Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinesin, putative

Species:

Leishmania mexicana

UniProt:

E9AVN8_LEIMU

TriTrypDb:

LmxM.22.0560

Length:

890

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	17
GO:0099080	supramolecular complex	2	17
GO:0099081	supramolecular polymer	3	17
GO:0099512	supramolecular fiber	4	17
GO:0099513	polymeric cytoskeletal fiber	5	17
GO:0110165	cellular anatomical entity	1	18
GO:0005737	cytoplasm	2	2
GO:0005871	kinesin complex	3	2
GO:0005875	microtubule associated complex	2	2
GO:0032991	protein-containing complex	1	2

Expansion

Sequence features

E9AVN8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVN8

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	22
GO:0007018	microtubule-based movement	3	22
GO:0009987	cellular process	1	22
GO:0006810	transport	3	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	22
GO:0003774	cytoskeletal motor activity	1	22
GO:0003777	microtubule motor activity	2	22
GO:0005488	binding	1	22
GO:0005515	protein binding	2	22
GO:0005524	ATP binding	5	22
GO:0008017	microtubule binding	5	22
GO:0008092	cytoskeletal protein binding	3	22
GO:0015631	tubulin binding	4	22
GO:0017076	purine nucleotide binding	4	22
GO:0030554	adenyl nucleotide binding	5	22
GO:0032553	ribonucleotide binding	3	22
GO:0032555	purine ribonucleotide binding	4	22
GO:0032559	adenyl ribonucleotide binding	5	22
GO:0035639	purine ribonucleoside triphosphate binding	4	22
GO:0036094	small molecule binding	2	22
GO:0043167	ion binding	2	22
GO:0043168	anion binding	3	22
GO:0097159	organic cyclic compound binding	2	22
GO:0097367	carbohydrate derivative binding	2	22
GO:0140657	ATP-dependent activity	1	22
GO:1901265	nucleoside phosphate binding	3	22
GO:1901363	heterocyclic compound binding	2	22
GO:0003824	catalytic activity	1	9
GO:0016787	hydrolase activity	2	9
GO:0008574	plus-end-directed microtubule motor activity	3	1
GO:0016462	pyrophosphatase activity	5	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0016887	ATP hydrolysis activity	7	2
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.634
CLV_C14_Caspase3-7	752	756	PF00656	0.556
CLV_NRD_NRD_1	300	302	PF00675	0.565
CLV_NRD_NRD_1	457	459	PF00675	0.566
CLV_NRD_NRD_1	618	620	PF00675	0.394
CLV_NRD_NRD_1	774	776	PF00675	0.779
CLV_PCSK_FUR_1	427	431	PF00082	0.389
CLV_PCSK_KEX2_1	300	302	PF00082	0.548
CLV_PCSK_KEX2_1	429	431	PF00082	0.416
CLV_PCSK_KEX2_1	618	620	PF00082	0.524
CLV_PCSK_KEX2_1	774	776	PF00082	0.757
CLV_PCSK_KEX2_1	816	818	PF00082	0.428
CLV_PCSK_PC1ET2_1	429	431	PF00082	0.416
CLV_PCSK_PC1ET2_1	816	818	PF00082	0.429
CLV_PCSK_SKI1_1	147	151	PF00082	0.272
CLV_PCSK_SKI1_1	313	317	PF00082	0.473
CLV_PCSK_SKI1_1	334	338	PF00082	0.296
CLV_PCSK_SKI1_1	353	357	PF00082	0.338
CLV_PCSK_SKI1_1	429	433	PF00082	0.259
CLV_PCSK_SKI1_1	458	462	PF00082	0.521
CLV_PCSK_SKI1_1	531	535	PF00082	0.553
CLV_PCSK_SKI1_1	581	585	PF00082	0.654
CLV_PCSK_SKI1_1	763	767	PF00082	0.469
CLV_Separin_Metazoa	625	629	PF03568	0.561
DEG_SCF_FBW7_2	408	413	PF00400	0.389
DOC_CYCLIN_RxL_1	455	465	PF00134	0.477
DOC_MAPK_gen_1	427	437	PF00069	0.422
DOC_MAPK_gen_1	531	539	PF00069	0.440
DOC_MAPK_gen_1	579	587	PF00069	0.631
DOC_MAPK_gen_1	688	696	PF00069	0.345
DOC_MAPK_gen_1	814	823	PF00069	0.458
DOC_MAPK_gen_1	824	832	PF00069	0.436
DOC_MAPK_HePTP_8	813	825	PF00069	0.344
DOC_MAPK_MEF2A_6	104	113	PF00069	0.396
DOC_MAPK_MEF2A_6	240	249	PF00069	0.265
DOC_MAPK_MEF2A_6	807	815	PF00069	0.334
DOC_MAPK_MEF2A_6	816	825	PF00069	0.426
DOC_USP7_MATH_1	155	159	PF00917	0.378
DOC_USP7_MATH_1	173	177	PF00917	0.435
DOC_USP7_MATH_1	411	415	PF00917	0.344
DOC_USP7_MATH_1	497	501	PF00917	0.721
DOC_USP7_MATH_1	761	765	PF00917	0.527
DOC_USP7_UBL2_3	855	859	PF12436	0.440
DOC_WW_Pin1_4	102	107	PF00397	0.398
DOC_WW_Pin1_4	174	179	PF00397	0.402
DOC_WW_Pin1_4	406	411	PF00397	0.362
DOC_WW_Pin1_4	493	498	PF00397	0.689
LIG_14-3-3_CanoR_1	170	178	PF00244	0.269
LIG_14-3-3_CanoR_1	218	228	PF00244	0.272
LIG_14-3-3_CanoR_1	246	250	PF00244	0.391
LIG_14-3-3_CanoR_1	284	292	PF00244	0.693
LIG_14-3-3_CanoR_1	364	372	PF00244	0.388
LIG_14-3-3_CanoR_1	419	423	PF00244	0.262
LIG_14-3-3_CanoR_1	568	572	PF00244	0.604
LIG_14-3-3_CanoR_1	618	627	PF00244	0.526
LIG_14-3-3_CanoR_1	702	710	PF00244	0.557
LIG_APCC_ABBA_1	139	144	PF00400	0.333
LIG_APCC_ABBA_1	380	385	PF00400	0.273
LIG_APCC_ABBAyCdc20_2	127	133	PF00400	0.389
LIG_FHA_1	179	185	PF00498	0.254
LIG_FHA_1	387	393	PF00498	0.336
LIG_FHA_1	400	406	PF00498	0.333
LIG_FHA_1	407	413	PF00498	0.334
LIG_FHA_1	455	461	PF00498	0.505
LIG_FHA_1	463	469	PF00498	0.456
LIG_FHA_1	57	63	PF00498	0.266
LIG_FHA_1	572	578	PF00498	0.572
LIG_FHA_1	582	588	PF00498	0.601
LIG_FHA_1	651	657	PF00498	0.499
LIG_FHA_1	668	674	PF00498	0.646
LIG_FHA_2	272	278	PF00498	0.666
LIG_FHA_2	358	364	PF00498	0.406
LIG_FHA_2	533	539	PF00498	0.523
LIG_FHA_2	56	62	PF00498	0.407
LIG_FHA_2	707	713	PF00498	0.668
LIG_FHA_2	750	756	PF00498	0.740
LIG_Integrin_RGD_1	660	662	PF01839	0.461
LIG_LIR_Gen_1	115	122	PF02991	0.313
LIG_LIR_Gen_1	132	142	PF02991	0.377
LIG_LIR_Gen_1	400	408	PF02991	0.266
LIG_LIR_Gen_1	48	57	PF02991	0.333
LIG_LIR_Gen_1	681	689	PF02991	0.630
LIG_LIR_Gen_1	94	103	PF02991	0.272
LIG_LIR_Nem_3	115	120	PF02991	0.307
LIG_LIR_Nem_3	132	138	PF02991	0.385
LIG_LIR_Nem_3	195	201	PF02991	0.337
LIG_LIR_Nem_3	379	383	PF02991	0.283
LIG_LIR_Nem_3	400	404	PF02991	0.270
LIG_LIR_Nem_3	48	52	PF02991	0.335
LIG_LIR_Nem_3	681	685	PF02991	0.591
LIG_LIR_Nem_3	726	732	PF02991	0.458
LIG_LIR_Nem_3	94	98	PF02991	0.260
LIG_NRBOX	145	151	PF00104	0.334
LIG_NRBOX	387	393	PF00104	0.319
LIG_NRBOX	727	733	PF00104	0.459
LIG_PCNA_yPIPBox_3	143	151	PF02747	0.384
LIG_SH2_CRK	682	686	PF00017	0.567
LIG_SH2_NCK_1	221	225	PF00017	0.389
LIG_SH2_NCK_1	53	57	PF00017	0.233
LIG_SH2_SRC	53	56	PF00017	0.350
LIG_SH2_STAP1	221	225	PF00017	0.254
LIG_SH2_STAP1	53	57	PF00017	0.381
LIG_SH2_STAP1	63	67	PF00017	0.296
LIG_SH2_STAT3	142	145	PF00017	0.240
LIG_SH2_STAT3	478	481	PF00017	0.551
LIG_SH2_STAT5	201	204	PF00017	0.279
LIG_SH2_STAT5	221	224	PF00017	0.243
LIG_SH2_STAT5	254	257	PF00017	0.632
LIG_SH2_STAT5	467	470	PF00017	0.452
LIG_SH2_STAT5	664	667	PF00017	0.519
LIG_SH2_STAT5	95	98	PF00017	0.285
LIG_SH3_3	880	886	PF00018	0.456
LIG_SUMO_SIM_anti_2	692	698	PF11976	0.474
LIG_SUMO_SIM_anti_2	766	772	PF11976	0.419
LIG_SUMO_SIM_par_1	189	195	PF11976	0.314
LIG_SUMO_SIM_par_1	582	588	PF11976	0.471
LIG_SxIP_EBH_1	374	384	PF03271	0.233
LIG_TRAF2_1	212	215	PF00917	0.331
LIG_TRAF2_1	273	276	PF00917	0.672
LIG_TRAF2_1	525	528	PF00917	0.491
LIG_TRAF2_1	629	632	PF00917	0.514
LIG_TRAF2_2	743	748	PF00917	0.479
LIG_UBA3_1	845	852	PF00899	0.487
MOD_CK1_1	165	171	PF00069	0.501
MOD_CK1_1	174	180	PF00069	0.426
MOD_CK1_1	226	232	PF00069	0.311
MOD_CK1_1	238	244	PF00069	0.371
MOD_CK1_1	287	293	PF00069	0.681
MOD_CK1_1	3	9	PF00069	0.470
MOD_CK1_1	354	360	PF00069	0.329
MOD_CK1_1	367	373	PF00069	0.282
MOD_CK1_1	386	392	PF00069	0.352
MOD_CK1_1	418	424	PF00069	0.325
MOD_CK1_1	493	499	PF00069	0.704
MOD_CK1_1	570	576	PF00069	0.603
MOD_CK1_1	706	712	PF00069	0.435
MOD_CK1_1	91	97	PF00069	0.326
MOD_CK2_1	134	140	PF00069	0.306
MOD_CK2_1	189	195	PF00069	0.260
MOD_CK2_1	209	215	PF00069	0.272
MOD_CK2_1	270	276	PF00069	0.681
MOD_CK2_1	33	39	PF00069	0.262
MOD_CK2_1	411	417	PF00069	0.335
MOD_CK2_1	5	11	PF00069	0.423
MOD_CK2_1	532	538	PF00069	0.610
MOD_CK2_1	55	61	PF00069	0.356
MOD_CK2_1	588	594	PF00069	0.508
MOD_CK2_1	618	624	PF00069	0.491
MOD_Cter_Amidation	298	301	PF01082	0.537
MOD_GlcNHglycan	155	158	PF01048	0.410
MOD_GlcNHglycan	164	167	PF01048	0.480
MOD_GlcNHglycan	173	176	PF01048	0.326
MOD_GlcNHglycan	184	187	PF01048	0.444
MOD_GlcNHglycan	228	231	PF01048	0.338
MOD_GlcNHglycan	27	30	PF01048	0.459
MOD_GlcNHglycan	413	416	PF01048	0.452
MOD_GlcNHglycan	499	502	PF01048	0.689
MOD_GlcNHglycan	554	557	PF01048	0.586
MOD_GlcNHglycan	732	735	PF01048	0.562
MOD_GlcNHglycan	90	93	PF01048	0.326
MOD_GSK3_1	173	180	PF00069	0.490
MOD_GSK3_1	219	226	PF00069	0.306
MOD_GSK3_1	245	252	PF00069	0.379
MOD_GSK3_1	283	290	PF00069	0.666
MOD_GSK3_1	353	360	PF00069	0.295
MOD_GSK3_1	367	374	PF00069	0.338
MOD_GSK3_1	411	418	PF00069	0.367
MOD_GSK3_1	493	500	PF00069	0.698
MOD_GSK3_1	567	574	PF00069	0.597
MOD_GSK3_1	581	588	PF00069	0.690
MOD_GSK3_1	719	726	PF00069	0.439
MOD_GSK3_1	732	739	PF00069	0.576
MOD_GSK3_1	749	756	PF00069	0.618
MOD_GSK3_1	98	105	PF00069	0.356
MOD_LATS_1	317	323	PF00433	0.176
MOD_N-GLC_1	153	158	PF02516	0.176
MOD_N-GLC_1	351	356	PF02516	0.333
MOD_N-GLC_1	706	711	PF02516	0.453
MOD_N-GLC_1	79	84	PF02516	0.292
MOD_NEK2_1	184	189	PF00069	0.207
MOD_NEK2_1	391	396	PF00069	0.286
MOD_NEK2_1	454	459	PF00069	0.500
MOD_NEK2_1	571	576	PF00069	0.621
MOD_NEK2_1	585	590	PF00069	0.563
MOD_NEK2_1	643	648	PF00069	0.440
MOD_NEK2_1	678	683	PF00069	0.603
MOD_NEK2_1	703	708	PF00069	0.421
MOD_NEK2_1	723	728	PF00069	0.434
MOD_NEK2_1	732	737	PF00069	0.562
MOD_NEK2_1	851	856	PF00069	0.563
MOD_NEK2_1	98	103	PF00069	0.323
MOD_NEK2_2	189	194	PF00069	0.424
MOD_NEK2_2	749	754	PF00069	0.508
MOD_NEK2_2	79	84	PF00069	0.349
MOD_NEK2_2	863	868	PF00069	0.418
MOD_PIKK_1	271	277	PF00454	0.717
MOD_PIKK_1	571	577	PF00454	0.556
MOD_PIKK_1	585	591	PF00454	0.450
MOD_PIKK_1	643	649	PF00454	0.503
MOD_PIKK_1	680	686	PF00454	0.390
MOD_PIKK_1	736	742	PF00454	0.625
MOD_PIKK_1	753	759	PF00454	0.442
MOD_PIKK_1	853	859	PF00454	0.656
MOD_PKA_1	618	624	PF00069	0.386
MOD_PKA_1	774	780	PF00069	0.514
MOD_PKA_2	226	232	PF00069	0.332
MOD_PKA_2	245	251	PF00069	0.321
MOD_PKA_2	283	289	PF00069	0.715
MOD_PKA_2	293	299	PF00069	0.694
MOD_PKA_2	383	389	PF00069	0.333
MOD_PKA_2	418	424	PF00069	0.286
MOD_PKA_2	454	460	PF00069	0.582
MOD_PKA_2	567	573	PF00069	0.600
MOD_PKA_2	618	624	PF00069	0.413
MOD_PKA_2	701	707	PF00069	0.558
MOD_PKA_2	719	725	PF00069	0.566
MOD_PKA_2	753	759	PF00069	0.624
MOD_PKA_2	774	780	PF00069	0.652
MOD_Plk_1	249	255	PF00069	0.327
MOD_Plk_1	32	38	PF00069	0.426
MOD_Plk_1	351	357	PF00069	0.324
MOD_Plk_1	581	587	PF00069	0.543
MOD_Plk_1	666	672	PF00069	0.405
MOD_Plk_1	706	712	PF00069	0.595
MOD_Plk_2-3	257	263	PF00069	0.599
MOD_Plk_2-3	33	39	PF00069	0.389
MOD_Plk_4	134	140	PF00069	0.375
MOD_Plk_4	357	363	PF00069	0.291
MOD_Plk_4	376	382	PF00069	0.317
MOD_Plk_4	462	468	PF00069	0.471
MOD_Plk_4	510	516	PF00069	0.666
MOD_Plk_4	719	725	PF00069	0.486
MOD_Plk_4	79	85	PF00069	0.331
MOD_Plk_4	93	99	PF00069	0.316
MOD_ProDKin_1	102	108	PF00069	0.398
MOD_ProDKin_1	174	180	PF00069	0.402
MOD_ProDKin_1	406	412	PF00069	0.362
MOD_ProDKin_1	493	499	PF00069	0.690
MOD_SUMO_rev_2	528	535	PF00179	0.587
MOD_SUMO_rev_2	601	608	PF00179	0.556
MOD_SUMO_rev_2	808	815	PF00179	0.410
TRG_DiLeu_BaEn_1	622	627	PF01217	0.473
TRG_DiLeu_BaEn_1	692	697	PF01217	0.514
TRG_DiLeu_BaEn_4	528	534	PF01217	0.607
TRG_DiLeu_BaEn_4	632	638	PF01217	0.557
TRG_DiLeu_BaLyEn_6	651	656	PF01217	0.441
TRG_DiLeu_BaLyEn_6	727	732	PF01217	0.440
TRG_ENDOCYTIC_2	682	685	PF00928	0.526
TRG_ENDOCYTIC_2	95	98	PF00928	0.257
TRG_ER_diArg_1	14	17	PF00400	0.383
TRG_ER_diArg_1	789	792	PF00400	0.552
TRG_ER_diArg_1	876	879	PF00400	0.592
TRG_NES_CRM1_1	663	676	PF08389	0.413
TRG_NLS_MonoExtN_4	427	433	PF00514	0.389
TRG_Pf-PMV_PEXEL_1	600	605	PF00026	0.458
TRG_Pf-PMV_PEXEL_1	794	798	PF00026	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVM1	Leptomonas seymouri	65%	96%
A0A0S4INA4	Bodo saltans	41%	100%
A0A0S4JAQ8	Bodo saltans	27%	73%
A0A1X0NUN6	Trypanosomatidae	42%	95%
A0A3R7NW09	Trypanosoma rangeli	30%	85%
A0A3S5H5N6	Leishmania donovani	26%	100%
A0A3S7WX05	Leishmania donovani	91%	100%
A0A422N2N4	Trypanosoma rangeli	42%	100%
A4H4I4	Leishmania braziliensis	24%	100%
A4HCA1	Leishmania braziliensis	77%	100%
A4HMM9	Leishmania braziliensis	30%	100%
A4HSQ9	Leishmania infantum	26%	100%
A4HZT3	Leishmania infantum	91%	100%
E9AKP6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AXS9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	83%
E9B0F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
Q4Q7S4	Leishmania major	26%	100%
Q4QBU1	Leishmania major	90%	100%
Q4QJ61	Leishmania major	26%	100%
V5BLH7	Trypanosoma cruzi	43%	100%