EngB-type G domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

50S ribosome-binding GTPase, putative

Species:

Leishmania mexicana

UniProt:

E9AVR6_LEIMU

TriTrypDb:

LmxM.22.0820

Length:

934

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVR6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVR6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	14
GO:0005488	binding	1	14
GO:0005525	GTP binding	5	14
GO:0017076	purine nucleotide binding	4	14
GO:0019001	guanyl nucleotide binding	5	14
GO:0032553	ribonucleotide binding	3	14
GO:0032555	purine ribonucleotide binding	4	14
GO:0032561	guanyl ribonucleotide binding	5	14
GO:0035639	purine ribonucleoside triphosphate binding	4	14
GO:0036094	small molecule binding	2	14
GO:0043167	ion binding	2	14
GO:0043168	anion binding	3	14
GO:0097159	organic cyclic compound binding	2	14
GO:0097367	carbohydrate derivative binding	2	14
GO:1901265	nucleoside phosphate binding	3	14
GO:1901363	heterocyclic compound binding	2	14
GO:0003676	nucleic acid binding	3	2
GO:0003746	translation elongation factor activity	4	2
GO:0008135	translation factor activity, RNA binding	3	2
GO:0045182	translation regulator activity	1	2
GO:0090079	translation regulator activity, nucleic acid binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	295	299	PF00656	0.489
CLV_C14_Caspase3-7	382	386	PF00656	0.391
CLV_C14_Caspase3-7	429	433	PF00656	0.546
CLV_C14_Caspase3-7	601	605	PF00656	0.629
CLV_NRD_NRD_1	236	238	PF00675	0.314
CLV_NRD_NRD_1	304	306	PF00675	0.258
CLV_NRD_NRD_1	368	370	PF00675	0.454
CLV_NRD_NRD_1	371	373	PF00675	0.441
CLV_NRD_NRD_1	474	476	PF00675	0.712
CLV_NRD_NRD_1	494	496	PF00675	0.661
CLV_NRD_NRD_1	544	546	PF00675	0.514
CLV_NRD_NRD_1	547	549	PF00675	0.497
CLV_NRD_NRD_1	555	557	PF00675	0.526
CLV_NRD_NRD_1	60	62	PF00675	0.558
CLV_NRD_NRD_1	676	678	PF00675	0.587
CLV_NRD_NRD_1	743	745	PF00675	0.577
CLV_NRD_NRD_1	799	801	PF00675	0.547
CLV_NRD_NRD_1	829	831	PF00675	0.548
CLV_NRD_NRD_1	845	847	PF00675	0.537
CLV_PCSK_FUR_1	492	496	PF00082	0.558
CLV_PCSK_FUR_1	545	549	PF00082	0.605
CLV_PCSK_KEX2_1	304	306	PF00082	0.281
CLV_PCSK_KEX2_1	368	370	PF00082	0.432
CLV_PCSK_KEX2_1	474	476	PF00082	0.703
CLV_PCSK_KEX2_1	494	496	PF00082	0.639
CLV_PCSK_KEX2_1	544	546	PF00082	0.529
CLV_PCSK_KEX2_1	547	549	PF00082	0.520
CLV_PCSK_KEX2_1	555	557	PF00082	0.544
CLV_PCSK_KEX2_1	59	61	PF00082	0.555
CLV_PCSK_KEX2_1	676	678	PF00082	0.587
CLV_PCSK_KEX2_1	742	744	PF00082	0.567
CLV_PCSK_KEX2_1	799	801	PF00082	0.532
CLV_PCSK_KEX2_1	829	831	PF00082	0.566
CLV_PCSK_KEX2_1	845	847	PF00082	0.546
CLV_PCSK_KEX2_1	910	912	PF00082	0.600
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.605
CLV_PCSK_PC1ET2_1	742	744	PF00082	0.589
CLV_PCSK_PC1ET2_1	910	912	PF00082	0.600
CLV_PCSK_SKI1_1	102	106	PF00082	0.526
CLV_PCSK_SKI1_1	164	168	PF00082	0.683
CLV_PCSK_SKI1_1	318	322	PF00082	0.258
CLV_PCSK_SKI1_1	372	376	PF00082	0.449
CLV_PCSK_SKI1_1	409	413	PF00082	0.477
CLV_PCSK_SKI1_1	416	420	PF00082	0.471
CLV_PCSK_SKI1_1	421	425	PF00082	0.404
CLV_PCSK_SKI1_1	61	65	PF00082	0.530
CLV_PCSK_SKI1_1	810	814	PF00082	0.622
CLV_Separin_Metazoa	390	394	PF03568	0.452
DEG_APCC_DBOX_1	60	68	PF00400	0.537
DEG_APCC_KENBOX_2	814	818	PF00400	0.652
DEG_ODPH_VHL_1	713	725	PF01847	0.452
DEG_SPOP_SBC_1	227	231	PF00917	0.458
DEG_SPOP_SBC_1	706	710	PF00917	0.503
DOC_ANK_TNKS_1	676	683	PF00023	0.714
DOC_ANK_TNKS_1	901	908	PF00023	0.674
DOC_CDC14_PxL_1	879	887	PF14671	0.582
DOC_CYCLIN_RxL_1	805	816	PF00134	0.601
DOC_CYCLIN_yCln2_LP_2	81	84	PF00134	0.577
DOC_MAPK_DCC_7	80	89	PF00069	0.595
DOC_MAPK_gen_1	288	296	PF00069	0.551
DOC_MAPK_gen_1	492	500	PF00069	0.632
DOC_MAPK_gen_1	676	683	PF00069	0.620
DOC_MAPK_MEF2A_6	80	89	PF00069	0.576
DOC_PP1_RVXF_1	235	242	PF00149	0.458
DOC_PP1_RVXF_1	324	331	PF00149	0.520
DOC_PP1_RVXF_1	548	555	PF00149	0.484
DOC_PP2B_LxvP_1	154	157	PF13499	0.666
DOC_PP2B_LxvP_1	81	84	PF13499	0.577
DOC_PP4_FxxP_1	377	380	PF00568	0.374
DOC_USP7_MATH_1	117	121	PF00917	0.520
DOC_USP7_MATH_1	127	131	PF00917	0.513
DOC_USP7_MATH_1	146	150	PF00917	0.745
DOC_USP7_MATH_1	177	181	PF00917	0.634
DOC_USP7_MATH_1	212	216	PF00917	0.458
DOC_USP7_MATH_1	227	231	PF00917	0.458
DOC_USP7_MATH_1	24	28	PF00917	0.737
DOC_USP7_MATH_1	426	430	PF00917	0.476
DOC_USP7_MATH_1	488	492	PF00917	0.762
DOC_USP7_MATH_1	515	519	PF00917	0.557
DOC_USP7_MATH_1	531	535	PF00917	0.763
DOC_USP7_MATH_1	6	10	PF00917	0.623
DOC_USP7_MATH_1	619	623	PF00917	0.774
DOC_USP7_MATH_1	645	649	PF00917	0.734
DOC_USP7_MATH_1	652	656	PF00917	0.760
DOC_USP7_MATH_1	696	700	PF00917	0.769
DOC_USP7_MATH_1	707	711	PF00917	0.642
DOC_USP7_MATH_1	789	793	PF00917	0.608
DOC_USP7_UBL2_3	322	326	PF12436	0.564
DOC_USP7_UBL2_3	366	370	PF12436	0.420
DOC_WW_Pin1_4	142	147	PF00397	0.722
DOC_WW_Pin1_4	229	234	PF00397	0.469
DOC_WW_Pin1_4	243	248	PF00397	0.442
DOC_WW_Pin1_4	561	566	PF00397	0.712
DOC_WW_Pin1_4	659	664	PF00397	0.723
LIG_14-3-3_CanoR_1	118	126	PF00244	0.708
LIG_14-3-3_CanoR_1	237	242	PF00244	0.458
LIG_14-3-3_CanoR_1	304	308	PF00244	0.458
LIG_14-3-3_CanoR_1	352	357	PF00244	0.369
LIG_14-3-3_CanoR_1	393	403	PF00244	0.542
LIG_14-3-3_CanoR_1	4	11	PF00244	0.716
LIG_14-3-3_CanoR_1	676	681	PF00244	0.666
LIG_14-3-3_CanoR_1	858	864	PF00244	0.664
LIG_APCC_ABBA_1	613	618	PF00400	0.627
LIG_APCC_Cbox_1	549	555	PF00515	0.559
LIG_BIR_II_1	1	5	PF00653	0.570
LIG_BIR_III_4	627	631	PF00653	0.599
LIG_BIR_III_4	772	776	PF00653	0.563
LIG_DLG_GKlike_1	237	245	PF00625	0.458
LIG_EVH1_2	85	89	PF00568	0.591
LIG_FHA_1	106	112	PF00498	0.637
LIG_FHA_1	234	240	PF00498	0.458
LIG_FHA_1	397	403	PF00498	0.453
LIG_FHA_1	420	426	PF00498	0.572
LIG_FHA_1	577	583	PF00498	0.690
LIG_FHA_1	6	12	PF00498	0.606
LIG_FHA_1	714	720	PF00498	0.545
LIG_FHA_1	894	900	PF00498	0.558
LIG_FHA_1	919	925	PF00498	0.572
LIG_FHA_2	271	277	PF00498	0.458
LIG_FHA_2	319	325	PF00498	0.458
LIG_FHA_2	341	347	PF00498	0.478
LIG_FHA_2	385	391	PF00498	0.410
LIG_FHA_2	599	605	PF00498	0.611
LIG_FHA_2	629	635	PF00498	0.676
LIG_FHA_2	832	838	PF00498	0.461
LIG_HCF-1_HBM_1	190	193	PF13415	0.667
LIG_LIR_Gen_1	108	117	PF02991	0.621
LIG_LIR_Gen_1	199	207	PF02991	0.296
LIG_LIR_Gen_1	240	250	PF02991	0.458
LIG_LIR_Gen_1	273	282	PF02991	0.475
LIG_LIR_Gen_1	564	574	PF02991	0.685
LIG_LIR_Gen_1	819	828	PF02991	0.537
LIG_LIR_Gen_1	860	870	PF02991	0.533
LIG_LIR_Nem_3	108	112	PF02991	0.375
LIG_LIR_Nem_3	199	204	PF02991	0.414
LIG_LIR_Nem_3	240	245	PF02991	0.458
LIG_LIR_Nem_3	273	277	PF02991	0.489
LIG_LIR_Nem_3	297	303	PF02991	0.461
LIG_LIR_Nem_3	564	570	PF02991	0.582
LIG_LIR_Nem_3	720	725	PF02991	0.558
LIG_LIR_Nem_3	819	825	PF02991	0.556
LIG_LIR_Nem_3	860	866	PF02991	0.537
LIG_LIR_Nem_3	88	92	PF02991	0.579
LIG_NRBOX	217	223	PF00104	0.458
LIG_NRBOX	407	413	PF00104	0.555
LIG_NRBOX	808	814	PF00104	0.596
LIG_PCNA_yPIPBox_3	214	226	PF02747	0.385
LIG_SH2_CRK	109	113	PF00017	0.531
LIG_SH2_CRK	242	246	PF00017	0.458
LIG_SH2_CRK	361	365	PF00017	0.381
LIG_SH2_CRK	371	375	PF00017	0.408
LIG_SH2_CRK	567	571	PF00017	0.622
LIG_SH2_GRB2like	875	878	PF00017	0.541
LIG_SH2_NCK_1	361	365	PF00017	0.381
LIG_SH2_PTP2	496	499	PF00017	0.718
LIG_SH2_SRC	201	204	PF00017	0.401
LIG_SH2_STAT3	729	732	PF00017	0.684
LIG_SH2_STAT5	193	196	PF00017	0.613
LIG_SH2_STAT5	225	228	PF00017	0.387
LIG_SH2_STAT5	300	303	PF00017	0.458
LIG_SH2_STAT5	312	315	PF00017	0.458
LIG_SH2_STAT5	327	330	PF00017	0.400
LIG_SH2_STAT5	445	448	PF00017	0.594
LIG_SH2_STAT5	496	499	PF00017	0.631
LIG_SH2_STAT5	75	78	PF00017	0.563
LIG_SH2_STAT5	852	855	PF00017	0.517
LIG_SH3_1	80	86	PF00018	0.570
LIG_SH3_1	815	821	PF00018	0.666
LIG_SH3_2	21	26	PF14604	0.606
LIG_SH3_3	18	24	PF00018	0.630
LIG_SH3_3	260	266	PF00018	0.458
LIG_SH3_3	272	278	PF00018	0.458
LIG_SH3_3	456	462	PF00018	0.484
LIG_SH3_3	662	668	PF00018	0.653
LIG_SH3_3	782	788	PF00018	0.656
LIG_SH3_3	79	85	PF00018	0.580
LIG_SH3_3	815	821	PF00018	0.536
LIG_SUMO_SIM_anti_2	387	393	PF11976	0.522
LIG_SUMO_SIM_anti_2	40	47	PF11976	0.534
LIG_SUMO_SIM_par_1	40	47	PF11976	0.534
LIG_TRAF2_1	585	588	PF00917	0.589
LIG_TRAF2_1	834	837	PF00917	0.568
LIG_WRC_WIRS_1	158	163	PF05994	0.630
MOD_CK1_1	130	136	PF00069	0.663
MOD_CK1_1	145	151	PF00069	0.611
MOD_CK1_1	159	165	PF00069	0.719
MOD_CK1_1	306	312	PF00069	0.458
MOD_CK1_1	561	567	PF00069	0.733
MOD_CK1_1	648	654	PF00069	0.796
MOD_CK1_1	659	665	PF00069	0.663
MOD_CK1_1	792	798	PF00069	0.587
MOD_CK2_1	145	151	PF00069	0.761
MOD_CK2_1	384	390	PF00069	0.409
MOD_CK2_1	4	10	PF00069	0.645
MOD_CK2_1	582	588	PF00069	0.712
MOD_CK2_1	619	625	PF00069	0.732
MOD_CK2_1	628	634	PF00069	0.768
MOD_CK2_1	652	658	PF00069	0.604
MOD_CK2_1	831	837	PF00069	0.481
MOD_CK2_1	925	931	PF00069	0.674
MOD_Cter_Amidation	542	545	PF01082	0.530
MOD_Cter_Amidation	674	677	PF01082	0.592
MOD_GlcNHglycan	119	122	PF01048	0.639
MOD_GlcNHglycan	129	132	PF01048	0.634
MOD_GlcNHglycan	381	384	PF01048	0.367
MOD_GlcNHglycan	455	458	PF01048	0.726
MOD_GlcNHglycan	478	482	PF01048	0.803
MOD_GlcNHglycan	567	570	PF01048	0.643
MOD_GlcNHglycan	593	596	PF01048	0.692
MOD_GlcNHglycan	620	624	PF01048	0.580
MOD_GlcNHglycan	654	657	PF01048	0.773
MOD_GlcNHglycan	683	686	PF01048	0.566
MOD_GlcNHglycan	698	701	PF01048	0.751
MOD_GlcNHglycan	737	740	PF01048	0.695
MOD_GlcNHglycan	771	776	PF01048	0.635
MOD_GlcNHglycan	777	780	PF01048	0.641
MOD_GlcNHglycan	791	794	PF01048	0.383
MOD_GSK3_1	135	142	PF00069	0.699
MOD_GSK3_1	156	163	PF00069	0.753
MOD_GSK3_1	228	235	PF00069	0.474
MOD_GSK3_1	237	244	PF00069	0.473
MOD_GSK3_1	340	347	PF00069	0.458
MOD_GSK3_1	348	355	PF00069	0.392
MOD_GSK3_1	43	50	PF00069	0.637
MOD_GSK3_1	446	453	PF00069	0.659
MOD_GSK3_1	515	522	PF00069	0.678
MOD_GSK3_1	559	566	PF00069	0.626
MOD_GSK3_1	648	655	PF00069	0.660
MOD_GSK3_1	681	688	PF00069	0.672
MOD_GSK3_1	713	720	PF00069	0.590
MOD_GSK3_1	771	778	PF00069	0.598
MOD_GSK3_1	914	921	PF00069	0.563
MOD_GSK3_1	925	932	PF00069	0.589
MOD_LATS_1	350	356	PF00433	0.386
MOD_LATS_1	674	680	PF00433	0.554
MOD_N-GLC_1	233	238	PF02516	0.258
MOD_N-GLC_1	893	898	PF02516	0.542
MOD_NEK2_1	105	110	PF00069	0.623
MOD_NEK2_1	241	246	PF00069	0.472
MOD_NEK2_1	270	275	PF00069	0.491
MOD_NEK2_1	340	345	PF00069	0.493
MOD_NEK2_1	419	424	PF00069	0.527
MOD_NEK2_1	446	451	PF00069	0.505
MOD_NEK2_1	591	596	PF00069	0.503
MOD_NEK2_1	893	898	PF00069	0.542
MOD_PIKK_1	884	890	PF00454	0.559
MOD_PIKK_1	919	925	PF00454	0.539
MOD_PK_1	344	350	PF00069	0.382
MOD_PK_1	352	358	PF00069	0.376
MOD_PK_1	676	682	PF00069	0.590
MOD_PKA_1	237	243	PF00069	0.514
MOD_PKA_1	676	682	PF00069	0.590
MOD_PKA_2	117	123	PF00069	0.700
MOD_PKA_2	135	141	PF00069	0.736
MOD_PKA_2	303	309	PF00069	0.458
MOD_PKA_2	628	634	PF00069	0.710
MOD_PKA_2	645	651	PF00069	0.745
MOD_PKA_2	675	681	PF00069	0.663
MOD_PKA_2	775	781	PF00069	0.569
MOD_PKA_2	857	863	PF00069	0.620
MOD_PKB_1	475	483	PF00069	0.784
MOD_PKB_1	596	604	PF00069	0.740
MOD_Plk_1	426	432	PF00069	0.545
MOD_Plk_1	532	538	PF00069	0.690
MOD_Plk_1	73	79	PF00069	0.560
MOD_Plk_1	836	842	PF00069	0.607
MOD_Plk_4	107	113	PF00069	0.524
MOD_Plk_4	213	219	PF00069	0.458
MOD_Plk_4	270	276	PF00069	0.459
MOD_Plk_4	306	312	PF00069	0.458
MOD_Plk_4	352	358	PF00069	0.393
MOD_Plk_4	676	682	PF00069	0.606
MOD_Plk_4	808	814	PF00069	0.650
MOD_Plk_4	914	920	PF00069	0.564
MOD_ProDKin_1	142	148	PF00069	0.721
MOD_ProDKin_1	229	235	PF00069	0.469
MOD_ProDKin_1	243	249	PF00069	0.442
MOD_ProDKin_1	561	567	PF00069	0.717
MOD_ProDKin_1	659	665	PF00069	0.720
TRG_DiLeu_BaEn_1	508	513	PF01217	0.632
TRG_DiLeu_BaEn_4	836	842	PF01217	0.565
TRG_DiLeu_BaEn_4	94	100	PF01217	0.555
TRG_ENDOCYTIC_2	109	112	PF00928	0.527
TRG_ENDOCYTIC_2	201	204	PF00928	0.376
TRG_ENDOCYTIC_2	242	245	PF00928	0.460
TRG_ENDOCYTIC_2	300	303	PF00928	0.458
TRG_ENDOCYTIC_2	361	364	PF00928	0.373
TRG_ENDOCYTIC_2	371	374	PF00928	0.414
TRG_ENDOCYTIC_2	445	448	PF00928	0.630
TRG_ENDOCYTIC_2	567	570	PF00928	0.602
TRG_ENDOCYTIC_2	901	904	PF00928	0.545
TRG_ER_diArg_1	178	181	PF00400	0.614
TRG_ER_diArg_1	303	305	PF00400	0.458
TRG_ER_diArg_1	492	495	PF00400	0.625
TRG_ER_diArg_1	554	556	PF00400	0.522
TRG_ER_diArg_1	828	830	PF00400	0.624
TRG_ER_diArg_1	844	846	PF00400	0.599
TRG_NLS_MonoExtC_3	368	373	PF00514	0.386
TRG_NLS_MonoExtN_4	366	373	PF00514	0.383
TRG_Pf-PMV_PEXEL_1	393	398	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	409	413	PF00026	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILH8	Leptomonas seymouri	57%	79%
A0A1X0NT82	Trypanosomatidae	47%	100%
A0A3Q8IC70	Leishmania donovani	89%	96%
A0A3R7NJM0	Trypanosoma rangeli	45%	100%
A0A3S7WX68	Leishmania donovani	88%	80%
A4HCB6	Leishmania braziliensis	77%	100%
A4HZV0	Leishmania infantum	89%	96%
C9ZSF9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AVQ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%
Q4QBR5	Leishmania major	87%	100%
Q4QBS5	Leishmania major	87%	100%
V5BVT0	Trypanosoma cruzi	45%	100%