Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVQ5_LEIMU

TriTrypDb:

LmxM.22.0710

Length:

370

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVQ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVQ5

PDB structure(s): 7ane_an

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	21	23	PF00675	0.458
CLV_NRD_NRD_1	218	220	PF00675	0.633
CLV_NRD_NRD_1	254	256	PF00675	0.506
CLV_NRD_NRD_1	27	29	PF00675	0.461
CLV_NRD_NRD_1	319	321	PF00675	0.468
CLV_NRD_NRD_1	41	43	PF00675	0.501
CLV_NRD_NRD_1	52	54	PF00675	0.469
CLV_NRD_NRD_1	73	75	PF00675	0.388
CLV_NRD_NRD_1	88	90	PF00675	0.466
CLV_PCSK_KEX2_1	139	141	PF00082	0.420
CLV_PCSK_KEX2_1	21	23	PF00082	0.458
CLV_PCSK_KEX2_1	218	220	PF00082	0.633
CLV_PCSK_KEX2_1	253	255	PF00082	0.522
CLV_PCSK_KEX2_1	27	29	PF00082	0.461
CLV_PCSK_KEX2_1	319	321	PF00082	0.353
CLV_PCSK_KEX2_1	52	54	PF00082	0.484
CLV_PCSK_KEX2_1	73	75	PF00082	0.388
CLV_PCSK_KEX2_1	88	90	PF00082	0.466
CLV_PCSK_PC1ET2_1	139	141	PF00082	0.420
CLV_PCSK_SKI1_1	157	161	PF00082	0.517
CLV_PCSK_SKI1_1	183	187	PF00082	0.378
CLV_PCSK_SKI1_1	80	84	PF00082	0.420
DEG_Nend_Nbox_1	1	3	PF02207	0.413
DEG_SCF_FBW7_2	308	314	PF00400	0.443
DOC_CKS1_1	131	136	PF01111	0.368
DOC_CKS1_1	308	313	PF01111	0.449
DOC_CYCLIN_RxL_1	296	304	PF00134	0.571
DOC_CYCLIN_yCln2_LP_2	305	311	PF00134	0.398
DOC_MAPK_gen_1	187	196	PF00069	0.288
DOC_MAPK_JIP1_4	190	196	PF00069	0.469
DOC_MAPK_MEF2A_6	187	196	PF00069	0.440
DOC_MAPK_RevD_3	8	22	PF00069	0.416
DOC_PP2B_LxvP_1	305	308	PF13499	0.388
DOC_USP7_MATH_1	206	210	PF00917	0.452
DOC_USP7_UBL2_3	183	187	PF12436	0.360
DOC_WW_Pin1_4	12	17	PF00397	0.445
DOC_WW_Pin1_4	130	135	PF00397	0.362
DOC_WW_Pin1_4	148	153	PF00397	0.272
DOC_WW_Pin1_4	21	26	PF00397	0.443
DOC_WW_Pin1_4	307	312	PF00397	0.454
DOC_WW_Pin1_4	33	38	PF00397	0.500
DOC_WW_Pin1_4	43	48	PF00397	0.477
LIG_14-3-3_CanoR_1	116	120	PF00244	0.516
LIG_14-3-3_CanoR_1	270	276	PF00244	0.491
LIG_14-3-3_CanoR_1	61	69	PF00244	0.404
LIG_Actin_WH2_2	124	141	PF00022	0.407
LIG_FHA_1	296	302	PF00498	0.534
LIG_FHA_1	61	67	PF00498	0.405
LIG_FHA_2	202	208	PF00498	0.436
LIG_FHA_2	308	314	PF00498	0.403
LIG_FHA_2	44	50	PF00498	0.479
LIG_Integrin_isoDGR_2	40	42	PF01839	0.517
LIG_LIR_Apic_2	201	206	PF02991	0.489
LIG_LIR_Gen_1	300	311	PF02991	0.548
LIG_LIR_Gen_1	93	104	PF02991	0.377
LIG_LIR_Nem_3	201	205	PF02991	0.426
LIG_LIR_Nem_3	300	306	PF02991	0.561
LIG_LIR_Nem_3	70	75	PF02991	0.390
LIG_LIR_Nem_3	93	99	PF02991	0.386
LIG_PTB_Apo_2	102	109	PF02174	0.368
LIG_PTB_Apo_2	196	203	PF02174	0.413
LIG_PTB_Phospho_1	102	108	PF10480	0.367
LIG_SH2_CRK	72	76	PF00017	0.368
LIG_SH2_NCK_1	203	207	PF00017	0.477
LIG_SH2_SRC	163	166	PF00017	0.406
LIG_SH2_STAP1	108	112	PF00017	0.379
LIG_SH2_STAT3	108	111	PF00017	0.367
LIG_SH2_STAT5	102	105	PF00017	0.388
LIG_SH2_STAT5	203	206	PF00017	0.439
LIG_SH2_STAT5	280	283	PF00017	0.449
LIG_SH2_STAT5	309	312	PF00017	0.421
LIG_SH3_3	305	311	PF00018	0.450
LIG_SUMO_SIM_par_1	3	9	PF11976	0.395
MOD_CDC14_SPxK_1	24	27	PF00782	0.503
MOD_CDK_SPxK_1	21	27	PF00069	0.446
MOD_CDK_SPxxK_3	21	28	PF00069	0.449
MOD_CK1_1	209	215	PF00069	0.424
MOD_CK1_1	334	340	PF00069	0.517
MOD_CK1_1	9	15	PF00069	0.433
MOD_CK2_1	201	207	PF00069	0.432
MOD_CK2_1	43	49	PF00069	0.512
MOD_Cter_Amidation	40	43	PF01082	0.517
MOD_GSK3_1	12	19	PF00069	0.533
MOD_GSK3_1	43	50	PF00069	0.483
MOD_N-GLC_1	61	66	PF02516	0.405
MOD_NEK2_2	16	21	PF00069	0.426
MOD_NEK2_2	271	276	PF00069	0.431
MOD_PKA_2	115	121	PF00069	0.510
MOD_PKA_2	55	61	PF00069	0.447
MOD_Plk_1	206	212	PF00069	0.433
MOD_Plk_1	61	67	PF00069	0.405
MOD_Plk_2-3	201	207	PF00069	0.432
MOD_Plk_2-3	220	226	PF00069	0.541
MOD_Plk_4	115	121	PF00069	0.510
MOD_Plk_4	331	337	PF00069	0.520
MOD_Plk_4	6	12	PF00069	0.407
MOD_ProDKin_1	12	18	PF00069	0.448
MOD_ProDKin_1	130	136	PF00069	0.363
MOD_ProDKin_1	148	154	PF00069	0.270
MOD_ProDKin_1	21	27	PF00069	0.445
MOD_ProDKin_1	307	313	PF00069	0.448
MOD_ProDKin_1	33	39	PF00069	0.498
MOD_ProDKin_1	43	49	PF00069	0.475
MOD_SUMO_rev_2	175	181	PF00179	0.446
TRG_DiLeu_BaLyEn_6	13	18	PF01217	0.417
TRG_DiLeu_BaLyEn_6	313	318	PF01217	0.379
TRG_ENDOCYTIC_2	182	185	PF00928	0.372
TRG_ENDOCYTIC_2	309	312	PF00928	0.408
TRG_ENDOCYTIC_2	72	75	PF00928	0.377
TRG_ER_diArg_1	140	143	PF00400	0.422
TRG_ER_diArg_1	20	22	PF00400	0.440
TRG_ER_diArg_1	217	219	PF00400	0.608
TRG_ER_diArg_1	252	255	PF00400	0.434
TRG_ER_diArg_1	27	29	PF00400	0.461
TRG_ER_diArg_1	288	291	PF00400	0.488
TRG_ER_diArg_1	318	320	PF00400	0.393
TRG_ER_diArg_1	72	74	PF00400	0.386
TRG_ER_diArg_1	88	90	PF00400	0.466
TRG_Pf-PMV_PEXEL_1	171	175	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	299	304	PF00026	0.567
TRG_Pf-PMV_PEXEL_1	349	353	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	360	364	PF00026	0.465
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.366
TRG_Pf-PMV_PEXEL_1	88	93	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCB7	Leptomonas seymouri	81%	100%
A0A0S4IJG6	Bodo saltans	58%	100%
A0A1X0NT90	Trypanosomatidae	71%	100%
A0A381MHF5	Leishmania infantum	99%	100%
A0A3Q8IAP3	Leishmania donovani	98%	100%
A0A3S7WX26	Leishmania donovani	99%	100%
A0A422NDI7	Trypanosoma rangeli	72%	100%
A4HCB5	Leishmania braziliensis	93%	98%
C9ZSF8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
Q4QBR4	Leishmania major	98%	100%
V5DMI7	Trypanosoma cruzi	71%	100%