TFIIS N-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVN3_LEIMU

TriTrypDb:

LmxM.22.0500

Length:

516

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9AVN3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVN3

Function

Biological processes
Term	Name	Level	Count
GO:0006405	RNA export from nucleus	5	1
GO:0006406	mRNA export from nucleus	6	1
GO:0006810	transport	3	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0009987	cellular process	1	1
GO:0015931	nucleobase-containing compound transport	5	1
GO:0016973	poly(A)+ mRNA export from nucleus	7	1
GO:0046907	intracellular transport	3	1
GO:0050657	nucleic acid transport	6	1
GO:0050658	RNA transport	4	1
GO:0051028	mRNA transport	5	1
GO:0051168	nuclear export	6	1
GO:0051169	nuclear transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051236	establishment of RNA localization	3	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.585
CLV_C14_Caspase3-7	221	225	PF00656	0.506
CLV_C14_Caspase3-7	234	238	PF00656	0.551
CLV_C14_Caspase3-7	409	413	PF00656	0.494
CLV_C14_Caspase3-7	84	88	PF00656	0.659
CLV_NRD_NRD_1	192	194	PF00675	0.637
CLV_NRD_NRD_1	267	269	PF00675	0.653
CLV_NRD_NRD_1	404	406	PF00675	0.541
CLV_PCSK_KEX2_1	142	144	PF00082	0.460
CLV_PCSK_KEX2_1	146	148	PF00082	0.448
CLV_PCSK_KEX2_1	150	152	PF00082	0.410
CLV_PCSK_KEX2_1	192	194	PF00082	0.575
CLV_PCSK_KEX2_1	404	406	PF00082	0.580
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.459
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.435
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.389
CLV_PCSK_SKI1_1	139	143	PF00082	0.494
CLV_PCSK_SKI1_1	248	252	PF00082	0.559
CLV_PCSK_SKI1_1	260	264	PF00082	0.622
CLV_PCSK_SKI1_1	311	315	PF00082	0.434
DEG_APCC_DBOX_1	310	318	PF00400	0.420
DEG_Nend_UBRbox_2	1	3	PF02207	0.704
DOC_CYCLIN_yCln2_LP_2	229	235	PF00134	0.629
DOC_MAPK_MEF2A_6	358	366	PF00069	0.338
DOC_PP4_FxxP_1	472	475	PF00568	0.615
DOC_USP7_MATH_1	115	119	PF00917	0.582
DOC_USP7_MATH_1	313	317	PF00917	0.528
DOC_USP7_MATH_1	74	78	PF00917	0.809
DOC_USP7_UBL2_3	138	142	PF12436	0.430
DOC_USP7_UBL2_3	146	150	PF12436	0.418
DOC_USP7_UBL2_3	163	167	PF12436	0.525
DOC_USP7_UBL2_3	171	175	PF12436	0.580
DOC_USP7_UBL2_3	176	180	PF12436	0.558
DOC_USP7_UBL2_3	195	199	PF12436	0.706
DOC_USP7_UBL2_3	260	264	PF12436	0.579
DOC_USP7_UBL2_3	443	447	PF12436	0.655
DOC_USP7_UBL2_3	470	474	PF12436	0.458
DOC_WW_Pin1_4	453	458	PF00397	0.629
LIG_14-3-3_CanoR_1	268	278	PF00244	0.513
LIG_14-3-3_CanoR_1	300	304	PF00244	0.533
LIG_14-3-3_CanoR_1	358	366	PF00244	0.414
LIG_14-3-3_CanoR_1	58	62	PF00244	0.422
LIG_Actin_WH2_2	239	254	PF00022	0.577
LIG_APCC_ABBA_1	15	20	PF00400	0.618
LIG_BRCT_BRCA1_1	464	468	PF00533	0.559
LIG_BRCT_BRCA1_2	464	470	PF00533	0.508
LIG_eIF4E_1	326	332	PF01652	0.424
LIG_FHA_1	128	134	PF00498	0.399
LIG_FHA_1	357	363	PF00498	0.416
LIG_FHA_1	375	381	PF00498	0.696
LIG_FHA_2	238	244	PF00498	0.355
LIG_FHA_2	358	364	PF00498	0.485
LIG_FHA_2	461	467	PF00498	0.484
LIG_GBD_Chelix_1	278	286	PF00786	0.479
LIG_LIR_Apic_2	471	475	PF02991	0.595
LIG_LIR_Gen_1	211	220	PF02991	0.623
LIG_LIR_Gen_1	422	431	PF02991	0.529
LIG_LIR_Gen_1	456	462	PF02991	0.628
LIG_LIR_Nem_3	339	345	PF02991	0.403
LIG_LIR_Nem_3	381	386	PF02991	0.492
LIG_LIR_Nem_3	422	427	PF02991	0.500
LIG_LIR_Nem_3	456	461	PF02991	0.631
LIG_LIR_Nem_3	481	486	PF02991	0.536
LIG_NRP_CendR_1	515	516	PF00754	0.697
LIG_Pex14_2	468	472	PF04695	0.571
LIG_SH2_CRK	483	487	PF00017	0.641
LIG_SH2_STAT5	506	509	PF00017	0.594
LIG_SH3_1	474	480	PF00018	0.528
LIG_SH3_3	363	369	PF00018	0.435
LIG_SH3_3	451	457	PF00018	0.509
LIG_SH3_3	474	480	PF00018	0.504
LIG_SH3_3	485	491	PF00018	0.528
LIG_SUMO_SIM_anti_2	2	12	PF11976	0.537
LIG_SUMO_SIM_anti_2	359	367	PF11976	0.370
LIG_SUMO_SIM_par_1	128	137	PF11976	0.550
LIG_TYR_ITSM	479	486	PF00017	0.584
LIG_UBA3_1	131	139	PF00899	0.501
LIG_WRC_WIRS_1	421	426	PF05994	0.496
MOD_CK1_1	169	175	PF00069	0.656
MOD_CK1_1	21	27	PF00069	0.657
MOD_CK1_1	429	435	PF00069	0.693
MOD_CK1_1	49	55	PF00069	0.732
MOD_CK2_1	106	112	PF00069	0.769
MOD_CK2_1	117	123	PF00069	0.592
MOD_CK2_1	237	243	PF00069	0.499
MOD_CK2_1	268	274	PF00069	0.578
MOD_CK2_1	453	459	PF00069	0.536
MOD_CK2_1	460	466	PF00069	0.469
MOD_Cter_Amidation	144	147	PF01082	0.547
MOD_Cter_Amidation	190	193	PF01082	0.571
MOD_GlcNHglycan	108	111	PF01048	0.698
MOD_GlcNHglycan	117	120	PF01048	0.596
MOD_GlcNHglycan	189	192	PF01048	0.735
MOD_GlcNHglycan	25	28	PF01048	0.683
MOD_GlcNHglycan	271	274	PF01048	0.577
MOD_GlcNHglycan	297	300	PF01048	0.456
MOD_GlcNHglycan	34	37	PF01048	0.611
MOD_GlcNHglycan	428	431	PF01048	0.489
MOD_GlcNHglycan	46	51	PF01048	0.764
MOD_GlcNHglycan	499	502	PF01048	0.632
MOD_GlcNHglycan	76	79	PF01048	0.784
MOD_GSK3_1	127	134	PF00069	0.343
MOD_GSK3_1	154	161	PF00069	0.549
MOD_GSK3_1	165	172	PF00069	0.584
MOD_GSK3_1	21	28	PF00069	0.676
MOD_GSK3_1	233	240	PF00069	0.551
MOD_GSK3_1	251	258	PF00069	0.544
MOD_GSK3_1	263	270	PF00069	0.584
MOD_GSK3_1	295	302	PF00069	0.432
MOD_GSK3_1	370	377	PF00069	0.580
MOD_GSK3_1	42	49	PF00069	0.774
MOD_GSK3_1	422	429	PF00069	0.501
MOD_GSK3_1	57	64	PF00069	0.479
MOD_N-GLC_1	412	417	PF02516	0.262
MOD_N-GLC_1	497	502	PF02516	0.639
MOD_N-GLC_1	66	71	PF02516	0.506
MOD_NEK2_1	131	136	PF00069	0.504
MOD_NEK2_1	155	160	PF00069	0.470
MOD_NEK2_1	251	256	PF00069	0.629
MOD_NEK2_1	357	362	PF00069	0.410
MOD_NEK2_1	370	375	PF00069	0.518
MOD_NEK2_1	420	425	PF00069	0.479
MOD_NEK2_1	468	473	PF00069	0.610
MOD_NEK2_1	57	62	PF00069	0.570
MOD_NEK2_2	208	213	PF00069	0.597
MOD_PIKK_1	263	269	PF00454	0.587
MOD_PIKK_1	34	40	PF00454	0.531
MOD_PKA_1	187	193	PF00069	0.689
MOD_PKA_1	195	201	PF00069	0.708
MOD_PKA_1	263	269	PF00069	0.546
MOD_PKA_2	251	257	PF00069	0.486
MOD_PKA_2	267	273	PF00069	0.593
MOD_PKA_2	299	305	PF00069	0.539
MOD_PKA_2	357	363	PF00069	0.348
MOD_PKA_2	57	63	PF00069	0.635
MOD_Plk_1	127	133	PF00069	0.408
MOD_Plk_1	21	27	PF00069	0.470
MOD_Plk_1	3	9	PF00069	0.658
MOD_Plk_1	338	344	PF00069	0.315
MOD_Plk_1	378	384	PF00069	0.606
MOD_Plk_1	407	413	PF00069	0.512
MOD_Plk_2-3	66	72	PF00069	0.609
MOD_Plk_4	127	133	PF00069	0.481
MOD_Plk_4	208	214	PF00069	0.598
MOD_Plk_4	3	9	PF00069	0.675
MOD_Plk_4	313	319	PF00069	0.489
MOD_Plk_4	338	344	PF00069	0.320
MOD_Plk_4	468	474	PF00069	0.518
MOD_ProDKin_1	453	459	PF00069	0.627
MOD_SUMO_rev_2	134	141	PF00179	0.495
MOD_SUMO_rev_2	408	415	PF00179	0.283
MOD_SUMO_rev_2	433	442	PF00179	0.656
TRG_DiLeu_BaEn_2	208	214	PF01217	0.598
TRG_DiLeu_BaEn_3	2	8	PF01217	0.696
TRG_DiLeu_BaEn_4	3	9	PF01217	0.697
TRG_ENDOCYTIC_2	483	486	PF00928	0.547
TRG_ER_diArg_1	403	405	PF00400	0.560
TRG_ER_diArg_1	514	516	PF00400	0.642
TRG_NLS_Bipartite_1	138	154	PF00514	0.461
TRG_NLS_Bipartite_1	162	179	PF00514	0.585
TRG_NLS_MonoCore_2	192	197	PF00514	0.601
TRG_NLS_MonoExtC_3	149	154	PF00514	0.398
TRG_NLS_MonoExtN_4	147	154	PF00514	0.461
TRG_NLS_MonoExtN_4	192	198	PF00514	0.607
TRG_Pf-PMV_PEXEL_1	290	294	PF00026	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAB7	Leptomonas seymouri	58%	100%
A0A3Q8IAL9	Leishmania donovani	88%	100%
A0A422N2J9	Trypanosoma rangeli	35%	100%
A4HC96	Leishmania braziliensis	74%	98%
A4HZS8	Leishmania infantum	88%	100%
C9ZRL3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
Q4QBU6	Leishmania major	87%	99%
V5BLH2	Trypanosoma cruzi	34%	100%