Peptidylprolyl isomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peptidyl-prolyl cis-trans isomerase, putative

Species:

Leishmania mexicana

UniProt:

E9AVN6_LEIMU

TriTrypDb:

LmxM.22.0530

Length:

438

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AVN6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVN6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	10
GO:0003824	catalytic activity	1	10
GO:0016853	isomerase activity	2	10
GO:0016859	cis-trans isomerase activity	3	10
GO:0140096	catalytic activity, acting on a protein	2	10
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	291	295	PF00656	0.584
CLV_C14_Caspase3-7	343	347	PF00656	0.397
CLV_NRD_NRD_1	144	146	PF00675	0.342
CLV_NRD_NRD_1	148	150	PF00675	0.332
CLV_NRD_NRD_1	360	362	PF00675	0.440
CLV_NRD_NRD_1	417	419	PF00675	0.319
CLV_PCSK_FUR_1	415	419	PF00082	0.222
CLV_PCSK_KEX2_1	144	146	PF00082	0.302
CLV_PCSK_KEX2_1	180	182	PF00082	0.587
CLV_PCSK_KEX2_1	360	362	PF00082	0.425
CLV_PCSK_KEX2_1	393	395	PF00082	0.360
CLV_PCSK_KEX2_1	417	419	PF00082	0.319
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.587
CLV_PCSK_PC1ET2_1	393	395	PF00082	0.339
CLV_PCSK_PC7_1	140	146	PF00082	0.328
CLV_PCSK_SKI1_1	352	356	PF00082	0.504
DEG_APCC_DBOX_1	393	401	PF00400	0.397
DOC_CKS1_1	372	377	PF01111	0.397
DOC_MAPK_gen_1	149	156	PF00069	0.377
DOC_MAPK_gen_1	391	399	PF00069	0.343
DOC_MAPK_MEF2A_6	149	156	PF00069	0.371
DOC_MAPK_MEF2A_6	81	89	PF00069	0.470
DOC_PP4_FxxP_1	60	63	PF00568	0.396
DOC_USP7_MATH_1	155	159	PF00917	0.354
DOC_USP7_MATH_1	255	259	PF00917	0.787
DOC_USP7_MATH_1	265	269	PF00917	0.739
DOC_USP7_MATH_1	272	276	PF00917	0.704
DOC_USP7_MATH_1	36	40	PF00917	0.527
DOC_WW_Pin1_4	23	28	PF00397	0.614
DOC_WW_Pin1_4	296	301	PF00397	0.707
DOC_WW_Pin1_4	368	373	PF00397	0.499
LIG_Actin_WH2_2	402	419	PF00022	0.397
LIG_BIR_II_1	1	5	PF00653	0.537
LIG_BIR_III_4	294	298	PF00653	0.617
LIG_BRCT_BRCA1_1	110	114	PF00533	0.269
LIG_BRCT_BRCA1_1	69	73	PF00533	0.478
LIG_CSL_BTD_1	372	375	PF09270	0.388
LIG_eIF4E_1	311	317	PF01652	0.471
LIG_FHA_1	134	140	PF00498	0.335
LIG_FHA_1	166	172	PF00498	0.511
LIG_FHA_1	26	32	PF00498	0.496
LIG_FHA_1	46	52	PF00498	0.537
LIG_FHA_2	289	295	PF00498	0.662
LIG_FHA_2	372	378	PF00498	0.497
LIG_FHA_2	402	408	PF00498	0.303
LIG_Integrin_RGD_1	394	396	PF01839	0.397
LIG_LIR_Apic_2	58	63	PF02991	0.402
LIG_LIR_Gen_1	383	390	PF02991	0.390
LIG_LIR_Nem_3	310	314	PF02991	0.554
LIG_LIR_Nem_3	383	388	PF02991	0.340
LIG_LYPXL_yS_3	84	87	PF13949	0.459
LIG_SH2_CRK	311	315	PF00017	0.431
LIG_SH2_SRC	311	314	PF00017	0.492
LIG_SH2_STAP1	169	173	PF00017	0.502
LIG_SH2_STAT5	105	108	PF00017	0.291
LIG_SH2_STAT5	353	356	PF00017	0.476
LIG_SH2_STAT5	385	388	PF00017	0.425
LIG_SH2_STAT5	95	98	PF00017	0.262
LIG_SH3_1	145	151	PF00018	0.397
LIG_SH3_3	145	151	PF00018	0.474
LIG_SH3_3	240	246	PF00018	0.637
LIG_SH3_3	26	32	PF00018	0.611
LIG_SH3_3	323	329	PF00018	0.448
LIG_SH3_3	369	375	PF00018	0.378
LIG_SH3_3	418	424	PF00018	0.291
LIG_SH3_3	66	72	PF00018	0.454
LIG_SH3_3	79	85	PF00018	0.437
LIG_SH3_5	101	105	PF00018	0.319
LIG_SUMO_SIM_par_1	129	136	PF11976	0.335
LIG_SUMO_SIM_par_1	152	158	PF11976	0.418
LIG_TRAF2_1	374	377	PF00917	0.481
LIG_TYR_ITIM	82	87	PF00017	0.469
LIG_UBA3_1	316	324	PF00899	0.452
LIG_WRC_WIRS_1	1	6	PF05994	0.577
MOD_CK1_1	165	171	PF00069	0.494
MOD_CK1_1	201	207	PF00069	0.731
MOD_CK1_1	235	241	PF00069	0.601
MOD_CK1_1	258	264	PF00069	0.545
MOD_CK1_1	371	377	PF00069	0.440
MOD_CK2_1	371	377	PF00069	0.396
MOD_Cter_Amidation	142	145	PF01082	0.369
MOD_GlcNHglycan	18	21	PF01048	0.613
MOD_GlcNHglycan	214	217	PF01048	0.640
MOD_GlcNHglycan	229	232	PF01048	0.579
MOD_GlcNHglycan	234	237	PF01048	0.708
MOD_GlcNHglycan	258	261	PF01048	0.713
MOD_GlcNHglycan	267	270	PF01048	0.683
MOD_GlcNHglycan	274	277	PF01048	0.579
MOD_GlcNHglycan	305	308	PF01048	0.701
MOD_GlcNHglycan	387	391	PF01048	0.341
MOD_GlcNHglycan	420	424	PF01048	0.342
MOD_GSK3_1	220	227	PF00069	0.605
MOD_GSK3_1	261	268	PF00069	0.752
MOD_GSK3_1	289	296	PF00069	0.662
MOD_NEK2_1	133	138	PF00069	0.291
MOD_NEK2_1	162	167	PF00069	0.352
MOD_PIKK_1	424	430	PF00454	0.422
MOD_PK_1	55	61	PF00069	0.405
MOD_PKA_2	255	261	PF00069	0.544
MOD_Plk_2-3	401	407	PF00069	0.303
MOD_Plk_4	155	161	PF00069	0.418
MOD_Plk_4	55	61	PF00069	0.480
MOD_ProDKin_1	23	29	PF00069	0.612
MOD_ProDKin_1	296	302	PF00069	0.706
MOD_ProDKin_1	368	374	PF00069	0.499
TRG_DiLeu_BaEn_2	123	129	PF01217	0.335
TRG_ENDOCYTIC_2	311	314	PF00928	0.437
TRG_ENDOCYTIC_2	385	388	PF00928	0.424
TRG_ENDOCYTIC_2	84	87	PF00928	0.518
TRG_ENDOCYTIC_2	94	97	PF00928	0.403
TRG_ER_diArg_1	144	146	PF00400	0.238
TRG_ER_diArg_1	360	362	PF00400	0.517
TRG_ER_diArg_1	414	417	PF00400	0.387
TRG_NLS_MonoCore_2	390	395	PF00514	0.397
TRG_NLS_MonoExtC_3	390	396	PF00514	0.418
TRG_Pf-PMV_PEXEL_1	180	184	PF00026	0.621

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSF6	Leptomonas seymouri	61%	100%
A0A0S4J8C1	Bodo saltans	33%	100%
A0A3Q8IE70	Leishmania donovani	91%	100%
A0A3R7K0E7	Trypanosoma rangeli	43%	100%
A4HC99	Leishmania braziliensis	77%	100%
C9ZRL7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
Q4QBU3	Leishmania major	90%	100%
V5BR42	Trypanosoma cruzi	42%	100%