Lactamase_B domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Beta-lactamase superfamily domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AVU4_LEIMU

TriTrypDb:

LmxM.22.1120

Length:

468

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVU4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVU4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.633
CLV_C14_Caspase3-7	150	154	PF00656	0.302
CLV_NRD_NRD_1	275	277	PF00675	0.367
CLV_NRD_NRD_1	74	76	PF00675	0.506
CLV_PCSK_KEX2_1	275	277	PF00082	0.368
CLV_PCSK_KEX2_1	74	76	PF00082	0.500
CLV_PCSK_SKI1_1	414	418	PF00082	0.437
DEG_APCC_DBOX_1	73	81	PF00400	0.577
DEG_Nend_UBRbox_3	1	3	PF02207	0.568
DEG_SPOP_SBC_1	113	117	PF00917	0.501
DOC_CKS1_1	236	241	PF01111	0.378
DOC_MAPK_DCC_7	74	82	PF00069	0.415
DOC_MAPK_gen_1	275	282	PF00069	0.343
DOC_MAPK_gen_1	289	297	PF00069	0.448
DOC_MAPK_gen_1	74	82	PF00069	0.493
DOC_MAPK_MEF2A_6	289	297	PF00069	0.511
DOC_MAPK_MEF2A_6	63	72	PF00069	0.362
DOC_MAPK_MEF2A_6	74	82	PF00069	0.481
DOC_MAPK_NFAT4_5	63	71	PF00069	0.332
DOC_USP7_MATH_1	121	125	PF00917	0.755
DOC_USP7_MATH_1	338	342	PF00917	0.449
DOC_USP7_MATH_1	367	371	PF00917	0.473
DOC_USP7_MATH_1	437	441	PF00917	0.367
DOC_USP7_MATH_1	55	59	PF00917	0.563
DOC_USP7_UBL2_3	216	220	PF12436	0.283
DOC_WW_Pin1_4	208	213	PF00397	0.429
DOC_WW_Pin1_4	235	240	PF00397	0.550
DOC_WW_Pin1_4	386	391	PF00397	0.470
DOC_WW_Pin1_4	392	397	PF00397	0.528
DOC_WW_Pin1_4	87	92	PF00397	0.656
LIG_14-3-3_CanoR_1	227	231	PF00244	0.329
LIG_14-3-3_CanoR_1	275	283	PF00244	0.359
LIG_14-3-3_CanoR_1	63	69	PF00244	0.383
LIG_Actin_WH2_2	435	450	PF00022	0.485
LIG_BIR_III_4	109	113	PF00653	0.476
LIG_BRCT_BRCA1_1	369	373	PF00533	0.466
LIG_Clathr_ClatBox_1	282	286	PF01394	0.474
LIG_Clathr_ClatBox_1	377	381	PF01394	0.347
LIG_deltaCOP1_diTrp_1	199	205	PF00928	0.425
LIG_FHA_1	114	120	PF00498	0.698
LIG_FHA_1	135	141	PF00498	0.316
LIG_FHA_1	167	173	PF00498	0.425
LIG_FHA_1	429	435	PF00498	0.360
LIG_FHA_2	148	154	PF00498	0.261
LIG_FHA_2	236	242	PF00498	0.446
LIG_FHA_2	276	282	PF00498	0.353
LIG_FHA_2	81	87	PF00498	0.614
LIG_LIR_Apic_2	208	212	PF02991	0.408
LIG_LIR_Gen_1	266	274	PF02991	0.429
LIG_LIR_Nem_3	153	158	PF02991	0.301
LIG_LIR_Nem_3	266	272	PF02991	0.497
LIG_LIR_Nem_3	312	318	PF02991	0.365
LIG_SH2_CRK	316	320	PF00017	0.349
LIG_SH2_STAT5	134	137	PF00017	0.511
LIG_SH2_STAT5	155	158	PF00017	0.310
LIG_SH2_STAT5	209	212	PF00017	0.275
LIG_SH2_STAT5	224	227	PF00017	0.219
LIG_SH2_STAT5	326	329	PF00017	0.413
LIG_SH2_STAT5	359	362	PF00017	0.317
LIG_SH2_STAT5	399	402	PF00017	0.356
LIG_SH3_1	75	81	PF00018	0.373
LIG_SH3_3	14	20	PF00018	0.411
LIG_SH3_3	461	467	PF00018	0.302
LIG_SH3_3	51	57	PF00018	0.491
LIG_SH3_3	75	81	PF00018	0.571
LIG_SUMO_SIM_par_1	168	173	PF11976	0.437
LIG_UBA3_1	404	412	PF00899	0.313
LIG_WRC_WIRS_1	202	207	PF05994	0.418
MOD_CDK_SPxxK_3	386	393	PF00069	0.326
MOD_CK1_1	211	217	PF00069	0.288
MOD_CK1_1	229	235	PF00069	0.387
MOD_CK1_1	237	243	PF00069	0.486
MOD_CK1_1	32	38	PF00069	0.315
MOD_CK1_1	361	367	PF00069	0.320
MOD_CK1_1	428	434	PF00069	0.304
MOD_CK1_1	87	93	PF00069	0.761
MOD_CK2_1	235	241	PF00069	0.438
MOD_CK2_1	80	86	PF00069	0.591
MOD_GlcNHglycan	105	108	PF01048	0.734
MOD_GlcNHglycan	231	234	PF01048	0.532
MOD_GlcNHglycan	31	34	PF01048	0.351
MOD_GlcNHglycan	390	393	PF01048	0.539
MOD_GlcNHglycan	56	60	PF01048	0.512
MOD_GSK3_1	166	173	PF00069	0.417
MOD_GSK3_1	201	208	PF00069	0.365
MOD_GSK3_1	210	217	PF00069	0.332
MOD_GSK3_1	25	32	PF00069	0.313
MOD_GSK3_1	300	307	PF00069	0.632
MOD_GSK3_1	334	341	PF00069	0.405
MOD_GSK3_1	388	395	PF00069	0.489
MOD_GSK3_1	64	71	PF00069	0.394
MOD_GSK3_1	80	87	PF00069	0.603
MOD_N-GLC_1	1	6	PF02516	0.376
MOD_N-GLC_1	103	108	PF02516	0.680
MOD_N-GLC_1	64	69	PF02516	0.370
MOD_NEK2_1	1	6	PF00069	0.477
MOD_NEK2_1	170	175	PF00069	0.420
MOD_NEK2_1	25	30	PF00069	0.412
MOD_NEK2_1	425	430	PF00069	0.277
MOD_NEK2_1	68	73	PF00069	0.380
MOD_NEK2_2	121	126	PF00069	0.548
MOD_NEK2_2	147	152	PF00069	0.289
MOD_PIKK_1	11	17	PF00454	0.418
MOD_PIKK_1	338	344	PF00454	0.584
MOD_PKA_1	275	281	PF00069	0.387
MOD_PKA_2	119	125	PF00069	0.547
MOD_PKA_2	129	135	PF00069	0.348
MOD_PKA_2	226	232	PF00069	0.256
MOD_PKA_2	274	280	PF00069	0.352
MOD_PKA_2	334	340	PF00069	0.465
MOD_PKA_2	95	101	PF00069	0.502
MOD_Plk_1	1	7	PF00069	0.668
MOD_Plk_1	218	224	PF00069	0.362
MOD_Plk_1	361	367	PF00069	0.362
MOD_Plk_1	455	461	PF00069	0.479
MOD_Plk_1	64	70	PF00069	0.360
MOD_Plk_4	166	172	PF00069	0.395
MOD_Plk_4	201	207	PF00069	0.392
MOD_Plk_4	25	31	PF00069	0.392
MOD_ProDKin_1	208	214	PF00069	0.429
MOD_ProDKin_1	235	241	PF00069	0.554
MOD_ProDKin_1	386	392	PF00069	0.481
MOD_ProDKin_1	87	93	PF00069	0.656
TRG_ENDOCYTIC_2	155	158	PF00928	0.351
TRG_ENDOCYTIC_2	326	329	PF00928	0.354
TRG_ENDOCYTIC_2	459	462	PF00928	0.389
TRG_ER_diArg_1	274	276	PF00400	0.457
TRG_ER_diArg_1	73	75	PF00400	0.361
TRG_NES_CRM1_1	375	386	PF08389	0.354
TRG_Pf-PMV_PEXEL_1	75	79	PF00026	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0M2	Leptomonas seymouri	65%	100%
A0A0N1PFX0	Leptomonas seymouri	36%	100%
A0A0S4J8Q0	Bodo saltans	39%	100%
A0A1X0NTE2	Trypanosomatidae	39%	100%
A0A1X0NX03	Trypanosomatidae	23%	100%
A0A3Q8IFK3	Leishmania donovani	90%	100%
A0A3S7WXD8	Leishmania donovani	47%	100%
A0A422NHR8	Trypanosoma rangeli	39%	100%
A4HCF4	Leishmania braziliensis	86%	100%
A4HZY3	Leishmania infantum	90%	100%
A4HZY4	Leishmania infantum	47%	100%
C9ZSM3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
C9ZVB8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9AVU5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
Q4QBN4	Leishmania major	45%	100%
Q4QBN5	Leishmania major	90%	99%
V5BJ96	Trypanosoma cruzi	24%	100%
V5BVW3	Trypanosoma cruzi	41%	100%