MFS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

major facilitator superfamily, putative

Species:

Leishmania mexicana

UniProt:

E9AVT7_LEIMU

TriTrypDb:

LmxM.22.1050

Length:

964

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9AVT7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVT7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	7
GO:0022857	transmembrane transporter activity	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	314	318	PF00656	0.476
CLV_C14_Caspase3-7	57	61	PF00656	0.681
CLV_C14_Caspase3-7	66	70	PF00656	0.633
CLV_NRD_NRD_1	299	301	PF00675	0.284
CLV_NRD_NRD_1	377	379	PF00675	0.284
CLV_NRD_NRD_1	475	477	PF00675	0.386
CLV_PCSK_KEX2_1	180	182	PF00082	0.269
CLV_PCSK_KEX2_1	471	473	PF00082	0.276
CLV_PCSK_KEX2_1	475	477	PF00082	0.333
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.269
CLV_PCSK_PC1ET2_1	471	473	PF00082	0.251
CLV_PCSK_PC7_1	176	182	PF00082	0.269
CLV_PCSK_SKI1_1	12	16	PF00082	0.466
CLV_PCSK_SKI1_1	180	184	PF00082	0.269
CLV_PCSK_SKI1_1	278	282	PF00082	0.304
CLV_PCSK_SKI1_1	378	382	PF00082	0.209
CLV_PCSK_SKI1_1	476	480	PF00082	0.323
CLV_PCSK_SKI1_1	502	506	PF00082	0.516
CLV_PCSK_SKI1_1	800	804	PF00082	0.690
DEG_APCC_DBOX_1	501	509	PF00400	0.316
DEG_COP1_1	69	79	PF00400	0.683
DEG_ODPH_VHL_1	451	464	PF01847	0.369
DEG_SCF_TRCP1_1	127	132	PF00400	0.304
DEG_SPOP_SBC_1	154	158	PF00917	0.325
DEG_SPOP_SBC_1	264	268	PF00917	0.317
DEG_SPOP_SBC_1	29	33	PF00917	0.654
DEG_SPOP_SBC_1	90	94	PF00917	0.690
DOC_CKS1_1	222	227	PF01111	0.304
DOC_CKS1_1	752	757	PF01111	0.500
DOC_CKS1_1	770	775	PF01111	0.404
DOC_MAPK_gen_1	12	20	PF00069	0.692
DOC_MAPK_gen_1	471	480	PF00069	0.451
DOC_MAPK_gen_1	499	507	PF00069	0.278
DOC_MAPK_gen_1	664	672	PF00069	0.401
DOC_MAPK_gen_1	829	839	PF00069	0.373
DOC_MAPK_HePTP_8	207	219	PF00069	0.369
DOC_MAPK_MEF2A_6	210	219	PF00069	0.369
DOC_MAPK_MEF2A_6	569	577	PF00069	0.469
DOC_PP1_RVXF_1	473	480	PF00149	0.514
DOC_PP2B_LxvP_1	135	138	PF13499	0.369
DOC_PP2B_LxvP_1	281	284	PF13499	0.304
DOC_PP2B_LxvP_1	677	680	PF13499	0.444
DOC_PP2B_LxvP_1	695	698	PF13499	0.405
DOC_PP2B_PxIxI_1	584	590	PF00149	0.303
DOC_PP4_FxxP_1	552	555	PF00568	0.469
DOC_SPAK_OSR1_1	210	214	PF12202	0.304
DOC_USP7_MATH_1	154	158	PF00917	0.325
DOC_USP7_MATH_1	264	268	PF00917	0.317
DOC_USP7_MATH_1	355	359	PF00917	0.533
DOC_USP7_MATH_1	54	58	PF00917	0.696
DOC_USP7_MATH_1	564	568	PF00917	0.535
DOC_USP7_MATH_1	682	686	PF00917	0.521
DOC_USP7_MATH_1	7	11	PF00917	0.748
DOC_USP7_MATH_1	734	738	PF00917	0.507
DOC_USP7_MATH_1	774	778	PF00917	0.623
DOC_USP7_MATH_1	805	809	PF00917	0.467
DOC_USP7_MATH_1	878	882	PF00917	0.546
DOC_USP7_MATH_1	902	906	PF00917	0.502
DOC_USP7_MATH_1	908	912	PF00917	0.527
DOC_USP7_MATH_1	91	95	PF00917	0.677
DOC_WW_Pin1_4	221	226	PF00397	0.304
DOC_WW_Pin1_4	344	349	PF00397	0.469
DOC_WW_Pin1_4	698	703	PF00397	0.503
DOC_WW_Pin1_4	740	745	PF00397	0.555
DOC_WW_Pin1_4	751	756	PF00397	0.534
DOC_WW_Pin1_4	759	764	PF00397	0.615
DOC_WW_Pin1_4	769	774	PF00397	0.465
DOC_WW_Pin1_4	819	824	PF00397	0.452
DOC_WW_Pin1_4	921	926	PF00397	0.451
LIG_14-3-3_CanoR_1	181	189	PF00244	0.270
LIG_14-3-3_CanoR_1	300	307	PF00244	0.398
LIG_14-3-3_CanoR_1	356	360	PF00244	0.490
LIG_14-3-3_CanoR_1	365	371	PF00244	0.477
LIG_14-3-3_CanoR_1	378	385	PF00244	0.418
LIG_14-3-3_CanoR_1	389	399	PF00244	0.473
LIG_14-3-3_CanoR_1	687	695	PF00244	0.422
LIG_14-3-3_CanoR_1	736	744	PF00244	0.462
LIG_14-3-3_CanoR_1	748	753	PF00244	0.466
LIG_14-3-3_CanoR_1	800	805	PF00244	0.436
LIG_14-3-3_CanoR_1	848	853	PF00244	0.532
LIG_14-3-3_CanoR_1	935	941	PF00244	0.443
LIG_Actin_WH2_2	460	477	PF00022	0.351
LIG_Actin_WH2_2	554	571	PF00022	0.505
LIG_BIR_III_4	563	567	PF00653	0.513
LIG_BRCT_BRCA1_1	127	131	PF00533	0.304
LIG_BRCT_BRCA1_1	156	160	PF00533	0.304
LIG_BRCT_BRCA1_1	215	219	PF00533	0.369
LIG_BRCT_BRCA1_1	271	275	PF00533	0.325
LIG_BRCT_BRCA1_1	412	416	PF00533	0.352
LIG_Clathr_ClatBox_1	839	843	PF01394	0.436
LIG_EH1_1	569	577	PF00400	0.469
LIG_eIF4E_1	111	117	PF01652	0.553
LIG_eIF4E_1	276	282	PF01652	0.369
LIG_eIF4E_1	570	576	PF01652	0.469
LIG_FHA_1	154	160	PF00498	0.273
LIG_FHA_1	183	189	PF00498	0.494
LIG_FHA_1	264	270	PF00498	0.356
LIG_FHA_1	372	378	PF00498	0.477
LIG_FHA_1	424	430	PF00498	0.290
LIG_FHA_1	445	451	PF00498	0.317
LIG_FHA_1	563	569	PF00498	0.520
LIG_FHA_1	572	578	PF00498	0.304
LIG_FHA_1	619	625	PF00498	0.513
LIG_FHA_1	672	678	PF00498	0.585
LIG_FHA_1	692	698	PF00498	0.499
LIG_FHA_2	365	371	PF00498	0.510
LIG_FHA_2	498	504	PF00498	0.284
LIG_FHA_2	722	728	PF00498	0.425
LIG_FHA_2	783	789	PF00498	0.408
LIG_GBD_Chelix_1	482	490	PF00786	0.205
LIG_LIR_Gen_1	108	118	PF02991	0.555
LIG_LIR_Gen_1	191	201	PF02991	0.308
LIG_LIR_Gen_1	216	226	PF02991	0.304
LIG_LIR_Gen_1	501	512	PF02991	0.269
LIG_LIR_Gen_1	544	552	PF02991	0.475
LIG_LIR_Nem_3	108	114	PF02991	0.561
LIG_LIR_Nem_3	191	196	PF02991	0.324
LIG_LIR_Nem_3	216	222	PF02991	0.333
LIG_LIR_Nem_3	270	276	PF02991	0.344
LIG_LIR_Nem_3	501	507	PF02991	0.269
LIG_LIR_Nem_3	544	549	PF02991	0.475
LIG_LIR_Nem_3	567	573	PF02991	0.577
LIG_MLH1_MIPbox_1	412	416	PF16413	0.304
LIG_MYND_1	874	878	PF01753	0.507
LIG_NRBOX	253	259	PF00104	0.369
LIG_Pex14_1	227	231	PF04695	0.469
LIG_Pex14_1	271	275	PF04695	0.304
LIG_Pex14_2	480	484	PF04695	0.304
LIG_PTB_Apo_2	206	213	PF02174	0.304
LIG_PTB_Apo_2	306	313	PF02174	0.398
LIG_PTB_Apo_2	398	405	PF02174	0.285
LIG_PTB_Phospho_1	306	312	PF10480	0.398
LIG_PTB_Phospho_1	398	404	PF10480	0.285
LIG_SH2_CRK	546	550	PF00017	0.455
LIG_SH2_CRK	570	574	PF00017	0.504
LIG_SH2_CRK	706	710	PF00017	0.451
LIG_SH2_SRC	312	315	PF00017	0.484
LIG_SH2_STAP1	392	396	PF00017	0.552
LIG_SH2_STAT5	111	114	PF00017	0.554
LIG_SH2_STAT5	223	226	PF00017	0.454
LIG_SH2_STAT5	256	259	PF00017	0.309
LIG_SH2_STAT5	276	279	PF00017	0.382
LIG_SH2_STAT5	288	291	PF00017	0.244
LIG_SH2_STAT5	415	418	PF00017	0.372
LIG_SH2_STAT5	428	431	PF00017	0.269
LIG_SH3_2	874	879	PF14604	0.512
LIG_SH3_3	219	225	PF00018	0.304
LIG_SH3_3	318	324	PF00018	0.398
LIG_SH3_3	447	453	PF00018	0.272
LIG_SH3_3	702	708	PF00018	0.467
LIG_SH3_3	81	87	PF00018	0.723
LIG_SH3_3	868	874	PF00018	0.495
LIG_SH3_3	891	897	PF00018	0.513
LIG_SH3_3	920	926	PF00018	0.453
LIG_SUMO_SIM_anti_2	503	509	PF11976	0.325
LIG_SUMO_SIM_anti_2	836	841	PF11976	0.439
LIG_SUMO_SIM_par_1	279	285	PF11976	0.304
LIG_SUMO_SIM_par_1	407	413	PF11976	0.304
LIG_SUMO_SIM_par_1	573	579	PF11976	0.304
LIG_TRAF2_1	643	646	PF00917	0.393
LIG_TYR_ITIM	221	226	PF00017	0.304
LIG_TYR_ITIM	568	573	PF00017	0.498
LIG_UBA3_1	116	121	PF00899	0.304
LIG_UBA3_1	463	471	PF00899	0.308
LIG_WRC_WIRS_1	123	128	PF05994	0.304
LIG_WRC_WIRS_1	192	197	PF05994	0.304
LIG_WW_3	876	880	PF00397	0.514
MOD_CK1_1	125	131	PF00069	0.304
MOD_CK1_1	267	273	PF00069	0.316
MOD_CK1_1	296	302	PF00069	0.500
MOD_CK1_1	407	413	PF00069	0.326
MOD_CK1_1	603	609	PF00069	0.412
MOD_CK1_1	738	744	PF00069	0.539
MOD_CK1_1	751	757	PF00069	0.547
MOD_CK1_1	881	887	PF00069	0.550
MOD_CK1_1	911	917	PF00069	0.535
MOD_CK2_1	364	370	PF00069	0.510
MOD_CK2_1	721	727	PF00069	0.416
MOD_CK2_1	885	891	PF00069	0.536
MOD_DYRK1A_RPxSP_1	740	744	PF00069	0.412
MOD_GlcNHglycan	127	130	PF01048	0.304
MOD_GlcNHglycan	131	134	PF01048	0.304
MOD_GlcNHglycan	302	305	PF01048	0.333
MOD_GlcNHglycan	327	330	PF01048	0.305
MOD_GlcNHglycan	332	335	PF01048	0.335
MOD_GlcNHglycan	341	344	PF01048	0.256
MOD_GlcNHglycan	357	360	PF01048	0.287
MOD_GlcNHglycan	44	47	PF01048	0.512
MOD_GlcNHglycan	552	555	PF01048	0.269
MOD_GlcNHglycan	598	601	PF01048	0.683
MOD_GlcNHglycan	602	605	PF01048	0.625
MOD_GlcNHglycan	611	614	PF01048	0.590
MOD_GlcNHglycan	666	669	PF01048	0.680
MOD_GlcNHglycan	688	691	PF01048	0.762
MOD_GlcNHglycan	72	75	PF01048	0.393
MOD_GlcNHglycan	788	792	PF01048	0.673
MOD_GlcNHglycan	916	919	PF01048	0.737
MOD_GlcNHglycan	93	96	PF01048	0.438
MOD_GSK3_1	125	132	PF00069	0.304
MOD_GSK3_1	263	270	PF00069	0.341
MOD_GSK3_1	27	34	PF00069	0.693
MOD_GSK3_1	289	296	PF00069	0.354
MOD_GSK3_1	339	346	PF00069	0.424
MOD_GSK3_1	360	367	PF00069	0.479
MOD_GSK3_1	40	47	PF00069	0.792
MOD_GSK3_1	571	578	PF00069	0.469
MOD_GSK3_1	596	603	PF00069	0.453
MOD_GSK3_1	671	678	PF00069	0.544
MOD_GSK3_1	682	689	PF00069	0.473
MOD_GSK3_1	734	741	PF00069	0.443
MOD_GSK3_1	783	790	PF00069	0.533
MOD_GSK3_1	879	886	PF00069	0.598
MOD_GSK3_1	907	914	PF00069	0.534
MOD_N-GLC_1	434	439	PF02516	0.516
MOD_N-GLC_1	550	555	PF02516	0.269
MOD_N-GLC_1	908	913	PF02516	0.701
MOD_NEK2_1	155	160	PF00069	0.300
MOD_NEK2_1	265	270	PF00069	0.316
MOD_NEK2_1	364	369	PF00069	0.446
MOD_NEK2_1	391	396	PF00069	0.536
MOD_NEK2_1	416	421	PF00069	0.324
MOD_NEK2_1	434	439	PF00069	0.280
MOD_NEK2_1	497	502	PF00069	0.304
MOD_NEK2_1	506	511	PF00069	0.321
MOD_NEK2_1	541	546	PF00069	0.480
MOD_NEK2_1	575	580	PF00069	0.308
MOD_NEK2_1	608	613	PF00069	0.551
MOD_NEK2_1	63	68	PF00069	0.605
MOD_NEK2_1	636	641	PF00069	0.462
MOD_NEK2_1	686	691	PF00069	0.431
MOD_NEK2_1	735	740	PF00069	0.499
MOD_NEK2_1	885	890	PF00069	0.517
MOD_NEK2_1	98	103	PF00069	0.636
MOD_NEK2_2	271	276	PF00069	0.369
MOD_NEK2_2	360	365	PF00069	0.445
MOD_NEK2_2	384	389	PF00069	0.516
MOD_NEK2_2	564	569	PF00069	0.591
MOD_NEK2_2	682	687	PF00069	0.514
MOD_PIKK_1	371	377	PF00454	0.508
MOD_PIKK_1	423	429	PF00454	0.269
MOD_PIKK_1	539	545	PF00454	0.469
MOD_PIKK_1	930	936	PF00454	0.476
MOD_PKA_1	300	306	PF00069	0.484
MOD_PKA_1	378	384	PF00069	0.398
MOD_PKA_2	106	112	PF00069	0.465
MOD_PKA_2	235	241	PF00069	0.469
MOD_PKA_2	299	305	PF00069	0.451
MOD_PKA_2	355	361	PF00069	0.476
MOD_PKA_2	364	370	PF00069	0.460
MOD_PKA_2	498	504	PF00069	0.253
MOD_PKA_2	686	692	PF00069	0.426
MOD_PKA_2	70	76	PF00069	0.613
MOD_PKA_2	735	741	PF00069	0.456
MOD_PKA_2	805	811	PF00069	0.563
MOD_PKA_2	878	884	PF00069	0.534
MOD_Plk_1	434	440	PF00069	0.269
MOD_Plk_1	908	914	PF00069	0.500
MOD_Plk_1	99	105	PF00069	0.607
MOD_Plk_2-3	941	947	PF00069	0.509
MOD_Plk_4	106	112	PF00069	0.582
MOD_Plk_4	155	161	PF00069	0.314
MOD_Plk_4	188	194	PF00069	0.304
MOD_Plk_4	215	221	PF00069	0.304
MOD_Plk_4	235	241	PF00069	0.383
MOD_Plk_4	282	288	PF00069	0.325
MOD_Plk_4	404	410	PF00069	0.304
MOD_Plk_4	506	512	PF00069	0.315
MOD_Plk_4	541	547	PF00069	0.455
MOD_Plk_4	576	582	PF00069	0.303
MOD_ProDKin_1	221	227	PF00069	0.304
MOD_ProDKin_1	344	350	PF00069	0.469
MOD_ProDKin_1	698	704	PF00069	0.504
MOD_ProDKin_1	740	746	PF00069	0.555
MOD_ProDKin_1	751	757	PF00069	0.533
MOD_ProDKin_1	759	765	PF00069	0.616
MOD_ProDKin_1	769	775	PF00069	0.466
MOD_ProDKin_1	819	825	PF00069	0.453
MOD_ProDKin_1	921	927	PF00069	0.454
MOD_SUMO_rev_2	175	182	PF00179	0.516
TRG_DiLeu_BaLyEn_6	94	99	PF01217	0.719
TRG_ENDOCYTIC_2	111	114	PF00928	0.554
TRG_ENDOCYTIC_2	197	200	PF00928	0.369
TRG_ENDOCYTIC_2	223	226	PF00928	0.304
TRG_ENDOCYTIC_2	392	395	PF00928	0.561
TRG_ENDOCYTIC_2	546	549	PF00928	0.469
TRG_ENDOCYTIC_2	570	573	PF00928	0.530
TRG_ENDOCYTIC_2	706	709	PF00928	0.450
TRG_ER_diArg_1	474	476	PF00400	0.500
TRG_Pf-PMV_PEXEL_1	378	382	PF00026	0.316
TRG_Pf-PMV_PEXEL_1	640	644	PF00026	0.599
TRG_Pf-PMV_PEXEL_1	887	891	PF00026	0.720
TRG_PTS1	961	964	PF00515	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAL7	Leptomonas seymouri	51%	100%
A0A3S5H7B0	Leishmania donovani	87%	100%
A4HCC5	Leishmania braziliensis	70%	97%
A4HZX7	Leishmania infantum	87%	100%
Q4QBP2	Leishmania major	84%	100%