AAA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial chaperone, putative

Species:

Leishmania mexicana

UniProt:

E9AVS5_LEIMU

TriTrypDb:

LmxM.22.0930

Length:

722

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9AVS5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVS5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	18
GO:0003824	catalytic activity	1	18
GO:0005488	binding	1	18
GO:0005524	ATP binding	5	18
GO:0016462	pyrophosphatase activity	5	18
GO:0016787	hydrolase activity	2	18
GO:0016817	hydrolase activity, acting on acid anhydrides	3	18
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	18
GO:0016887	ATP hydrolysis activity	7	18
GO:0017076	purine nucleotide binding	4	18
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	18
GO:0030554	adenyl nucleotide binding	5	18
GO:0032553	ribonucleotide binding	3	18
GO:0032555	purine ribonucleotide binding	4	18
GO:0032559	adenyl ribonucleotide binding	5	18
GO:0035639	purine ribonucleoside triphosphate binding	4	18
GO:0036094	small molecule binding	2	18
GO:0043167	ion binding	2	18
GO:0043168	anion binding	3	18
GO:0097159	organic cyclic compound binding	2	18
GO:0097367	carbohydrate derivative binding	2	18
GO:1901265	nucleoside phosphate binding	3	18
GO:1901363	heterocyclic compound binding	2	18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	380	384	PF00656	0.591
CLV_C14_Caspase3-7	398	402	PF00656	0.411
CLV_C14_Caspase3-7	472	476	PF00656	0.699
CLV_C14_Caspase3-7	6	10	PF00656	0.364
CLV_NRD_NRD_1	226	228	PF00675	0.406
CLV_NRD_NRD_1	314	316	PF00675	0.398
CLV_NRD_NRD_1	413	415	PF00675	0.295
CLV_NRD_NRD_1	418	420	PF00675	0.303
CLV_NRD_NRD_1	491	493	PF00675	0.543
CLV_NRD_NRD_1	605	607	PF00675	0.590
CLV_PCSK_KEX2_1	226	228	PF00082	0.375
CLV_PCSK_KEX2_1	314	316	PF00082	0.447
CLV_PCSK_KEX2_1	413	415	PF00082	0.311
CLV_PCSK_KEX2_1	418	420	PF00082	0.315
CLV_PCSK_KEX2_1	491	493	PF00082	0.634
CLV_PCSK_KEX2_1	605	607	PF00082	0.590
CLV_PCSK_PC7_1	414	420	PF00082	0.323
CLV_PCSK_SKI1_1	189	193	PF00082	0.364
CLV_PCSK_SKI1_1	267	271	PF00082	0.308
CLV_PCSK_SKI1_1	279	283	PF00082	0.400
CLV_PCSK_SKI1_1	301	305	PF00082	0.360
CLV_PCSK_SKI1_1	339	343	PF00082	0.301
CLV_PCSK_SKI1_1	68	72	PF00082	0.410
DEG_APCC_DBOX_1	186	194	PF00400	0.516
DEG_APCC_DBOX_1	578	586	PF00400	0.559
DOC_ANK_TNKS_1	316	323	PF00023	0.580
DOC_CKS1_1	689	694	PF01111	0.641
DOC_CYCLIN_RxL_1	65	73	PF00134	0.656
DOC_CYCLIN_yClb1_LxF_4	324	329	PF00134	0.527
DOC_CYCLIN_yClb5_NLxxxL_5	535	542	PF00134	0.520
DOC_CYCLIN_yCln2_LP_2	147	153	PF00134	0.533
DOC_MAPK_gen_1	288	298	PF00069	0.665
DOC_MAPK_gen_1	387	396	PF00069	0.526
DOC_MAPK_gen_1	572	582	PF00069	0.565
DOC_MAPK_MEF2A_6	352	359	PF00069	0.486
DOC_MAPK_MEF2A_6	575	582	PF00069	0.575
DOC_PP1_RVXF_1	277	283	PF00149	0.590
DOC_PP1_RVXF_1	324	330	PF00149	0.525
DOC_SPAK_OSR1_1	317	321	PF12202	0.588
DOC_SPAK_OSR1_1	575	579	PF12202	0.611
DOC_SPAK_OSR1_1	687	691	PF12202	0.579
DOC_USP7_MATH_1	13	17	PF00917	0.455
DOC_USP7_MATH_1	132	136	PF00917	0.575
DOC_USP7_MATH_1	194	198	PF00917	0.484
DOC_USP7_MATH_1	200	204	PF00917	0.497
DOC_USP7_UBL2_3	192	196	PF12436	0.497
DOC_WW_Pin1_4	15	20	PF00397	0.452
DOC_WW_Pin1_4	159	164	PF00397	0.595
DOC_WW_Pin1_4	196	201	PF00397	0.468
DOC_WW_Pin1_4	688	693	PF00397	0.560
LIG_14-3-3_CanoR_1	226	232	PF00244	0.587
LIG_14-3-3_CanoR_1	352	358	PF00244	0.474
LIG_14-3-3_CanoR_1	423	430	PF00244	0.520
LIG_14-3-3_CanoR_1	575	579	PF00244	0.557
LIG_14-3-3_CterR_2	717	722	PF00244	0.499
LIG_Actin_RPEL_3	445	464	PF02755	0.564
LIG_APCC_ABBA_1	251	256	PF00400	0.590
LIG_APCC_ABBA_1	394	399	PF00400	0.501
LIG_BIR_II_1	1	5	PF00653	0.359
LIG_BIR_III_1	1	5	PF00653	0.359
LIG_BIR_III_3	1	5	PF00653	0.359
LIG_BRCT_BRCA1_1	134	138	PF00533	0.504
LIG_EVH1_2	101	105	PF00568	0.542
LIG_FHA_1	140	146	PF00498	0.579
LIG_FHA_1	226	232	PF00498	0.481
LIG_FHA_1	302	308	PF00498	0.563
LIG_FHA_1	434	440	PF00498	0.682
LIG_FHA_1	455	461	PF00498	0.648
LIG_FHA_2	181	187	PF00498	0.598
LIG_FHA_2	4	10	PF00498	0.377
LIG_FHA_2	689	695	PF00498	0.611
LIG_LIR_Apic_2	162	168	PF02991	0.601
LIG_LIR_Apic_2	35	40	PF02991	0.455
LIG_LIR_Apic_2	564	568	PF02991	0.587
LIG_LIR_Gen_1	12	22	PF02991	0.395
LIG_LIR_Gen_1	48	59	PF02991	0.311
LIG_LIR_Gen_1	583	591	PF02991	0.543
LIG_LIR_Nem_3	12	17	PF02991	0.393
LIG_LIR_Nem_3	48	54	PF02991	0.329
LIG_MLH1_MIPbox_1	134	138	PF16413	0.504
LIG_NRBOX	537	543	PF00104	0.553
LIG_PCNA_PIPBox_1	702	711	PF02747	0.571
LIG_PDZ_Class_2	717	722	PF00595	0.588
LIG_Pex14_1	268	272	PF04695	0.550
LIG_Pex14_2	293	297	PF04695	0.526
LIG_Pex14_2	373	377	PF04695	0.459
LIG_Rb_pABgroove_1	391	399	PF01858	0.501
LIG_RPA_C_Fungi	408	420	PF08784	0.328
LIG_SH2_CRK	332	336	PF00017	0.308
LIG_SH2_CRK	369	373	PF00017	0.203
LIG_SH2_GRB2like	139	142	PF00017	0.495
LIG_SH2_NCK_1	369	373	PF00017	0.203
LIG_SH2_PTP2	157	160	PF00017	0.390
LIG_SH2_PTP2	165	168	PF00017	0.399
LIG_SH2_PTP2	37	40	PF00017	0.365
LIG_SH2_PTP2	51	54	PF00017	0.339
LIG_SH2_SRC	369	372	PF00017	0.203
LIG_SH2_SRC	37	40	PF00017	0.359
LIG_SH2_STAP1	29	33	PF00017	0.431
LIG_SH2_STAP1	369	373	PF00017	0.333
LIG_SH2_STAT3	29	32	PF00017	0.574
LIG_SH2_STAT3	686	689	PF00017	0.530
LIG_SH2_STAT5	122	125	PF00017	0.378
LIG_SH2_STAT5	157	160	PF00017	0.443
LIG_SH2_STAT5	165	168	PF00017	0.432
LIG_SH2_STAT5	209	212	PF00017	0.390
LIG_SH2_STAT5	285	288	PF00017	0.466
LIG_SH2_STAT5	33	36	PF00017	0.448
LIG_SH2_STAT5	37	40	PF00017	0.419
LIG_SH2_STAT5	51	54	PF00017	0.290
LIG_SH2_STAT5	91	94	PF00017	0.471
LIG_SH3_3	103	109	PF00018	0.465
LIG_SH3_3	147	153	PF00018	0.351
LIG_SH3_3	157	163	PF00018	0.472
LIG_SH3_3	328	334	PF00018	0.353
LIG_SH3_3	352	358	PF00018	0.458
LIG_SH3_3	546	552	PF00018	0.432
LIG_SH3_3	63	69	PF00018	0.437
LIG_SH3_3	95	101	PF00018	0.325
LIG_SUMO_SIM_anti_2	304	309	PF11976	0.414
LIG_SUMO_SIM_par_1	142	149	PF11976	0.358
LIG_SUMO_SIM_par_1	555	561	PF11976	0.400
LIG_TYR_ITIM	596	601	PF00017	0.607
LIG_UBA3_1	190	196	PF00899	0.350
LIG_WRPW_2	151	154	PF00400	0.328
MOD_CK1_1	15	21	PF00069	0.618
MOD_CK1_1	3	9	PF00069	0.521
MOD_CK1_1	678	684	PF00069	0.624
MOD_CK1_1	78	84	PF00069	0.542
MOD_CK2_1	180	186	PF00069	0.409
MOD_CK2_1	688	694	PF00069	0.414
MOD_Cter_Amidation	489	492	PF01082	0.815
MOD_GlcNHglycan	238	241	PF01048	0.513
MOD_GlcNHglycan	538	541	PF01048	0.360
MOD_GlcNHglycan	678	681	PF01048	0.721
MOD_GSK3_1	196	203	PF00069	0.517
MOD_GSK3_1	218	225	PF00069	0.542
MOD_GSK3_1	353	360	PF00069	0.490
MOD_GSK3_1	41	48	PF00069	0.611
MOD_GSK3_1	601	608	PF00069	0.664
MOD_GSK3_1	672	679	PF00069	0.709
MOD_LATS_1	603	609	PF00433	0.586
MOD_N-GLC_1	171	176	PF02516	0.495
MOD_N-GLC_1	536	541	PF02516	0.285
MOD_NEK2_1	180	185	PF00069	0.429
MOD_NEK2_1	41	46	PF00069	0.553
MOD_NEK2_1	536	541	PF00069	0.476
MOD_NEK2_1	70	75	PF00069	0.514
MOD_NEK2_1	76	81	PF00069	0.453
MOD_NEK2_2	292	297	PF00069	0.432
MOD_NEK2_2	574	579	PF00069	0.424
MOD_PIKK_1	180	186	PF00454	0.462
MOD_PIKK_1	707	713	PF00454	0.430
MOD_PKA_1	605	611	PF00069	0.603
MOD_PKA_2	225	231	PF00069	0.446
MOD_PKA_2	422	428	PF00069	0.369
MOD_PKA_2	574	580	PF00069	0.444
MOD_PKA_2	605	611	PF00069	0.712
MOD_PKA_2	716	722	PF00069	0.521
MOD_Plk_1	211	217	PF00069	0.416
MOD_Plk_1	301	307	PF00069	0.476
MOD_Plk_1	454	460	PF00069	0.524
MOD_Plk_2-3	376	382	PF00069	0.287
MOD_Plk_4	292	298	PF00069	0.415
MOD_Plk_4	303	309	PF00069	0.405
MOD_Plk_4	45	51	PF00069	0.517
MOD_Plk_4	70	76	PF00069	0.641
MOD_Plk_4	87	93	PF00069	0.481
MOD_ProDKin_1	15	21	PF00069	0.565
MOD_ProDKin_1	159	165	PF00069	0.480
MOD_ProDKin_1	196	202	PF00069	0.311
MOD_ProDKin_1	688	694	PF00069	0.430
MOD_SUMO_for_1	210	213	PF00179	0.321
TRG_DiLeu_BaEn_1	186	191	PF01217	0.368
TRG_DiLeu_BaEn_1	586	591	PF01217	0.528
TRG_DiLeu_BaEn_2	390	396	PF01217	0.333
TRG_DiLeu_BaLyEn_6	66	71	PF01217	0.566
TRG_ENDOCYTIC_2	157	160	PF00928	0.485
TRG_ENDOCYTIC_2	369	372	PF00928	0.308
TRG_ENDOCYTIC_2	51	54	PF00928	0.439
TRG_ENDOCYTIC_2	57	60	PF00928	0.255
TRG_ENDOCYTIC_2	584	587	PF00928	0.425
TRG_ENDOCYTIC_2	598	601	PF00928	0.455
TRG_ER_diArg_1	187	190	PF00400	0.478
TRG_ER_diArg_1	231	234	PF00400	0.443
TRG_ER_diArg_1	314	317	PF00400	0.534
TRG_ER_diArg_1	413	415	PF00400	0.360
TRG_ER_diArg_1	578	581	PF00400	0.434
TRG_NES_CRM1_1	586	600	PF08389	0.432
TRG_Pf-PMV_PEXEL_1	646	650	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	68	72	PF00026	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P906	Leptomonas seymouri	30%	98%
A0A1X0NTT2	Trypanosomatidae	35%	100%
A0A3Q8IC80	Leishmania donovani	71%	98%
A0A3Q8IC95	Leishmania donovani	86%	100%
A0A3Q8IHZ0	Leishmania donovani	29%	100%
A0A422NUH1	Trypanosoma rangeli	35%	100%
A4HCE5	Leishmania braziliensis	60%	100%
A4HZW7	Leishmania infantum	87%	100%
A4IDZ9	Leishmania infantum	29%	100%
C9ZSJ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AU21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AVS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	98%
Q4Q0H4	Leishmania major	28%	100%
Q4QBQ3	Leishmania major	72%	100%
Q4QBQ4	Leishmania major	86%	99%
V5DMJ8	Trypanosoma cruzi	34%	100%