Putative kinesin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative kinesin

Gene product:

kinesin, putative

Species:

Leishmania mexicana

UniProt:

E9AVS8_LEIMU

TriTrypDb:

LmxM.22.0960

Length:

1223

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005871	kinesin complex	3	1
GO:0005874	microtubule	6	1
GO:0005875	microtubule associated complex	2	1
GO:0020016	ciliary pocket	2	1
GO:0032991	protein-containing complex	1	1
GO:0099080	supramolecular complex	2	1
GO:0099081	supramolecular polymer	3	1
GO:0099512	supramolecular fiber	4	1
GO:0099513	polymeric cytoskeletal fiber	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AVS8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVS8

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	8
GO:0007018	microtubule-based movement	3	8
GO:0009987	cellular process	1	8

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003774	cytoskeletal motor activity	1	8
GO:0003777	microtubule motor activity	2	8
GO:0005488	binding	1	8
GO:0005515	protein binding	2	8
GO:0005524	ATP binding	5	8
GO:0008017	microtubule binding	5	8
GO:0008092	cytoskeletal protein binding	3	8
GO:0015631	tubulin binding	4	8
GO:0017076	purine nucleotide binding	4	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:0140657	ATP-dependent activity	1	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8
GO:0003824	catalytic activity	1	4
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	4
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1
GO:0003779	actin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	359	363	PF00656	0.699
CLV_C14_Caspase3-7	530	534	PF00656	0.590
CLV_C14_Caspase3-7	976	980	PF00656	0.582
CLV_NRD_NRD_1	338	340	PF00675	0.658
CLV_NRD_NRD_1	394	396	PF00675	0.537
CLV_NRD_NRD_1	872	874	PF00675	0.592
CLV_NRD_NRD_1	954	956	PF00675	0.777
CLV_PCSK_KEX2_1	338	340	PF00082	0.658
CLV_PCSK_KEX2_1	365	367	PF00082	0.558
CLV_PCSK_KEX2_1	396	398	PF00082	0.524
CLV_PCSK_KEX2_1	446	448	PF00082	0.620
CLV_PCSK_KEX2_1	553	555	PF00082	0.693
CLV_PCSK_KEX2_1	644	646	PF00082	0.670
CLV_PCSK_KEX2_1	953	955	PF00082	0.796
CLV_PCSK_PC1ET2_1	365	367	PF00082	0.593
CLV_PCSK_PC1ET2_1	396	398	PF00082	0.577
CLV_PCSK_PC1ET2_1	446	448	PF00082	0.620
CLV_PCSK_PC1ET2_1	553	555	PF00082	0.596
CLV_PCSK_PC1ET2_1	644	646	PF00082	0.664
CLV_PCSK_PC1ET2_1	953	955	PF00082	0.722
CLV_PCSK_PC7_1	640	646	PF00082	0.665
CLV_PCSK_SKI1_1	1063	1067	PF00082	0.573
CLV_PCSK_SKI1_1	1202	1206	PF00082	0.523
CLV_PCSK_SKI1_1	162	166	PF00082	0.376
CLV_PCSK_SKI1_1	368	372	PF00082	0.688
CLV_PCSK_SKI1_1	396	400	PF00082	0.501
CLV_PCSK_SKI1_1	418	422	PF00082	0.574
CLV_PCSK_SKI1_1	494	498	PF00082	0.582
CLV_PCSK_SKI1_1	640	644	PF00082	0.666
CLV_PCSK_SKI1_1	645	649	PF00082	0.659
CLV_PCSK_SKI1_1	826	830	PF00082	0.565
CLV_PCSK_SKI1_1	889	893	PF00082	0.567
CLV_PCSK_SKI1_1	981	985	PF00082	0.647
DEG_APCC_DBOX_1	991	999	PF00400	0.602
DEG_Nend_UBRbox_4	1	3	PF02207	0.210
DEG_SPOP_SBC_1	462	466	PF00917	0.637
DEG_SPOP_SBC_1	754	758	PF00917	0.585
DOC_CYCLIN_RxL_1	159	166	PF00134	0.424
DOC_MAPK_gen_1	1140	1148	PF00069	0.695
DOC_MAPK_gen_1	1164	1172	PF00069	0.585
DOC_MAPK_gen_1	212	221	PF00069	0.408
DOC_MAPK_gen_1	338	346	PF00069	0.664
DOC_MAPK_gen_1	432	440	PF00069	0.398
DOC_MAPK_gen_1	623	631	PF00069	0.580
DOC_MAPK_gen_1	953	962	PF00069	0.741
DOC_MAPK_MEF2A_6	1140	1148	PF00069	0.570
DOC_MAPK_MEF2A_6	184	193	PF00069	0.376
DOC_MAPK_MEF2A_6	338	346	PF00069	0.539
DOC_MAPK_MEF2A_6	57	64	PF00069	0.424
DOC_MAPK_MEF2A_6	623	631	PF00069	0.580
DOC_PP4_FxxP_1	719	722	PF00568	0.663
DOC_USP7_MATH_1	113	117	PF00917	0.478
DOC_USP7_MATH_1	120	124	PF00917	0.476
DOC_USP7_MATH_1	4	8	PF00917	0.430
DOC_USP7_MATH_1	40	44	PF00917	0.501
DOC_USP7_MATH_1	471	475	PF00917	0.508
DOC_USP7_MATH_1	476	480	PF00917	0.504
DOC_USP7_MATH_1	579	583	PF00917	0.755
DOC_USP7_MATH_1	755	759	PF00917	0.674
DOC_USP7_MATH_1	763	767	PF00917	0.610
DOC_USP7_UBL2_3	260	264	PF12436	0.376
DOC_WW_Pin1_4	38	43	PF00397	0.317
DOC_WW_Pin1_4	464	469	PF00397	0.667
DOC_WW_Pin1_4	48	53	PF00397	0.404
DOC_WW_Pin1_4	718	723	PF00397	0.625
DOC_WW_Pin1_4	734	739	PF00397	0.635
DOC_WW_Pin1_4	932	937	PF00397	0.733
LIG_14-3-3_CanoR_1	169	178	PF00244	0.377
LIG_14-3-3_CanoR_1	210	219	PF00244	0.441
LIG_14-3-3_CanoR_1	226	232	PF00244	0.347
LIG_14-3-3_CanoR_1	343	347	PF00244	0.599
LIG_14-3-3_CanoR_1	418	426	PF00244	0.557
LIG_14-3-3_CanoR_1	562	568	PF00244	0.625
LIG_14-3-3_CanoR_1	645	654	PF00244	0.654
LIG_14-3-3_CanoR_1	676	684	PF00244	0.639
LIG_14-3-3_CanoR_1	73	82	PF00244	0.430
LIG_14-3-3_CanoR_1	915	923	PF00244	0.600
LIG_14-3-3_CanoR_1	954	962	PF00244	0.737
LIG_Actin_WH2_2	1183	1200	PF00022	0.524
LIG_Actin_WH2_2	629	646	PF00022	0.650
LIG_APCC_ABBA_1	101	106	PF00400	0.376
LIG_BIR_III_4	156	160	PF00653	0.346
LIG_BRCT_BRCA1_1	75	79	PF00533	0.501
LIG_CORNRBOX	189	197	PF00104	0.424
LIG_FHA_1	1157	1163	PF00498	0.694
LIG_FHA_1	192	198	PF00498	0.410
LIG_FHA_1	202	208	PF00498	0.382
LIG_FHA_1	211	217	PF00498	0.287
LIG_FHA_1	274	280	PF00498	0.376
LIG_FHA_1	287	293	PF00498	0.376
LIG_FHA_1	29	35	PF00498	0.408
LIG_FHA_1	343	349	PF00498	0.555
LIG_FHA_1	386	392	PF00498	0.686
LIG_FHA_1	421	427	PF00498	0.552
LIG_FHA_1	564	570	PF00498	0.684
LIG_FHA_1	589	595	PF00498	0.672
LIG_FHA_1	601	607	PF00498	0.677
LIG_FHA_1	735	741	PF00498	0.774
LIG_FHA_1	91	97	PF00498	0.393
LIG_FHA_2	321	327	PF00498	0.540
LIG_FHA_2	443	449	PF00498	0.445
LIG_FHA_2	538	544	PF00498	0.599
LIG_FHA_2	571	577	PF00498	0.649
LIG_FHA_2	605	611	PF00498	0.621
LIG_LIR_Gen_1	1112	1122	PF02991	0.580
LIG_LIR_Gen_1	1127	1137	PF02991	0.557
LIG_LIR_Gen_1	24	33	PF02991	0.392
LIG_LIR_Gen_1	327	337	PF02991	0.540
LIG_LIR_Gen_1	669	677	PF02991	0.627
LIG_LIR_Gen_1	956	964	PF02991	0.597
LIG_LIR_Gen_1	97	108	PF02991	0.353
LIG_LIR_Nem_3	1028	1033	PF02991	0.393
LIG_LIR_Nem_3	1127	1132	PF02991	0.569
LIG_LIR_Nem_3	24	28	PF02991	0.392
LIG_LIR_Nem_3	308	314	PF02991	0.364
LIG_LIR_Nem_3	327	333	PF02991	0.394
LIG_LIR_Nem_3	956	960	PF02991	0.530
LIG_LIR_Nem_3	97	103	PF02991	0.376
LIG_MYND_1	724	728	PF01753	0.736
LIG_NRBOX	1145	1151	PF00104	0.629
LIG_NRBOX	274	280	PF00104	0.347
LIG_NRBOX	656	662	PF00104	0.610
LIG_Pex14_1	454	458	PF04695	0.519
LIG_SH2_CRK	25	29	PF00017	0.430
LIG_SH2_CRK	458	462	PF00017	0.605
LIG_SH2_CRK	957	961	PF00017	0.525
LIG_SH2_NCK_1	25	29	PF00017	0.430
LIG_SH2_PTP2	1147	1150	PF00017	0.622
LIG_SH2_SRC	145	148	PF00017	0.374
LIG_SH2_STAP1	1048	1052	PF00017	0.561
LIG_SH2_STAP1	776	780	PF00017	0.591
LIG_SH2_STAP1	847	851	PF00017	0.726
LIG_SH2_STAT3	300	303	PF00017	0.376
LIG_SH2_STAT3	776	779	PF00017	0.633
LIG_SH2_STAT3	835	838	PF00017	0.691
LIG_SH2_STAT5	104	107	PF00017	0.376
LIG_SH2_STAT5	1115	1118	PF00017	0.650
LIG_SH2_STAT5	1147	1150	PF00017	0.569
LIG_SH2_STAT5	127	130	PF00017	0.326
LIG_SH2_STAT5	145	148	PF00017	0.341
LIG_SH2_STAT5	300	303	PF00017	0.376
LIG_SH2_STAT5	619	622	PF00017	0.580
LIG_SH3_1	735	741	PF00018	0.650
LIG_SH3_2	738	743	PF14604	0.528
LIG_SH3_3	59	65	PF00018	0.424
LIG_SH3_3	735	741	PF00018	0.665
LIG_SUMO_SIM_anti_2	1040	1045	PF11976	0.387
LIG_SUMO_SIM_anti_2	796	801	PF11976	0.385
LIG_SUMO_SIM_par_1	287	294	PF11976	0.430
LIG_TRAF2_1	1089	1092	PF00917	0.617
LIG_TRAF2_1	1100	1103	PF00917	0.451
LIG_TRAF2_1	527	530	PF00917	0.602
LIG_TRAF2_1	877	880	PF00917	0.572
LIG_UBA3_1	188	195	PF00899	0.430
MOD_CDK_SPxxK_3	50	57	PF00069	0.210
MOD_CDK_SPxxK_3	932	939	PF00069	0.738
MOD_CK1_1	1042	1048	PF00069	0.667
MOD_CK1_1	116	122	PF00069	0.474
MOD_CK1_1	123	129	PF00069	0.453
MOD_CK1_1	182	188	PF00069	0.376
MOD_CK1_1	203	209	PF00069	0.404
MOD_CK1_1	21	27	PF00069	0.420
MOD_CK1_1	230	236	PF00069	0.417
MOD_CK1_1	246	252	PF00069	0.376
MOD_CK1_1	273	279	PF00069	0.376
MOD_CK1_1	35	41	PF00069	0.376
MOD_CK1_1	464	470	PF00069	0.673
MOD_CK1_1	565	571	PF00069	0.632
MOD_CK1_1	582	588	PF00069	0.704
MOD_CK1_1	711	717	PF00069	0.592
MOD_CK1_1	928	934	PF00069	0.657
MOD_CK2_1	1157	1163	PF00069	0.686
MOD_CK2_1	320	326	PF00069	0.475
MOD_CK2_1	442	448	PF00069	0.535
MOD_CK2_1	519	525	PF00069	0.571
MOD_CK2_1	565	571	PF00069	0.632
MOD_CK2_1	581	587	PF00069	0.644
MOD_CK2_1	604	610	PF00069	0.616
MOD_CK2_1	677	683	PF00069	0.643
MOD_CK2_1	96	102	PF00069	0.376
MOD_GlcNHglycan	1078	1081	PF01048	0.620
MOD_GlcNHglycan	1217	1223	PF01048	0.674
MOD_GlcNHglycan	130	133	PF01048	0.395
MOD_GlcNHglycan	165	168	PF01048	0.375
MOD_GlcNHglycan	20	23	PF01048	0.309
MOD_GlcNHglycan	229	232	PF01048	0.341
MOD_GlcNHglycan	297	300	PF01048	0.376
MOD_GlcNHglycan	34	37	PF01048	0.376
MOD_GlcNHglycan	349	352	PF01048	0.629
MOD_GlcNHglycan	383	386	PF01048	0.602
MOD_GlcNHglycan	423	426	PF01048	0.427
MOD_GlcNHglycan	473	476	PF01048	0.771
MOD_GlcNHglycan	478	481	PF01048	0.522
MOD_GlcNHglycan	520	524	PF01048	0.655
MOD_GlcNHglycan	576	580	PF01048	0.649
MOD_GlcNHglycan	587	590	PF01048	0.633
MOD_GlcNHglycan	6	9	PF01048	0.411
MOD_GlcNHglycan	639	643	PF01048	0.657
MOD_GlcNHglycan	703	706	PF01048	0.734
MOD_GlcNHglycan	710	713	PF01048	0.771
MOD_GlcNHglycan	750	753	PF01048	0.770
MOD_GlcNHglycan	757	760	PF01048	0.751
MOD_GlcNHglycan	916	919	PF01048	0.665
MOD_GlcNHglycan	957	960	PF01048	0.720
MOD_GlcNHglycan	975	978	PF01048	0.366
MOD_GSK3_1	116	123	PF00069	0.502
MOD_GSK3_1	197	204	PF00069	0.430
MOD_GSK3_1	206	213	PF00069	0.402
MOD_GSK3_1	221	228	PF00069	0.333
MOD_GSK3_1	23	30	PF00069	0.510
MOD_GSK3_1	273	280	PF00069	0.498
MOD_GSK3_1	291	298	PF00069	0.376
MOD_GSK3_1	38	45	PF00069	0.424
MOD_GSK3_1	381	388	PF00069	0.595
MOD_GSK3_1	46	53	PF00069	0.332
MOD_GSK3_1	462	469	PF00069	0.662
MOD_GSK3_1	565	572	PF00069	0.631
MOD_GSK3_1	575	582	PF00069	0.671
MOD_GSK3_1	600	607	PF00069	0.724
MOD_GSK3_1	708	715	PF00069	0.648
MOD_GSK3_1	718	725	PF00069	0.670
MOD_GSK3_1	901	908	PF00069	0.367
MOD_GSK3_1	92	99	PF00069	0.444
MOD_GSK3_1	925	932	PF00069	0.730
MOD_LATS_1	560	566	PF00433	0.604
MOD_N-GLC_1	123	128	PF02516	0.501
MOD_N-GLC_1	243	248	PF02516	0.376
MOD_N-GLC_1	604	609	PF02516	0.637
MOD_N-GLC_2	10	12	PF02516	0.376
MOD_NEK2_1	1058	1063	PF00069	0.583
MOD_NEK2_1	1114	1119	PF00069	0.464
MOD_NEK2_1	191	196	PF00069	0.376
MOD_NEK2_1	245	250	PF00069	0.376
MOD_NEK2_1	279	284	PF00069	0.376
MOD_NEK2_1	291	296	PF00069	0.353
MOD_NEK2_1	419	424	PF00069	0.554
MOD_NEK2_1	461	466	PF00069	0.603
MOD_NEK2_1	507	512	PF00069	0.614
MOD_NEK2_1	537	542	PF00069	0.593
MOD_NEK2_1	563	568	PF00069	0.568
MOD_NEK2_1	569	574	PF00069	0.582
MOD_NEK2_1	598	603	PF00069	0.649
MOD_NEK2_1	708	713	PF00069	0.678
MOD_NEK2_1	905	910	PF00069	0.373
MOD_NEK2_1	962	967	PF00069	0.483
MOD_PIKK_1	1004	1010	PF00454	0.595
MOD_PIKK_1	225	231	PF00454	0.376
MOD_PIKK_1	570	576	PF00454	0.642
MOD_PIKK_1	645	651	PF00454	0.730
MOD_PKA_1	953	959	PF00069	0.682
MOD_PKA_2	1076	1082	PF00069	0.611
MOD_PKA_2	1107	1113	PF00069	0.611
MOD_PKA_2	170	176	PF00069	0.376
MOD_PKA_2	225	231	PF00069	0.376
MOD_PKA_2	270	276	PF00069	0.344
MOD_PKA_2	342	348	PF00069	0.574
MOD_PKA_2	914	920	PF00069	0.650
MOD_PKA_2	953	959	PF00069	0.760
MOD_Plk_1	1039	1045	PF00069	0.677
MOD_Plk_1	1067	1073	PF00069	0.628
MOD_Plk_1	1156	1162	PF00069	0.648
MOD_Plk_1	1205	1211	PF00069	0.604
MOD_Plk_1	123	129	PF00069	0.501
MOD_Plk_1	243	249	PF00069	0.372
MOD_Plk_1	449	455	PF00069	0.408
MOD_Plk_1	575	581	PF00069	0.649
MOD_Plk_1	638	644	PF00069	0.660
MOD_Plk_1	96	102	PF00069	0.411
MOD_Plk_1	962	968	PF00069	0.389
MOD_Plk_2-3	1157	1163	PF00069	0.686
MOD_Plk_2-3	58	64	PF00069	0.424
MOD_Plk_2-3	944	950	PF00069	0.740
MOD_Plk_4	1157	1163	PF00069	0.615
MOD_Plk_4	123	129	PF00069	0.326
MOD_Plk_4	203	209	PF00069	0.412
MOD_Plk_4	23	29	PF00069	0.366
MOD_Plk_4	270	276	PF00069	0.376
MOD_Plk_4	286	292	PF00069	0.376
MOD_Plk_4	565	571	PF00069	0.632
MOD_Plk_4	901	907	PF00069	0.629
MOD_Plk_4	96	102	PF00069	0.376
MOD_Plk_4	962	968	PF00069	0.389
MOD_ProDKin_1	38	44	PF00069	0.317
MOD_ProDKin_1	464	470	PF00069	0.673
MOD_ProDKin_1	48	54	PF00069	0.404
MOD_ProDKin_1	718	724	PF00069	0.621
MOD_ProDKin_1	734	740	PF00069	0.634
MOD_ProDKin_1	932	938	PF00069	0.734
MOD_SUMO_for_1	364	367	PF00179	0.595
MOD_SUMO_for_1	527	530	PF00179	0.488
MOD_SUMO_rev_2	233	243	PF00179	0.412
MOD_SUMO_rev_2	505	512	PF00179	0.489
MOD_SUMO_rev_2	821	828	PF00179	0.394
MOD_SUMO_rev_2	856	861	PF00179	0.550
MOD_SUMO_rev_2	867	875	PF00179	0.634
TRG_DiLeu_BaEn_1	367	372	PF01217	0.686
TRG_DiLeu_BaEn_1	656	661	PF01217	0.610
TRG_DiLeu_BaEn_1	796	801	PF01217	0.599
TRG_DiLeu_BaEn_1	919	924	PF01217	0.640
TRG_ENDOCYTIC_2	1115	1118	PF00928	0.608
TRG_ENDOCYTIC_2	1129	1132	PF00928	0.407
TRG_ENDOCYTIC_2	1147	1150	PF00928	0.569
TRG_ENDOCYTIC_2	25	28	PF00928	0.399
TRG_ENDOCYTIC_2	441	444	PF00928	0.617
TRG_ENDOCYTIC_2	458	461	PF00928	0.473
TRG_ENDOCYTIC_2	672	675	PF00928	0.630
TRG_ENDOCYTIC_2	957	960	PF00928	0.604
TRG_ER_diArg_1	134	137	PF00400	0.376
TRG_ER_diArg_1	168	171	PF00400	0.210
TRG_ER_diArg_1	337	339	PF00400	0.666
TRG_ER_diArg_1	394	397	PF00400	0.542
TRG_ER_diArg_1	545	548	PF00400	0.698
TRG_ER_diArg_1	673	676	PF00400	0.711
TRG_ER_diArg_1	868	871	PF00400	0.569
TRG_NES_CRM1_1	336	349	PF08389	0.578
TRG_NES_CRM1_1	557	571	PF08389	0.627
TRG_NES_CRM1_1	653	666	PF08389	0.654
TRG_NLS_MonoExtC_3	394	399	PF00514	0.586
TRG_NLS_MonoExtN_4	952	957	PF00514	0.696
TRG_Pf-PMV_PEXEL_1	1134	1138	PF00026	0.629
TRG_Pf-PMV_PEXEL_1	1152	1156	PF00026	0.420
TRG_Pf-PMV_PEXEL_1	252	256	PF00026	0.376
TRG_Pf-PMV_PEXEL_1	827	831	PF00026	0.624

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P817	Leptomonas seymouri	57%	84%
A0A3S7WX59	Leishmania donovani	88%	97%
A4HCE7	Leishmania braziliensis	76%	100%
A4HZW9	Leishmania infantum	88%	97%
Q4QBQ1	Leishmania major	89%	100%
V5BVU5	Trypanosoma cruzi	39%	97%