania donovani	80%	95%
A4HCF9	Leishmania braziliensis	59%	99%
A4HZY8	Leishmania infantum	80%	90%
Q4QBN0	Leishmania major	78%	100%