Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVT2_LEIMU

TriTrypDb:

LmxM.22.1000

Length:

587

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVT2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVT2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	281	285	PF00656	0.525
CLV_C14_Caspase3-7	309	313	PF00656	0.750
CLV_NRD_NRD_1	162	164	PF00675	0.736
CLV_NRD_NRD_1	458	460	PF00675	0.773
CLV_PCSK_KEX2_1	162	164	PF00082	0.736
CLV_PCSK_KEX2_1	318	320	PF00082	0.731
CLV_PCSK_KEX2_1	458	460	PF00082	0.773
CLV_PCSK_PC1ET2_1	318	320	PF00082	0.439
CLV_PCSK_SKI1_1	203	207	PF00082	0.642
CLV_PCSK_SKI1_1	315	319	PF00082	0.494
CLV_PCSK_SKI1_1	444	448	PF00082	0.519
DEG_SPOP_SBC_1	102	106	PF00917	0.677
DEG_SPOP_SBC_1	129	133	PF00917	0.735
DEG_SPOP_SBC_1	75	79	PF00917	0.615
DOC_CDC14_PxL_1	536	544	PF14671	0.336
DOC_CKS1_1	65	70	PF01111	0.727
DOC_CYCLIN_RxL_1	441	450	PF00134	0.520
DOC_MAPK_MEF2A_6	580	587	PF00069	0.644
DOC_PP2B_PxIxI_1	438	444	PF00149	0.550
DOC_PP4_FxxP_1	201	204	PF00568	0.729
DOC_SPAK_OSR1_1	580	584	PF12202	0.569
DOC_USP7_MATH_1	120	124	PF00917	0.749
DOC_USP7_MATH_1	129	133	PF00917	0.707
DOC_USP7_MATH_1	191	195	PF00917	0.598
DOC_USP7_MATH_1	271	275	PF00917	0.766
DOC_USP7_MATH_1	311	315	PF00917	0.641
DOC_USP7_MATH_1	391	395	PF00917	0.596
DOC_USP7_MATH_1	411	415	PF00917	0.568
DOC_USP7_MATH_1	437	441	PF00917	0.532
DOC_USP7_MATH_1	53	57	PF00917	0.777
DOC_USP7_MATH_1	76	80	PF00917	0.638
DOC_WW_Pin1_4	146	151	PF00397	0.770
DOC_WW_Pin1_4	267	272	PF00397	0.703
DOC_WW_Pin1_4	377	382	PF00397	0.677
DOC_WW_Pin1_4	42	47	PF00397	0.702
DOC_WW_Pin1_4	422	427	PF00397	0.716
DOC_WW_Pin1_4	429	434	PF00397	0.579
DOC_WW_Pin1_4	530	535	PF00397	0.466
DOC_WW_Pin1_4	64	69	PF00397	0.731
LIG_14-3-3_CanoR_1	197	205	PF00244	0.590
LIG_14-3-3_CanoR_1	255	261	PF00244	0.559
LIG_14-3-3_CanoR_1	293	299	PF00244	0.567
LIG_14-3-3_CanoR_1	359	364	PF00244	0.610
LIG_14-3-3_CanoR_1	400	408	PF00244	0.403
LIG_14-3-3_CanoR_1	484	490	PF00244	0.586
LIG_14-3-3_CanoR_1	508	517	PF00244	0.532
LIG_14-3-3_CanoR_1	54	61	PF00244	0.595
LIG_Actin_WH2_2	495	512	PF00022	0.530
LIG_BRCT_BRCA1_1	21	25	PF00533	0.624
LIG_BRCT_BRCA1_1	99	103	PF00533	0.661
LIG_CSL_BTD_1	534	537	PF09270	0.519
LIG_deltaCOP1_diTrp_1	6	12	PF00928	0.596
LIG_FHA_1	166	172	PF00498	0.579
LIG_FHA_1	200	206	PF00498	0.574
LIG_FHA_1	335	341	PF00498	0.372
LIG_FHA_1	362	368	PF00498	0.678
LIG_FHA_1	400	406	PF00498	0.654
LIG_FHA_1	440	446	PF00498	0.617
LIG_FHA_1	564	570	PF00498	0.468
LIG_FHA_2	131	137	PF00498	0.761
LIG_HP1_1	325	329	PF01393	0.599
LIG_LIR_Apic_2	199	204	PF02991	0.622
LIG_LIR_Gen_1	194	201	PF02991	0.665
LIG_LIR_Gen_1	22	32	PF02991	0.672
LIG_LIR_Gen_1	432	443	PF02991	0.481
LIG_LIR_Gen_1	559	569	PF02991	0.622
LIG_LIR_Nem_3	10	15	PF02991	0.569
LIG_LIR_Nem_3	153	159	PF02991	0.748
LIG_LIR_Nem_3	194	198	PF02991	0.684
LIG_LIR_Nem_3	22	28	PF02991	0.536
LIG_LIR_Nem_3	432	438	PF02991	0.496
LIG_LIR_Nem_3	488	494	PF02991	0.581
LIG_LIR_Nem_3	559	565	PF02991	0.524
LIG_MAD2	38	46	PF02301	0.746
LIG_PCNA_PIPBox_1	1	10	PF02747	0.575
LIG_PDZ_Class_2	582	587	PF00595	0.541
LIG_Pex14_1	8	12	PF04695	0.546
LIG_RPA_C_Fungi	253	265	PF08784	0.590
LIG_SH2_CRK	156	160	PF00017	0.642
LIG_SH2_NCK_1	547	551	PF00017	0.631
LIG_SH2_NCK_1	562	566	PF00017	0.389
LIG_SH2_PTP2	435	438	PF00017	0.545
LIG_SH2_STAP1	296	300	PF00017	0.569
LIG_SH2_STAP1	401	405	PF00017	0.502
LIG_SH2_STAT3	292	295	PF00017	0.386
LIG_SH2_STAT5	195	198	PF00017	0.682
LIG_SH2_STAT5	296	299	PF00017	0.633
LIG_SH2_STAT5	401	404	PF00017	0.467
LIG_SH2_STAT5	435	438	PF00017	0.545
LIG_SH3_3	114	120	PF00018	0.629
LIG_SH3_3	185	191	PF00018	0.665
LIG_SH3_3	299	305	PF00018	0.655
LIG_SH3_3	324	330	PF00018	0.681
LIG_SH3_3	337	343	PF00018	0.433
LIG_SH3_3	360	366	PF00018	0.573
LIG_SH3_3	371	377	PF00018	0.601
LIG_SH3_3	420	426	PF00018	0.730
LIG_SH3_3	433	439	PF00018	0.549
LIG_SH3_3	45	51	PF00018	0.764
LIG_SH3_3	531	537	PF00018	0.500
LIG_SH3_3	62	68	PF00018	0.759
LIG_SUMO_SIM_par_1	342	349	PF11976	0.467
LIG_SUMO_SIM_par_1	444	450	PF11976	0.540
LIG_SUMO_SIM_par_1	528	533	PF11976	0.511
LIG_TYR_ITIM	560	565	PF00017	0.633
MOD_CDC14_SPxK_1	149	152	PF00782	0.618
MOD_CDK_SPxK_1	146	152	PF00069	0.752
MOD_CK1_1	123	129	PF00069	0.741
MOD_CK1_1	130	136	PF00069	0.693
MOD_CK1_1	146	152	PF00069	0.646
MOD_CK1_1	210	216	PF00069	0.811
MOD_CK1_1	361	367	PF00069	0.665
MOD_CK1_1	382	388	PF00069	0.703
MOD_CK1_1	412	418	PF00069	0.684
MOD_CK1_1	42	48	PF00069	0.719
MOD_CK1_1	425	431	PF00069	0.685
MOD_CK1_1	462	468	PF00069	0.664
MOD_CK1_1	479	485	PF00069	0.473
MOD_CK1_1	512	518	PF00069	0.519
MOD_CK1_1	70	76	PF00069	0.653
MOD_CK1_1	77	83	PF00069	0.585
MOD_CK2_1	130	136	PF00069	0.760
MOD_CK2_1	273	279	PF00069	0.740
MOD_GlcNHglycan	123	126	PF01048	0.698
MOD_GlcNHglycan	145	148	PF01048	0.564
MOD_GlcNHglycan	153	156	PF01048	0.649
MOD_GlcNHglycan	238	241	PF01048	0.677
MOD_GlcNHglycan	260	263	PF01048	0.576
MOD_GlcNHglycan	273	276	PF01048	0.560
MOD_GlcNHglycan	308	311	PF01048	0.651
MOD_GlcNHglycan	381	384	PF01048	0.606
MOD_GlcNHglycan	393	396	PF01048	0.745
MOD_GlcNHglycan	417	420	PF01048	0.739
MOD_GlcNHglycan	427	430	PF01048	0.613
MOD_GlcNHglycan	464	467	PF01048	0.752
MOD_GlcNHglycan	470	474	PF01048	0.560
MOD_GlcNHglycan	511	514	PF01048	0.537
MOD_GlcNHglycan	9	12	PF01048	0.621
MOD_GSK3_1	123	130	PF00069	0.702
MOD_GSK3_1	165	172	PF00069	0.734
MOD_GSK3_1	199	206	PF00069	0.691
MOD_GSK3_1	267	274	PF00069	0.720
MOD_GSK3_1	372	379	PF00069	0.662
MOD_GSK3_1	411	418	PF00069	0.634
MOD_GSK3_1	421	428	PF00069	0.697
MOD_GSK3_1	476	483	PF00069	0.625
MOD_GSK3_1	561	568	PF00069	0.506
MOD_GSK3_1	70	77	PF00069	0.570
MOD_GSK3_1	97	104	PF00069	0.663
MOD_N-GLC_1	236	241	PF02516	0.711
MOD_N-GLC_1	256	261	PF02516	0.332
MOD_N-GLC_1	462	467	PF02516	0.552
MOD_N-GLC_1	480	485	PF02516	0.686
MOD_NEK2_1	101	106	PF00069	0.581
MOD_NEK2_1	306	311	PF00069	0.728
MOD_NEK2_1	346	351	PF00069	0.542
MOD_NEK2_1	447	452	PF00069	0.470
MOD_NEK2_1	464	469	PF00069	0.766
MOD_NEK2_1	471	476	PF00069	0.598
MOD_NEK2_1	509	514	PF00069	0.537
MOD_NEK2_1	561	566	PF00069	0.482
MOD_NEK2_2	439	444	PF00069	0.524
MOD_NEK2_2	556	561	PF00069	0.501
MOD_PIKK_1	464	470	PF00454	0.768
MOD_PK_1	359	365	PF00069	0.616
MOD_PKA_2	127	133	PF00069	0.697
MOD_PKA_2	151	157	PF00069	0.730
MOD_PKA_2	196	202	PF00069	0.589
MOD_PKA_2	241	247	PF00069	0.583
MOD_PKA_2	358	364	PF00069	0.601
MOD_PKA_2	399	405	PF00069	0.405
MOD_PKA_2	509	515	PF00069	0.534
MOD_PKA_2	53	59	PF00069	0.713
MOD_Plk_1	140	146	PF00069	0.648
MOD_Plk_1	231	237	PF00069	0.570
MOD_Plk_1	256	262	PF00069	0.381
MOD_Plk_1	311	317	PF00069	0.453
MOD_Plk_1	480	486	PF00069	0.471
MOD_Plk_1	87	93	PF00069	0.578
MOD_Plk_4	140	146	PF00069	0.619
MOD_Plk_4	191	197	PF00069	0.695
MOD_Plk_4	346	352	PF00069	0.542
MOD_Plk_4	404	410	PF00069	0.707
MOD_Plk_4	452	458	PF00069	0.605
MOD_Plk_4	493	499	PF00069	0.518
MOD_Plk_4	512	518	PF00069	0.291
MOD_Plk_4	538	544	PF00069	0.487
MOD_Plk_4	556	562	PF00069	0.355
MOD_Plk_4	77	83	PF00069	0.646
MOD_ProDKin_1	146	152	PF00069	0.771
MOD_ProDKin_1	267	273	PF00069	0.707
MOD_ProDKin_1	377	383	PF00069	0.677
MOD_ProDKin_1	42	48	PF00069	0.705
MOD_ProDKin_1	422	428	PF00069	0.715
MOD_ProDKin_1	429	435	PF00069	0.570
MOD_ProDKin_1	530	536	PF00069	0.468
MOD_ProDKin_1	64	70	PF00069	0.729
TRG_DiLeu_BaLyEn_6	441	446	PF01217	0.618
TRG_ENDOCYTIC_2	156	159	PF00928	0.713
TRG_ENDOCYTIC_2	195	198	PF00928	0.681
TRG_ENDOCYTIC_2	435	438	PF00928	0.545
TRG_ENDOCYTIC_2	562	565	PF00928	0.622
TRG_ER_diArg_1	457	459	PF00400	0.770
TRG_ER_diArg_1	508	511	PF00400	0.536
TRG_NES_CRM1_1	493	507	PF08389	0.551
TRG_Pf-PMV_PEXEL_1	13	18	PF00026	0.600
TRG_Pf-PMV_PEXEL_1	444	449	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDA8	Leptomonas seymouri	49%	100%
A0A3Q8IEA0	Leishmania donovani	86%	100%
A4HCC4	Leishmania braziliensis	75%	99%
A4HZX3	Leishmania infantum	87%	100%
Q4QBP7	Leishmania major	87%	100%