RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Component of motile flagella 10, putative

Species:

Leishmania mexicana

UniProt:

E9AVS2_LEIMU

TriTrypDb:

LmxM.22.0900

Length:

925

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVS2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	156	160	PF00656	0.682
CLV_C14_Caspase3-7	38	42	PF00656	0.692
CLV_C14_Caspase3-7	452	456	PF00656	0.635
CLV_NRD_NRD_1	423	425	PF00675	0.493
CLV_NRD_NRD_1	597	599	PF00675	0.417
CLV_NRD_NRD_1	635	637	PF00675	0.482
CLV_NRD_NRD_1	696	698	PF00675	0.477
CLV_NRD_NRD_1	861	863	PF00675	0.510
CLV_NRD_NRD_1	916	918	PF00675	0.555
CLV_PCSK_FUR_1	490	494	PF00082	0.568
CLV_PCSK_KEX2_1	305	307	PF00082	0.440
CLV_PCSK_KEX2_1	423	425	PF00082	0.496
CLV_PCSK_KEX2_1	492	494	PF00082	0.579
CLV_PCSK_KEX2_1	597	599	PF00082	0.469
CLV_PCSK_KEX2_1	635	637	PF00082	0.489
CLV_PCSK_KEX2_1	695	697	PF00082	0.475
CLV_PCSK_PC1ET2_1	305	307	PF00082	0.455
CLV_PCSK_PC1ET2_1	492	494	PF00082	0.579
CLV_PCSK_SKI1_1	234	238	PF00082	0.503
CLV_PCSK_SKI1_1	281	285	PF00082	0.412
CLV_PCSK_SKI1_1	675	679	PF00082	0.479
DEG_APCC_DBOX_1	674	682	PF00400	0.390
DEG_COP1_1	21	30	PF00400	0.529
DEG_SCF_FBW7_2	726	732	PF00400	0.412
DEG_SPOP_SBC_1	90	94	PF00917	0.635
DOC_CKS1_1	548	553	PF01111	0.502
DOC_CKS1_1	726	731	PF01111	0.486
DOC_CYCLIN_RxL_1	299	312	PF00134	0.530
DOC_MAPK_DCC_7	411	420	PF00069	0.493
DOC_MAPK_gen_1	305	315	PF00069	0.525
DOC_MAPK_gen_1	406	414	PF00069	0.663
DOC_MAPK_gen_1	490	500	PF00069	0.500
DOC_MAPK_gen_1	526	536	PF00069	0.588
DOC_MAPK_JIP1_4	408	414	PF00069	0.510
DOC_MAPK_MEF2A_6	234	243	PF00069	0.483
DOC_MAPK_MEF2A_6	411	420	PF00069	0.493
DOC_MAPK_MEF2A_6	580	587	PF00069	0.434
DOC_MAPK_MEF2A_6	823	830	PF00069	0.334
DOC_MAPK_NFAT4_5	823	831	PF00069	0.391
DOC_PP1_RVXF_1	303	310	PF00149	0.472
DOC_PP1_RVXF_1	827	833	PF00149	0.420
DOC_PP1_RVXF_1	871	877	PF00149	0.320
DOC_PP2B_LxvP_1	197	200	PF13499	0.523
DOC_PP2B_LxvP_1	239	242	PF13499	0.511
DOC_PP2B_LxvP_1	412	415	PF13499	0.495
DOC_PP4_FxxP_1	787	790	PF00568	0.479
DOC_USP7_MATH_1	184	188	PF00917	0.653
DOC_USP7_MATH_1	259	263	PF00917	0.697
DOC_USP7_MATH_1	324	328	PF00917	0.635
DOC_USP7_MATH_1	381	385	PF00917	0.625
DOC_USP7_MATH_1	757	761	PF00917	0.618
DOC_USP7_MATH_1	798	802	PF00917	0.600
DOC_USP7_MATH_1	90	94	PF00917	0.702
DOC_WW_Pin1_4	103	108	PF00397	0.686
DOC_WW_Pin1_4	126	131	PF00397	0.678
DOC_WW_Pin1_4	511	516	PF00397	0.607
DOC_WW_Pin1_4	547	552	PF00397	0.502
DOC_WW_Pin1_4	667	672	PF00397	0.500
DOC_WW_Pin1_4	725	730	PF00397	0.496
DOC_WW_Pin1_4	786	791	PF00397	0.695
DOC_WW_Pin1_4	803	808	PF00397	0.548
LIG_14-3-3_CanoR_1	238	242	PF00244	0.509
LIG_14-3-3_CanoR_1	424	430	PF00244	0.465
LIG_14-3-3_CanoR_1	529	535	PF00244	0.523
LIG_14-3-3_CanoR_1	538	548	PF00244	0.468
LIG_14-3-3_CanoR_1	568	576	PF00244	0.395
LIG_14-3-3_CanoR_1	743	752	PF00244	0.439
LIG_14-3-3_CanoR_1	829	835	PF00244	0.497
LIG_14-3-3_CanoR_1	89	97	PF00244	0.713
LIG_14-3-3_CanoR_1	917	925	PF00244	0.551
LIG_BIR_II_1	1	5	PF00653	0.676
LIG_BRCT_BRCA1_1	349	353	PF00533	0.478
LIG_CaM_IQ_9	584	600	PF13499	0.384
LIG_CaM_IQ_9	907	922	PF13499	0.384
LIG_deltaCOP1_diTrp_1	345	353	PF00928	0.572
LIG_Dynein_DLC8_1	527	533	PF01221	0.522
LIG_EH1_1	467	475	PF00400	0.529
LIG_FHA_1	221	227	PF00498	0.511
LIG_FHA_1	238	244	PF00498	0.382
LIG_FHA_1	310	316	PF00498	0.546
LIG_FHA_1	529	535	PF00498	0.504
LIG_FHA_1	548	554	PF00498	0.448
LIG_FHA_1	71	77	PF00498	0.478
LIG_FHA_1	721	727	PF00498	0.533
LIG_FHA_1	794	800	PF00498	0.598
LIG_FHA_1	842	848	PF00498	0.380
LIG_FHA_2	154	160	PF00498	0.669
LIG_FHA_2	250	256	PF00498	0.510
LIG_FHA_2	36	42	PF00498	0.588
LIG_FHA_2	372	378	PF00498	0.603
LIG_FHA_2	540	546	PF00498	0.462
LIG_FHA_2	570	576	PF00498	0.507
LIG_FHA_2	680	686	PF00498	0.412
LIG_FHA_2	700	706	PF00498	0.328
LIG_FHA_2	831	837	PF00498	0.364
LIG_FHA_2	895	901	PF00498	0.526
LIG_LIR_Gen_1	106	115	PF02991	0.688
LIG_LIR_Gen_1	428	436	PF02991	0.521
LIG_LIR_Gen_1	562	571	PF02991	0.464
LIG_LIR_Gen_1	644	653	PF02991	0.394
LIG_LIR_Gen_1	739	746	PF02991	0.375
LIG_LIR_Nem_3	106	112	PF02991	0.662
LIG_LIR_Nem_3	282	287	PF02991	0.507
LIG_LIR_Nem_3	428	432	PF02991	0.479
LIG_LIR_Nem_3	510	516	PF02991	0.501
LIG_LIR_Nem_3	562	566	PF02991	0.460
LIG_LIR_Nem_3	644	648	PF02991	0.397
LIG_LIR_Nem_3	739	744	PF02991	0.370
LIG_LIR_Nem_3	884	890	PF02991	0.417
LIG_MYND_1	667	671	PF01753	0.503
LIG_NRBOX	823	829	PF00104	0.338
LIG_PTB_Apo_2	781	788	PF02174	0.482
LIG_RPA_C_Fungi	894	906	PF08784	0.494
LIG_SH2_CRK	68	72	PF00017	0.600
LIG_SH2_CRK	887	891	PF00017	0.431
LIG_SH2_NCK_1	109	113	PF00017	0.666
LIG_SH2_NCK_1	887	891	PF00017	0.431
LIG_SH2_SRC	109	112	PF00017	0.641
LIG_SH2_SRC	429	432	PF00017	0.485
LIG_SH2_STAP1	429	433	PF00017	0.518
LIG_SH2_STAT3	67	70	PF00017	0.621
LIG_SH2_STAT5	485	488	PF00017	0.509
LIG_SH2_STAT5	570	573	PF00017	0.389
LIG_SH3_1	204	210	PF00018	0.626
LIG_SH3_2	478	483	PF14604	0.564
LIG_SH3_3	131	137	PF00018	0.748
LIG_SH3_3	178	184	PF00018	0.519
LIG_SH3_3	204	210	PF00018	0.628
LIG_SH3_3	214	220	PF00018	0.544
LIG_SH3_3	240	246	PF00018	0.468
LIG_SH3_3	475	481	PF00018	0.561
LIG_SH3_3	50	56	PF00018	0.676
LIG_SH3_3	545	551	PF00018	0.507
LIG_SH3_3	563	569	PF00018	0.516
LIG_SH3_3	723	729	PF00018	0.518
LIG_SH3_3	779	785	PF00018	0.607
LIG_SUMO_SIM_anti_2	227	232	PF11976	0.495
LIG_SUMO_SIM_anti_2	751	756	PF11976	0.433
LIG_SUMO_SIM_par_1	222	227	PF11976	0.464
LIG_SUMO_SIM_par_1	276	282	PF11976	0.444
LIG_SUMO_SIM_par_1	677	685	PF11976	0.438
LIG_TRAF2_1	619	622	PF00917	0.418
LIG_TRAF2_1	702	705	PF00917	0.510
LIG_UBA3_1	586	595	PF00899	0.499
LIG_WW_3	54	58	PF00397	0.676
MOD_CDC14_SPxK_1	129	132	PF00782	0.678
MOD_CDK_SPK_2	547	552	PF00069	0.502
MOD_CDK_SPxK_1	126	132	PF00069	0.681
MOD_CK1_1	142	148	PF00069	0.780
MOD_CK1_1	186	192	PF00069	0.641
MOD_CK1_1	539	545	PF00069	0.510
MOD_CK1_1	748	754	PF00069	0.516
MOD_CK1_1	838	844	PF00069	0.479
MOD_CK1_1	866	872	PF00069	0.445
MOD_CK2_1	1	7	PF00069	0.633
MOD_CK2_1	249	255	PF00069	0.578
MOD_CK2_1	371	377	PF00069	0.610
MOD_CK2_1	425	431	PF00069	0.485
MOD_CK2_1	539	545	PF00069	0.467
MOD_CK2_1	569	575	PF00069	0.520
MOD_CK2_1	616	622	PF00069	0.389
MOD_CK2_1	667	673	PF00069	0.469
MOD_CK2_1	679	685	PF00069	0.342
MOD_CK2_1	699	705	PF00069	0.321
MOD_CK2_1	830	836	PF00069	0.367
MOD_Cter_Amidation	421	424	PF01082	0.486
MOD_Cter_Amidation	860	863	PF01082	0.508
MOD_GlcNHglycan	126	129	PF01048	0.622
MOD_GlcNHglycan	141	144	PF01048	0.595
MOD_GlcNHglycan	178	181	PF01048	0.629
MOD_GlcNHglycan	261	264	PF01048	0.648
MOD_GlcNHglycan	3	6	PF01048	0.670
MOD_GlcNHglycan	320	323	PF01048	0.671
MOD_GlcNHglycan	326	329	PF01048	0.759
MOD_GlcNHglycan	349	352	PF01048	0.481
MOD_GlcNHglycan	41	44	PF01048	0.691
MOD_GlcNHglycan	451	454	PF01048	0.634
MOD_GlcNHglycan	46	49	PF01048	0.644
MOD_GlcNHglycan	461	464	PF01048	0.506
MOD_GlcNHglycan	640	643	PF01048	0.492
MOD_GlcNHglycan	748	751	PF01048	0.513
MOD_GlcNHglycan	757	760	PF01048	0.621
MOD_GlcNHglycan	800	803	PF01048	0.698
MOD_GlcNHglycan	810	813	PF01048	0.628
MOD_GlcNHglycan	817	820	PF01048	0.488
MOD_GlcNHglycan	836	840	PF01048	0.329
MOD_GSK3_1	142	149	PF00069	0.695
MOD_GSK3_1	220	227	PF00069	0.519
MOD_GSK3_1	35	42	PF00069	0.655
MOD_GSK3_1	445	452	PF00069	0.650
MOD_GSK3_1	516	523	PF00069	0.656
MOD_GSK3_1	530	537	PF00069	0.450
MOD_GSK3_1	744	751	PF00069	0.417
MOD_GSK3_1	755	762	PF00069	0.594
MOD_GSK3_1	837	844	PF00069	0.470
MOD_N-GLC_1	118	123	PF02516	0.578
MOD_N-GLC_2	525	527	PF02516	0.528
MOD_NEK2_1	309	314	PF00069	0.530
MOD_NEK2_1	516	521	PF00069	0.559
MOD_NEK2_1	534	539	PF00069	0.549
MOD_NEK2_1	708	713	PF00069	0.482
MOD_NEK2_1	744	749	PF00069	0.446
MOD_NEK2_1	769	774	PF00069	0.650
MOD_NEK2_1	837	842	PF00069	0.483
MOD_NEK2_1	894	899	PF00069	0.512
MOD_NEK2_2	759	764	PF00069	0.465
MOD_NEK2_2	91	96	PF00069	0.648
MOD_PIKK_1	150	156	PF00454	0.636
MOD_PIKK_1	186	192	PF00454	0.641
MOD_PIKK_1	501	507	PF00454	0.511
MOD_PIKK_1	528	534	PF00454	0.524
MOD_PIKK_1	699	705	PF00454	0.386
MOD_PIKK_1	841	847	PF00454	0.440
MOD_PIKK_1	9	15	PF00454	0.520
MOD_PIKK_1	907	913	PF00454	0.496
MOD_PK_1	244	250	PF00069	0.416
MOD_PK_1	520	526	PF00069	0.435
MOD_PK_1	61	67	PF00069	0.507
MOD_PKA_2	139	145	PF00069	0.591
MOD_PKA_2	237	243	PF00069	0.503
MOD_PKA_2	249	255	PF00069	0.624
MOD_PKA_2	525	531	PF00069	0.530
MOD_PKA_2	616	622	PF00069	0.389
MOD_PKB_1	87	95	PF00069	0.679
MOD_Plk_1	224	230	PF00069	0.503
MOD_Plk_1	61	67	PF00069	0.507
MOD_Plk_1	863	869	PF00069	0.476
MOD_Plk_4	226	232	PF00069	0.507
MOD_Plk_4	244	250	PF00069	0.574
MOD_Plk_4	309	315	PF00069	0.534
MOD_Plk_4	838	844	PF00069	0.441
MOD_ProDKin_1	103	109	PF00069	0.686
MOD_ProDKin_1	126	132	PF00069	0.681
MOD_ProDKin_1	511	517	PF00069	0.605
MOD_ProDKin_1	547	553	PF00069	0.505
MOD_ProDKin_1	667	673	PF00069	0.497
MOD_ProDKin_1	725	731	PF00069	0.487
MOD_ProDKin_1	786	792	PF00069	0.691
MOD_ProDKin_1	803	809	PF00069	0.551
TRG_DiLeu_BaEn_1	846	851	PF01217	0.418
TRG_ENDOCYTIC_2	109	112	PF00928	0.689
TRG_ENDOCYTIC_2	221	224	PF00928	0.369
TRG_ENDOCYTIC_2	429	432	PF00928	0.522
TRG_ENDOCYTIC_2	513	516	PF00928	0.495
TRG_ENDOCYTIC_2	68	71	PF00928	0.657
TRG_ENDOCYTIC_2	741	744	PF00928	0.369
TRG_ENDOCYTIC_2	887	890	PF00928	0.429
TRG_ER_diArg_1	306	309	PF00400	0.424
TRG_ER_diArg_1	405	408	PF00400	0.476
TRG_ER_diArg_1	597	600	PF00400	0.468
TRG_ER_diArg_1	634	636	PF00400	0.481
TRG_ER_diArg_1	695	697	PF00400	0.446
TRG_ER_diArg_1	86	89	PF00400	0.663
TRG_ER_diArg_1	870	873	PF00400	0.364
TRG_ER_diArg_1	901	904	PF00400	0.504
TRG_NES_CRM1_1	282	296	PF08389	0.497
TRG_NES_CRM1_1	575	588	PF08389	0.440
TRG_Pf-PMV_PEXEL_1	281	285	PF00026	0.462
TRG_Pf-PMV_PEXEL_1	738	742	PF00026	0.380

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILI1	Leptomonas seymouri	52%	98%
A0A3S5H7A9	Leishmania donovani	88%	99%
A4HCD9	Leishmania braziliensis	71%	97%
A4HZW4	Leishmania infantum	88%	99%
Q4QBQ7	Leishmania major	87%	100%
V5BLJ4	Trypanosoma cruzi	33%	100%