Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVS0_LEIMU

TriTrypDb:

LmxM.22.0880

Length:

696

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVS0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVS0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.483
CLV_C14_Caspase3-7	205	209	PF00656	0.545
CLV_C14_Caspase3-7	368	372	PF00656	0.482
CLV_NRD_NRD_1	329	331	PF00675	0.447
CLV_NRD_NRD_1	373	375	PF00675	0.462
CLV_NRD_NRD_1	392	394	PF00675	0.402
CLV_NRD_NRD_1	4	6	PF00675	0.570
CLV_NRD_NRD_1	526	528	PF00675	0.516
CLV_NRD_NRD_1	587	589	PF00675	0.767
CLV_NRD_NRD_1	609	611	PF00675	0.612
CLV_NRD_NRD_1	627	629	PF00675	0.614
CLV_NRD_NRD_1	683	685	PF00675	0.525
CLV_PCSK_FUR_1	607	611	PF00082	0.630
CLV_PCSK_KEX2_1	329	331	PF00082	0.447
CLV_PCSK_KEX2_1	373	375	PF00082	0.462
CLV_PCSK_KEX2_1	392	394	PF00082	0.402
CLV_PCSK_KEX2_1	525	527	PF00082	0.535
CLV_PCSK_KEX2_1	587	589	PF00082	0.667
CLV_PCSK_KEX2_1	6	8	PF00082	0.567
CLV_PCSK_KEX2_1	609	611	PF00082	0.616
CLV_PCSK_KEX2_1	683	685	PF00082	0.525
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.567
CLV_PCSK_SKI1_1	104	108	PF00082	0.595
CLV_PCSK_SKI1_1	113	117	PF00082	0.611
CLV_PCSK_SKI1_1	17	21	PF00082	0.588
CLV_PCSK_SKI1_1	452	456	PF00082	0.594
CLV_PCSK_SKI1_1	629	633	PF00082	0.661
CLV_PCSK_SKI1_1	649	653	PF00082	0.537
DEG_APCC_DBOX_1	23	31	PF00400	0.551
DEG_COP1_1	208	218	PF00400	0.612
DEG_SCF_FBW7_1	394	400	PF00400	0.581
DEG_SPOP_SBC_1	106	110	PF00917	0.624
DEG_SPOP_SBC_1	406	410	PF00917	0.631
DEG_SPOP_SBC_1	487	491	PF00917	0.570
DOC_CKS1_1	394	399	PF01111	0.583
DOC_CYCLIN_RxL_1	353	361	PF00134	0.459
DOC_CYCLIN_RxL_1	646	655	PF00134	0.537
DOC_MAPK_gen_1	564	572	PF00069	0.712
DOC_MAPK_MEF2A_6	113	120	PF00069	0.480
DOC_MAPK_MEF2A_6	411	419	PF00069	0.472
DOC_MAPK_NFAT4_5	113	121	PF00069	0.474
DOC_PP2B_LxvP_1	118	121	PF13499	0.463
DOC_PP2B_LxvP_1	235	238	PF13499	0.580
DOC_PP2B_LxvP_1	96	99	PF13499	0.593
DOC_PP2B_PxIxI_1	217	223	PF00149	0.610
DOC_PP4_FxxP_1	38	41	PF00568	0.552
DOC_PP4_FxxP_1	484	487	PF00568	0.462
DOC_USP7_MATH_1	10	14	PF00917	0.485
DOC_USP7_MATH_1	106	110	PF00917	0.612
DOC_USP7_MATH_1	210	214	PF00917	0.646
DOC_USP7_MATH_1	216	220	PF00917	0.608
DOC_USP7_MATH_1	286	290	PF00917	0.641
DOC_USP7_MATH_1	365	369	PF00917	0.517
DOC_USP7_MATH_1	406	410	PF00917	0.612
DOC_USP7_MATH_1	424	428	PF00917	0.525
DOC_USP7_MATH_1	494	498	PF00917	0.595
DOC_USP7_MATH_1	515	519	PF00917	0.676
DOC_USP7_MATH_1	521	525	PF00917	0.561
DOC_USP7_MATH_1	54	58	PF00917	0.489
DOC_USP7_UBL2_3	100	104	PF12436	0.606
DOC_WW_Pin1_4	208	213	PF00397	0.661
DOC_WW_Pin1_4	214	219	PF00397	0.594
DOC_WW_Pin1_4	282	287	PF00397	0.545
DOC_WW_Pin1_4	393	398	PF00397	0.588
DOC_WW_Pin1_4	439	444	PF00397	0.547
DOC_WW_Pin1_4	483	488	PF00397	0.533
DOC_WW_Pin1_4	598	603	PF00397	0.515
LIG_14-3-3_CanoR_1	17	22	PF00244	0.597
LIG_14-3-3_CanoR_1	356	361	PF00244	0.489
LIG_14-3-3_CanoR_1	378	382	PF00244	0.423
LIG_14-3-3_CanoR_1	527	533	PF00244	0.508
LIG_14-3-3_CanoR_1	80	89	PF00244	0.542
LIG_BIR_II_1	1	5	PF00653	0.644
LIG_BIR_III_4	114	118	PF00653	0.537
LIG_BIR_III_4	275	279	PF00653	0.590
LIG_BRCT_BRCA1_1	34	38	PF00533	0.555
LIG_Clathr_ClatBox_1	27	31	PF01394	0.550
LIG_deltaCOP1_diTrp_1	340	344	PF00928	0.444
LIG_deltaCOP1_diTrp_1	687	692	PF00928	0.417
LIG_DLG_GKlike_1	356	364	PF00625	0.497
LIG_FHA_1	193	199	PF00498	0.579
LIG_FHA_1	412	418	PF00498	0.470
LIG_FHA_1	44	50	PF00498	0.489
LIG_FHA_1	493	499	PF00498	0.680
LIG_FHA_1	514	520	PF00498	0.553
LIG_FHA_1	620	626	PF00498	0.501
LIG_FHA_1	652	658	PF00498	0.558
LIG_FHA_1	93	99	PF00498	0.493
LIG_FHA_2	141	147	PF00498	0.564
LIG_FHA_2	18	24	PF00498	0.603
LIG_FHA_2	290	296	PF00498	0.636
LIG_FHA_2	477	483	PF00498	0.595
LIG_FHA_2	660	666	PF00498	0.734
LIG_FHA_2	670	676	PF00498	0.564
LIG_LIR_Apic_2	35	41	PF02991	0.552
LIG_LIR_Apic_2	482	487	PF02991	0.454
LIG_LIR_Gen_1	126	133	PF02991	0.474
LIG_LIR_Gen_1	52	63	PF02991	0.490
LIG_LIR_Gen_1	529	537	PF02991	0.591
LIG_LIR_Nem_3	126	130	PF02991	0.503
LIG_LIR_Nem_3	52	58	PF02991	0.544
LIG_LIR_Nem_3	529	533	PF02991	0.612
LIG_PDZ_Class_1	691	696	PF00595	0.429
LIG_SH2_CRK	530	534	PF00017	0.474
LIG_SH2_CRK	55	59	PF00017	0.458
LIG_SH2_GRB2like	62	65	PF00017	0.553
LIG_SH2_STAP1	311	315	PF00017	0.480
LIG_SH2_STAP1	540	544	PF00017	0.460
LIG_SH2_STAP1	55	59	PF00017	0.458
LIG_SH2_STAT3	540	543	PF00017	0.449
LIG_SH2_STAT5	36	39	PF00017	0.559
LIG_SH2_STAT5	475	478	PF00017	0.675
LIG_SH2_STAT5	483	486	PF00017	0.561
LIG_SH3_2	234	239	PF14604	0.578
LIG_SH3_2	394	399	PF14604	0.627
LIG_SH3_3	133	139	PF00018	0.545
LIG_SH3_3	212	218	PF00018	0.714
LIG_SH3_3	231	237	PF00018	0.499
LIG_SH3_3	38	44	PF00018	0.515
LIG_SH3_3	391	397	PF00018	0.588
LIG_SH3_3	437	443	PF00018	0.452
LIG_SH3_3	459	465	PF00018	0.685
LIG_SH3_CIN85_PxpxPR_1	234	239	PF14604	0.578
LIG_SUMO_SIM_par_1	356	361	PF11976	0.463
LIG_TRAF2_1	13	16	PF00917	0.497
LIG_TYR_ITIM	53	58	PF00017	0.454
LIG_WRC_WIRS_1	124	129	PF05994	0.515
LIG_WW_3	236	240	PF00397	0.577
MOD_CDK_SPxK_1	393	399	PF00069	0.582
MOD_CK1_1	108	114	PF00069	0.543
MOD_CK1_1	119	125	PF00069	0.554
MOD_CK1_1	192	198	PF00069	0.580
MOD_CK1_1	211	217	PF00069	0.622
MOD_CK1_1	247	253	PF00069	0.521
MOD_CK1_1	289	295	PF00069	0.666
MOD_CK1_1	347	353	PF00069	0.443
MOD_CK1_1	405	411	PF00069	0.625
MOD_CK1_1	420	426	PF00069	0.523
MOD_CK1_1	429	435	PF00069	0.545
MOD_CK1_1	486	492	PF00069	0.566
MOD_CK1_1	506	512	PF00069	0.489
MOD_CK1_1	545	551	PF00069	0.537
MOD_CK1_1	580	586	PF00069	0.532
MOD_CK1_1	75	81	PF00069	0.627
MOD_CK2_1	10	16	PF00069	0.494
MOD_CK2_1	158	164	PF00069	0.790
MOD_CK2_1	17	23	PF00069	0.544
MOD_CK2_1	239	245	PF00069	0.632
MOD_CK2_1	289	295	PF00069	0.636
MOD_CK2_1	36	42	PF00069	0.444
MOD_CK2_1	659	665	PF00069	0.660
MOD_CK2_1	669	675	PF00069	0.496
MOD_CMANNOS	341	344	PF00535	0.441
MOD_CMANNOS	385	388	PF00535	0.411
MOD_CMANNOS	689	692	PF00535	0.410
MOD_Cter_Amidation	626	629	PF01082	0.671
MOD_DYRK1A_RPxSP_1	282	286	PF00069	0.521
MOD_DYRK1A_RPxSP_1	393	397	PF00069	0.445
MOD_GlcNHglycan	110	113	PF01048	0.522
MOD_GlcNHglycan	12	15	PF01048	0.472
MOD_GlcNHglycan	160	163	PF01048	0.646
MOD_GlcNHglycan	167	170	PF01048	0.668
MOD_GlcNHglycan	200	203	PF01048	0.542
MOD_GlcNHglycan	251	254	PF01048	0.543
MOD_GlcNHglycan	268	272	PF01048	0.507
MOD_GlcNHglycan	288	291	PF01048	0.649
MOD_GlcNHglycan	292	295	PF01048	0.690
MOD_GlcNHglycan	298	301	PF01048	0.725
MOD_GlcNHglycan	313	316	PF01048	0.476
MOD_GlcNHglycan	367	371	PF01048	0.539
MOD_GlcNHglycan	404	407	PF01048	0.625
MOD_GlcNHglycan	419	422	PF01048	0.529
MOD_GlcNHglycan	492	495	PF01048	0.619
MOD_GlcNHglycan	505	508	PF01048	0.671
MOD_GlcNHglycan	579	582	PF01048	0.659
MOD_GlcNHglycan	83	86	PF01048	0.633
MOD_GSK3_1	100	107	PF00069	0.694
MOD_GSK3_1	119	126	PF00069	0.513
MOD_GSK3_1	194	201	PF00069	0.599
MOD_GSK3_1	210	217	PF00069	0.613
MOD_GSK3_1	282	289	PF00069	0.623
MOD_GSK3_1	32	39	PF00069	0.553
MOD_GSK3_1	340	347	PF00069	0.439
MOD_GSK3_1	393	400	PF00069	0.614
MOD_GSK3_1	402	409	PF00069	0.547
MOD_GSK3_1	420	427	PF00069	0.523
MOD_GSK3_1	435	442	PF00069	0.485
MOD_GSK3_1	483	490	PF00069	0.591
MOD_GSK3_1	503	510	PF00069	0.742
MOD_GSK3_1	511	518	PF00069	0.747
MOD_GSK3_1	598	605	PF00069	0.614
MOD_GSK3_1	619	626	PF00069	0.502
MOD_GSK3_1	651	658	PF00069	0.585
MOD_N-GLC_1	429	434	PF02516	0.592
MOD_N-GLC_1	511	516	PF02516	0.604
MOD_N-GLC_1	577	582	PF02516	0.660
MOD_NEK2_1	1	6	PF00069	0.576
MOD_NEK2_1	105	110	PF00069	0.628
MOD_NEK2_1	116	121	PF00069	0.599
MOD_NEK2_1	158	163	PF00069	0.642
MOD_NEK2_1	249	254	PF00069	0.508
MOD_NEK2_1	267	272	PF00069	0.548
MOD_NEK2_1	417	422	PF00069	0.481
MOD_NEK2_1	435	440	PF00069	0.560
MOD_NEK2_1	476	481	PF00069	0.688
MOD_NEK2_1	511	516	PF00069	0.746
MOD_NEK2_1	544	549	PF00069	0.639
MOD_NEK2_1	651	656	PF00069	0.504
MOD_NEK2_1	91	96	PF00069	0.520
MOD_NEK2_2	377	382	PF00069	0.428
MOD_NEK2_2	54	59	PF00069	0.457
MOD_PIKK_1	277	283	PF00454	0.682
MOD_PIKK_1	342	348	PF00454	0.434
MOD_PIKK_1	43	49	PF00454	0.491
MOD_PIKK_1	655	661	PF00454	0.550
MOD_PK_1	189	195	PF00069	0.581
MOD_PK_1	239	245	PF00069	0.653
MOD_PKA_1	526	532	PF00069	0.564
MOD_PKA_1	587	593	PF00069	0.663
MOD_PKA_1	683	689	PF00069	0.503
MOD_PKA_2	377	383	PF00069	0.432
MOD_PKA_2	526	532	PF00069	0.608
MOD_PKA_2	545	551	PF00069	0.404
MOD_PKA_2	587	593	PF00069	0.654
MOD_PKA_2	683	689	PF00069	0.503
MOD_Plk_1	244	250	PF00069	0.567
MOD_Plk_1	32	38	PF00069	0.553
MOD_Plk_1	397	403	PF00069	0.489
MOD_Plk_2-3	669	675	PF00069	0.626
MOD_Plk_4	189	195	PF00069	0.600
MOD_Plk_4	216	222	PF00069	0.591
MOD_Plk_4	244	250	PF00069	0.567
MOD_Plk_4	377	383	PF00069	0.432
MOD_Plk_4	515	521	PF00069	0.583
MOD_Plk_4	528	534	PF00069	0.479
MOD_Plk_4	54	60	PF00069	0.461
MOD_Plk_4	652	658	PF00069	0.650
MOD_Plk_4	669	675	PF00069	0.697
MOD_ProDKin_1	208	214	PF00069	0.661
MOD_ProDKin_1	282	288	PF00069	0.547
MOD_ProDKin_1	393	399	PF00069	0.597
MOD_ProDKin_1	439	445	PF00069	0.551
MOD_ProDKin_1	483	489	PF00069	0.535
MOD_ProDKin_1	598	604	PF00069	0.517
TRG_DiLeu_BaEn_1	23	28	PF01217	0.619
TRG_DiLeu_BaLyEn_6	176	181	PF01217	0.513
TRG_DiLeu_BaLyEn_6	466	471	PF01217	0.549
TRG_ENDOCYTIC_2	530	533	PF00928	0.481
TRG_ENDOCYTIC_2	55	58	PF00928	0.453
TRG_ENDOCYTIC_2	8	11	PF00928	0.529
TRG_ER_diArg_1	392	394	PF00400	0.417
TRG_ER_diArg_1	5	8	PF00400	0.569
TRG_ER_diArg_1	525	527	PF00400	0.535
TRG_ER_diArg_1	572	575	PF00400	0.534
TRG_ER_diArg_1	586	588	PF00400	0.651
TRG_ER_diArg_1	607	610	PF00400	0.698
TRG_ER_diArg_1	682	684	PF00400	0.547
TRG_NLS_MonoExtC_3	4	9	PF00514	0.560
TRG_NLS_MonoExtN_4	5	10	PF00514	0.552
TRG_Pf-PMV_PEXEL_1	330	334	PF00026	0.339
TRG_Pf-PMV_PEXEL_1	356	361	PF00026	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL70	Leptomonas seymouri	43%	93%
A0A3Q8IBF7	Leishmania donovani	87%	99%
A4HCD8	Leishmania braziliensis	74%	99%
A4HZW2	Leishmania infantum	87%	99%
Q4QBQ9	Leishmania major	86%	100%