CRAL-TRIO domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CRAL/TRIO domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AVU1_LEIMU

TriTrypDb:

LmxM.22.1090

Length:

713

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVU1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVU1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	518	522	PF00656	0.518
CLV_C14_Caspase3-7	70	74	PF00656	0.371
CLV_NRD_NRD_1	182	184	PF00675	0.385
CLV_NRD_NRD_1	610	612	PF00675	0.495
CLV_NRD_NRD_1	660	662	PF00675	0.448
CLV_NRD_NRD_1	97	99	PF00675	0.435
CLV_PCSK_FUR_1	180	184	PF00082	0.325
CLV_PCSK_FUR_1	608	612	PF00082	0.487
CLV_PCSK_FUR_1	95	99	PF00082	0.403
CLV_PCSK_KEX2_1	180	182	PF00082	0.362
CLV_PCSK_KEX2_1	608	610	PF00082	0.495
CLV_PCSK_KEX2_1	662	664	PF00082	0.469
CLV_PCSK_KEX2_1	95	97	PF00082	0.447
CLV_PCSK_PC1ET2_1	662	664	PF00082	0.469
CLV_PCSK_PC7_1	605	611	PF00082	0.486
CLV_PCSK_SKI1_1	132	136	PF00082	0.304
CLV_PCSK_SKI1_1	166	170	PF00082	0.416
CLV_PCSK_SKI1_1	457	461	PF00082	0.576
DEG_COP1_1	531	540	PF00400	0.618
DEG_SCF_FBW7_1	473	479	PF00400	0.705
DEG_SPOP_SBC_1	109	113	PF00917	0.331
DEG_SPOP_SBC_1	283	287	PF00917	0.325
DEG_SPOP_SBC_1	32	36	PF00917	0.580
DEG_SPOP_SBC_1	704	708	PF00917	0.567
DOC_CKS1_1	473	478	PF01111	0.708
DOC_CYCLIN_RxL_1	163	173	PF00134	0.353
DOC_CYCLIN_yCln2_LP_2	393	399	PF00134	0.492
DOC_CYCLIN_yCln2_LP_2	460	466	PF00134	0.637
DOC_MAPK_gen_1	22	29	PF00069	0.415
DOC_MAPK_gen_1	413	420	PF00069	0.504
DOC_MAPK_gen_1	608	620	PF00069	0.553
DOC_MAPK_gen_1	7	17	PF00069	0.383
DOC_MAPK_gen_1	78	87	PF00069	0.354
DOC_MAPK_MEF2A_6	132	139	PF00069	0.304
DOC_MAPK_MEF2A_6	154	162	PF00069	0.284
DOC_MAPK_MEF2A_6	22	29	PF00069	0.407
DOC_MAPK_MEF2A_6	621	629	PF00069	0.512
DOC_MAPK_NFAT4_5	22	30	PF00069	0.415
DOC_PP2B_LxvP_1	25	28	PF13499	0.378
DOC_PP2B_LxvP_1	397	400	PF13499	0.450
DOC_PP4_FxxP_1	142	145	PF00568	0.369
DOC_USP7_MATH_1	188	192	PF00917	0.342
DOC_USP7_MATH_1	32	36	PF00917	0.589
DOC_USP7_MATH_1	465	469	PF00917	0.775
DOC_USP7_MATH_1	545	549	PF00917	0.649
DOC_USP7_MATH_1	583	587	PF00917	0.475
DOC_USP7_MATH_1	680	684	PF00917	0.420
DOC_USP7_MATH_1	704	708	PF00917	0.546
DOC_WW_Pin1_4	205	210	PF00397	0.271
DOC_WW_Pin1_4	386	391	PF00397	0.547
DOC_WW_Pin1_4	436	441	PF00397	0.630
DOC_WW_Pin1_4	45	50	PF00397	0.788
DOC_WW_Pin1_4	459	464	PF00397	0.612
DOC_WW_Pin1_4	472	477	PF00397	0.650
DOC_WW_Pin1_4	489	494	PF00397	0.543
DOC_WW_Pin1_4	684	689	PF00397	0.536
LIG_14-3-3_CanoR_1	291	295	PF00244	0.325
LIG_14-3-3_CanoR_1	334	340	PF00244	0.313
LIG_14-3-3_CanoR_1	469	476	PF00244	0.661
LIG_14-3-3_CanoR_1	532	537	PF00244	0.501
LIG_14-3-3_CanoR_1	686	692	PF00244	0.508
LIG_14-3-3_CanoR_1	95	101	PF00244	0.346
LIG_Actin_WH2_2	102	120	PF00022	0.338
LIG_BIR_II_1	1	5	PF00653	0.466
LIG_BIR_III_4	383	387	PF00653	0.573
LIG_BRCT_BRCA1_1	324	328	PF00533	0.368
LIG_CtBP_PxDLS_1	312	316	PF00389	0.304
LIG_FHA_1	139	145	PF00498	0.364
LIG_FHA_1	226	232	PF00498	0.364
LIG_FHA_1	240	246	PF00498	0.254
LIG_FHA_1	28	34	PF00498	0.450
LIG_FHA_1	308	314	PF00498	0.284
LIG_FHA_1	537	543	PF00498	0.653
LIG_FHA_1	62	68	PF00498	0.357
LIG_FHA_2	218	224	PF00498	0.281
LIG_FHA_2	269	275	PF00498	0.205
LIG_FHA_2	677	683	PF00498	0.527
LIG_FHA_2	68	74	PF00498	0.472
LIG_LIR_Apic_2	141	145	PF02991	0.325
LIG_LIR_Gen_1	119	130	PF02991	0.325
LIG_LIR_Nem_3	119	125	PF02991	0.468
LIG_LIR_Nem_3	539	543	PF02991	0.656
LIG_LYPXL_yS_3	259	262	PF13949	0.304
LIG_MYND_3	144	148	PF01753	0.304
LIG_NRBOX	155	161	PF00104	0.284
LIG_NRBOX	669	675	PF00104	0.475
LIG_PCNA_PIPBox_1	69	78	PF02747	0.344
LIG_Pex3_1	670	681	PF04882	0.465
LIG_SH2_GRB2like	136	139	PF00017	0.304
LIG_SH2_NCK_1	543	547	PF00017	0.650
LIG_SH2_PTP2	136	139	PF00017	0.369
LIG_SH2_PTP2	398	401	PF00017	0.443
LIG_SH2_SRC	136	139	PF00017	0.369
LIG_SH2_SRC	398	401	PF00017	0.443
LIG_SH2_STAT5	136	139	PF00017	0.291
LIG_SH2_STAT5	398	401	PF00017	0.443
LIG_SH2_STAT5	543	546	PF00017	0.652
LIG_SH2_STAT5	619	622	PF00017	0.529
LIG_SH2_STAT5	75	78	PF00017	0.333
LIG_SH2_STAT5	79	82	PF00017	0.340
LIG_SH3_2	442	447	PF14604	0.645
LIG_SH3_3	396	402	PF00018	0.446
LIG_SH3_3	434	440	PF00018	0.636
LIG_SH3_3	46	52	PF00018	0.598
LIG_SH3_3	470	476	PF00018	0.660
LIG_SH3_3	591	597	PF00018	0.416
LIG_SUMO_SIM_anti_2	14	20	PF11976	0.296
LIG_SUMO_SIM_anti_2	249	256	PF11976	0.417
LIG_SUMO_SIM_anti_2	265	272	PF11976	0.209
LIG_SUMO_SIM_par_1	105	113	PF11976	0.406
LIG_SUMO_SIM_par_1	14	20	PF11976	0.296
LIG_SUMO_SIM_par_1	145	151	PF11976	0.350
LIG_SUMO_SIM_par_1	155	161	PF11976	0.356
LIG_SUMO_SIM_par_1	227	234	PF11976	0.278
LIG_SUMO_SIM_par_1	259	265	PF11976	0.259
LIG_SUMO_SIM_par_1	672	677	PF11976	0.519
LIG_TRAF2_1	51	54	PF00917	0.606
LIG_TRAF2_1	586	589	PF00917	0.491
LIG_TYR_ITIM	134	139	PF00017	0.369
LIG_UBA3_1	17	22	PF00899	0.317
LIG_UBA3_1	251	257	PF00899	0.366
LIG_UBA3_1	76	83	PF00899	0.341
LIG_WRC_WIRS_1	139	144	PF05994	0.325
MOD_CAAXbox	710	713	PF01239	0.551
MOD_CDK_SPK_2	45	50	PF00069	0.760
MOD_CK1_1	108	114	PF00069	0.334
MOD_CK1_1	191	197	PF00069	0.262
MOD_CK1_1	34	40	PF00069	0.713
MOD_CK1_1	426	432	PF00069	0.557
MOD_CK1_1	468	474	PF00069	0.576
MOD_CK1_1	508	514	PF00069	0.639
MOD_CK1_1	576	582	PF00069	0.704
MOD_CK2_1	268	274	PF00069	0.241
MOD_CK2_1	282	288	PF00069	0.310
MOD_CK2_1	338	344	PF00069	0.387
MOD_CK2_1	48	54	PF00069	0.617
MOD_CK2_1	583	589	PF00069	0.510
MOD_CK2_1	676	682	PF00069	0.521
MOD_GlcNHglycan	1	4	PF01048	0.471
MOD_GlcNHglycan	190	193	PF01048	0.347
MOD_GlcNHglycan	36	39	PF01048	0.713
MOD_GlcNHglycan	363	366	PF01048	0.630
MOD_GlcNHglycan	425	428	PF01048	0.535
MOD_GlcNHglycan	451	454	PF01048	0.624
MOD_GlcNHglycan	507	510	PF01048	0.615
MOD_GlcNHglycan	561	564	PF01048	0.649
MOD_GlcNHglycan	578	581	PF01048	0.548
MOD_GlcNHglycan	682	685	PF01048	0.388
MOD_GSK3_1	105	112	PF00069	0.417
MOD_GSK3_1	246	253	PF00069	0.356
MOD_GSK3_1	27	34	PF00069	0.542
MOD_GSK3_1	322	329	PF00069	0.471
MOD_GSK3_1	422	429	PF00069	0.659
MOD_GSK3_1	432	439	PF00069	0.593
MOD_GSK3_1	467	474	PF00069	0.661
MOD_GSK3_1	528	535	PF00069	0.669
MOD_GSK3_1	541	548	PF00069	0.553
MOD_GSK3_1	579	586	PF00069	0.538
MOD_GSK3_1	61	68	PF00069	0.361
MOD_GSK3_1	676	683	PF00069	0.473
MOD_GSK3_1	96	103	PF00069	0.577
MOD_LATS_1	530	536	PF00433	0.628
MOD_N-GLC_1	246	251	PF02516	0.369
MOD_N-GLC_1	326	331	PF02516	0.372
MOD_NEK2_1	100	105	PF00069	0.420
MOD_NEK2_1	107	112	PF00069	0.427
MOD_NEK2_1	239	244	PF00069	0.342
MOD_NEK2_1	262	267	PF00069	0.399
MOD_NEK2_1	306	311	PF00069	0.336
MOD_NEK2_1	337	342	PF00069	0.356
MOD_NEK2_1	404	409	PF00069	0.513
MOD_NEK2_1	423	428	PF00069	0.560
MOD_NEK2_1	549	554	PF00069	0.634
MOD_NEK2_1	559	564	PF00069	0.569
MOD_NEK2_1	573	578	PF00069	0.660
MOD_NEK2_1	67	72	PF00069	0.337
MOD_NEK2_1	674	679	PF00069	0.462
MOD_PIKK_1	338	344	PF00454	0.366
MOD_PIKK_1	404	410	PF00454	0.515
MOD_PIKK_1	479	485	PF00454	0.658
MOD_PKA_1	96	102	PF00069	0.350
MOD_PKA_2	290	296	PF00069	0.369
MOD_PKA_2	468	474	PF00069	0.659
MOD_PKA_2	96	102	PF00069	0.350
MOD_Plk_1	100	106	PF00069	0.402
MOD_Plk_1	173	179	PF00069	0.205
MOD_Plk_1	246	252	PF00069	0.369
MOD_Plk_1	306	312	PF00069	0.311
MOD_Plk_1	674	680	PF00069	0.455
MOD_Plk_2-3	499	505	PF00069	0.596
MOD_Plk_4	240	246	PF00069	0.352
MOD_Plk_4	247	253	PF00069	0.352
MOD_Plk_4	262	268	PF00069	0.284
MOD_Plk_4	426	432	PF00069	0.603
MOD_Plk_4	532	538	PF00069	0.497
MOD_ProDKin_1	205	211	PF00069	0.271
MOD_ProDKin_1	386	392	PF00069	0.542
MOD_ProDKin_1	436	442	PF00069	0.629
MOD_ProDKin_1	45	51	PF00069	0.781
MOD_ProDKin_1	459	465	PF00069	0.612
MOD_ProDKin_1	472	478	PF00069	0.650
MOD_ProDKin_1	489	495	PF00069	0.543
MOD_ProDKin_1	684	690	PF00069	0.541
MOD_SUMO_for_1	655	658	PF00179	0.502
MOD_SUMO_rev_2	350	360	PF00179	0.621
TRG_DiLeu_BaEn_1	151	156	PF01217	0.278
TRG_DiLeu_BaEn_3	588	594	PF01217	0.423
TRG_DiLeu_BaLyEn_6	257	262	PF01217	0.325
TRG_DiLeu_LyEn_5	151	156	PF01217	0.278
TRG_ENDOCYTIC_2	136	139	PF00928	0.304
TRG_ENDOCYTIC_2	258	261	PF00928	0.480
TRG_ER_diArg_1	180	183	PF00400	0.362
TRG_ER_diArg_1	608	611	PF00400	0.500
TRG_ER_diArg_1	94	97	PF00400	0.389
TRG_NES_CRM1_1	6	20	PF08389	0.321
TRG_NES_CRM1_1	638	652	PF08389	0.449
TRG_NLS_MonoExtC_3	660	665	PF00514	0.457
TRG_NLS_MonoExtN_4	661	666	PF00514	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P818	Leptomonas seymouri	50%	100%
A0A3Q8IAR1	Leishmania donovani	88%	100%
A4HCF0	Leishmania braziliensis	67%	99%
A4HZY1	Leishmania infantum	88%	100%
Q4QBN8	Leishmania major	86%	98%