Pre-mRNA-splicing factor 18

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Prp18 domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AVS3_LEIMU

TriTrypDb:

LmxM.22.0910

Length:

555

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	7
GO:0032991	protein-containing complex	1	7
GO:0140513	nuclear protein-containing complex	2	7
GO:1990904	ribonucleoprotein complex	2	7
GO:0005682	U5 snRNP	5	1
GO:0005684	U2-type spliceosomal complex	4	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0046540	U4/U6 x U5 tri-snRNP complex	6	1
GO:0071020	post-spliceosomal complex	4	1
GO:0071021	U2-type post-spliceosomal complex	5	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0097526	spliceosomal tri-snRNP complex	5	1
GO:0120114	Sm-like protein family complex	2	1

Expansion

Sequence features

E9AVS3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVS3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006396	RNA processing	6	6
GO:0006397	mRNA processing	7	6
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0008380	RNA splicing	7	6
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	6
GO:0016071	mRNA metabolic process	6	6
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0043170	macromolecule metabolic process	3	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0046483	heterocycle metabolic process	3	6
GO:0071704	organic substance metabolic process	2	6
GO:0090304	nucleic acid metabolic process	4	6
GO:1901360	organic cyclic compound metabolic process	3	6
GO:0000350	generation of catalytic spliceosome for second transesterification step	7	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	305	309	PF00656	0.777
CLV_NRD_NRD_1	449	451	PF00675	0.365
CLV_NRD_NRD_1	497	499	PF00675	0.346
CLV_PCSK_KEX2_1	115	117	PF00082	0.617
CLV_PCSK_KEX2_1	497	499	PF00082	0.346
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.617
CLV_PCSK_SKI1_1	525	529	PF00082	0.330
CLV_Separin_Metazoa	329	333	PF03568	0.346
DEG_APCC_DBOX_1	449	457	PF00400	0.546
DEG_ODPH_VHL_1	368	381	PF01847	0.626
DEG_SPOP_SBC_1	54	58	PF00917	0.557
DOC_CKS1_1	162	167	PF01111	0.562
DOC_CYCLIN_yCln2_LP_2	162	168	PF00134	0.675
DOC_MAPK_gen_1	411	419	PF00069	0.455
DOC_MAPK_gen_1	450	458	PF00069	0.546
DOC_MAPK_MEF2A_6	471	479	PF00069	0.619
DOC_PP2B_LxvP_1	251	254	PF13499	0.558
DOC_PP4_FxxP_1	265	268	PF00568	0.576
DOC_PP4_FxxP_1	443	446	PF00568	0.585
DOC_PP4_FxxP_1	542	545	PF00568	0.527
DOC_USP7_MATH_1	140	144	PF00917	0.758
DOC_USP7_MATH_1	152	156	PF00917	0.612
DOC_USP7_MATH_1	158	162	PF00917	0.489
DOC_USP7_MATH_1	207	211	PF00917	0.639
DOC_USP7_MATH_1	222	226	PF00917	0.575
DOC_USP7_MATH_1	306	310	PF00917	0.725
DOC_USP7_MATH_1	33	37	PF00917	0.742
DOC_USP7_MATH_1	431	435	PF00917	0.642
DOC_USP7_MATH_1	49	53	PF00917	0.732
DOC_USP7_MATH_1	61	65	PF00917	0.677
DOC_USP7_MATH_1	88	92	PF00917	0.675
DOC_WW_Pin1_4	153	158	PF00397	0.721
DOC_WW_Pin1_4	161	166	PF00397	0.587
DOC_WW_Pin1_4	244	249	PF00397	0.514
DOC_WW_Pin1_4	373	378	PF00397	0.491
DOC_WW_Pin1_4	432	437	PF00397	0.598
DOC_WW_Pin1_4	537	542	PF00397	0.634
DOC_WW_Pin1_4	546	551	PF00397	0.399
LIG_14-3-3_CanoR_1	149	158	PF00244	0.809
LIG_14-3-3_CanoR_1	202	208	PF00244	0.598
LIG_14-3-3_CanoR_1	497	501	PF00244	0.546
LIG_APCC_ABBA_1	527	532	PF00400	0.619
LIG_BIR_II_1	1	5	PF00653	0.684
LIG_BRCT_BRCA1_1	539	543	PF00533	0.619
LIG_FHA_1	157	163	PF00498	0.664
LIG_FHA_1	216	222	PF00498	0.667
LIG_FHA_1	37	43	PF00498	0.717
LIG_FHA_1	436	442	PF00498	0.457
LIG_FHA_1	453	459	PF00498	0.612
LIG_FHA_1	516	522	PF00498	0.580
LIG_FHA_1	526	532	PF00498	0.504
LIG_FHA_1	57	63	PF00498	0.504
LIG_FHA_2	190	196	PF00498	0.591
LIG_FHA_2	280	286	PF00498	0.618
LIG_FHA_2	437	443	PF00498	0.494
LIG_FHA_2	78	84	PF00498	0.671
LIG_LIR_Apic_2	442	446	PF02991	0.574
LIG_LIR_Apic_2	540	545	PF02991	0.517
LIG_LIR_Gen_1	285	296	PF02991	0.499
LIG_LIR_Gen_1	464	475	PF02991	0.504
LIG_LIR_Nem_3	2	6	PF02991	0.674
LIG_LIR_Nem_3	285	291	PF02991	0.485
LIG_LIR_Nem_3	404	409	PF02991	0.606
LIG_LIR_Nem_3	464	470	PF02991	0.504
LIG_LIR_Nem_3	473	477	PF02991	0.504
LIG_LIR_Nem_3	79	85	PF02991	0.660
LIG_MLH1_MIPbox_1	539	543	PF16413	0.619
LIG_NRBOX	326	332	PF00104	0.511
LIG_NRBOX	336	342	PF00104	0.403
LIG_NRBOX	5	11	PF00104	0.667
LIG_PCNA_yPIPBox_3	324	332	PF02747	0.388
LIG_SH2_PTP2	474	477	PF00017	0.619
LIG_SH2_SRC	474	477	PF00017	0.619
LIG_SH2_STAP1	427	431	PF00017	0.513
LIG_SH2_STAP1	85	89	PF00017	0.553
LIG_SH2_STAT5	260	263	PF00017	0.426
LIG_SH2_STAT5	336	339	PF00017	0.424
LIG_SH2_STAT5	380	383	PF00017	0.411
LIG_SH2_STAT5	422	425	PF00017	0.449
LIG_SH2_STAT5	474	477	PF00017	0.569
LIG_SH3_1	364	370	PF00018	0.659
LIG_SH3_3	214	220	PF00018	0.586
LIG_SH3_3	221	227	PF00018	0.681
LIG_SH3_3	267	273	PF00018	0.412
LIG_SH3_3	364	370	PF00018	0.659
LIG_UBA3_1	290	295	PF00899	0.600
MOD_CK1_1	108	114	PF00069	0.699
MOD_CK1_1	134	140	PF00069	0.802
MOD_CK1_1	150	156	PF00069	0.601
MOD_CK1_1	161	167	PF00069	0.613
MOD_CK1_1	169	175	PF00069	0.526
MOD_CK1_1	249	255	PF00069	0.487
MOD_CK1_1	309	315	PF00069	0.637
MOD_CK1_1	36	42	PF00069	0.755
MOD_CK1_1	434	440	PF00069	0.694
MOD_CK1_1	45	51	PF00069	0.690
MOD_CK1_1	69	75	PF00069	0.756
MOD_CK1_1	77	83	PF00069	0.678
MOD_CK2_1	135	141	PF00069	0.729
MOD_CK2_1	189	195	PF00069	0.482
MOD_CK2_1	487	493	PF00069	0.546
MOD_GlcNHglycan	137	140	PF01048	0.792
MOD_GlcNHglycan	149	152	PF01048	0.647
MOD_GlcNHglycan	232	235	PF01048	0.729
MOD_GlcNHglycan	308	311	PF01048	0.759
MOD_GlcNHglycan	35	38	PF01048	0.770
MOD_GlcNHglycan	351	354	PF01048	0.690
MOD_GlcNHglycan	42	45	PF01048	0.670
MOD_GlcNHglycan	428	432	PF01048	0.516
MOD_GlcNHglycan	489	492	PF01048	0.346
MOD_GlcNHglycan	51	54	PF01048	0.633
MOD_GlcNHglycan	63	66	PF01048	0.758
MOD_GlcNHglycan	76	79	PF01048	0.693
MOD_GSK3_1	131	138	PF00069	0.804
MOD_GSK3_1	152	159	PF00069	0.660
MOD_GSK3_1	207	214	PF00069	0.692
MOD_GSK3_1	238	245	PF00069	0.717
MOD_GSK3_1	308	315	PF00069	0.770
MOD_GSK3_1	36	43	PF00069	0.664
MOD_GSK3_1	418	425	PF00069	0.463
MOD_GSK3_1	427	434	PF00069	0.485
MOD_GSK3_1	45	52	PF00069	0.751
MOD_GSK3_1	548	555	PF00069	0.456
MOD_GSK3_1	56	63	PF00069	0.632
MOD_GSK3_1	66	73	PF00069	0.627
MOD_GSK3_1	74	81	PF00069	0.749
MOD_N-GLC_1	134	139	PF02516	0.787
MOD_N-GLC_1	33	38	PF02516	0.741
MOD_NEK2_1	107	112	PF00069	0.701
MOD_NEK2_1	189	194	PF00069	0.412
MOD_NEK2_1	208	213	PF00069	0.457
MOD_NEK2_1	409	414	PF00069	0.575
MOD_NEK2_1	42	47	PF00069	0.830
MOD_NEK2_2	166	171	PF00069	0.404
MOD_PIKK_1	222	228	PF00454	0.655
MOD_PIKK_1	36	42	PF00454	0.740
MOD_PIKK_1	515	521	PF00454	0.563
MOD_PKA_2	201	207	PF00069	0.588
MOD_PKA_2	238	244	PF00069	0.478
MOD_PKA_2	273	279	PF00069	0.651
MOD_PKA_2	496	502	PF00069	0.546
MOD_Plk_1	279	285	PF00069	0.627
MOD_Plk_1	463	469	PF00069	0.555
MOD_Plk_1	475	481	PF00069	0.542
MOD_Plk_1	525	531	PF00069	0.530
MOD_Plk_4	279	285	PF00069	0.627
MOD_Plk_4	312	318	PF00069	0.523
MOD_Plk_4	418	424	PF00069	0.545
MOD_Plk_4	452	458	PF00069	0.619
MOD_Plk_4	525	531	PF00069	0.534
MOD_ProDKin_1	153	159	PF00069	0.720
MOD_ProDKin_1	161	167	PF00069	0.582
MOD_ProDKin_1	244	250	PF00069	0.509
MOD_ProDKin_1	373	379	PF00069	0.487
MOD_ProDKin_1	432	438	PF00069	0.601
MOD_ProDKin_1	537	543	PF00069	0.625
MOD_ProDKin_1	546	552	PF00069	0.399
MOD_SUMO_for_1	294	297	PF00179	0.622
TRG_DiLeu_BaEn_2	525	531	PF01217	0.546
TRG_DiLeu_BaEn_4	322	328	PF01217	0.514
TRG_DiLeu_BaLyEn_6	389	394	PF01217	0.499
TRG_ENDOCYTIC_2	380	383	PF00928	0.474
TRG_ENDOCYTIC_2	474	477	PF00928	0.569
TRG_ER_diArg_1	496	498	PF00400	0.546
TRG_ER_diArg_1	505	508	PF00400	0.546
TRG_NES_CRM1_1	181	195	PF08389	0.511
TRG_NES_CRM1_1	280	293	PF08389	0.605
TRG_NES_CRM1_1	329	343	PF08389	0.444
TRG_NES_CRM1_1	448	462	PF08389	0.530
TRG_NES_CRM1_1	519	532	PF08389	0.563
TRG_NLS_MonoCore_2	10	15	PF00514	0.620
TRG_NLS_MonoExtC_3	10	16	PF00514	0.689
TRG_Pf-PMV_PEXEL_1	255	259	PF00026	0.596
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.494
TRG_Pf-PMV_PEXEL_1	397	401	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	459	463	PF00026	0.419

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I883	Leptomonas seymouri	45%	100%
A0A3Q8ICC8	Leishmania donovani	89%	100%
A4HCE1	Leishmania braziliensis	72%	99%
A4HZW5	Leishmania infantum	88%	100%
Q4QBQ6	Leishmania major	86%	99%