N-acetyltransferase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Acetyltransferase (GNAT) domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AVP2_LEIMU

TriTrypDb:

LmxM.22.0600

Length:

493

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVP2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVP2

Function

Biological processes
Term	Name	Level	Count
GO:0006473	protein acetylation	6	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0008080	N-acetyltransferase activity	6	8
GO:0016407	acetyltransferase activity	5	8
GO:0016410	N-acyltransferase activity	5	8
GO:0016740	transferase activity	2	8
GO:0016746	acyltransferase activity	3	8
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	294	296	PF00675	0.235
CLV_NRD_NRD_1	336	338	PF00675	0.266
CLV_NRD_NRD_1	405	407	PF00675	0.601
CLV_PCSK_FUR_1	403	407	PF00082	0.315
CLV_PCSK_KEX2_1	214	216	PF00082	0.537
CLV_PCSK_KEX2_1	294	296	PF00082	0.235
CLV_PCSK_KEX2_1	335	337	PF00082	0.264
CLV_PCSK_KEX2_1	405	407	PF00082	0.499
CLV_PCSK_PC1ET2_1	214	216	PF00082	0.564
CLV_PCSK_SKI1_1	222	226	PF00082	0.542
CLV_PCSK_SKI1_1	385	389	PF00082	0.445
CLV_PCSK_SKI1_1	487	491	PF00082	0.705
DEG_APCC_DBOX_1	5	13	PF00400	0.533
DEG_ODPH_VHL_1	317	329	PF01847	0.487
DOC_CDC14_PxL_1	49	57	PF14671	0.385
DOC_CKS1_1	310	315	PF01111	0.521
DOC_CYCLIN_RxL_1	219	228	PF00134	0.571
DOC_CYCLIN_yCln2_LP_2	103	109	PF00134	0.465
DOC_MAPK_gen_1	385	395	PF00069	0.448
DOC_MAPK_MEF2A_6	321	329	PF00069	0.507
DOC_PP1_RVXF_1	376	382	PF00149	0.380
DOC_PP2B_LxvP_1	103	106	PF13499	0.464
DOC_PP4_FxxP_1	170	173	PF00568	0.609
DOC_PP4_FxxP_1	33	36	PF00568	0.393
DOC_USP7_MATH_1	157	161	PF00917	0.724
DOC_USP7_MATH_1	163	167	PF00917	0.627
DOC_USP7_MATH_1	302	306	PF00917	0.578
DOC_USP7_MATH_1	442	446	PF00917	0.619
DOC_USP7_MATH_1	74	78	PF00917	0.508
DOC_WW_Pin1_4	159	164	PF00397	0.698
DOC_WW_Pin1_4	294	299	PF00397	0.504
DOC_WW_Pin1_4	306	311	PF00397	0.431
DOC_WW_Pin1_4	32	37	PF00397	0.428
DOC_WW_Pin1_4	4	9	PF00397	0.631
DOC_WW_Pin1_4	455	460	PF00397	0.637
LIG_14-3-3_CanoR_1	11	17	PF00244	0.536
LIG_14-3-3_CanoR_1	202	211	PF00244	0.581
LIG_14-3-3_CanoR_1	345	349	PF00244	0.454
LIG_14-3-3_CanoR_1	422	428	PF00244	0.453
LIG_APCC_ABBA_1	381	386	PF00400	0.391
LIG_APCC_ABBA_1	387	392	PF00400	0.349
LIG_BRCT_BRCA1_1	319	323	PF00533	0.507
LIG_Clathr_ClatBox_1	263	267	PF01394	0.487
LIG_CSL_BTD_1	233	236	PF09270	0.451
LIG_EH1_1	322	330	PF00400	0.507
LIG_FHA_1	188	194	PF00498	0.692
LIG_FHA_1	320	326	PF00498	0.507
LIG_FHA_1	356	362	PF00498	0.501
LIG_FHA_1	367	373	PF00498	0.454
LIG_FHA_1	374	380	PF00498	0.532
LIG_FHA_1	98	104	PF00498	0.359
LIG_FHA_2	183	189	PF00498	0.632
LIG_FHA_2	399	405	PF00498	0.470
LIG_FHA_2	73	79	PF00498	0.450
LIG_HCF-1_HBM_1	40	43	PF13415	0.371
LIG_LIR_Apic_2	168	173	PF02991	0.653
LIG_LIR_Apic_2	30	36	PF02991	0.416
LIG_LIR_Apic_2	472	477	PF02991	0.571
LIG_LIR_Gen_1	100	109	PF02991	0.385
LIG_LIR_Gen_1	254	263	PF02991	0.244
LIG_LIR_Nem_3	100	104	PF02991	0.347
LIG_LIR_Nem_3	254	258	PF02991	0.300
LIG_MYND_1	53	57	PF01753	0.434
LIG_MYND_3	149	153	PF01753	0.595
LIG_RPA_C_Fungi	332	344	PF08784	0.311
LIG_SH2_PTP2	255	258	PF00017	0.343
LIG_SH2_SRC	216	219	PF00017	0.653
LIG_SH2_SRC	43	46	PF00017	0.328
LIG_SH2_STAP1	350	354	PF00017	0.393
LIG_SH2_STAT5	255	258	PF00017	0.343
LIG_SH2_STAT5	43	46	PF00017	0.502
LIG_SH2_STAT5	54	57	PF00017	0.428
LIG_SH3_1	54	60	PF00018	0.435
LIG_SH3_3	230	236	PF00018	0.531
LIG_SH3_3	307	313	PF00018	0.381
LIG_SH3_3	448	454	PF00018	0.802
LIG_SH3_3	47	53	PF00018	0.484
LIG_SH3_3	54	60	PF00018	0.499
LIG_SUMO_SIM_anti_2	324	329	PF11976	0.362
LIG_SUMO_SIM_anti_2	48	53	PF11976	0.401
LIG_SUMO_SIM_par_1	75	85	PF11976	0.475
LIG_TRAF2_1	151	154	PF00917	0.600
LIG_TRAF2_1	81	84	PF00917	0.416
LIG_WRC_WIRS_1	167	172	PF05994	0.609
LIG_WW_3	197	201	PF00397	0.468
MOD_CDK_SPxxK_3	4	11	PF00069	0.533
MOD_CK1_1	15	21	PF00069	0.580
MOD_CK1_1	166	172	PF00069	0.643
MOD_CK1_1	182	188	PF00069	0.711
MOD_CK1_1	297	303	PF00069	0.448
MOD_CK1_1	305	311	PF00069	0.350
MOD_CK1_1	398	404	PF00069	0.600
MOD_CK1_1	467	473	PF00069	0.590
MOD_CK2_1	269	275	PF00069	0.229
MOD_CK2_1	398	404	PF00069	0.468
MOD_CK2_1	72	78	PF00069	0.437
MOD_GlcNHglycan	12	15	PF01048	0.587
MOD_GlcNHglycan	17	20	PF01048	0.548
MOD_GlcNHglycan	205	208	PF01048	0.569
MOD_GlcNHglycan	299	302	PF01048	0.334
MOD_GlcNHglycan	314	317	PF01048	0.212
MOD_GlcNHglycan	455	458	PF01048	0.723
MOD_GSK3_1	155	162	PF00069	0.632
MOD_GSK3_1	175	182	PF00069	0.630
MOD_GSK3_1	183	190	PF00069	0.604
MOD_GSK3_1	224	231	PF00069	0.591
MOD_GSK3_1	302	309	PF00069	0.348
MOD_GSK3_1	364	371	PF00069	0.284
MOD_GSK3_1	455	462	PF00069	0.814
MOD_GSK3_1	74	81	PF00069	0.446
MOD_GSK3_1	88	95	PF00069	0.406
MOD_N-GLC_1	423	428	PF02516	0.482
MOD_NEK2_1	10	15	PF00069	0.544
MOD_NEK2_1	145	150	PF00069	0.595
MOD_NEK2_1	251	256	PF00069	0.378
MOD_NEK2_1	283	288	PF00069	0.311
MOD_NEK2_1	395	400	PF00069	0.544
MOD_NEK2_1	469	474	PF00069	0.601
MOD_NEK2_2	423	428	PF00069	0.438
MOD_PIKK_1	216	222	PF00454	0.663
MOD_PIKK_1	373	379	PF00454	0.194
MOD_PIKK_1	43	49	PF00454	0.325
MOD_PIKK_1	459	465	PF00454	0.642
MOD_PIKK_1	487	493	PF00454	0.657
MOD_PKA_2	10	16	PF00069	0.537
MOD_PKA_2	120	126	PF00069	0.623
MOD_PKA_2	344	350	PF00069	0.258
MOD_PKA_2	412	418	PF00069	0.527
MOD_PKB_1	200	208	PF00069	0.600
MOD_Plk_1	423	429	PF00069	0.630
MOD_Plk_2-3	270	276	PF00069	0.194
MOD_Plk_2-3	78	84	PF00069	0.445
MOD_Plk_4	12	18	PF00069	0.532
MOD_Plk_4	179	185	PF00069	0.587
MOD_Plk_4	229	235	PF00069	0.462
MOD_Plk_4	251	257	PF00069	0.395
MOD_Plk_4	469	475	PF00069	0.560
MOD_Plk_4	88	94	PF00069	0.419
MOD_Plk_4	97	103	PF00069	0.345
MOD_ProDKin_1	159	165	PF00069	0.699
MOD_ProDKin_1	294	300	PF00069	0.357
MOD_ProDKin_1	306	312	PF00069	0.255
MOD_ProDKin_1	32	38	PF00069	0.411
MOD_ProDKin_1	4	10	PF00069	0.632
MOD_ProDKin_1	455	461	PF00069	0.637
TRG_DiLeu_BaEn_1	40	45	PF01217	0.460
TRG_DiLeu_BaLyEn_6	208	213	PF01217	0.553
TRG_DiLeu_LyEn_5	5	10	PF01217	0.529
TRG_ENDOCYTIC_2	255	258	PF00928	0.343
TRG_ER_diArg_1	199	202	PF00400	0.505
TRG_ER_diArg_1	22	25	PF00400	0.442
TRG_ER_diArg_1	334	337	PF00400	0.302
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	337	341	PF00026	0.362
TRG_Pf-PMV_PEXEL_1	397	402	PF00026	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Y0	Leptomonas seymouri	41%	100%
A0A3S7WX61	Leishmania donovani	86%	100%
A4HCA5	Leishmania braziliensis	69%	100%
A4HZT7	Leishmania infantum	86%	100%
Q4QBT7	Leishmania major	84%	100%
V5BR45	Trypanosoma cruzi	32%	100%