Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVU8_LEIMU

TriTrypDb:

LmxM.22.1160

Length:

450

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVU8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVU8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.511
CLV_NRD_NRD_1	102	104	PF00675	0.628
CLV_NRD_NRD_1	19	21	PF00675	0.519
CLV_PCSK_KEX2_1	102	104	PF00082	0.628
CLV_PCSK_KEX2_1	19	21	PF00082	0.519
CLV_PCSK_KEX2_1	65	67	PF00082	0.510
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.570
CLV_PCSK_SKI1_1	302	306	PF00082	0.439
CLV_PCSK_SKI1_1	324	328	PF00082	0.511
CLV_PCSK_SKI1_1	414	418	PF00082	0.542
CLV_PCSK_SKI1_1	87	91	PF00082	0.665
DEG_APCC_DBOX_1	21	29	PF00400	0.544
DOC_CKS1_1	88	93	PF01111	0.672
DOC_CYCLIN_RxL_1	296	309	PF00134	0.434
DOC_CYCLIN_yClb5_NLxxxL_5	54	63	PF00134	0.423
DOC_CYCLIN_yCln2_LP_2	189	195	PF00134	0.548
DOC_MAPK_gen_1	265	273	PF00069	0.505
DOC_PP1_RVXF_1	205	211	PF00149	0.508
DOC_USP7_MATH_1	117	121	PF00917	0.704
DOC_USP7_MATH_1	122	126	PF00917	0.725
DOC_USP7_MATH_1	181	185	PF00917	0.595
DOC_USP7_MATH_1	8	12	PF00917	0.521
DOC_WW_Pin1_4	129	134	PF00397	0.743
DOC_WW_Pin1_4	141	146	PF00397	0.601
DOC_WW_Pin1_4	176	181	PF00397	0.312
DOC_WW_Pin1_4	279	284	PF00397	0.468
DOC_WW_Pin1_4	345	350	PF00397	0.493
DOC_WW_Pin1_4	370	375	PF00397	0.495
DOC_WW_Pin1_4	87	92	PF00397	0.604
LIG_14-3-3_CanoR_1	212	216	PF00244	0.576
LIG_14-3-3_CanoR_1	279	283	PF00244	0.449
LIG_14-3-3_CanoR_1	342	346	PF00244	0.545
LIG_14-3-3_CanoR_1	427	432	PF00244	0.582
LIG_14-3-3_CanoR_1	436	441	PF00244	0.522
LIG_BIR_II_1	1	5	PF00653	0.654
LIG_FHA_1	16	22	PF00498	0.494
LIG_FHA_1	170	176	PF00498	0.405
LIG_FHA_1	211	217	PF00498	0.538
LIG_FHA_1	251	257	PF00498	0.430
LIG_FHA_1	306	312	PF00498	0.484
LIG_FHA_1	37	43	PF00498	0.566
LIG_FHA_1	379	385	PF00498	0.489
LIG_FHA_1	415	421	PF00498	0.525
LIG_FHA_1	49	55	PF00498	0.447
LIG_FHA_2	121	127	PF00498	0.505
LIG_FHA_2	301	307	PF00498	0.456
LIG_FHA_2	31	37	PF00498	0.686
LIG_FHA_2	408	414	PF00498	0.556
LIG_FHA_2	437	443	PF00498	0.553
LIG_FHA_2	88	94	PF00498	0.669
LIG_GBD_Chelix_1	216	224	PF00786	0.487
LIG_LIR_Apic_2	239	243	PF02991	0.522
LIG_LIR_Apic_2	277	283	PF02991	0.340
LIG_LIR_Apic_2	344	349	PF02991	0.538
LIG_LIR_Apic_2	51	55	PF02991	0.405
LIG_LIR_Gen_1	439	448	PF02991	0.572
LIG_LIR_Nem_3	223	229	PF02991	0.442
LIG_LIR_Nem_3	359	365	PF02991	0.420
LIG_LIR_Nem_3	439	443	PF02991	0.558
LIG_LIR_Nem_3	51	56	PF02991	0.403
LIG_NRBOX	185	191	PF00104	0.402
LIG_PALB2_WD40_1	48	56	PF16756	0.434
LIG_Pex14_2	362	366	PF04695	0.379
LIG_PTB_Apo_2	239	246	PF02174	0.486
LIG_PTB_Apo_2	55	62	PF02174	0.414
LIG_PTB_Phospho_1	239	245	PF10480	0.494
LIG_PTB_Phospho_1	55	61	PF10480	0.408
LIG_SH2_CRK	240	244	PF00017	0.500
LIG_SH2_CRK	280	284	PF00017	0.368
LIG_SH2_GRB2like	157	160	PF00017	0.604
LIG_SH2_NCK_1	280	284	PF00017	0.368
LIG_SH2_STAP1	440	444	PF00017	0.577
LIG_SH2_STAT5	157	160	PF00017	0.560
LIG_SH2_STAT5	245	248	PF00017	0.435
LIG_SH2_STAT5	27	30	PF00017	0.680
LIG_SH2_STAT5	280	283	PF00017	0.382
LIG_SH2_STAT5	369	372	PF00017	0.433
LIG_SH2_STAT5	61	64	PF00017	0.638
LIG_SH3_3	26	32	PF00018	0.575
LIG_SH3_3	346	352	PF00018	0.494
LIG_SH3_3	372	378	PF00018	0.457
LIG_SH3_3	85	91	PF00018	0.686
LIG_UBA3_1	233	241	PF00899	0.502
LIG_WRC_WIRS_1	428	433	PF05994	0.456
MOD_CDC14_SPxK_1	179	182	PF00782	0.355
MOD_CDK_SPxK_1	176	182	PF00069	0.325
MOD_CK1_1	120	126	PF00069	0.808
MOD_CK1_1	136	142	PF00069	0.670
MOD_CK1_1	143	149	PF00069	0.618
MOD_CK1_1	2	8	PF00069	0.634
MOD_CK1_1	219	225	PF00069	0.550
MOD_CK1_1	347	353	PF00069	0.474
MOD_CK1_1	407	413	PF00069	0.554
MOD_CK1_1	41	47	PF00069	0.535
MOD_CK2_1	143	149	PF00069	0.658
MOD_CK2_1	181	187	PF00069	0.488
MOD_CK2_1	361	367	PF00069	0.430
MOD_CK2_1	412	418	PF00069	0.533
MOD_CK2_1	436	442	PF00069	0.604
MOD_CK2_1	87	93	PF00069	0.646
MOD_GlcNHglycan	119	122	PF01048	0.698
MOD_GlcNHglycan	246	249	PF01048	0.480
MOD_GlcNHglycan	319	322	PF01048	0.464
MOD_GlcNHglycan	4	7	PF01048	0.712
MOD_GlcNHglycan	406	409	PF01048	0.564
MOD_GlcNHglycan	93	97	PF01048	0.569
MOD_GSK3_1	129	136	PF00069	0.642
MOD_GSK3_1	139	146	PF00069	0.595
MOD_GSK3_1	216	223	PF00069	0.455
MOD_GSK3_1	274	281	PF00069	0.434
MOD_GSK3_1	300	307	PF00069	0.486
MOD_GSK3_1	341	348	PF00069	0.508
MOD_GSK3_1	37	44	PF00069	0.484
MOD_N-GLC_1	176	181	PF02516	0.312
MOD_N-GLC_1	317	322	PF02516	0.459
MOD_NEK2_1	112	117	PF00069	0.705
MOD_NEK2_1	216	221	PF00069	0.481
MOD_NEK2_1	304	309	PF00069	0.495
MOD_NEK2_1	336	341	PF00069	0.482
MOD_NEK2_2	196	201	PF00069	0.425
MOD_PIKK_1	136	142	PF00454	0.632
MOD_PIKK_1	274	280	PF00454	0.448
MOD_PK_1	103	109	PF00069	0.631
MOD_PK_1	232	238	PF00069	0.470
MOD_PKA_2	117	123	PF00069	0.705
MOD_PKA_2	15	21	PF00069	0.530
MOD_PKA_2	211	217	PF00069	0.540
MOD_PKA_2	278	284	PF00069	0.496
MOD_PKA_2	341	347	PF00069	0.524
MOD_Plk_1	317	323	PF00069	0.465
MOD_Plk_1	387	393	PF00069	0.491
MOD_Plk_1	412	418	PF00069	0.528
MOD_Plk_2-3	361	367	PF00069	0.430
MOD_Plk_4	103	109	PF00069	0.675
MOD_Plk_4	161	167	PF00069	0.453
MOD_Plk_4	169	175	PF00069	0.362
MOD_Plk_4	181	187	PF00069	0.361
MOD_Plk_4	211	217	PF00069	0.513
MOD_Plk_4	300	306	PF00069	0.404
MOD_Plk_4	336	342	PF00069	0.481
MOD_Plk_4	361	367	PF00069	0.382
MOD_Plk_4	378	384	PF00069	0.412
MOD_Plk_4	387	393	PF00069	0.431
MOD_Plk_4	48	54	PF00069	0.365
MOD_ProDKin_1	129	135	PF00069	0.744
MOD_ProDKin_1	141	147	PF00069	0.600
MOD_ProDKin_1	176	182	PF00069	0.325
MOD_ProDKin_1	279	285	PF00069	0.464
MOD_ProDKin_1	345	351	PF00069	0.488
MOD_ProDKin_1	370	376	PF00069	0.504
MOD_ProDKin_1	87	93	PF00069	0.607
MOD_SUMO_for_1	295	298	PF00179	0.458
MOD_SUMO_rev_2	235	243	PF00179	0.502
TRG_DiLeu_BaLyEn_6	185	190	PF01217	0.532
TRG_DiLeu_BaLyEn_6	258	263	PF01217	0.447
TRG_ENDOCYTIC_2	27	30	PF00928	0.662
TRG_ENDOCYTIC_2	428	431	PF00928	0.495
TRG_ENDOCYTIC_2	440	443	PF00928	0.502
TRG_ER_diArg_1	19	22	PF00400	0.531
TRG_Pf-PMV_PEXEL_1	19	23	PF00026	0.629
TRG_Pf-PMV_PEXEL_1	414	418	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P811	Leptomonas seymouri	80%	100%
A0A0S4JBD1	Bodo saltans	47%	100%
A0A3R7MFR3	Trypanosoma rangeli	53%	100%
A0A3S7WX76	Leishmania donovani	92%	100%
A4HCF8	Leishmania braziliensis	90%	100%
A4HZY7	Leishmania infantum	92%	93%
Q4QBN1	Leishmania major	94%	100%
V5BVW6	Trypanosoma cruzi	52%	100%