WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

F-box and WD40 domain containing protein

Species:

Leishmania mexicana

UniProt:

E9AVT0_LEIMU

TriTrypDb:

LmxM.22.0980

Length:

708

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	1
GO:0010494	cytoplasmic stress granule	5	1
GO:0032991	protein-containing complex	1	2
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990904	ribonucleoprotein complex	2	2
GO:0005840	ribosome	5	1

Expansion

Sequence features

E9AVT0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVT0

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.485
CLV_C14_Caspase3-7	311	315	PF00656	0.588
CLV_NRD_NRD_1	255	257	PF00675	0.557
CLV_NRD_NRD_1	272	274	PF00675	0.479
CLV_NRD_NRD_1	402	404	PF00675	0.561
CLV_PCSK_KEX2_1	255	257	PF00082	0.557
CLV_PCSK_KEX2_1	272	274	PF00082	0.479
CLV_PCSK_KEX2_1	633	635	PF00082	0.466
CLV_PCSK_PC1ET2_1	633	635	PF00082	0.453
CLV_PCSK_SKI1_1	189	193	PF00082	0.552
CLV_PCSK_SKI1_1	255	259	PF00082	0.515
CLV_PCSK_SKI1_1	261	265	PF00082	0.541
CLV_PCSK_SKI1_1	651	655	PF00082	0.408
DEG_APCC_DBOX_1	188	196	PF00400	0.421
DEG_Nend_Nbox_1	1	3	PF02207	0.679
DEG_SPOP_SBC_1	37	41	PF00917	0.483
DEG_SPOP_SBC_1	417	421	PF00917	0.611
DOC_CKS1_1	628	633	PF01111	0.281
DOC_CYCLIN_yClb1_LxF_4	525	530	PF00134	0.426
DOC_MAPK_DCC_7	367	376	PF00069	0.433
DOC_MAPK_FxFP_2	637	640	PF00069	0.458
DOC_MAPK_gen_1	253	260	PF00069	0.437
DOC_MAPK_gen_1	367	374	PF00069	0.470
DOC_MAPK_HePTP_8	364	376	PF00069	0.504
DOC_MAPK_MEF2A_6	184	192	PF00069	0.426
DOC_MAPK_MEF2A_6	207	215	PF00069	0.420
DOC_MAPK_MEF2A_6	283	290	PF00069	0.428
DOC_MAPK_MEF2A_6	367	376	PF00069	0.414
DOC_MAPK_MEF2A_6	658	665	PF00069	0.401
DOC_PP1_RVXF_1	525	531	PF00149	0.423
DOC_PP4_FxxP_1	63	66	PF00568	0.718
DOC_PP4_FxxP_1	637	640	PF00568	0.458
DOC_PP4_MxPP_1	479	482	PF00568	0.456
DOC_SPAK_OSR1_1	283	287	PF12202	0.377
DOC_USP7_MATH_1	142	146	PF00917	0.600
DOC_USP7_MATH_1	22	26	PF00917	0.648
DOC_USP7_MATH_1	347	351	PF00917	0.611
DOC_USP7_MATH_1	362	366	PF00917	0.357
DOC_USP7_MATH_1	37	41	PF00917	0.650
DOC_USP7_MATH_1	399	403	PF00917	0.537
DOC_USP7_UBL2_3	404	408	PF12436	0.553
DOC_WW_Pin1_4	295	300	PF00397	0.454
DOC_WW_Pin1_4	580	585	PF00397	0.501
DOC_WW_Pin1_4	627	632	PF00397	0.288
LIG_14-3-3_CanoR_1	416	423	PF00244	0.489
LIG_14-3-3_CanoR_1	527	531	PF00244	0.408
LIG_14-3-3_CanoR_1	658	664	PF00244	0.402
LIG_BIR_III_4	78	82	PF00653	0.621
LIG_deltaCOP1_diTrp_1	122	126	PF00928	0.424
LIG_EH1_1	184	192	PF00400	0.426
LIG_FHA_1	123	129	PF00498	0.416
LIG_FHA_1	227	233	PF00498	0.537
LIG_FHA_1	338	344	PF00498	0.318
LIG_FHA_1	581	587	PF00498	0.487
LIG_FHA_1	590	596	PF00498	0.493
LIG_FHA_1	611	617	PF00498	0.506
LIG_FHA_1	655	661	PF00498	0.437
LIG_FHA_1	679	685	PF00498	0.558
LIG_FHA_2	462	468	PF00498	0.392
LIG_FHA_2	552	558	PF00498	0.448
LIG_FHA_2	99	105	PF00498	0.509
LIG_GBD_Chelix_1	186	194	PF00786	0.403
LIG_LIR_Apic_2	342	347	PF02991	0.510
LIG_LIR_Apic_2	60	66	PF02991	0.705
LIG_LIR_Gen_1	122	128	PF02991	0.425
LIG_LIR_Gen_1	168	177	PF02991	0.497
LIG_LIR_Gen_1	206	216	PF02991	0.442
LIG_LIR_Gen_1	301	308	PF02991	0.496
LIG_LIR_Gen_1	389	400	PF02991	0.430
LIG_LIR_Gen_1	529	538	PF02991	0.435
LIG_LIR_Gen_1	606	617	PF02991	0.417
LIG_LIR_Nem_3	122	126	PF02991	0.424
LIG_LIR_Nem_3	168	172	PF02991	0.491
LIG_LIR_Nem_3	206	211	PF02991	0.432
LIG_LIR_Nem_3	301	306	PF02991	0.495
LIG_LIR_Nem_3	389	395	PF02991	0.432
LIG_LIR_Nem_3	529	533	PF02991	0.409
LIG_LIR_Nem_3	558	564	PF02991	0.437
LIG_LIR_Nem_3	606	612	PF02991	0.427
LIG_LYPXL_SIV_4	638	646	PF13949	0.400
LIG_PDZ_Class_1	703	708	PF00595	0.464
LIG_SH2_CRK	303	307	PF00017	0.519
LIG_SH2_CRK	609	613	PF00017	0.409
LIG_SH2_GRB2like	165	168	PF00017	0.453
LIG_SH2_NCK_1	609	613	PF00017	0.409
LIG_SH2_PTP2	208	211	PF00017	0.413
LIG_SH2_PTP2	561	564	PF00017	0.416
LIG_SH2_STAT5	208	211	PF00017	0.532
LIG_SH2_STAT5	303	306	PF00017	0.520
LIG_SH2_STAT5	325	328	PF00017	0.412
LIG_SH2_STAT5	392	395	PF00017	0.348
LIG_SH2_STAT5	409	412	PF00017	0.642
LIG_SH2_STAT5	549	552	PF00017	0.363
LIG_SH2_STAT5	561	564	PF00017	0.416
LIG_SH3_2	44	49	PF14604	0.532
LIG_SH3_3	24	30	PF00018	0.473
LIG_SH3_3	369	375	PF00018	0.466
LIG_SH3_3	41	47	PF00018	0.686
LIG_SH3_3	434	440	PF00018	0.659
LIG_SH3_3	475	481	PF00018	0.482
LIG_SH3_4	404	411	PF00018	0.558
LIG_SUMO_SIM_anti_2	287	292	PF11976	0.385
LIG_SUMO_SIM_anti_2	529	535	PF11976	0.447
LIG_SUMO_SIM_anti_2	551	560	PF11976	0.455
LIG_SUMO_SIM_par_1	459	464	PF11976	0.410
LIG_SUMO_SIM_par_1	495	502	PF11976	0.400
LIG_SUMO_SIM_par_1	661	667	PF11976	0.422
LIG_TYR_ITSM	299	306	PF00017	0.490
LIG_TYR_ITSM	605	612	PF00017	0.399
MOD_CDK_SPxK_1	627	633	PF00069	0.284
MOD_CDK_SPxxK_3	627	634	PF00069	0.285
MOD_CK1_1	145	151	PF00069	0.511
MOD_CK1_1	418	424	PF00069	0.689
MOD_CK1_1	445	451	PF00069	0.540
MOD_CK1_1	502	508	PF00069	0.536
MOD_CK1_1	603	609	PF00069	0.479
MOD_CK2_1	1	7	PF00069	0.627
MOD_CK2_1	461	467	PF00069	0.376
MOD_CK2_1	54	60	PF00069	0.789
MOD_CK2_1	551	557	PF00069	0.461
MOD_GlcNHglycan	129	132	PF01048	0.479
MOD_GlcNHglycan	160	163	PF01048	0.416
MOD_GlcNHglycan	336	340	PF01048	0.479
MOD_GlcNHglycan	353	356	PF01048	0.500
MOD_GlcNHglycan	420	423	PF01048	0.741
MOD_GlcNHglycan	501	504	PF01048	0.439
MOD_GlcNHglycan	518	521	PF01048	0.575
MOD_GlcNHglycan	522	525	PF01048	0.528
MOD_GlcNHglycan	534	537	PF01048	0.495
MOD_GlcNHglycan	564	567	PF01048	0.369
MOD_GSK3_1	219	226	PF00069	0.465
MOD_GSK3_1	247	254	PF00069	0.497
MOD_GSK3_1	298	305	PF00069	0.521
MOD_GSK3_1	308	315	PF00069	0.467
MOD_GSK3_1	32	39	PF00069	0.499
MOD_GSK3_1	331	338	PF00069	0.444
MOD_GSK3_1	347	354	PF00069	0.546
MOD_GSK3_1	418	425	PF00069	0.632
MOD_GSK3_1	516	523	PF00069	0.700
MOD_GSK3_1	576	583	PF00069	0.459
MOD_GSK3_1	585	592	PF00069	0.419
MOD_GSK3_1	596	603	PF00069	0.241
MOD_GSK3_1	61	68	PF00069	0.723
MOD_N-GLC_1	520	525	PF02516	0.584
MOD_NEK2_1	1	6	PF00069	0.661
MOD_NEK2_1	251	256	PF00069	0.496
MOD_NEK2_1	308	313	PF00069	0.494
MOD_NEK2_1	337	342	PF00069	0.290
MOD_NEK2_1	492	497	PF00069	0.429
MOD_NEK2_1	534	539	PF00069	0.569
MOD_NEK2_1	556	561	PF00069	0.478
MOD_NEK2_1	654	659	PF00069	0.436
MOD_NEK2_1	703	708	PF00069	0.503
MOD_NEK2_2	362	367	PF00069	0.496
MOD_PIKK_1	142	148	PF00454	0.485
MOD_PIKK_1	308	314	PF00454	0.555
MOD_PIKK_1	65	71	PF00454	0.776
MOD_PKA_2	415	421	PF00069	0.634
MOD_PKA_2	492	498	PF00069	0.423
MOD_PKA_2	526	532	PF00069	0.415
MOD_Plk_1	247	253	PF00069	0.386
MOD_Plk_1	466	472	PF00069	0.482
MOD_Plk_1	556	562	PF00069	0.497
MOD_Plk_1	597	603	PF00069	0.464
MOD_Plk_1	642	648	PF00069	0.440
MOD_Plk_2-3	83	89	PF00069	0.568
MOD_Plk_4	122	128	PF00069	0.442
MOD_Plk_4	22	28	PF00069	0.467
MOD_Plk_4	298	304	PF00069	0.471
MOD_Plk_4	339	345	PF00069	0.576
MOD_Plk_4	492	498	PF00069	0.397
MOD_Plk_4	526	532	PF00069	0.400
MOD_Plk_4	534	540	PF00069	0.430
MOD_Plk_4	551	557	PF00069	0.279
MOD_Plk_4	642	648	PF00069	0.440
MOD_ProDKin_1	295	301	PF00069	0.450
MOD_ProDKin_1	580	586	PF00069	0.496
MOD_ProDKin_1	627	633	PF00069	0.284
MOD_SUMO_rev_2	145	152	PF00179	0.312
TRG_DiLeu_BaEn_2	121	127	PF01217	0.425
TRG_DiLeu_BaLyEn_6	41	46	PF01217	0.492
TRG_DiLeu_BaLyEn_6	679	684	PF01217	0.443
TRG_ENDOCYTIC_2	208	211	PF00928	0.413
TRG_ENDOCYTIC_2	303	306	PF00928	0.520
TRG_ENDOCYTIC_2	325	328	PF00928	0.457
TRG_ENDOCYTIC_2	392	395	PF00928	0.348
TRG_ENDOCYTIC_2	561	564	PF00928	0.416
TRG_ENDOCYTIC_2	609	612	PF00928	0.417
TRG_ENDOCYTIC_2	617	620	PF00928	0.398
TRG_ER_diArg_1	255	257	PF00400	0.483
TRG_ER_diArg_1	267	270	PF00400	0.312
TRG_ER_diArg_1	272	274	PF00400	0.324
TRG_ER_diArg_1	366	369	PF00400	0.482
TRG_ER_diArg_1	577	580	PF00400	0.520
TRG_Pf-PMV_PEXEL_1	272	276	PF00026	0.465
TRG_Pf-PMV_PEXEL_1	593	598	PF00026	0.339
TRG_Pf-PMV_PEXEL_1	682	687	PF00026	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8E7	Leptomonas seymouri	44%	72%
A0A3S7WX75	Leishmania donovani	93%	100%
A4HCB8	Leishmania braziliensis	74%	96%
A4HZX1	Leishmania infantum	93%	100%
Q4QBP9	Leishmania major	92%	100%
V5DMK2	Trypanosoma cruzi	27%	100%