Putative small nuclear ribonucleoprotein (Smd-1 like small nuclear ribonucleoprotein)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

small nuclear ribonucleoprotein, putative

Species:

Leishmania mexicana

UniProt:

E9AVT8_LEIMU

TriTrypDb:

LmxM.22.1060

Length:

103

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	7
GO:0032991	protein-containing complex	1	9
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	8
GO:1990904	ribonucleoprotein complex	2	9
GO:0000243	commitment complex	5	1
GO:0005681	spliceosomal complex	3	1
GO:0005682	U5 snRNP	5	1
GO:0005684	U2-type spliceosomal complex	4	1
GO:0005685	U1 snRNP	5	1
GO:0005686	U2 snRNP	5	1
GO:0005687	U4 snRNP	5	1
GO:0005689	U12-type spliceosomal complex	4	1
GO:0005737	cytoplasm	2	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0034715	pICln-Sm protein complex	3	1
GO:0034719	SMN-Sm protein complex	3	1
GO:0071011	precatalytic spliceosome	4	1
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0097526	spliceosomal tri-snRNP complex	5	1
GO:0120114	Sm-like protein family complex	2	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

E9AVT8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVT8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006396	RNA processing	6	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	9
GO:0016070	RNA metabolic process	5	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:0000387	spliceosomal snRNP assembly	7	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0022618	ribonucleoprotein complex assembly	6	2
GO:0043933	protein-containing complex organization	4	2
GO:0065003	protein-containing complex assembly	5	2
GO:0071826	ribonucleoprotein complex subunit organization	5	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	40	44	PF00656	0.411
DEG_APCC_DBOX_1	20	28	PF00400	0.546
DOC_MAPK_gen_1	58	65	PF00069	0.581
DOC_MAPK_MEF2A_6	21	29	PF00069	0.518
DOC_USP7_UBL2_3	54	58	PF12436	0.522
DOC_WW_Pin1_4	2	7	PF00397	0.672
LIG_Actin_WH2_2	17	32	PF00022	0.581
LIG_Actin_WH2_2	77	93	PF00022	0.620
LIG_BIR_II_1	1	5	PF00653	0.693
LIG_Clathr_ClatBox_1	24	28	PF01394	0.546
LIG_FHA_1	84	90	PF00498	0.475
LIG_FHA_2	21	27	PF00498	0.522
LIG_LIR_Gen_1	74	84	PF02991	0.546
LIG_LIR_Gen_1	86	93	PF02991	0.572
LIG_LIR_Nem_3	86	90	PF02991	0.564
LIG_SH2_CRK	87	91	PF00017	0.570
LIG_SH2_SRC	41	44	PF00017	0.581
LIG_SH2_STAT5	41	44	PF00017	0.581
LIG_SH2_STAT5	77	80	PF00017	0.532
LIG_SUMO_SIM_par_1	23	28	PF11976	0.544
LIG_SUMO_SIM_par_1	61	67	PF11976	0.581
LIG_WRC_WIRS_1	13	18	PF05994	0.598
MOD_CK1_1	33	39	PF00069	0.546
MOD_CK1_1	83	89	PF00069	0.562
MOD_CK2_1	2	8	PF00069	0.724
MOD_CK2_1	20	26	PF00069	0.522
MOD_GlcNHglycan	35	38	PF01048	0.346
MOD_GSK3_1	2	9	PF00069	0.661
MOD_GSK3_1	33	40	PF00069	0.415
MOD_LATS_1	52	58	PF00433	0.581
MOD_N-GLC_1	30	35	PF02516	0.322
MOD_N-GLC_1	97	102	PF02516	0.498
MOD_NEK2_1	20	25	PF00069	0.514
MOD_PK_1	30	36	PF00069	0.581
MOD_PKA_2	20	26	PF00069	0.520
MOD_PKA_2	70	76	PF00069	0.619
MOD_Plk_1	30	36	PF00069	0.522
MOD_Plk_1	37	43	PF00069	0.522
MOD_Plk_4	20	26	PF00069	0.535
MOD_Plk_4	30	36	PF00069	0.522
MOD_Plk_4	45	51	PF00069	0.546
MOD_Plk_4	9	15	PF00069	0.498
MOD_ProDKin_1	2	8	PF00069	0.670
MOD_SUMO_rev_2	26	32	PF00179	0.581
TRG_ENDOCYTIC_2	77	80	PF00928	0.546
TRG_ENDOCYTIC_2	87	90	PF00928	0.562

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P814	Leptomonas seymouri	88%	98%
A0A1X0PAE8	Trypanosomatidae	36%	90%
A0A3Q8ICE0	Leishmania donovani	98%	100%
A0A422NSZ6	Trypanosoma rangeli	35%	90%
A4HCC3	Leishmania braziliensis	91%	100%
A4HZX8	Leishmania infantum	98%	100%
C9ZSL7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	97%
O42661	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	48%	88%
P62314	Homo sapiens	46%	87%
P62315	Mus musculus	46%	87%
P62318	Homo sapiens	29%	82%
P62320	Mus musculus	29%	82%
P62323	Xenopus laevis	29%	82%
Q10013	Caenorhabditis elegans	46%	82%
Q3ZC10	Bos taurus	46%	87%
Q4QBP1	Leishmania major	98%	100%
Q4R5F6	Macaca fascicularis	46%	87%
Q54F84	Dictyostelium discoideum	31%	75%
Q8QZX5	Mus musculus	30%	84%
Q969L4	Homo sapiens	30%	84%
Q9SSF1	Arabidopsis thaliana	43%	90%
Q9SY09	Arabidopsis thaliana	46%	89%
Q9UUC6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
Q9VU02	Drosophila melanogaster	41%	83%
V5BVX9	Trypanosoma cruzi	60%	100%