Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytoskeleton associated protein, putative

Species:

Leishmania mexicana

UniProt:

E9AVQ7_LEIMU

TriTrypDb:

LmxM.22.0730

Length:

416

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005856	cytoskeleton	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AVQ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVQ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	253	257	PF00656	0.649
CLV_C14_Caspase3-7	42	46	PF00656	0.578
CLV_NRD_NRD_1	148	150	PF00675	0.524
CLV_NRD_NRD_1	317	319	PF00675	0.599
CLV_NRD_NRD_1	33	35	PF00675	0.723
CLV_NRD_NRD_1	362	364	PF00675	0.614
CLV_NRD_NRD_1	84	86	PF00675	0.763
CLV_PCSK_FUR_1	315	319	PF00082	0.579
CLV_PCSK_KEX2_1	311	313	PF00082	0.637
CLV_PCSK_KEX2_1	317	319	PF00082	0.612
CLV_PCSK_KEX2_1	32	34	PF00082	0.718
CLV_PCSK_KEX2_1	348	350	PF00082	0.564
CLV_PCSK_KEX2_1	361	363	PF00082	0.506
CLV_PCSK_KEX2_1	84	86	PF00082	0.763
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.706
CLV_PCSK_PC1ET2_1	348	350	PF00082	0.607
CLV_PCSK_PC1ET2_1	361	363	PF00082	0.526
CLV_PCSK_SKI1_1	345	349	PF00082	0.567
CLV_PCSK_SKI1_1	355	359	PF00082	0.521
CLV_PCSK_SKI1_1	380	384	PF00082	0.623
CLV_PCSK_SKI1_1	394	398	PF00082	0.491
DOC_CKS1_1	108	113	PF01111	0.765
DOC_MAPK_gen_1	258	265	PF00069	0.430
DOC_MAPK_gen_1	315	324	PF00069	0.624
DOC_USP7_MATH_1	191	195	PF00917	0.559
DOC_WW_Pin1_4	107	112	PF00397	0.777
DOC_WW_Pin1_4	43	48	PF00397	0.732
DOC_WW_Pin1_4	49	54	PF00397	0.716
LIG_14-3-3_CanoR_1	127	131	PF00244	0.486
LIG_14-3-3_CanoR_1	284	294	PF00244	0.558
LIG_14-3-3_CanoR_1	32	37	PF00244	0.728
LIG_14-3-3_CanoR_1	325	333	PF00244	0.613
LIG_14-3-3_CanoR_1	60	68	PF00244	0.637
LIG_14-3-3_CanoR_1	84	90	PF00244	0.559
LIG_APCC_ABBA_1	139	144	PF00400	0.522
LIG_APCC_ABBAyCdc20_2	138	144	PF00400	0.558
LIG_BIR_II_1	1	5	PF00653	0.695
LIG_FHA_1	167	173	PF00498	0.627
LIG_FHA_1	325	331	PF00498	0.538
LIG_FHA_2	108	114	PF00498	0.762
LIG_FHA_2	127	133	PF00498	0.481
LIG_FHA_2	26	32	PF00498	0.535
LIG_FHA_2	262	268	PF00498	0.688
LIG_LIR_Gen_1	124	130	PF02991	0.633
LIG_LIR_Gen_1	211	222	PF02991	0.584
LIG_LIR_LC3C_4	151	154	PF02991	0.376
LIG_LIR_Nem_3	124	128	PF02991	0.585
LIG_LIR_Nem_3	211	217	PF02991	0.573
LIG_PCNA_PIPBox_1	193	202	PF02747	0.620
LIG_RPA_C_Fungi	15	27	PF08784	0.672
LIG_SH2_NCK_1	125	129	PF00017	0.491
LIG_SH2_STAP1	114	118	PF00017	0.660
LIG_SH2_STAP1	142	146	PF00017	0.493
LIG_SH2_STAP1	365	369	PF00017	0.631
LIG_SH2_STAT3	244	247	PF00017	0.620
LIG_SH2_STAT5	406	409	PF00017	0.517
LIG_SH2_STAT5	96	99	PF00017	0.551
LIG_SH3_3	105	111	PF00018	0.786
LIG_SUMO_SIM_par_1	181	190	PF11976	0.555
LIG_SUMO_SIM_par_1	302	307	PF11976	0.698
LIG_TRAF2_1	110	113	PF00917	0.679
LIG_TRAF2_1	117	120	PF00917	0.633
LIG_TRAF2_1	371	374	PF00917	0.480
MOD_CDK_SPxK_1	51	57	PF00069	0.787
MOD_CK1_1	176	182	PF00069	0.633
MOD_CK1_1	35	41	PF00069	0.707
MOD_CK1_1	87	93	PF00069	0.735
MOD_CK1_1	95	101	PF00069	0.797
MOD_CK2_1	107	113	PF00069	0.732
MOD_CK2_1	182	188	PF00069	0.637
MOD_CK2_1	25	31	PF00069	0.689
MOD_CK2_1	261	267	PF00069	0.684
MOD_DYRK1A_RPxSP_1	43	47	PF00069	0.775
MOD_GlcNHglycan	1	4	PF01048	0.733
MOD_GlcNHglycan	193	196	PF01048	0.621
MOD_GlcNHglycan	65	68	PF01048	0.636
MOD_GlcNHglycan	89	92	PF01048	0.776
MOD_GlcNHglycan	99	102	PF01048	0.666
MOD_GSK3_1	172	179	PF00069	0.598
MOD_GSK3_1	351	358	PF00069	0.619
MOD_GSK3_1	37	44	PF00069	0.607
MOD_GSK3_1	87	94	PF00069	0.690
MOD_N-GLC_1	251	256	PF02516	0.572
MOD_NEK2_1	324	329	PF00069	0.624
MOD_NEK2_1	351	356	PF00069	0.618
MOD_NEK2_1	382	387	PF00069	0.402
MOD_NEK2_1	92	97	PF00069	0.559
MOD_NEK2_2	365	370	PF00069	0.631
MOD_PK_1	182	188	PF00069	0.480
MOD_PK_1	85	91	PF00069	0.557
MOD_PKA_1	310	316	PF00069	0.623
MOD_PKA_1	32	38	PF00069	0.731
MOD_PKA_1	84	90	PF00069	0.759
MOD_PKA_2	126	132	PF00069	0.580
MOD_PKA_2	261	267	PF00069	0.674
MOD_PKA_2	295	301	PF00069	0.595
MOD_PKA_2	311	317	PF00069	0.506
MOD_PKA_2	32	38	PF00069	0.731
MOD_PKA_2	324	330	PF00069	0.611
MOD_PKA_2	62	68	PF00069	0.774
MOD_PKA_2	84	90	PF00069	0.759
MOD_Plk_1	365	371	PF00069	0.628
MOD_Plk_2-3	126	132	PF00069	0.590
MOD_Plk_2-3	261	267	PF00069	0.632
MOD_Plk_4	382	388	PF00069	0.627
MOD_ProDKin_1	107	113	PF00069	0.772
MOD_ProDKin_1	43	49	PF00069	0.733
MOD_ProDKin_1	51	57	PF00069	0.713
MOD_SUMO_for_1	130	133	PF00179	0.478
MOD_SUMO_for_1	21	24	PF00179	0.627
MOD_SUMO_for_1	333	336	PF00179	0.669
MOD_SUMO_for_1	387	390	PF00179	0.616
MOD_SUMO_rev_2	213	222	PF00179	0.454
MOD_SUMO_rev_2	375	385	PF00179	0.609
MOD_SUMO_rev_2	389	398	PF00179	0.604
TRG_DiLeu_BaEn_1	336	341	PF01217	0.662
TRG_DiLeu_BaEn_4	136	142	PF01217	0.588
TRG_DiLeu_BaEn_4	391	397	PF01217	0.661
TRG_ENDOCYTIC_2	125	128	PF00928	0.672
TRG_ENDOCYTIC_2	142	145	PF00928	0.423
TRG_ER_diArg_1	222	225	PF00400	0.471
TRG_ER_diArg_1	315	318	PF00400	0.587
TRG_ER_diArg_1	32	34	PF00400	0.718
TRG_Pf-PMV_PEXEL_1	349	353	PF00026	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I875	Leptomonas seymouri	68%	92%
A0A1X0NT91	Trypanosomatidae	37%	90%
A0A3Q8IFG4	Leishmania donovani	82%	95%
A4HCB9	Leishmania braziliensis	68%	100%
C9ZSG0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	92%
Q4QBS4	Leishmania major	77%	100%