Protein RER1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Protein RER1

Gene product:

rer1 family-like protein

Species:

Leishmania mexicana

UniProt:

E9AVP0_LEIMU

TriTrypDb:

LmxM.22.0580

Length:

183

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	9
GO:0016020	membrane	2	9
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:0005783	endoplasmic reticulum	5	1

Expansion

Sequence features

E9AVP0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVP0

Function

Biological processes
Term	Name	Level	Count
GO:0051179	localization	1	10
GO:0006621	protein retention in ER lumen	6	1
GO:0006810	transport	3	1
GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	6	1
GO:0009987	cellular process	1	1
GO:0016192	vesicle-mediated transport	4	1
GO:0032507	maintenance of protein location in cell	3	1
GO:0035437	maintenance of protein localization in endoplasmic reticulum	5	1
GO:0045185	maintenance of protein location	3	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051234	establishment of localization	2	1
GO:0051235	maintenance of location	2	1
GO:0051651	maintenance of location in cell	2	1
GO:0072595	maintenance of protein localization in organelle	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	85	89	PF00656	0.380
CLV_NRD_NRD_1	17	19	PF00675	0.259
CLV_PCSK_KEX2_1	25	27	PF00082	0.281
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.281
CLV_PCSK_PC7_1	21	27	PF00082	0.320
CLV_PCSK_SKI1_1	116	120	PF00082	0.323
CLV_PCSK_SKI1_1	52	56	PF00082	0.338
DEG_SPOP_SBC_1	179	183	PF00917	0.708
DOC_CKS1_1	77	82	PF01111	0.295
DOC_MAPK_RevD_3	10	26	PF00069	0.344
DOC_PP1_RVXF_1	33	40	PF00149	0.447
DOC_PP1_RVXF_1	50	57	PF00149	0.339
DOC_PP2B_LxvP_1	134	137	PF13499	0.256
DOC_PP4_FxxP_1	7	10	PF00568	0.503
DOC_USP7_UBL2_3	176	180	PF12436	0.604
DOC_WW_Pin1_4	76	81	PF00397	0.295
LIG_14-3-3_CanoR_1	21	25	PF00244	0.471
LIG_14-3-3_CanoR_1	52	57	PF00244	0.368
LIG_APCC_ABBA_1	130	135	PF00400	0.157
LIG_BIR_II_1	1	5	PF00653	0.589
LIG_BRCT_BRCA1_1	3	7	PF00533	0.500
LIG_CaM_IQ_9	150	166	PF13499	0.295
LIG_eIF4E_1	72	78	PF01652	0.338
LIG_FHA_1	61	67	PF00498	0.373
LIG_FHA_2	93	99	PF00498	0.527
LIG_LIR_Apic_2	4	10	PF02991	0.501
LIG_LIR_Gen_1	120	131	PF02991	0.316
LIG_LIR_Nem_3	100	105	PF02991	0.444
LIG_LIR_Nem_3	120	126	PF02991	0.303
LIG_LIR_Nem_3	129	134	PF02991	0.265
LIG_LIR_Nem_3	23	27	PF02991	0.461
LIG_LIR_Nem_3	55	59	PF02991	0.368
LIG_NRBOX	69	75	PF00104	0.317
LIG_Pex14_1	115	119	PF04695	0.331
LIG_Pex14_2	119	123	PF04695	0.333
LIG_Pex14_2	127	131	PF04695	0.257
LIG_Pex14_2	147	151	PF04695	0.110
LIG_PTB_Apo_2	11	18	PF02174	0.473
LIG_SH2_SRC	27	30	PF00017	0.522
LIG_SH2_STAT5	146	149	PF00017	0.295
LIG_SH2_STAT5	167	170	PF00017	0.431
LIG_SH2_STAT5	27	30	PF00017	0.484
LIG_SH2_STAT5	49	52	PF00017	0.321
LIG_SH2_STAT5	60	63	PF00017	0.247
LIG_SH2_STAT5	72	75	PF00017	0.314
LIG_SH3_3	101	107	PF00018	0.431
LIG_SH3_3	135	141	PF00018	0.242
LIG_SH3_3	9	15	PF00018	0.483
LIG_SUMO_SIM_par_1	73	79	PF11976	0.315
LIG_TYR_ITIM	144	149	PF00017	0.191
LIG_TYR_ITIM	70	75	PF00017	0.314
LIG_WRC_WIRS_1	53	58	PF05994	0.437
LIG_WRPW_2	102	105	PF00400	0.442
MOD_CK1_1	91	97	PF00069	0.470
MOD_CK2_1	92	98	PF00069	0.418
MOD_GSK3_1	87	94	PF00069	0.518
MOD_NEK2_1	126	131	PF00069	0.300
MOD_NEK2_1	150	155	PF00069	0.314
MOD_NEK2_1	28	33	PF00069	0.462
MOD_PIKK_1	150	156	PF00454	0.314
MOD_PKA_2	20	26	PF00069	0.497
MOD_Plk_1	28	34	PF00069	0.455
MOD_Plk_4	126	132	PF00069	0.333
MOD_ProDKin_1	76	82	PF00069	0.295
TRG_DiLeu_BaEn_2	100	106	PF01217	0.494
TRG_ENDOCYTIC_2	102	105	PF00928	0.522
TRG_ENDOCYTIC_2	146	149	PF00928	0.257
TRG_ENDOCYTIC_2	72	75	PF00928	0.361
TRG_NLS_MonoExtN_4	15	22	PF00514	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2L3	Leptomonas seymouri	78%	100%
A0A0S4INL9	Bodo saltans	55%	100%
A0A1X0NTI3	Trypanosomatidae	60%	99%
A0A3R7MCZ0	Trypanosoma rangeli	60%	99%
A0A3S7WX19	Leishmania donovani	92%	100%
A4HZT5	Leishmania infantum	92%	100%
A5PJ65	Bos taurus	38%	93%
C9ZRM1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
O15258	Homo sapiens	37%	93%
O48670	Arabidopsis thaliana	40%	96%
O48671	Arabidopsis thaliana	39%	94%
P25560	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	97%
P52879	Caenorhabditis elegans	37%	96%
P79003	Saccharomyces pastorianus	34%	97%
Q10358	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	99%
Q498C8	Rattus norvegicus	38%	93%
Q4QBT9	Leishmania major	89%	100%
Q54D10	Dictyostelium discoideum	41%	97%
Q5R5U4	Pongo abelii	37%	93%
Q5ZHM5	Gallus gallus	38%	93%
Q9CQU3	Mus musculus	38%	93%
Q9ZPV7	Arabidopsis thaliana	40%	83%
Q9ZWI7	Arabidopsis thaliana	37%	86%