UAA transporter family-domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UDP-galactose transporter, putative

Species:

Leishmania mexicana

UniProt:

E9AVT3_LEIMU

TriTrypDb:

LmxM.22.1010

Length:

588

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	9
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

E9AVT3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVT3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	9
GO:0009987	cellular process	1	9
GO:0051179	localization	1	9
GO:0051234	establishment of localization	2	9
GO:0055085	transmembrane transport	2	9
GO:0006811	monoatomic ion transport	4	1
GO:0006820	monoatomic anion transport	5	1
GO:0015711	organic anion transport	5	1
GO:0015780	nucleotide-sugar transmembrane transport	3	1
GO:0015931	nucleobase-containing compound transport	5	1
GO:0034220	monoatomic ion transmembrane transport	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0072334	UDP-galactose transmembrane transport	5	1
GO:0090481	pyrimidine nucleotide-sugar transmembrane transport	4	1
GO:0098656	monoatomic anion transmembrane transport	4	1
GO:1901264	carbohydrate derivative transport	5	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0005338	nucleotide-sugar transmembrane transporter activity	4	1
GO:0005459	UDP-galactose transmembrane transporter activity	6	1
GO:0005460	UDP-glucose transmembrane transporter activity	6	1
GO:0008509	monoatomic anion transmembrane transporter activity	4	1
GO:0008514	organic anion transmembrane transporter activity	5	1
GO:0015075	monoatomic ion transmembrane transporter activity	3	1
GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	5	1
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:1901505	carbohydrate derivative transmembrane transporter activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.606
CLV_NRD_NRD_1	154	156	PF00675	0.378
CLV_NRD_NRD_1	188	190	PF00675	0.406
CLV_NRD_NRD_1	213	215	PF00675	0.252
CLV_NRD_NRD_1	460	462	PF00675	0.264
CLV_NRD_NRD_1	581	583	PF00675	0.388
CLV_PCSK_KEX2_1	103	105	PF00082	0.606
CLV_PCSK_KEX2_1	154	156	PF00082	0.379
CLV_PCSK_KEX2_1	188	190	PF00082	0.410
CLV_PCSK_KEX2_1	213	215	PF00082	0.255
CLV_PCSK_KEX2_1	25	27	PF00082	0.381
CLV_PCSK_KEX2_1	291	293	PF00082	0.352
CLV_PCSK_KEX2_1	513	515	PF00082	0.359
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.381
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.352
CLV_PCSK_PC1ET2_1	513	515	PF00082	0.338
CLV_PCSK_SKI1_1	14	18	PF00082	0.367
CLV_PCSK_SKI1_1	168	172	PF00082	0.459
CLV_PCSK_SKI1_1	192	196	PF00082	0.274
CLV_PCSK_SKI1_1	48	52	PF00082	0.256
CLV_PCSK_SKI1_1	531	535	PF00082	0.356
CLV_PCSK_SKI1_1	582	586	PF00082	0.393
CLV_PCSK_SKI1_1	75	79	PF00082	0.482
DEG_APCC_DBOX_1	337	345	PF00400	0.340
DEG_SCF_FBW7_1	29	36	PF00400	0.565
DEG_SPOP_SBC_1	280	284	PF00917	0.209
DEG_SPOP_SBC_1	294	298	PF00917	0.207
DEG_SPOP_SBC_1	43	47	PF00917	0.587
DEG_SPOP_SBC_1	526	530	PF00917	0.686
DOC_CKS1_1	17	22	PF01111	0.663
DOC_MAPK_gen_1	188	199	PF00069	0.366
DOC_MAPK_gen_1	213	221	PF00069	0.428
DOC_MAPK_gen_1	224	234	PF00069	0.428
DOC_MAPK_gen_1	246	254	PF00069	0.447
DOC_MAPK_gen_1	25	31	PF00069	0.566
DOC_MAPK_gen_1	461	468	PF00069	0.228
DOC_MAPK_HePTP_8	221	233	PF00069	0.428
DOC_MAPK_MEF2A_6	224	233	PF00069	0.428
DOC_MAPK_MEF2A_6	461	470	PF00069	0.233
DOC_PP2B_LxvP_1	379	382	PF13499	0.152
DOC_USP7_MATH_1	110	114	PF00917	0.432
DOC_USP7_MATH_1	140	144	PF00917	0.359
DOC_USP7_MATH_1	172	176	PF00917	0.718
DOC_USP7_MATH_1	18	22	PF00917	0.688
DOC_USP7_MATH_1	272	276	PF00917	0.305
DOC_USP7_MATH_1	279	283	PF00917	0.243
DOC_USP7_MATH_1	294	298	PF00917	0.253
DOC_USP7_MATH_1	375	379	PF00917	0.266
DOC_USP7_MATH_1	524	528	PF00917	0.685
DOC_USP7_MATH_1	544	548	PF00917	0.555
DOC_WW_Pin1_4	16	21	PF00397	0.704
DOC_WW_Pin1_4	29	34	PF00397	0.673
DOC_WW_Pin1_4	535	540	PF00397	0.723
DOC_WW_Pin1_4	577	582	PF00397	0.700
LIG_14-3-3_CanoR_1	11	17	PF00244	0.646
LIG_14-3-3_CanoR_1	155	161	PF00244	0.530
LIG_14-3-3_CanoR_1	163	170	PF00244	0.571
LIG_14-3-3_CanoR_1	213	218	PF00244	0.495
LIG_14-3-3_CanoR_1	26	32	PF00244	0.573
LIG_14-3-3_CanoR_1	292	302	PF00244	0.152
LIG_14-3-3_CanoR_1	531	536	PF00244	0.557
LIG_Actin_WH2_2	445	463	PF00022	0.264
LIG_Actin_WH2_2	491	508	PF00022	0.386
LIG_APCC_ABBA_1	405	410	PF00400	0.240
LIG_BIR_II_1	1	5	PF00653	0.721
LIG_BRCT_BRCA1_1	199	203	PF00533	0.482
LIG_BRCT_BRCA1_1	348	352	PF00533	0.292
LIG_Clathr_ClatBox_1	351	355	PF01394	0.299
LIG_deltaCOP1_diTrp_1	358	367	PF00928	0.295
LIG_FHA_1	11	17	PF00498	0.655
LIG_FHA_1	132	138	PF00498	0.353
LIG_FHA_1	253	259	PF00498	0.272
LIG_FHA_1	26	32	PF00498	0.569
LIG_FHA_1	318	324	PF00498	0.428
LIG_FHA_1	337	343	PF00498	0.135
LIG_FHA_1	369	375	PF00498	0.238
LIG_FHA_1	401	407	PF00498	0.270
LIG_FHA_1	443	449	PF00498	0.455
LIG_LIR_Gen_1	206	217	PF02991	0.442
LIG_LIR_Gen_1	358	367	PF02991	0.279
LIG_LIR_Gen_1	412	422	PF02991	0.247
LIG_LIR_Gen_1	495	505	PF02991	0.345
LIG_LIR_Nem_3	358	364	PF02991	0.279
LIG_LIR_Nem_3	412	417	PF02991	0.223
LIG_LIR_Nem_3	447	452	PF02991	0.302
LIG_LIR_Nem_3	495	500	PF02991	0.368
LIG_MAD2	531	539	PF02301	0.555
LIG_NRBOX	307	313	PF00104	0.292
LIG_NRBOX	429	435	PF00104	0.340
LIG_PCNA_yPIPBox_3	150	163	PF02747	0.478
LIG_PCNA_yPIPBox_3	377	390	PF02747	0.152
LIG_Pex14_1	363	367	PF04695	0.295
LIG_Pex14_2	199	203	PF04695	0.452
LIG_PTAP_UEV_1	19	24	PF05743	0.617
LIG_SH2_GRB2like	316	319	PF00017	0.479
LIG_SH2_GRB2like	497	500	PF00017	0.435
LIG_SH2_NCK_1	543	547	PF00017	0.616
LIG_SH2_PTP2	497	500	PF00017	0.435
LIG_SH2_SRC	497	500	PF00017	0.435
LIG_SH2_SRC	543	546	PF00017	0.571
LIG_SH2_STAT5	124	127	PF00017	0.423
LIG_SH2_STAT5	316	319	PF00017	0.479
LIG_SH2_STAT5	497	500	PF00017	0.435
LIG_SH2_STAT5	81	84	PF00017	0.413
LIG_SH3_2	20	25	PF14604	0.618
LIG_SH3_3	114	120	PF00018	0.453
LIG_SH3_3	17	23	PF00018	0.719
LIG_SH3_3	212	218	PF00018	0.357
LIG_SH3_3	28	34	PF00018	0.625
LIG_SH3_3	416	422	PF00018	0.152
LIG_SUMO_SIM_anti_2	45	53	PF11976	0.501
LIG_SUMO_SIM_par_1	216	222	PF11976	0.447
LIG_WRC_WIRS_1	364	369	PF05994	0.295
LIG_WW_3	32	36	PF00397	0.543
MOD_CDC14_SPxK_1	580	583	PF00782	0.679
MOD_CDK_SPK_2	577	582	PF00069	0.573
MOD_CDK_SPxK_1	29	35	PF00069	0.639
MOD_CDK_SPxK_1	577	583	PF00069	0.672
MOD_CK1_1	10	16	PF00069	0.679
MOD_CK1_1	266	272	PF00069	0.338
MOD_CK1_1	273	279	PF00069	0.321
MOD_CK1_1	283	289	PF00069	0.295
MOD_CK1_1	296	302	PF00069	0.306
MOD_CK1_1	331	337	PF00069	0.434
MOD_CK1_1	368	374	PF00069	0.228
MOD_CK1_1	398	404	PF00069	0.324
MOD_CK1_1	432	438	PF00069	0.358
MOD_CK1_1	527	533	PF00069	0.650
MOD_CK1_1	553	559	PF00069	0.625
MOD_GlcNHglycan	142	145	PF01048	0.313
MOD_GlcNHglycan	163	166	PF01048	0.403
MOD_GlcNHglycan	174	177	PF01048	0.507
MOD_GlcNHglycan	20	23	PF01048	0.529
MOD_GlcNHglycan	255	258	PF01048	0.311
MOD_GlcNHglycan	270	273	PF01048	0.467
MOD_GlcNHglycan	275	278	PF01048	0.472
MOD_GlcNHglycan	288	291	PF01048	0.431
MOD_GlcNHglycan	330	333	PF01048	0.212
MOD_GlcNHglycan	35	38	PF01048	0.525
MOD_GlcNHglycan	383	386	PF01048	0.553
MOD_GlcNHglycan	397	400	PF01048	0.481
MOD_GlcNHglycan	434	437	PF01048	0.358
MOD_GlcNHglycan	462	465	PF01048	0.397
MOD_GlcNHglycan	545	549	PF01048	0.466
MOD_GlcNHglycan	85	88	PF01048	0.576
MOD_GSK3_1	12	19	PF00069	0.612
MOD_GSK3_1	129	136	PF00069	0.316
MOD_GSK3_1	180	187	PF00069	0.540
MOD_GSK3_1	25	32	PF00069	0.747
MOD_GSK3_1	263	270	PF00069	0.320
MOD_GSK3_1	275	282	PF00069	0.236
MOD_GSK3_1	293	300	PF00069	0.316
MOD_GSK3_1	336	343	PF00069	0.286
MOD_GSK3_1	359	366	PF00069	0.260
MOD_GSK3_1	444	451	PF00069	0.451
MOD_GSK3_1	462	469	PF00069	0.290
MOD_GSK3_1	520	527	PF00069	0.673
MOD_GSK3_1	531	538	PF00069	0.668
MOD_GSK3_1	88	95	PF00069	0.400
MOD_N-GLC_1	172	177	PF02516	0.450
MOD_N-GLC_1	180	185	PF02516	0.318
MOD_N-GLC_1	317	322	PF02516	0.251
MOD_N-GLC_1	535	540	PF02516	0.449
MOD_N-GLC_1	550	555	PF02516	0.370
MOD_N-GLC_2	63	65	PF02516	0.358
MOD_NEK2_1	133	138	PF00069	0.402
MOD_NEK2_1	156	161	PF00069	0.631
MOD_NEK2_1	197	202	PF00069	0.495
MOD_NEK2_1	203	208	PF00069	0.520
MOD_NEK2_1	252	257	PF00069	0.477
MOD_NEK2_1	263	268	PF00069	0.169
MOD_NEK2_1	336	341	PF00069	0.302
MOD_NEK2_1	429	434	PF00069	0.346
MOD_NEK2_1	452	457	PF00069	0.317
MOD_NEK2_1	460	465	PF00069	0.328
MOD_NEK2_1	88	93	PF00069	0.359
MOD_NEK2_2	124	129	PF00069	0.362
MOD_NEK2_2	67	72	PF00069	0.307
MOD_PIKK_1	131	137	PF00454	0.340
MOD_PIKK_1	163	169	PF00454	0.525
MOD_PIKK_1	317	323	PF00454	0.439
MOD_PK_1	462	468	PF00069	0.252
MOD_PKA_1	213	219	PF00069	0.495
MOD_PKA_1	25	31	PF00069	0.566
MOD_PKA_2	10	16	PF00069	0.635
MOD_PKA_2	213	219	PF00069	0.495
MOD_PKA_2	25	31	PF00069	0.605
MOD_PKA_2	266	272	PF00069	0.243
MOD_PKA_2	328	334	PF00069	0.394
MOD_PKA_2	395	401	PF00069	0.371
MOD_PKA_2	460	466	PF00069	0.203
MOD_Plk_1	180	186	PF00069	0.509
MOD_Plk_1	409	415	PF00069	0.282
MOD_Plk_1	501	507	PF00069	0.540
MOD_Plk_1	556	562	PF00069	0.529
MOD_Plk_4	12	18	PF00069	0.561
MOD_Plk_4	124	130	PF00069	0.304
MOD_Plk_4	148	154	PF00069	0.441
MOD_Plk_4	181	187	PF00069	0.596
MOD_Plk_4	297	303	PF00069	0.358
MOD_Plk_4	331	337	PF00069	0.499
MOD_Plk_4	346	352	PF00069	0.263
MOD_Plk_4	401	407	PF00069	0.358
MOD_Plk_4	429	435	PF00069	0.298
MOD_Plk_4	455	461	PF00069	0.282
MOD_Plk_4	462	468	PF00069	0.230
MOD_ProDKin_1	16	22	PF00069	0.703
MOD_ProDKin_1	29	35	PF00069	0.671
MOD_ProDKin_1	535	541	PF00069	0.723
MOD_ProDKin_1	577	583	PF00069	0.704
MOD_SUMO_for_1	71	74	PF00179	0.253
TRG_ENDOCYTIC_2	209	212	PF00928	0.428
TRG_ENDOCYTIC_2	497	500	PF00928	0.435
TRG_ENDOCYTIC_2	543	546	PF00928	0.666
TRG_ER_diArg_1	153	155	PF00400	0.576
TRG_ER_diArg_1	212	214	PF00400	0.453
TRG_ER_diArg_1	239	242	PF00400	0.482
TRG_ER_diArg_1	327	330	PF00400	0.482
TRG_ER_diLys_1	583	588	PF00400	0.718
TRG_NES_CRM1_1	410	423	PF08389	0.178
TRG_NLS_MonoExtC_3	581	586	PF00514	0.589
TRG_NLS_MonoExtN_4	581	586	PF00514	0.589

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7F6	Leptomonas seymouri	48%	100%
A0A1X0NV21	Trypanosomatidae	38%	100%
A0A3Q8IBG5	Leishmania donovani	85%	100%
A0A422N3L8	Trypanosoma rangeli	35%	100%
A4HCB7	Leishmania braziliensis	68%	98%
A4HZX4	Leishmania infantum	85%	100%
P0CP32	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	27%	100%
P0CP33	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	27%	100%
Q4QBP6	Leishmania major	82%	98%