Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVN4_LEIMU

TriTrypDb:

LmxM.22.0510

Length:

560

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVN4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVN4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	232	236	PF00656	0.801
CLV_C14_Caspase3-7	412	416	PF00656	0.536
CLV_NRD_NRD_1	153	155	PF00675	0.639
CLV_NRD_NRD_1	294	296	PF00675	0.534
CLV_NRD_NRD_1	529	531	PF00675	0.721
CLV_PCSK_KEX2_1	153	155	PF00082	0.582
CLV_PCSK_KEX2_1	294	296	PF00082	0.534
CLV_PCSK_KEX2_1	404	406	PF00082	0.558
CLV_PCSK_KEX2_1	529	531	PF00082	0.685
CLV_PCSK_PC1ET2_1	404	406	PF00082	0.559
CLV_PCSK_SKI1_1	146	150	PF00082	0.636
CLV_PCSK_SKI1_1	224	228	PF00082	0.615
CLV_PCSK_SKI1_1	294	298	PF00082	0.634
CLV_PCSK_SKI1_1	409	413	PF00082	0.599
CLV_PCSK_SKI1_1	55	59	PF00082	0.479
DEG_APCC_DBOX_1	145	153	PF00400	0.636
DEG_MDM2_SWIB_1	480	488	PF02201	0.608
DEG_Nend_UBRbox_3	1	3	PF02207	0.575
DEG_SCF_FBW7_1	240	247	PF00400	0.521
DEG_SPOP_SBC_1	226	230	PF00917	0.582
DEG_SPOP_SBC_1	245	249	PF00917	0.783
DEG_SPOP_SBC_1	267	271	PF00917	0.498
DEG_SPOP_SBC_1	534	538	PF00917	0.541
DOC_CYCLIN_yCln2_LP_2	352	358	PF00134	0.698
DOC_CYCLIN_yCln2_LP_2	476	482	PF00134	0.713
DOC_MAPK_gen_1	294	303	PF00069	0.516
DOC_PP1_RVXF_1	53	59	PF00149	0.510
DOC_PP2B_LxvP_1	476	479	PF13499	0.687
DOC_PP2B_LxvP_1	521	524	PF13499	0.795
DOC_PP2B_LxvP_1	59	62	PF13499	0.532
DOC_PP4_FxxP_1	264	267	PF00568	0.629
DOC_PP4_FxxP_1	32	35	PF00568	0.554
DOC_SPAK_OSR1_1	71	75	PF12202	0.598
DOC_USP7_MATH_1	159	163	PF00917	0.533
DOC_USP7_MATH_1	204	208	PF00917	0.808
DOC_USP7_MATH_1	213	217	PF00917	0.815
DOC_USP7_MATH_1	244	248	PF00917	0.794
DOC_USP7_MATH_1	305	309	PF00917	0.684
DOC_USP7_MATH_1	310	314	PF00917	0.683
DOC_USP7_MATH_1	325	329	PF00917	0.541
DOC_USP7_MATH_1	332	336	PF00917	0.678
DOC_USP7_MATH_1	392	396	PF00917	0.757
DOC_USP7_MATH_1	418	422	PF00917	0.637
DOC_USP7_UBL2_3	220	224	PF12436	0.603
DOC_WW_Pin1_4	13	18	PF00397	0.673
DOC_WW_Pin1_4	190	195	PF00397	0.748
DOC_WW_Pin1_4	240	245	PF00397	0.739
DOC_WW_Pin1_4	31	36	PF00397	0.525
DOC_WW_Pin1_4	321	326	PF00397	0.718
DOC_WW_Pin1_4	351	356	PF00397	0.627
DOC_WW_Pin1_4	367	372	PF00397	0.763
DOC_WW_Pin1_4	373	378	PF00397	0.729
DOC_WW_Pin1_4	538	543	PF00397	0.805
LIG_14-3-3_CanoR_1	246	251	PF00244	0.723
LIG_14-3-3_CanoR_1	423	432	PF00244	0.774
LIG_14-3-3_CanoR_1	513	517	PF00244	0.709
LIG_14-3-3_CanoR_1	553	560	PF00244	0.686
LIG_14-3-3_CanoR_1	71	77	PF00244	0.380
LIG_Actin_WH2_2	281	299	PF00022	0.634
LIG_Actin_WH2_2	38	54	PF00022	0.608
LIG_BRCT_BRCA1_1	229	233	PF00533	0.723
LIG_BRCT_BRCA1_1	63	67	PF00533	0.544
LIG_CSL_BTD_1	521	524	PF09270	0.795
LIG_deltaCOP1_diTrp_1	445	450	PF00928	0.585
LIG_EH1_1	285	293	PF00400	0.611
LIG_FHA_1	175	181	PF00498	0.708
LIG_FHA_1	226	232	PF00498	0.594
LIG_FHA_1	268	274	PF00498	0.618
LIG_FHA_1	504	510	PF00498	0.787
LIG_FHA_2	159	165	PF00498	0.649
LIG_FHA_2	177	183	PF00498	0.473
LIG_FHA_2	247	253	PF00498	0.703
LIG_FHA_2	410	416	PF00498	0.543
LIG_FHA_2	492	498	PF00498	0.629
LIG_Integrin_RGD_1	345	347	PF01839	0.525
LIG_LIR_Apic_2	262	267	PF02991	0.443
LIG_LIR_Apic_2	30	35	PF02991	0.571
LIG_LIR_Gen_1	445	453	PF02991	0.591
LIG_LIR_Gen_1	77	86	PF02991	0.628
LIG_LIR_Nem_3	164	169	PF02991	0.589
LIG_LIR_Nem_3	174	178	PF02991	0.548
LIG_LIR_Nem_3	445	449	PF02991	0.685
LIG_LIR_Nem_3	554	560	PF02991	0.606
LIG_LIR_Nem_3	77	83	PF02991	0.620
LIG_Pex14_2	480	484	PF04695	0.607
LIG_SH2_CRK	173	177	PF00017	0.651
LIG_SH2_NCK_1	43	47	PF00017	0.598
LIG_SH2_STAP1	43	47	PF00017	0.505
LIG_SH2_STAT5	173	176	PF00017	0.532
LIG_SH2_STAT5	287	290	PF00017	0.508
LIG_SH2_STAT5	443	446	PF00017	0.580
LIG_SH2_STAT5	547	550	PF00017	0.734
LIG_SH3_3	191	197	PF00018	0.843
LIG_SH3_3	319	325	PF00018	0.530
LIG_SH3_3	446	452	PF00018	0.695
LIG_SH3_3	514	520	PF00018	0.722
LIG_SH3_4	129	136	PF00018	0.471
LIG_SUMO_SIM_anti_2	252	257	PF11976	0.507
LIG_SUMO_SIM_par_1	176	182	PF11976	0.670
LIG_SUMO_SIM_par_1	430	436	PF11976	0.739
LIG_WRC_WIRS_1	29	34	PF05994	0.590
MOD_CDC14_SPxK_1	16	19	PF00782	0.693
MOD_CDK_SPxK_1	13	19	PF00069	0.677
MOD_CDK_SPxK_1	240	246	PF00069	0.522
MOD_CDK_SPxK_1	538	544	PF00069	0.510
MOD_CK1_1	119	125	PF00069	0.716
MOD_CK1_1	188	194	PF00069	0.763
MOD_CK1_1	196	202	PF00069	0.846
MOD_CK1_1	229	235	PF00069	0.741
MOD_CK1_1	31	37	PF00069	0.666
MOD_CK1_1	313	319	PF00069	0.705
MOD_CK1_1	323	329	PF00069	0.766
MOD_CK1_1	330	336	PF00069	0.616
MOD_CK1_1	421	427	PF00069	0.662
MOD_CK1_1	515	521	PF00069	0.702
MOD_CK1_1	537	543	PF00069	0.694
MOD_CK2_1	195	201	PF00069	0.686
MOD_CK2_1	246	252	PF00069	0.717
MOD_CK2_1	27	33	PF00069	0.495
MOD_CK2_1	323	329	PF00069	0.806
MOD_CK2_1	392	398	PF00069	0.698
MOD_CK2_1	491	497	PF00069	0.581
MOD_Cter_Amidation	407	410	PF01082	0.746
MOD_GlcNHglycan	111	114	PF01048	0.548
MOD_GlcNHglycan	119	122	PF01048	0.768
MOD_GlcNHglycan	186	190	PF01048	0.747
MOD_GlcNHglycan	20	23	PF01048	0.775
MOD_GlcNHglycan	235	238	PF01048	0.763
MOD_GlcNHglycan	270	273	PF01048	0.692
MOD_GlcNHglycan	277	280	PF01048	0.612
MOD_GlcNHglycan	312	315	PF01048	0.661
MOD_GlcNHglycan	332	335	PF01048	0.658
MOD_GlcNHglycan	337	340	PF01048	0.682
MOD_GlcNHglycan	419	423	PF01048	0.734
MOD_GlcNHglycan	517	520	PF01048	0.699
MOD_GlcNHglycan	531	534	PF01048	0.661
MOD_GSK3_1	105	112	PF00069	0.563
MOD_GSK3_1	113	120	PF00069	0.624
MOD_GSK3_1	125	132	PF00069	0.683
MOD_GSK3_1	193	200	PF00069	0.836
MOD_GSK3_1	225	232	PF00069	0.610
MOD_GSK3_1	240	247	PF00069	0.721
MOD_GSK3_1	27	34	PF00069	0.700
MOD_GSK3_1	321	328	PF00069	0.804
MOD_GSK3_1	414	421	PF00069	0.578
MOD_GSK3_1	525	532	PF00069	0.716
MOD_GSK3_1	533	540	PF00069	0.755
MOD_GSK3_1	547	554	PF00069	0.579
MOD_GSK3_1	57	64	PF00069	0.517
MOD_N-GLC_1	105	110	PF02516	0.689
MOD_NEK2_1	227	232	PF00069	0.656
MOD_NEK2_1	233	238	PF00069	0.791
MOD_NEK2_1	490	495	PF00069	0.568
MOD_NEK2_1	525	530	PF00069	0.669
MOD_NEK2_1	535	540	PF00069	0.808
MOD_NEK2_1	545	550	PF00069	0.555
MOD_NEK2_1	552	557	PF00069	0.430
MOD_NEK2_1	57	62	PF00069	0.403
MOD_PIKK_1	105	111	PF00454	0.684
MOD_PIKK_1	129	135	PF00454	0.527
MOD_PIKK_1	424	430	PF00454	0.777
MOD_PIKK_1	468	474	PF00454	0.472
MOD_PIKK_1	552	558	PF00454	0.616
MOD_PIKK_1	61	67	PF00454	0.646
MOD_PKA_1	409	415	PF00069	0.553
MOD_PKA_1	529	535	PF00069	0.745
MOD_PKA_2	18	24	PF00069	0.805
MOD_PKA_2	211	217	PF00069	0.795
MOD_PKA_2	245	251	PF00069	0.725
MOD_PKA_2	275	281	PF00069	0.607
MOD_PKA_2	512	518	PF00069	0.806
MOD_PKA_2	525	531	PF00069	0.712
MOD_PKA_2	552	558	PF00069	0.616
MOD_Plk_1	105	111	PF00069	0.689
MOD_Plk_4	229	235	PF00069	0.508
MOD_Plk_4	505	511	PF00069	0.527
MOD_Plk_4	547	553	PF00069	0.611
MOD_ProDKin_1	13	19	PF00069	0.677
MOD_ProDKin_1	190	196	PF00069	0.748
MOD_ProDKin_1	240	246	PF00069	0.741
MOD_ProDKin_1	31	37	PF00069	0.516
MOD_ProDKin_1	321	327	PF00069	0.715
MOD_ProDKin_1	351	357	PF00069	0.623
MOD_ProDKin_1	367	373	PF00069	0.768
MOD_ProDKin_1	538	544	PF00069	0.802
MOD_SUMO_rev_2	214	221	PF00179	0.732
TRG_DiLeu_BaLyEn_6	280	285	PF01217	0.610
TRG_ER_diArg_1	141	144	PF00400	0.510
TRG_ER_diArg_1	152	154	PF00400	0.308
TRG_ER_diArg_1	294	296	PF00400	0.534
TRG_ER_diArg_1	342	345	PF00400	0.615
TRG_ER_diArg_1	529	531	PF00400	0.717
TRG_Pf-PMV_PEXEL_1	451	456	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	92	97	PF00026	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZL6	Leptomonas seymouri	33%	97%
A0A3Q8IFE8	Leishmania donovani	79%	97%
A4HC97	Leishmania braziliensis	60%	100%
A4HZS9	Leishmania infantum	79%	97%
Q4QBU5	Leishmania major	79%	100%