SUI1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

translation initiation factor SUI1, putative

Species:

Leishmania mexicana

UniProt:

E9AVR3_LEIMU

TriTrypDb:

LmxM.22.0790

Length:

664

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AVR3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVR3

Function

Biological processes
Term	Name	Level	Count
GO:0001731	formation of translation preinitiation complex	7	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0022618	ribonucleoprotein complex assembly	6	12
GO:0043933	protein-containing complex organization	4	12
GO:0065003	protein-containing complex assembly	5	12
GO:0071826	ribonucleoprotein complex subunit organization	5	12
GO:0071840	cellular component organization or biogenesis	2	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003743	translation initiation factor activity	4	12
GO:0005488	binding	1	12
GO:0008135	translation factor activity, RNA binding	3	12
GO:0045182	translation regulator activity	1	12
GO:0090079	translation regulator activity, nucleic acid binding	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	475	479	PF00656	0.444
CLV_C14_Caspase3-7	81	85	PF00656	0.416
CLV_C14_Caspase3-7	87	91	PF00656	0.492
CLV_NRD_NRD_1	152	154	PF00675	0.512
CLV_NRD_NRD_1	3	5	PF00675	0.375
CLV_NRD_NRD_1	472	474	PF00675	0.420
CLV_NRD_NRD_1	50	52	PF00675	0.468
CLV_PCSK_KEX2_1	291	293	PF00082	0.319
CLV_PCSK_KEX2_1	3	5	PF00082	0.356
CLV_PCSK_KEX2_1	50	52	PF00082	0.477
CLV_PCSK_KEX2_1	560	562	PF00082	0.434
CLV_PCSK_KEX2_1	581	583	PF00082	0.184
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.319
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.356
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.340
CLV_PCSK_PC1ET2_1	560	562	PF00082	0.451
CLV_PCSK_PC1ET2_1	581	583	PF00082	0.176
CLV_PCSK_SKI1_1	136	140	PF00082	0.392
CLV_PCSK_SKI1_1	211	215	PF00082	0.496
CLV_PCSK_SKI1_1	331	335	PF00082	0.381
CLV_PCSK_SKI1_1	427	431	PF00082	0.436
CLV_PCSK_SKI1_1	5	9	PF00082	0.354
CLV_PCSK_SKI1_1	511	515	PF00082	0.389
CLV_PCSK_SKI1_1	561	565	PF00082	0.497
CLV_PCSK_SKI1_1	582	586	PF00082	0.234
CLV_PCSK_SKI1_1	622	626	PF00082	0.265
DEG_COP1_1	90	100	PF00400	0.234
DEG_Nend_Nbox_1	1	3	PF02207	0.372
DOC_CKS1_1	458	463	PF01111	0.394
DOC_CYCLIN_RxL_1	131	140	PF00134	0.292
DOC_CYCLIN_RxL_1	424	434	PF00134	0.483
DOC_MAPK_DCC_7	496	505	PF00069	0.461
DOC_MAPK_DCC_7	564	573	PF00069	0.284
DOC_MAPK_gen_1	153	160	PF00069	0.404
DOC_MAPK_gen_1	20	29	PF00069	0.406
DOC_MAPK_gen_1	326	336	PF00069	0.438
DOC_MAPK_gen_1	536	543	PF00069	0.396
DOC_MAPK_gen_1	622	632	PF00069	0.476
DOC_MAPK_MEF2A_6	187	196	PF00069	0.406
DOC_MAPK_MEF2A_6	496	505	PF00069	0.437
DOC_MAPK_MEF2A_6	564	573	PF00069	0.284
DOC_MAPK_MEF2A_6	625	634	PF00069	0.428
DOC_MAPK_RevD_3	38	52	PF00069	0.358
DOC_MAPK_RevD_3	569	582	PF00069	0.361
DOC_PP1_RVXF_1	330	337	PF00149	0.532
DOC_PP2B_LxvP_1	144	147	PF13499	0.349
DOC_PP2B_LxvP_1	223	226	PF13499	0.300
DOC_PP2B_LxvP_1	298	301	PF13499	0.362
DOC_PP2B_LxvP_1	435	438	PF13499	0.525
DOC_PP2B_LxvP_1	95	98	PF13499	0.364
DOC_PP4_FxxP_1	654	657	PF00568	0.455
DOC_USP7_MATH_1	318	322	PF00917	0.500
DOC_USP7_MATH_1	517	521	PF00917	0.468
DOC_USP7_UBL2_3	16	20	PF12436	0.379
DOC_USP7_UBL2_3	481	485	PF12436	0.514
DOC_USP7_UBL2_3	5	9	PF12436	0.402
DOC_USP7_UBL2_3	560	564	PF12436	0.483
DOC_USP7_UBL2_3	577	581	PF12436	0.491
DOC_USP7_UBL2_3	625	629	PF12436	0.486
DOC_USP7_UBL2_3	639	643	PF12436	0.491
DOC_WW_Pin1_4	153	158	PF00397	0.444
DOC_WW_Pin1_4	263	268	PF00397	0.716
DOC_WW_Pin1_4	347	352	PF00397	0.572
DOC_WW_Pin1_4	457	462	PF00397	0.553
LIG_14-3-3_CanoR_1	292	298	PF00244	0.304
LIG_14-3-3_CanoR_1	473	477	PF00244	0.409
LIG_14-3-3_CanoR_1	582	587	PF00244	0.361
LIG_BRCT_BRCA1_1	509	513	PF00533	0.343
LIG_BRCT_BRCA1_1	58	62	PF00533	0.463
LIG_BRCT_BRCA1_1	591	595	PF00533	0.536
LIG_BRCT_BRCA1_1	90	94	PF00533	0.411
LIG_deltaCOP1_diTrp_1	202	212	PF00928	0.342
LIG_deltaCOP1_diTrp_1	602	608	PF00928	0.522
LIG_eIF4E_1	471	477	PF01652	0.488
LIG_FHA_1	116	122	PF00498	0.479
LIG_FHA_1	154	160	PF00498	0.456
LIG_FHA_1	264	270	PF00498	0.682
LIG_FHA_1	304	310	PF00498	0.463
LIG_FHA_1	318	324	PF00498	0.480
LIG_FHA_1	351	357	PF00498	0.557
LIG_FHA_1	449	455	PF00498	0.495
LIG_FHA_1	484	490	PF00498	0.433
LIG_FHA_1	568	574	PF00498	0.361
LIG_FHA_2	249	255	PF00498	0.719
LIG_FHA_2	343	349	PF00498	0.388
LIG_FHA_2	458	464	PF00498	0.490
LIG_FHA_2	473	479	PF00498	0.470
LIG_FHA_2	543	549	PF00498	0.517
LIG_FHA_2	85	91	PF00498	0.533
LIG_IRF3_LxIS_1	69	74	PF10401	0.220
LIG_LIR_Apic_2	412	418	PF02991	0.547
LIG_LIR_Apic_2	651	657	PF02991	0.387
LIG_LIR_Gen_1	115	125	PF02991	0.522
LIG_LIR_Gen_1	202	213	PF02991	0.408
LIG_LIR_Gen_1	270	275	PF02991	0.516
LIG_LIR_Gen_1	303	313	PF02991	0.386
LIG_LIR_Gen_1	36	42	PF02991	0.409
LIG_LIR_Gen_1	90	100	PF02991	0.413
LIG_LIR_LC3C_4	39	42	PF02991	0.403
LIG_LIR_Nem_3	115	120	PF02991	0.477
LIG_LIR_Nem_3	202	208	PF02991	0.368
LIG_LIR_Nem_3	270	274	PF02991	0.537
LIG_LIR_Nem_3	303	308	PF02991	0.384
LIG_LIR_Nem_3	36	41	PF02991	0.402
LIG_LIR_Nem_3	401	407	PF02991	0.383
LIG_LIR_Nem_3	440	446	PF02991	0.582
LIG_LIR_Nem_3	90	95	PF02991	0.439
LIG_LIR_Nem_3	99	104	PF02991	0.314
LIG_NRBOX	105	111	PF00104	0.479
LIG_NRP_CendR_1	662	664	PF00754	0.471
LIG_OCRL_FandH_1	102	114	PF00620	0.471
LIG_PCNA_yPIPBox_3	525	538	PF02747	0.315
LIG_Pex14_1	604	608	PF04695	0.433
LIG_Pex14_2	208	212	PF04695	0.485
LIG_Pex14_2	336	340	PF04695	0.478
LIG_PTB_Apo_2	577	584	PF02174	0.361
LIG_REV1ctd_RIR_1	334	340	PF16727	0.368
LIG_REV1ctd_RIR_1	99	109	PF16727	0.437
LIG_SH2_CRK	415	419	PF00017	0.480
LIG_SH2_NCK_1	271	275	PF00017	0.477
LIG_SH2_SRC	271	274	PF00017	0.450
LIG_SH2_STAP1	271	275	PF00017	0.553
LIG_SH2_STAP1	373	377	PF00017	0.376
LIG_SH2_STAP1	518	522	PF00017	0.459
LIG_SH2_STAT5	407	410	PF00017	0.443
LIG_SH2_STAT5	471	474	PF00017	0.433
LIG_SH2_STAT5	483	486	PF00017	0.336
LIG_SH3_3	168	174	PF00018	0.451
LIG_SH3_3	611	617	PF00018	0.476
LIG_SH3_4	625	632	PF00018	0.549
LIG_SH3_5	267	271	PF00018	0.558
LIG_Sin3_3	645	652	PF02671	0.442
LIG_SUMO_SIM_anti_2	162	168	PF11976	0.363
LIG_SUMO_SIM_par_1	156	162	PF11976	0.485
LIG_SUMO_SIM_par_1	342	350	PF11976	0.409
LIG_SUMO_SIM_par_1	427	434	PF11976	0.492
LIG_SUMO_SIM_par_1	488	494	PF11976	0.462
LIG_TRAF2_1	244	247	PF00917	0.535
LIG_TYR_ITIM	269	274	PF00017	0.512
LIG_UBA3_1	145	154	PF00899	0.385
LIG_UBA3_1	531	538	PF00899	0.477
LIG_UBA3_1	71	80	PF00899	0.223
LIG_WRC_WIRS_1	590	595	PF05994	0.528
MOD_CK1_1	182	188	PF00069	0.488
MOD_CK1_1	217	223	PF00069	0.468
MOD_CK1_1	303	309	PF00069	0.314
MOD_CK1_1	350	356	PF00069	0.464
MOD_CK1_1	551	557	PF00069	0.501
MOD_CK1_1	589	595	PF00069	0.524
MOD_CK2_1	240	246	PF00069	0.636
MOD_CK2_1	253	259	PF00069	0.594
MOD_CK2_1	342	348	PF00069	0.395
MOD_CK2_1	542	548	PF00069	0.497
MOD_CK2_1	62	68	PF00069	0.493
MOD_Cter_Amidation	262	265	PF01082	0.473
MOD_Cter_Amidation	42	45	PF01082	0.408
MOD_GlcNHglycan	139	142	PF01048	0.327
MOD_GlcNHglycan	242	245	PF01048	0.756
MOD_GlcNHglycan	320	323	PF01048	0.493
MOD_GlcNHglycan	361	364	PF01048	0.534
MOD_GlcNHglycan	409	412	PF01048	0.467
MOD_GlcNHglycan	553	556	PF01048	0.541
MOD_GlcNHglycan	574	577	PF01048	0.226
MOD_GSK3_1	10	17	PF00069	0.448
MOD_GSK3_1	149	156	PF00069	0.460
MOD_GSK3_1	178	185	PF00069	0.442
MOD_GSK3_1	254	261	PF00069	0.565
MOD_GSK3_1	273	280	PF00069	0.509
MOD_GSK3_1	300	307	PF00069	0.486
MOD_GSK3_1	342	349	PF00069	0.422
MOD_GSK3_1	350	357	PF00069	0.468
MOD_GSK3_1	438	445	PF00069	0.447
MOD_GSK3_1	507	514	PF00069	0.430
MOD_GSK3_1	547	554	PF00069	0.480
MOD_GSK3_1	572	579	PF00069	0.520
MOD_GSK3_1	582	589	PF00069	0.500
MOD_GSK3_1	84	91	PF00069	0.524
MOD_N-GLC_1	182	187	PF02516	0.460
MOD_N-GLC_1	214	219	PF02516	0.474
MOD_N-GLC_1	359	364	PF02516	0.399
MOD_N-GLC_2	283	285	PF02516	0.342
MOD_NEK2_1	137	142	PF00069	0.375
MOD_NEK2_1	165	170	PF00069	0.323
MOD_NEK2_1	216	221	PF00069	0.374
MOD_NEK2_1	325	330	PF00069	0.384
MOD_NEK2_1	376	381	PF00069	0.473
MOD_NEK2_1	512	517	PF00069	0.577
MOD_NEK2_1	57	62	PF00069	0.410
MOD_NEK2_1	608	613	PF00069	0.485
MOD_NEK2_2	438	443	PF00069	0.383
MOD_NEK2_2	530	535	PF00069	0.291
MOD_NEK2_2	617	622	PF00069	0.361
MOD_PIKK_1	217	223	PF00454	0.424
MOD_PIKK_1	300	306	PF00454	0.466
MOD_PIKK_1	354	360	PF00454	0.392
MOD_PIKK_1	84	90	PF00454	0.454
MOD_PKA_1	291	297	PF00069	0.284
MOD_PKA_2	291	297	PF00069	0.363
MOD_PKA_2	438	444	PF00069	0.380
MOD_PKA_2	472	478	PF00069	0.475
MOD_Plk_1	115	121	PF00069	0.319
MOD_Plk_1	214	220	PF00069	0.474
MOD_Plk_1	277	283	PF00069	0.456
MOD_Plk_1	505	511	PF00069	0.427
MOD_Plk_1	57	63	PF00069	0.282
MOD_Plk_2-3	242	248	PF00069	0.488
MOD_Plk_2-3	273	279	PF00069	0.330
MOD_Plk_4	116	122	PF00069	0.438
MOD_Plk_4	124	130	PF00069	0.264
MOD_Plk_4	219	225	PF00069	0.424
MOD_Plk_4	25	31	PF00069	0.467
MOD_Plk_4	277	283	PF00069	0.409
MOD_Plk_4	293	299	PF00069	0.365
MOD_Plk_4	304	310	PF00069	0.378
MOD_Plk_4	438	444	PF00069	0.622
MOD_Plk_4	472	478	PF00069	0.409
MOD_Plk_4	530	536	PF00069	0.517
MOD_Plk_4	542	548	PF00069	0.371
MOD_Plk_4	57	63	PF00069	0.340
MOD_Plk_4	96	102	PF00069	0.323
MOD_ProDKin_1	153	159	PF00069	0.443
MOD_ProDKin_1	263	269	PF00069	0.705
MOD_ProDKin_1	347	353	PF00069	0.571
MOD_ProDKin_1	457	463	PF00069	0.550
MOD_SUMO_for_1	537	540	PF00179	0.329
MOD_SUMO_rev_2	13	22	PF00179	0.433
MOD_SUMO_rev_2	256	266	PF00179	0.753
MOD_SUMO_rev_2	76	85	PF00179	0.297
TRG_DiLeu_BaEn_1	116	121	PF01217	0.398
TRG_DiLeu_BaEn_2	57	63	PF01217	0.392
TRG_DiLeu_BaEn_2	67	73	PF01217	0.473
TRG_ENDOCYTIC_2	271	274	PF00928	0.571
TRG_ENDOCYTIC_2	373	376	PF00928	0.358
TRG_NES_CRM1_1	588	602	PF08389	0.472
TRG_NLS_Bipartite_1	3	24	PF00514	0.448
TRG_NLS_MonoExtC_3	152	157	PF00514	0.448
TRG_Pf-PMV_PEXEL_1	395	399	PF00026	0.385
TRG_Pf-PMV_PEXEL_1	419	423	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I577	Leptomonas seymouri	57%	95%
A0A0S4INV2	Bodo saltans	24%	75%
A0A1X0NTA4	Trypanosomatidae	31%	100%
A0A3S5H7A8	Leishmania donovani	85%	100%
A0A422N4G3	Trypanosoma rangeli	32%	100%
A4HCD6	Leishmania braziliensis	76%	100%
A4HZV3	Leishmania infantum	85%	100%
C9ZSH9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
Q4QBR8	Leishmania major	83%	100%
V5BLJ1	Trypanosoma cruzi	32%	92%