AAA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial chaperone, putative

Species:

Leishmania mexicana

UniProt:

E9AVS6_LEIMU

TriTrypDb:

LmxM.22.0940

Length:

734

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9AVS6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVS6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	18
GO:0003824	catalytic activity	1	18
GO:0005488	binding	1	18
GO:0005524	ATP binding	5	18
GO:0016462	pyrophosphatase activity	5	18
GO:0016787	hydrolase activity	2	18
GO:0016817	hydrolase activity, acting on acid anhydrides	3	18
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	18
GO:0016887	ATP hydrolysis activity	7	18
GO:0017076	purine nucleotide binding	4	18
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	18
GO:0030554	adenyl nucleotide binding	5	18
GO:0032553	ribonucleotide binding	3	18
GO:0032555	purine ribonucleotide binding	4	18
GO:0032559	adenyl ribonucleotide binding	5	18
GO:0035639	purine ribonucleoside triphosphate binding	4	18
GO:0036094	small molecule binding	2	18
GO:0043167	ion binding	2	18
GO:0043168	anion binding	3	18
GO:0097159	organic cyclic compound binding	2	18
GO:0097367	carbohydrate derivative binding	2	18
GO:1901265	nucleoside phosphate binding	3	18
GO:1901363	heterocyclic compound binding	2	18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.724
CLV_C14_Caspase3-7	392	396	PF00656	0.588
CLV_C14_Caspase3-7	410	414	PF00656	0.406
CLV_C14_Caspase3-7	484	488	PF00656	0.686
CLV_NRD_NRD_1	326	328	PF00675	0.393
CLV_NRD_NRD_1	425	427	PF00675	0.299
CLV_NRD_NRD_1	430	432	PF00675	0.313
CLV_NRD_NRD_1	503	505	PF00675	0.542
CLV_NRD_NRD_1	617	619	PF00675	0.492
CLV_PCSK_KEX2_1	326	328	PF00082	0.452
CLV_PCSK_KEX2_1	425	427	PF00082	0.315
CLV_PCSK_KEX2_1	430	432	PF00082	0.324
CLV_PCSK_KEX2_1	503	505	PF00082	0.631
CLV_PCSK_KEX2_1	617	619	PF00082	0.492
CLV_PCSK_PC7_1	426	432	PF00082	0.315
CLV_PCSK_SKI1_1	158	162	PF00082	0.360
CLV_PCSK_SKI1_1	201	205	PF00082	0.365
CLV_PCSK_SKI1_1	279	283	PF00082	0.298
CLV_PCSK_SKI1_1	291	295	PF00082	0.393
CLV_PCSK_SKI1_1	313	317	PF00082	0.367
CLV_PCSK_SKI1_1	351	355	PF00082	0.285
DEG_APCC_DBOX_1	590	598	PF00400	0.559
DEG_Nend_UBRbox_3	1	3	PF02207	0.420
DOC_ANK_TNKS_1	328	335	PF00023	0.564
DOC_CKS1_1	701	706	PF01111	0.622
DOC_CYCLIN_yClb1_LxF_4	336	341	PF00134	0.520
DOC_CYCLIN_yClb5_NLxxxL_5	547	554	PF00134	0.515
DOC_CYCLIN_yCln2_LP_2	74	80	PF00134	0.279
DOC_MAPK_gen_1	199	207	PF00069	0.576
DOC_MAPK_gen_1	300	310	PF00069	0.553
DOC_MAPK_gen_1	399	408	PF00069	0.507
DOC_MAPK_gen_1	584	594	PF00069	0.554
DOC_MAPK_MEF2A_6	199	207	PF00069	0.545
DOC_MAPK_MEF2A_6	364	371	PF00069	0.478
DOC_MAPK_MEF2A_6	587	594	PF00069	0.558
DOC_PIKK_1	120	128	PF02985	0.531
DOC_PP1_RVXF_1	289	295	PF00149	0.585
DOC_PP1_RVXF_1	336	342	PF00149	0.519
DOC_SPAK_OSR1_1	329	333	PF12202	0.570
DOC_SPAK_OSR1_1	587	591	PF12202	0.610
DOC_SPAK_OSR1_1	699	703	PF12202	0.532
DOC_WW_Pin1_4	172	177	PF00397	0.607
DOC_WW_Pin1_4	700	705	PF00397	0.545
LIG_14-3-3_CanoR_1	166	176	PF00244	0.597
LIG_14-3-3_CanoR_1	238	244	PF00244	0.593
LIG_14-3-3_CanoR_1	364	370	PF00244	0.466
LIG_14-3-3_CanoR_1	435	442	PF00244	0.521
LIG_14-3-3_CanoR_1	587	591	PF00244	0.556
LIG_14-3-3_CanoR_1	93	97	PF00244	0.612
LIG_14-3-3_CterR_2	729	734	PF00244	0.489
LIG_Actin_RPEL_3	457	476	PF02755	0.532
LIG_Actin_WH2_2	79	95	PF00022	0.359
LIG_APCC_ABBA_1	116	121	PF00400	0.570
LIG_APCC_ABBA_1	263	268	PF00400	0.580
LIG_APCC_ABBA_1	406	411	PF00400	0.485
LIG_BRCT_BRCA1_1	173	177	PF00533	0.523
LIG_deltaCOP1_diTrp_1	62	71	PF00928	0.467
LIG_eIF4E_1	105	111	PF01652	0.500
LIG_EVH1_1	65	69	PF00568	0.343
LIG_FHA_1	192	198	PF00498	0.671
LIG_FHA_1	314	320	PF00498	0.535
LIG_FHA_1	446	452	PF00498	0.609
LIG_FHA_1	467	473	PF00498	0.619
LIG_FHA_2	251	257	PF00498	0.574
LIG_FHA_2	701	707	PF00498	0.598
LIG_LIR_Apic_2	170	176	PF02991	0.622
LIG_LIR_Apic_2	576	580	PF02991	0.558
LIG_LIR_Apic_2	62	66	PF02991	0.458
LIG_LIR_Gen_1	127	137	PF02991	0.608
LIG_LIR_Gen_1	595	603	PF02991	0.508
LIG_LIR_Gen_1	70	79	PF02991	0.310
LIG_LIR_Nem_3	127	133	PF02991	0.625
LIG_LIR_Nem_3	163	168	PF02991	0.563
LIG_LIR_Nem_3	62	67	PF02991	0.475
LIG_LIR_Nem_3	70	74	PF02991	0.317
LIG_LIR_Nem_3	95	101	PF02991	0.588
LIG_NRBOX	549	555	PF00104	0.549
LIG_PCNA_PIPBox_1	714	723	PF02747	0.550
LIG_PDZ_Class_2	729	734	PF00595	0.567
LIG_Pex14_1	280	284	PF04695	0.535
LIG_Pex14_2	305	309	PF04695	0.536
LIG_Pex14_2	385	389	PF04695	0.448
LIG_Pex14_2	67	71	PF04695	0.449
LIG_Pex14_2	78	82	PF04695	0.289
LIG_Rb_pABgroove_1	403	411	PF01858	0.485
LIG_RPA_C_Fungi	420	432	PF08784	0.308
LIG_SH2_CRK	173	177	PF00017	0.486
LIG_SH2_CRK	344	348	PF00017	0.297
LIG_SH2_CRK	381	385	PF00017	0.199
LIG_SH2_CRK	98	102	PF00017	0.427
LIG_SH2_NCK_1	119	123	PF00017	0.440
LIG_SH2_NCK_1	173	177	PF00017	0.474
LIG_SH2_NCK_1	381	385	PF00017	0.199
LIG_SH2_SRC	119	122	PF00017	0.520
LIG_SH2_SRC	210	213	PF00017	0.320
LIG_SH2_SRC	381	384	PF00017	0.199
LIG_SH2_STAP1	105	109	PF00017	0.583
LIG_SH2_STAP1	381	385	PF00017	0.322
LIG_SH2_STAT3	698	701	PF00017	0.441
LIG_SH2_STAT5	136	139	PF00017	0.363
LIG_SH2_STAT5	210	213	PF00017	0.429
LIG_SH2_STAT5	222	225	PF00017	0.580
LIG_SH2_STAT5	297	300	PF00017	0.442
LIG_SH3_1	63	69	PF00018	0.437
LIG_SH3_3	200	206	PF00018	0.392
LIG_SH3_3	340	346	PF00018	0.330
LIG_SH3_3	364	370	PF00018	0.455
LIG_SH3_3	558	564	PF00018	0.430
LIG_SH3_3	63	69	PF00018	0.437
LIG_SUMO_SIM_anti_2	316	321	PF11976	0.393
LIG_SUMO_SIM_anti_2	70	76	PF11976	0.310
LIG_SUMO_SIM_par_1	567	573	PF11976	0.394
LIG_TRAF2_1	180	183	PF00917	0.545
LIG_TRAF2_2	212	217	PF00917	0.311
LIG_TYR_ITIM	608	613	PF00017	0.594
LIG_TYR_ITIM	96	101	PF00017	0.434
MOD_CDC14_SPxK_1	175	178	PF00782	0.457
MOD_CDK_SPxK_1	172	178	PF00069	0.463
MOD_CK1_1	10	16	PF00069	0.733
MOD_CK1_1	171	177	PF00069	0.539
MOD_CK1_1	20	26	PF00069	0.645
MOD_CK1_1	690	696	PF00069	0.749
MOD_CK2_1	121	127	PF00069	0.385
MOD_CK2_1	700	706	PF00069	0.406
MOD_Cter_Amidation	501	504	PF01082	0.635
MOD_GlcNHglycan	54	57	PF01048	0.431
MOD_GlcNHglycan	550	553	PF01048	0.357
MOD_GlcNHglycan	690	693	PF01048	0.662
MOD_GlcNHglycan	98	101	PF01048	0.577
MOD_GSK3_1	13	20	PF00069	0.653
MOD_GSK3_1	167	174	PF00069	0.539
MOD_GSK3_1	191	198	PF00069	0.449
MOD_GSK3_1	223	230	PF00069	0.495
MOD_GSK3_1	246	253	PF00069	0.516
MOD_GSK3_1	365	372	PF00069	0.425
MOD_GSK3_1	613	620	PF00069	0.693
MOD_GSK3_1	684	691	PF00069	0.683
MOD_GSK3_1	88	95	PF00069	0.620
MOD_LATS_1	615	621	PF00433	0.585
MOD_N-GLC_1	1	6	PF02516	0.492
MOD_N-GLC_1	17	22	PF02516	0.472
MOD_N-GLC_1	239	244	PF02516	0.318
MOD_N-GLC_1	24	29	PF02516	0.481
MOD_N-GLC_1	246	251	PF02516	0.361
MOD_N-GLC_1	548	553	PF02516	0.287
MOD_NEK2_1	1	6	PF00069	0.776
MOD_NEK2_1	227	232	PF00069	0.366
MOD_NEK2_1	49	54	PF00069	0.560
MOD_NEK2_1	548	553	PF00069	0.470
MOD_NEK2_1	92	97	PF00069	0.514
MOD_NEK2_2	304	309	PF00069	0.407
MOD_NEK2_2	586	591	PF00069	0.423
MOD_NEK2_2	88	93	PF00069	0.471
MOD_PIKK_1	719	725	PF00454	0.397
MOD_PKA_1	617	623	PF00069	0.595
MOD_PKA_2	434	440	PF00069	0.372
MOD_PKA_2	586	592	PF00069	0.443
MOD_PKA_2	617	623	PF00069	0.706
MOD_PKA_2	728	734	PF00069	0.499
MOD_PKA_2	92	98	PF00069	0.525
MOD_Plk_1	17	23	PF00069	0.462
MOD_Plk_1	223	229	PF00069	0.410
MOD_Plk_1	239	245	PF00069	0.292
MOD_Plk_1	24	30	PF00069	0.463
MOD_Plk_1	313	319	PF00069	0.496
MOD_Plk_1	466	472	PF00069	0.474
MOD_Plk_2-3	121	127	PF00069	0.378
MOD_Plk_2-3	24	30	PF00069	0.453
MOD_Plk_2-3	388	394	PF00069	0.272
MOD_Plk_4	137	143	PF00069	0.443
MOD_Plk_4	17	23	PF00069	0.715
MOD_Plk_4	304	310	PF00069	0.390
MOD_Plk_4	315	321	PF00069	0.522
MOD_Plk_4	7	13	PF00069	0.486
MOD_Plk_4	92	98	PF00069	0.628
MOD_ProDKin_1	172	178	PF00069	0.507
MOD_ProDKin_1	700	706	PF00069	0.413
MOD_SUMO_for_1	192	195	PF00179	0.484
MOD_SUMO_rev_2	19	27	PF00179	0.451
TRG_DiLeu_BaEn_1	598	603	PF01217	0.486
TRG_DiLeu_BaEn_1	70	75	PF01217	0.329
TRG_DiLeu_BaEn_2	402	408	PF01217	0.322
TRG_DiLeu_BaLyEn_6	148	153	PF01217	0.367
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.457
TRG_ENDOCYTIC_2	119	122	PF00928	0.624
TRG_ENDOCYTIC_2	210	213	PF00928	0.401
TRG_ENDOCYTIC_2	381	384	PF00928	0.297
TRG_ENDOCYTIC_2	596	599	PF00928	0.374
TRG_ENDOCYTIC_2	610	613	PF00928	0.444
TRG_ENDOCYTIC_2	98	101	PF00928	0.439
TRG_ER_diArg_1	199	202	PF00400	0.487
TRG_ER_diArg_1	326	329	PF00400	0.527
TRG_ER_diArg_1	425	427	PF00400	0.349
TRG_ER_diArg_1	590	593	PF00400	0.402
TRG_NES_CRM1_1	598	612	PF08389	0.393
TRG_Pf-PMV_PEXEL_1	108	113	PF00026	0.345
TRG_Pf-PMV_PEXEL_1	145	149	PF00026	0.357
TRG_Pf-PMV_PEXEL_1	658	662	PF00026	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P906	Leptomonas seymouri	29%	100%
A0A1X0NTT2	Trypanosomatidae	35%	100%
A0A3Q8IC80	Leishmania donovani	88%	100%
A0A3Q8IC95	Leishmania donovani	71%	100%
A0A3Q8IHZ0	Leishmania donovani	28%	100%
A0A422NUH1	Trypanosoma rangeli	34%	100%
A4HCE5	Leishmania braziliensis	74%	98%
A4HZW7	Leishmania infantum	72%	100%
A4IDZ9	Leishmania infantum	28%	100%
C9ZSJ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AU21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AVS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q0H4	Leishmania major	28%	100%
Q4QBQ3	Leishmania major	88%	99%
Q4QBQ4	Leishmania major	72%	100%
V5DMJ8	Trypanosoma cruzi	33%	100%