Zf-LSD1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVR4_LEIMU

TriTrypDb:

LmxM.22.0800

Length:

215

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVR4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVR4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	49	53	PF00656	0.514
CLV_PCSK_KEX2_1	197	199	PF00082	0.574
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.574
DEG_Nend_UBRbox_3	1	3	PF02207	0.666
DEG_SPOP_SBC_1	98	102	PF00917	0.568
DOC_PP1_RVXF_1	195	202	PF00149	0.535
DOC_USP7_MATH_1	108	112	PF00917	0.560
DOC_USP7_MATH_1	43	47	PF00917	0.682
DOC_USP7_MATH_1	98	102	PF00917	0.574
DOC_USP7_UBL2_3	140	144	PF12436	0.600
DOC_WW_Pin1_4	35	40	PF00397	0.623
LIG_FHA_1	174	180	PF00498	0.442
LIG_FHA_1	189	195	PF00498	0.448
LIG_FHA_1	209	215	PF00498	0.548
LIG_FHA_2	111	117	PF00498	0.623
LIG_FHA_2	4	10	PF00498	0.575
LIG_LIR_Apic_2	78	84	PF02991	0.380
LIG_LIR_Nem_3	91	95	PF02991	0.500
LIG_SH2_CRK	81	85	PF00017	0.560
LIG_SH2_CRK	95	99	PF00017	0.438
LIG_SH3_3	31	37	PF00018	0.694
LIG_SUMO_SIM_par_1	157	164	PF11976	0.362
LIG_TRAF2_1	46	49	PF00917	0.608
LIG_TRAF2_1	77	80	PF00917	0.434
MOD_CK1_1	143	149	PF00069	0.636
MOD_CK1_1	167	173	PF00069	0.581
MOD_CK1_1	38	44	PF00069	0.697
MOD_CK1_1	75	81	PF00069	0.651
MOD_CK1_1	99	105	PF00069	0.524
MOD_CK2_1	110	116	PF00069	0.361
MOD_CK2_1	163	169	PF00069	0.638
MOD_CK2_1	3	9	PF00069	0.583
MOD_CK2_1	43	49	PF00069	0.694
MOD_CK2_1	98	104	PF00069	0.616
MOD_GlcNHglycan	120	123	PF01048	0.658
MOD_GlcNHglycan	29	32	PF01048	0.723
MOD_GlcNHglycan	40	43	PF01048	0.727
MOD_GlcNHglycan	74	77	PF01048	0.498
MOD_GSK3_1	118	125	PF00069	0.659
MOD_GSK3_1	163	170	PF00069	0.584
MOD_GSK3_1	188	195	PF00069	0.322
MOD_N-GLC_1	27	32	PF02516	0.615
MOD_NEK2_1	158	163	PF00069	0.550
MOD_NEK2_1	27	32	PF00069	0.522
MOD_Plk_4	182	188	PF00069	0.512
MOD_Plk_4	88	94	PF00069	0.445
MOD_ProDKin_1	35	41	PF00069	0.619
MOD_SUMO_for_1	4	7	PF00179	0.584
MOD_SUMO_rev_2	125	134	PF00179	0.439
MOD_SUMO_rev_2	75	84	PF00179	0.587
MOD_SUMO_rev_2	99	108	PF00179	0.344
TRG_ENDOCYTIC_2	155	158	PF00928	0.495
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.610
TRG_Pf-PMV_PEXEL_1	57	61	PF00026	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6M2	Leptomonas seymouri	56%	100%
A0A0S4IY29	Bodo saltans	31%	100%
A0A1X0NT95	Trypanosomatidae	38%	100%
A0A3Q8ICB8	Leishmania donovani	86%	100%
A0A3R7RDF2	Trypanosoma rangeli	35%	100%
A4HCD4	Leishmania braziliensis	71%	100%
A4HZV2	Leishmania infantum	86%	80%
C9ZSI6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%