Lactamase_B domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Beta-lactamase superfamily domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AVU5_LEIMU

TriTrypDb:

LmxM.22.1130

Length:

429

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVU5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVU5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	148	150	PF00675	0.491
CLV_NRD_NRD_1	351	353	PF00675	0.418
CLV_NRD_NRD_1	44	46	PF00675	0.346
CLV_NRD_NRD_1	5	7	PF00675	0.554
CLV_PCSK_KEX2_1	148	150	PF00082	0.491
CLV_PCSK_KEX2_1	351	353	PF00082	0.480
CLV_PCSK_KEX2_1	44	46	PF00082	0.346
CLV_PCSK_KEX2_1	5	7	PF00082	0.554
CLV_PCSK_SKI1_1	406	410	PF00082	0.485
DEG_APCC_DBOX_1	5	13	PF00400	0.346
DEG_ODPH_VHL_1	84	97	PF01847	0.463
DEG_SPOP_SBC_1	126	130	PF00917	0.417
DEG_SPOP_SBC_1	198	202	PF00917	0.519
DOC_CDC14_PxL_1	153	161	PF14671	0.359
DOC_MAPK_gen_1	219	228	PF00069	0.459
DOC_MAPK_gen_1	379	388	PF00069	0.518
DOC_MAPK_gen_1	44	52	PF00069	0.339
DOC_MAPK_gen_1	5	11	PF00069	0.484
DOC_MAPK_gen_1	74	83	PF00069	0.397
DOC_MAPK_HePTP_8	378	390	PF00069	0.405
DOC_MAPK_MEF2A_6	219	228	PF00069	0.553
DOC_MAPK_MEF2A_6	316	324	PF00069	0.293
DOC_MAPK_MEF2A_6	381	390	PF00069	0.555
DOC_MAPK_MEF2A_6	44	52	PF00069	0.383
DOC_PP1_RVXF_1	403	410	PF00149	0.370
DOC_PP1_RVXF_1	6	12	PF00149	0.335
DOC_USP7_MATH_1	126	130	PF00917	0.429
DOC_USP7_MATH_1	185	189	PF00917	0.566
DOC_USP7_MATH_1	198	202	PF00917	0.560
DOC_USP7_MATH_1	233	237	PF00917	0.635
DOC_USP7_MATH_1	275	279	PF00917	0.471
DOC_USP7_MATH_1	304	308	PF00917	0.487
DOC_USP7_MATH_1	331	335	PF00917	0.521
DOC_USP7_MATH_1	37	41	PF00917	0.598
DOC_USP7_MATH_1	391	395	PF00917	0.561
DOC_WW_Pin1_4	163	168	PF00397	0.561
DOC_WW_Pin1_4	229	234	PF00397	0.555
LIG_14-3-3_CanoR_1	199	207	PF00244	0.571
LIG_14-3-3_CanoR_1	351	355	PF00244	0.443
LIG_14-3-3_CanoR_1	45	51	PF00244	0.409
LIG_14-3-3_CanoR_1	6	12	PF00244	0.403
LIG_BRCT_BRCA1_1	306	310	PF00533	0.480
LIG_BRCT_BRCA1_1	52	56	PF00533	0.358
LIG_Clathr_ClatBox_1	314	318	PF01394	0.363
LIG_eIF4E_1	91	97	PF01652	0.395
LIG_FHA_1	351	357	PF00498	0.309
LIG_FHA_2	207	213	PF00498	0.426
LIG_IRF3_LxIS_1	48	53	PF10401	0.416
LIG_LIR_Gen_1	64	70	PF02991	0.424
LIG_LIR_Gen_1	78	87	PF02991	0.393
LIG_LIR_Nem_3	249	255	PF02991	0.395
LIG_LIR_Nem_3	64	68	PF02991	0.415
LIG_LIR_Nem_3	78	83	PF02991	0.368
LIG_Pex14_2	355	359	PF04695	0.450
LIG_SH2_CRK	253	257	PF00017	0.360
LIG_SH2_CRK	80	84	PF00017	0.465
LIG_SH2_SRC	91	94	PF00017	0.400
LIG_SH2_STAP1	122	126	PF00017	0.404
LIG_SH2_STAT3	420	423	PF00017	0.496
LIG_SH2_STAT5	122	125	PF00017	0.335
LIG_SH2_STAT5	263	266	PF00017	0.425
LIG_SH2_STAT5	296	299	PF00017	0.353
LIG_SH2_STAT5	336	339	PF00017	0.393
LIG_SH2_STAT5	354	357	PF00017	0.252
LIG_SH2_STAT5	91	94	PF00017	0.414
LIG_SH3_2	39	44	PF14604	0.450
LIG_SH3_3	151	157	PF00018	0.234
LIG_SH3_3	224	230	PF00018	0.463
LIG_SH3_3	36	42	PF00018	0.495
LIG_SH3_3	385	391	PF00018	0.451
LIG_SH3_3	80	86	PF00018	0.473
LIG_SUMO_SIM_anti_2	318	323	PF11976	0.296
LIG_SUMO_SIM_par_1	318	323	PF11976	0.296
LIG_UBA3_1	213	220	PF00899	0.489
LIG_WRC_WIRS_1	150	155	PF05994	0.471
MOD_CDK_SPK_2	234	239	PF00069	0.647
MOD_CK1_1	125	131	PF00069	0.642
MOD_CK1_1	200	206	PF00069	0.521
MOD_CK1_1	298	304	PF00069	0.355
MOD_CK2_1	199	205	PF00069	0.663
MOD_CK2_1	58	64	PF00069	0.486
MOD_GlcNHglycan	124	127	PF01048	0.547
MOD_GlcNHglycan	132	135	PF01048	0.713
MOD_GlcNHglycan	17	20	PF01048	0.413
MOD_GlcNHglycan	187	190	PF01048	0.546
MOD_GlcNHglycan	202	205	PF01048	0.592
MOD_GlcNHglycan	331	334	PF01048	0.549
MOD_GlcNHglycan	39	42	PF01048	0.564
MOD_GlcNHglycan	60	63	PF01048	0.545
MOD_GlcNHglycan	77	80	PF01048	0.475
MOD_GSK3_1	120	127	PF00069	0.535
MOD_GSK3_1	130	137	PF00069	0.602
MOD_GSK3_1	193	200	PF00069	0.632
MOD_GSK3_1	229	236	PF00069	0.705
MOD_GSK3_1	241	248	PF00069	0.710
MOD_GSK3_1	271	278	PF00069	0.431
MOD_GSK3_1	46	53	PF00069	0.377
MOD_GSK3_1	54	61	PF00069	0.437
MOD_GSK3_1	7	14	PF00069	0.311
MOD_N-GLC_1	46	51	PF02516	0.393
MOD_NEK2_1	50	55	PF00069	0.394
MOD_NEK2_1	7	12	PF00069	0.397
MOD_NEK2_1	95	100	PF00069	0.446
MOD_NEK2_2	72	77	PF00069	0.366
MOD_PIKK_1	120	126	PF00454	0.324
MOD_PIKK_1	275	281	PF00454	0.593
MOD_PKA_2	120	126	PF00069	0.398
MOD_PKA_2	198	204	PF00069	0.641
MOD_PKA_2	271	277	PF00069	0.474
MOD_PKA_2	350	356	PF00069	0.438
MOD_PKA_2	7	13	PF00069	0.395
MOD_Plk_1	298	304	PF00069	0.419
MOD_Plk_1	46	52	PF00069	0.388
MOD_Plk_4	149	155	PF00069	0.439
MOD_Plk_4	206	212	PF00069	0.504
MOD_Plk_4	46	52	PF00069	0.321
MOD_Plk_4	7	13	PF00069	0.390
MOD_ProDKin_1	163	169	PF00069	0.555
MOD_ProDKin_1	229	235	PF00069	0.563
MOD_SUMO_rev_2	212	221	PF00179	0.440
MOD_SUMO_rev_2	400	408	PF00179	0.401
MOD_SUMO_rev_2	53	61	PF00179	0.356
TRG_ENDOCYTIC_2	263	266	PF00928	0.367
TRG_ENDOCYTIC_2	80	83	PF00928	0.400
TRG_ER_diArg_1	147	149	PF00400	0.499
TRG_ER_diArg_1	350	352	PF00400	0.423
TRG_ER_diArg_1	4	6	PF00400	0.537
TRG_NES_CRM1_1	205	218	PF08389	0.394
TRG_NES_CRM1_1	312	323	PF08389	0.369
TRG_Pf-PMV_PEXEL_1	373	377	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0M2	Leptomonas seymouri	37%	94%
A0A0N1PFX0	Leptomonas seymouri	59%	94%
A0A0S4J8Q0	Bodo saltans	36%	100%
A0A1X0NTE2	Trypanosomatidae	41%	100%
A0A3Q8IFK3	Leishmania donovani	47%	92%
A0A3S7WXD8	Leishmania donovani	91%	100%
A0A422NHR8	Trypanosoma rangeli	40%	100%
A4HCF4	Leishmania braziliensis	40%	100%
A4HZY3	Leishmania infantum	47%	92%
A4HZY4	Leishmania infantum	91%	100%
C9ZSM3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZVB8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9AVU4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
Q4QBN4	Leishmania major	90%	99%
Q4QBN5	Leishmania major	42%	100%
V5BVW3	Trypanosoma cruzi	40%	100%