A2 protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

A2 protein

Gene product:

A2 protein

Species:

Leishmania mexicana

UniProt:

E9AVQ2_LEIMU

TriTrypDb:

LmxM.22.0691

Length:

774

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 0
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVQ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVQ2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_Nend_UBRbox_1	1	4	PF02207	0.535
DOC_MAPK_DCC_7	2	11	PF00069	0.502
DOC_MAPK_HePTP_8	4	16	PF00069	0.400
DOC_MAPK_JIP1_4	7	13	PF00069	0.400
DOC_MAPK_MEF2A_6	7	16	PF00069	0.604
LIG_FHA_1	1	7	PF00498	0.510
LIG_HP1_1	8	12	PF01393	0.480
LIG_SUMO_SIM_par_1	106	111	PF11976	0.541
LIG_SUMO_SIM_par_1	116	121	PF11976	0.520
LIG_SUMO_SIM_par_1	131	136	PF11976	0.575
LIG_SUMO_SIM_par_1	151	156	PF11976	0.692
LIG_SUMO_SIM_par_1	171	176	PF11976	0.543
LIG_SUMO_SIM_par_1	18	23	PF11976	0.545
LIG_SUMO_SIM_par_1	186	191	PF11976	0.562
LIG_SUMO_SIM_par_1	206	211	PF11976	0.548
LIG_SUMO_SIM_par_1	226	231	PF11976	0.548
LIG_SUMO_SIM_par_1	251	256	PF11976	0.565
LIG_SUMO_SIM_par_1	261	267	PF11976	0.534
LIG_SUMO_SIM_par_1	286	291	PF11976	0.565
LIG_SUMO_SIM_par_1	341	347	PF11976	0.549
LIG_SUMO_SIM_par_1	361	367	PF11976	0.554
LIG_SUMO_SIM_par_1	371	376	PF11976	0.538
LIG_SUMO_SIM_par_1	406	411	PF11976	0.567
LIG_SUMO_SIM_par_1	431	437	PF11976	0.550
LIG_SUMO_SIM_par_1	471	476	PF11976	0.561
LIG_SUMO_SIM_par_1	481	486	PF11976	0.550
LIG_SUMO_SIM_par_1	491	496	PF11976	0.549
LIG_SUMO_SIM_par_1	51	56	PF11976	0.647
LIG_SUMO_SIM_par_1	516	521	PF11976	0.520
LIG_SUMO_SIM_par_1	526	531	PF11976	0.531
LIG_SUMO_SIM_par_1	536	541	PF11976	0.582
LIG_SUMO_SIM_par_1	551	557	PF11976	0.519
LIG_SUMO_SIM_par_1	581	586	PF11976	0.519
LIG_SUMO_SIM_par_1	606	611	PF11976	0.535
LIG_SUMO_SIM_par_1	61	67	PF11976	0.569
LIG_SUMO_SIM_par_1	616	621	PF11976	0.555
LIG_SUMO_SIM_par_1	641	647	PF11976	0.518
LIG_SUMO_SIM_par_1	661	667	PF11976	0.536
LIG_SUMO_SIM_par_1	691	696	PF11976	0.528
LIG_SUMO_SIM_par_1	716	721	PF11976	0.538
LIG_SUMO_SIM_par_1	726	731	PF11976	0.530
LIG_SUMO_SIM_par_1	741	747	PF11976	0.512
LIG_SUMO_SIM_par_1	751	756	PF11976	0.499
LIG_SUMO_SIM_par_1	81	86	PF11976	0.555
LIG_SUMO_SIM_par_1	91	96	PF11976	0.555
MOD_CK1_1	264	270	PF00069	0.551
MOD_CK1_1	314	320	PF00069	0.632
MOD_CK1_1	329	335	PF00069	0.550
MOD_CK1_1	344	350	PF00069	0.537
MOD_CK1_1	364	370	PF00069	0.547
MOD_CK1_1	389	395	PF00069	0.693
MOD_CK1_1	434	440	PF00069	0.551
MOD_CK1_1	509	515	PF00069	0.566
MOD_CK1_1	554	560	PF00069	0.538
MOD_CK1_1	564	570	PF00069	0.516
MOD_CK1_1	594	600	PF00069	0.518
MOD_CK1_1	64	70	PF00069	0.543
MOD_CK1_1	644	650	PF00069	0.520
MOD_CK1_1	664	670	PF00069	0.510
MOD_CK1_1	674	680	PF00069	0.506
MOD_CK1_1	704	710	PF00069	0.566
MOD_CK1_1	744	750	PF00069	0.513
MOD_GlcNHglycan	22	25	PF01048	0.551
MOD_NEK2_1	20	25	PF00069	0.623
MOD_PIKK_1	264	270	PF00454	0.551
MOD_PIKK_1	314	320	PF00454	0.546
MOD_PIKK_1	329	335	PF00454	0.550
MOD_PIKK_1	344	350	PF00454	0.537
MOD_PIKK_1	364	370	PF00454	0.547
MOD_PIKK_1	389	395	PF00454	0.561
MOD_PIKK_1	434	440	PF00454	0.624
MOD_PIKK_1	509	515	PF00454	0.566
MOD_PIKK_1	554	560	PF00454	0.620
MOD_PIKK_1	564	570	PF00454	0.549
MOD_PIKK_1	594	600	PF00454	0.518
MOD_PIKK_1	64	70	PF00454	0.579
MOD_PIKK_1	644	650	PF00454	0.520
MOD_PIKK_1	664	670	PF00454	0.510
MOD_PIKK_1	674	680	PF00454	0.506
MOD_PIKK_1	704	710	PF00454	0.566
MOD_PIKK_1	744	750	PF00454	0.513
MOD_Plk_2-3	541	547	PF00069	0.539
MOD_Plk_2-3	621	627	PF00069	0.551
MOD_Plk_2-3	731	737	PF00069	0.521
MOD_Plk_2-3	96	102	PF00069	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IC81	Leishmania donovani	78%	100%
A0A3Q8IFH2	Leishmania donovani	79%	100%
A0A3S5H7A7	Leishmania donovani	78%	100%
A0A3S7WX44	Leishmania donovani	78%	100%
E9AVQ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	87%