TsaA-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterised protein family UPF0066, putative

Species:

Leishmania mexicana

UniProt:

E9AVP1_LEIMU

TriTrypDb:

LmxM.22.0590

Length:

492

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVP1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVP1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	465	469	PF00656	0.518
CLV_NRD_NRD_1	108	110	PF00675	0.638
CLV_NRD_NRD_1	116	118	PF00675	0.641
CLV_NRD_NRD_1	317	319	PF00675	0.679
CLV_NRD_NRD_1	378	380	PF00675	0.599
CLV_PCSK_KEX2_1	115	117	PF00082	0.696
CLV_PCSK_KEX2_1	377	379	PF00082	0.599
CLV_PCSK_KEX2_1	48	50	PF00082	0.668
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.668
CLV_PCSK_PC7_1	112	118	PF00082	0.675
CLV_PCSK_SKI1_1	121	125	PF00082	0.638
CLV_PCSK_SKI1_1	321	325	PF00082	0.493
CLV_PCSK_SKI1_1	401	405	PF00082	0.405
CLV_PCSK_SKI1_1	481	485	PF00082	0.510
CLV_PCSK_SKI1_1	66	70	PF00082	0.572
DEG_SPOP_SBC_1	132	136	PF00917	0.740
DOC_ANK_TNKS_1	38	45	PF00023	0.492
DOC_MAPK_gen_1	191	200	PF00069	0.714
DOC_MAPK_gen_1	205	215	PF00069	0.481
DOC_MAPK_MEF2A_6	193	202	PF00069	0.713
DOC_PP2B_LxvP_1	91	94	PF13499	0.671
DOC_PP4_FxxP_1	304	307	PF00568	0.581
DOC_PP4_FxxP_1	92	95	PF00568	0.431
DOC_USP7_MATH_1	13	17	PF00917	0.782
DOC_USP7_MATH_1	132	136	PF00917	0.740
DOC_USP7_MATH_1	146	150	PF00917	0.545
DOC_USP7_MATH_1	159	163	PF00917	0.489
DOC_USP7_MATH_1	19	23	PF00917	0.727
DOC_USP7_MATH_1	307	311	PF00917	0.630
DOC_USP7_MATH_1	326	330	PF00917	0.675
DOC_USP7_UBL2_3	124	128	PF12436	0.725
DOC_USP7_UBL2_3	474	478	PF12436	0.562
DOC_WW_Pin1_4	147	152	PF00397	0.635
DOC_WW_Pin1_4	15	20	PF00397	0.598
DOC_WW_Pin1_4	233	238	PF00397	0.570
DOC_WW_Pin1_4	347	352	PF00397	0.772
DOC_WW_Pin1_4	4	9	PF00397	0.736
DOC_WW_Pin1_4	405	410	PF00397	0.376
DOC_WW_Pin1_4	438	443	PF00397	0.376
LIG_14-3-3_CanoR_1	193	200	PF00244	0.705
LIG_14-3-3_CanoR_1	232	236	PF00244	0.648
LIG_14-3-3_CanoR_1	481	489	PF00244	0.675
LIG_APCC_ABBA_1	213	218	PF00400	0.637
LIG_BIR_II_1	1	5	PF00653	0.694
LIG_BIR_III_2	454	458	PF00653	0.445
LIG_BIR_III_4	468	472	PF00653	0.590
LIG_deltaCOP1_diTrp_1	294	304	PF00928	0.438
LIG_deltaCOP1_diTrp_1	397	404	PF00928	0.430
LIG_EH1_1	56	64	PF00400	0.589
LIG_FHA_1	193	199	PF00498	0.655
LIG_FHA_1	219	225	PF00498	0.651
LIG_FHA_1	272	278	PF00498	0.509
LIG_FHA_1	388	394	PF00498	0.353
LIG_FHA_1	439	445	PF00498	0.376
LIG_FHA_2	136	142	PF00498	0.787
LIG_FHA_2	192	198	PF00498	0.585
LIG_FHA_2	212	218	PF00498	0.382
LIG_FHA_2	22	28	PF00498	0.727
LIG_HCF-1_HBM_1	476	479	PF13415	0.610
LIG_LIR_Apic_2	303	307	PF02991	0.574
LIG_LIR_Apic_2	61	67	PF02991	0.503
LIG_LIR_Gen_1	294	305	PF02991	0.410
LIG_LIR_Nem_3	294	300	PF02991	0.383
LIG_LIR_Nem_3	397	403	PF02991	0.430
LIG_NBox_RRM_1	220	230	PF00076	0.638
LIG_Pex14_1	400	404	PF04695	0.430
LIG_Pex14_2	293	297	PF04695	0.429
LIG_Pex14_2	300	304	PF04695	0.461
LIG_REV1ctd_RIR_1	186	195	PF16727	0.579
LIG_SH2_NCK_1	216	220	PF00017	0.590
LIG_SH2_SRC	216	219	PF00017	0.638
LIG_SH2_STAP1	216	220	PF00017	0.590
LIG_SH2_STAP1	479	483	PF00017	0.551
LIG_SH2_STAT3	479	482	PF00017	0.631
LIG_SH2_STAT5	187	190	PF00017	0.579
LIG_SH2_STAT5	449	452	PF00017	0.376
LIG_SH2_STAT5	56	59	PF00017	0.552
LIG_SH3_3	166	172	PF00018	0.739
LIG_SH3_3	259	265	PF00018	0.494
LIG_SH3_3	406	412	PF00018	0.352
LIG_SH3_3	445	451	PF00018	0.376
LIG_SH3_3	68	74	PF00018	0.538
LIG_TRAF2_1	194	197	PF00917	0.611
LIG_WRC_WIRS_1	373	378	PF05994	0.650
LIG_WW_3	393	397	PF00397	0.376
MOD_CDC14_SPxK_1	150	153	PF00782	0.497
MOD_CDC14_SPxK_1	236	239	PF00782	0.553
MOD_CDC14_SPxK_1	408	411	PF00782	0.376
MOD_CDK_SPxK_1	147	153	PF00069	0.504
MOD_CDK_SPxK_1	233	239	PF00069	0.568
MOD_CDK_SPxK_1	405	411	PF00069	0.376
MOD_CK1_1	135	141	PF00069	0.753
MOD_CK1_1	18	24	PF00069	0.792
MOD_CK1_1	25	31	PF00069	0.783
MOD_CK2_1	135	141	PF00069	0.785
MOD_CK2_1	191	197	PF00069	0.623
MOD_CK2_1	211	217	PF00069	0.385
MOD_CK2_1	326	332	PF00069	0.648
MOD_CK2_1	360	366	PF00069	0.752
MOD_GlcNHglycan	1	4	PF01048	0.630
MOD_GlcNHglycan	143	146	PF01048	0.708
MOD_GlcNHglycan	157	160	PF01048	0.719
MOD_GlcNHglycan	161	164	PF01048	0.667
MOD_GlcNHglycan	21	24	PF01048	0.637
MOD_GlcNHglycan	309	312	PF01048	0.651
MOD_GlcNHglycan	325	329	PF01048	0.665
MOD_GlcNHglycan	335	338	PF01048	0.783
MOD_GlcNHglycan	468	472	PF01048	0.519
MOD_GSK3_1	13	20	PF00069	0.713
MOD_GSK3_1	131	138	PF00069	0.737
MOD_GSK3_1	155	162	PF00069	0.800
MOD_GSK3_1	173	180	PF00069	0.479
MOD_GSK3_1	21	28	PF00069	0.709
MOD_GSK3_1	324	331	PF00069	0.762
MOD_GSK3_1	338	345	PF00069	0.632
MOD_NEK2_1	1	6	PF00069	0.631
MOD_NEK2_1	300	305	PF00069	0.460
MOD_NEK2_1	467	472	PF00069	0.510
MOD_NEK2_2	313	318	PF00069	0.656
MOD_PIKK_1	1	7	PF00454	0.493
MOD_PIKK_1	218	224	PF00454	0.702
MOD_PIKK_1	481	487	PF00454	0.633
MOD_PKA_2	192	198	PF00069	0.635
MOD_PKA_2	231	237	PF00069	0.696
MOD_PKA_2	360	366	PF00069	0.603
MOD_Plk_1	211	217	PF00069	0.614
MOD_Plk_4	211	217	PF00069	0.638
MOD_Plk_4	250	256	PF00069	0.484
MOD_Plk_4	387	393	PF00069	0.358
MOD_ProDKin_1	147	153	PF00069	0.636
MOD_ProDKin_1	15	21	PF00069	0.598
MOD_ProDKin_1	233	239	PF00069	0.568
MOD_ProDKin_1	347	353	PF00069	0.770
MOD_ProDKin_1	4	10	PF00069	0.739
MOD_ProDKin_1	405	411	PF00069	0.376
MOD_ProDKin_1	438	444	PF00069	0.376
MOD_SUMO_rev_2	316	326	PF00179	0.453
TRG_ENDOCYTIC_2	449	452	PF00928	0.346
TRG_ENDOCYTIC_2	56	59	PF00928	0.605
TRG_ER_diArg_1	115	117	PF00400	0.618
TRG_ER_diArg_1	277	280	PF00400	0.536
TRG_ER_diArg_1	376	379	PF00400	0.619
TRG_ER_diArg_1	50	53	PF00400	0.697
TRG_ER_diArg_1	87	90	PF00400	0.635
TRG_NES_CRM1_1	289	301	PF08389	0.271
TRG_NLS_MonoExtC_3	46	51	PF00514	0.682
TRG_NLS_MonoExtN_4	47	52	PF00514	0.680

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB52	Leptomonas seymouri	65%	100%
A0A1X0NT94	Trypanosomatidae	54%	100%
A0A3S7WX66	Leishmania donovani	90%	100%
A4HCA4	Leishmania braziliensis	77%	100%
A4HZT6	Leishmania infantum	90%	100%
Q4QBT8	Leishmania major	89%	99%