Zinc_finger_protein_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVQ8_LEIMU

TriTrypDb:

LmxM.22.0740

Length:

592

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AVQ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVQ8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	83	87	PF00656	0.624
CLV_NRD_NRD_1	173	175	PF00675	0.429
CLV_NRD_NRD_1	287	289	PF00675	0.660
CLV_NRD_NRD_1	29	31	PF00675	0.472
CLV_NRD_NRD_1	62	64	PF00675	0.573
CLV_PCSK_KEX2_1	173	175	PF00082	0.429
CLV_PCSK_KEX2_1	287	289	PF00082	0.680
CLV_PCSK_SKI1_1	173	177	PF00082	0.495
CLV_PCSK_SKI1_1	235	239	PF00082	0.487
CLV_PCSK_SKI1_1	287	291	PF00082	0.712
CLV_PCSK_SKI1_1	30	34	PF00082	0.472
CLV_PCSK_SKI1_1	537	541	PF00082	0.710
DEG_APCC_DBOX_1	46	54	PF00400	0.484
DEG_SPOP_SBC_1	267	271	PF00917	0.796
DOC_CYCLIN_RxL_1	27	36	PF00134	0.582
DOC_CYCLIN_yCln2_LP_2	473	479	PF00134	0.511
DOC_MAPK_gen_1	483	493	PF00069	0.701
DOC_MAPK_MEF2A_6	483	491	PF00069	0.697
DOC_PP2B_LxvP_1	148	151	PF13499	0.552
DOC_PP2B_LxvP_1	32	35	PF13499	0.462
DOC_PP2B_LxvP_1	397	400	PF13499	0.711
DOC_PP2B_LxvP_1	491	494	PF13499	0.692
DOC_PP4_FxxP_1	583	586	PF00568	0.471
DOC_USP7_MATH_1	136	140	PF00917	0.588
DOC_USP7_MATH_1	151	155	PF00917	0.364
DOC_USP7_MATH_1	206	210	PF00917	0.599
DOC_USP7_MATH_1	249	253	PF00917	0.468
DOC_USP7_MATH_1	278	282	PF00917	0.560
DOC_USP7_MATH_1	354	358	PF00917	0.730
DOC_USP7_MATH_1	377	381	PF00917	0.706
DOC_USP7_MATH_1	391	395	PF00917	0.630
DOC_USP7_MATH_1	442	446	PF00917	0.631
DOC_USP7_MATH_1	481	485	PF00917	0.617
DOC_USP7_MATH_1	522	526	PF00917	0.763
DOC_WW_Pin1_4	244	249	PF00397	0.580
DOC_WW_Pin1_4	300	305	PF00397	0.643
DOC_WW_Pin1_4	373	378	PF00397	0.536
DOC_WW_Pin1_4	468	473	PF00397	0.667
DOC_WW_Pin1_4	494	499	PF00397	0.566
DOC_WW_Pin1_4	516	521	PF00397	0.751
LIG_14-3-3_CanoR_1	10	15	PF00244	0.523
LIG_14-3-3_CanoR_1	165	171	PF00244	0.466
LIG_14-3-3_CanoR_1	189	193	PF00244	0.616
LIG_14-3-3_CanoR_1	309	313	PF00244	0.676
LIG_14-3-3_CanoR_1	441	451	PF00244	0.575
LIG_14-3-3_CanoR_1	486	492	PF00244	0.693
LIG_14-3-3_CanoR_1	80	89	PF00244	0.619
LIG_Actin_WH2_2	97	112	PF00022	0.676
LIG_BRCT_BRCA1_1	421	425	PF00533	0.648
LIG_FHA_1	167	173	PF00498	0.470
LIG_FHA_1	248	254	PF00498	0.748
LIG_FHA_1	27	33	PF00498	0.478
LIG_FHA_1	34	40	PF00498	0.488
LIG_FHA_1	497	503	PF00498	0.767
LIG_FHA_2	21	27	PF00498	0.457
LIG_FHA_2	236	242	PF00498	0.501
LIG_FHA_2	281	287	PF00498	0.682
LIG_FHA_2	92	98	PF00498	0.616
LIG_IBAR_NPY_1	554	556	PF08397	0.679
LIG_LIR_Gen_1	227	237	PF02991	0.465
LIG_LIR_Gen_1	311	318	PF02991	0.684
LIG_LIR_Gen_1	74	81	PF02991	0.477
LIG_LIR_Nem_3	157	163	PF02991	0.469
LIG_LIR_Nem_3	227	233	PF02991	0.463
LIG_LIR_Nem_3	311	316	PF02991	0.687
LIG_LIR_Nem_3	422	428	PF02991	0.556
LIG_LIR_Nem_3	74	78	PF02991	0.472
LIG_NRBOX	171	177	PF00104	0.484
LIG_PTB_Apo_2	288	295	PF02174	0.522
LIG_PTB_Phospho_1	288	294	PF10480	0.520
LIG_SH2_PTP2	584	587	PF00017	0.468
LIG_SH2_SRC	149	152	PF00017	0.473
LIG_SH2_SRC	584	587	PF00017	0.468
LIG_SH2_STAT5	149	152	PF00017	0.473
LIG_SH2_STAT5	168	171	PF00017	0.475
LIG_SH2_STAT5	38	41	PF00017	0.507
LIG_SH2_STAT5	384	387	PF00017	0.803
LIG_SH2_STAT5	420	423	PF00017	0.671
LIG_SH2_STAT5	556	559	PF00017	0.783
LIG_SH2_STAT5	584	587	PF00017	0.573
LIG_SH3_2	304	309	PF14604	0.705
LIG_SH3_3	179	185	PF00018	0.513
LIG_SH3_3	21	27	PF00018	0.457
LIG_SH3_3	301	307	PF00018	0.708
LIG_SH3_3	436	442	PF00018	0.718
MOD_CK1_1	209	215	PF00069	0.595
MOD_CK1_1	247	253	PF00069	0.740
MOD_CK1_1	268	274	PF00069	0.707
MOD_CK1_1	298	304	PF00069	0.783
MOD_CK1_1	311	317	PF00069	0.752
MOD_CK1_1	348	354	PF00069	0.673
MOD_CK1_1	406	412	PF00069	0.772
MOD_CK1_1	457	463	PF00069	0.695
MOD_CK1_1	496	502	PF00069	0.670
MOD_CK1_1	511	517	PF00069	0.678
MOD_CK1_1	531	537	PF00069	0.763
MOD_CK1_1	546	552	PF00069	0.632
MOD_CK2_1	151	157	PF00069	0.493
MOD_GlcNHglycan	129	132	PF01048	0.667
MOD_GlcNHglycan	185	188	PF01048	0.440
MOD_GlcNHglycan	207	211	PF01048	0.600
MOD_GlcNHglycan	270	273	PF01048	0.664
MOD_GlcNHglycan	297	300	PF01048	0.806
MOD_GlcNHglycan	347	350	PF01048	0.586
MOD_GlcNHglycan	387	390	PF01048	0.611
MOD_GlcNHglycan	393	396	PF01048	0.527
MOD_GlcNHglycan	415	418	PF01048	0.773
MOD_GlcNHglycan	425	428	PF01048	0.597
MOD_GlcNHglycan	463	466	PF01048	0.757
MOD_GlcNHglycan	479	482	PF01048	0.609
MOD_GlcNHglycan	499	502	PF01048	0.566
MOD_GlcNHglycan	58	61	PF01048	0.411
MOD_GSK3_1	261	268	PF00069	0.722
MOD_GSK3_1	308	315	PF00069	0.591
MOD_GSK3_1	348	355	PF00069	0.695
MOD_GSK3_1	373	380	PF00069	0.814
MOD_GSK3_1	419	426	PF00069	0.607
MOD_GSK3_1	457	464	PF00069	0.779
MOD_GSK3_1	468	475	PF00069	0.636
MOD_GSK3_1	477	484	PF00069	0.456
MOD_GSK3_1	489	496	PF00069	0.795
MOD_GSK3_1	507	514	PF00069	0.692
MOD_GSK3_1	522	529	PF00069	0.619
MOD_GSK3_1	531	538	PF00069	0.586
MOD_GSK3_1	542	549	PF00069	0.660
MOD_GSK3_1	556	563	PF00069	0.692
MOD_GSK3_1	80	87	PF00069	0.584
MOD_N-GLC_1	406	411	PF02516	0.524
MOD_N-GLC_1	454	459	PF02516	0.775
MOD_N-GLC_1	467	472	PF02516	0.649
MOD_N-GLC_1	511	516	PF02516	0.795
MOD_NEK2_1	109	114	PF00069	0.647
MOD_NEK2_1	156	161	PF00069	0.574
MOD_NEK2_1	20	25	PF00069	0.555
MOD_NEK2_1	265	270	PF00069	0.728
MOD_NEK2_1	385	390	PF00069	0.707
MOD_NEK2_1	421	426	PF00069	0.665
MOD_NEK2_1	454	459	PF00069	0.683
MOD_NEK2_1	508	513	PF00069	0.700
MOD_NEK2_1	526	531	PF00069	0.777
MOD_NEK2_1	535	540	PF00069	0.613
MOD_NEK2_1	56	61	PF00069	0.452
MOD_NEK2_2	151	156	PF00069	0.587
MOD_PIKK_1	33	39	PF00454	0.584
MOD_PIKK_1	434	440	PF00454	0.607
MOD_PIKK_1	537	543	PF00454	0.710
MOD_PIKK_1	80	86	PF00454	0.595
MOD_PKA_2	109	115	PF00069	0.643
MOD_PKA_2	164	170	PF00069	0.469
MOD_PKA_2	188	194	PF00069	0.614
MOD_PKA_2	308	314	PF00069	0.745
MOD_PKA_2	46	52	PF00069	0.441
MOD_PKA_2	487	493	PF00069	0.695
MOD_Plk_1	137	143	PF00069	0.654
MOD_Plk_1	454	460	PF00069	0.563
MOD_Plk_4	151	157	PF00069	0.592
MOD_Plk_4	20	26	PF00069	0.454
MOD_Plk_4	308	314	PF00069	0.631
MOD_Plk_4	339	345	PF00069	0.696
MOD_Plk_4	362	368	PF00069	0.809
MOD_ProDKin_1	244	250	PF00069	0.591
MOD_ProDKin_1	300	306	PF00069	0.642
MOD_ProDKin_1	373	379	PF00069	0.535
MOD_ProDKin_1	468	474	PF00069	0.667
MOD_ProDKin_1	494	500	PF00069	0.567
MOD_ProDKin_1	516	522	PF00069	0.751
MOD_SUMO_for_1	561	564	PF00179	0.680
MOD_SUMO_rev_2	226	231	PF00179	0.481
TRG_DiLeu_BaEn_1	393	398	PF01217	0.806
TRG_DiLeu_BaEn_2	225	231	PF01217	0.480
TRG_DiLeu_BaEn_4	226	232	PF01217	0.474
TRG_DiLeu_BaLyEn_6	171	176	PF01217	0.476
TRG_DiLeu_LyEn_5	393	398	PF01217	0.806
TRG_ENDOCYTIC_2	160	163	PF00928	0.447
TRG_ER_diArg_1	172	174	PF00400	0.434
TRG_ER_diArg_1	221	224	PF00400	0.499
TRG_ER_diArg_1	287	289	PF00400	0.713
TRG_ER_diArg_1	486	489	PF00400	0.669
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.495
TRG_Pf-PMV_PEXEL_1	396	401	PF00026	0.812
TRG_Pf-PMV_PEXEL_1	441	446	PF00026	0.757

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6L3	Leptomonas seymouri	50%	100%
A0A3S7WX90	Leishmania donovani	90%	100%
A4HCC9	Leishmania braziliensis	79%	99%
Q4QBS3	Leishmania major	88%	100%