Mitochondrial import receptor subunit TOM22 homolog

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVU0_LEIMU

TriTrypDb:

LmxM.22.1080

Length:

255

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	4
GO:0016020	membrane	2	3

Expansion

Sequence features

E9AVU0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVU0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	175	179	PF00656	0.496
CLV_NRD_NRD_1	124	126	PF00675	0.401
CLV_NRD_NRD_1	200	202	PF00675	0.542
CLV_NRD_NRD_1	77	79	PF00675	0.496
CLV_PCSK_KEX2_1	200	202	PF00082	0.386
CLV_PCSK_KEX2_1	225	227	PF00082	0.468
CLV_PCSK_KEX2_1	77	79	PF00082	0.564
CLV_PCSK_PC1ET2_1	225	227	PF00082	0.492
CLV_PCSK_SKI1_1	200	204	PF00082	0.427
CLV_PCSK_SKI1_1	225	229	PF00082	0.439
DOC_CKS1_1	203	208	PF01111	0.283
DOC_PP1_RVXF_1	223	230	PF00149	0.554
DOC_PP4_FxxP_1	203	206	PF00568	0.288
DOC_USP7_MATH_1	176	180	PF00917	0.661
DOC_USP7_MATH_1	207	211	PF00917	0.455
DOC_WW_Pin1_4	147	152	PF00397	0.572
DOC_WW_Pin1_4	160	165	PF00397	0.548
DOC_WW_Pin1_4	202	207	PF00397	0.561
DOC_WW_Pin1_4	39	44	PF00397	0.733
LIG_14-3-3_CanoR_1	37	46	PF00244	0.476
LIG_14-3-3_CanoR_1	5	13	PF00244	0.435
LIG_APCC_ABBAyCdc20_2	77	83	PF00400	0.401
LIG_FHA_1	114	120	PF00498	0.360
LIG_FHA_1	161	167	PF00498	0.625
LIG_FHA_1	203	209	PF00498	0.518
LIG_FHA_1	244	250	PF00498	0.516
LIG_FHA_2	139	145	PF00498	0.512
LIG_FHA_2	173	179	PF00498	0.564
LIG_FHA_2	45	51	PF00498	0.622
LIG_LIR_Gen_1	210	218	PF02991	0.401
LIG_LIR_Nem_3	233	238	PF02991	0.337
LIG_LIR_Nem_3	92	96	PF02991	0.395
LIG_NRBOX	248	254	PF00104	0.477
LIG_SH2_CRK	250	254	PF00017	0.439
LIG_SH2_SRC	81	84	PF00017	0.514
LIG_SH2_STAP1	232	236	PF00017	0.422
LIG_SH2_STAT5	127	130	PF00017	0.569
LIG_SH2_STAT5	244	247	PF00017	0.449
LIG_SH2_STAT5	91	94	PF00017	0.388
LIG_SH3_3	145	151	PF00018	0.498
LIG_SUMO_SIM_anti_2	50	56	PF11976	0.600
LIG_SUMO_SIM_par_1	116	124	PF11976	0.478
LIG_UBA3_1	214	222	PF00899	0.274
LIG_ULM_U2AF65_1	225	230	PF00076	0.557
MOD_CK1_1	179	185	PF00069	0.714
MOD_CK1_1	6	12	PF00069	0.600
MOD_CK2_1	138	144	PF00069	0.603
MOD_CK2_1	44	50	PF00069	0.621
MOD_GlcNHglycan	186	189	PF01048	0.719
MOD_GlcNHglycan	8	11	PF01048	0.662
MOD_GlcNHglycan	93	96	PF01048	0.392
MOD_GSK3_1	100	107	PF00069	0.432
MOD_GSK3_1	110	117	PF00069	0.362
MOD_GSK3_1	128	135	PF00069	0.539
MOD_GSK3_1	136	143	PF00069	0.528
MOD_GSK3_1	147	154	PF00069	0.494
MOD_GSK3_1	156	163	PF00069	0.738
MOD_GSK3_1	172	179	PF00069	0.551
MOD_GSK3_1	180	187	PF00069	0.695
MOD_N-GLC_1	156	161	PF02516	0.697
MOD_NEK2_1	128	133	PF00069	0.638
MOD_NEK2_1	136	141	PF00069	0.521
MOD_NEK2_1	180	185	PF00069	0.446
MOD_NEK2_1	214	219	PF00069	0.378
MOD_NEK2_1	4	9	PF00069	0.541
MOD_NEK2_1	72	77	PF00069	0.460
MOD_PIKK_1	28	34	PF00454	0.555
MOD_PKA_2	136	142	PF00069	0.435
MOD_PKA_2	4	10	PF00069	0.544
MOD_Plk_4	104	110	PF00069	0.455
MOD_Plk_4	114	120	PF00069	0.363
MOD_Plk_4	207	213	PF00069	0.357
MOD_Plk_4	231	237	PF00069	0.396
MOD_ProDKin_1	147	153	PF00069	0.573
MOD_ProDKin_1	160	166	PF00069	0.549
MOD_ProDKin_1	202	208	PF00069	0.563
MOD_ProDKin_1	39	45	PF00069	0.726
MOD_SUMO_rev_2	121	128	PF00179	0.481
TRG_DiLeu_BaEn_1	50	55	PF01217	0.602
TRG_ENDOCYTIC_2	250	253	PF00928	0.445
TRG_ER_diArg_1	200	202	PF00400	0.344
TRG_NLS_MonoExtN_4	222	229	PF00514	0.474
TRG_Pf-PMV_PEXEL_1	126	130	PF00026	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8E4	Leptomonas seymouri	55%	100%
A0A1X0NTC5	Trypanosomatidae	37%	100%
A0A3Q8IC90	Leishmania donovani	82%	100%
A0A3R7NDY8	Trypanosoma rangeli	39%	100%
A4HCE9	Leishmania braziliensis	80%	100%
A4HZY0	Leishmania infantum	82%	100%
C9ZSL9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
Q4QBN9	Leishmania major	82%	99%
V5BVV8	Trypanosoma cruzi	39%	100%