Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania mexicana

UniProt:

E9AVN2_LEIMU

TriTrypDb:

LmxM.22.0490

Length:

723

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AVN2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVN2

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:0007165	signal transduction	2	1
GO:0035556	intracellular signal transduction	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0004674	protein serine/threonine kinase activity	4	1
GO:0004707	MAP kinase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.806
CLV_C14_Caspase3-7	639	643	PF00656	0.557
CLV_NRD_NRD_1	4	6	PF00675	0.716
CLV_NRD_NRD_1	596	598	PF00675	0.343
CLV_PCSK_KEX2_1	4	6	PF00082	0.716
CLV_PCSK_KEX2_1	443	445	PF00082	0.306
CLV_PCSK_KEX2_1	596	598	PF00082	0.343
CLV_PCSK_KEX2_1	621	623	PF00082	0.293
CLV_PCSK_KEX2_1	72	74	PF00082	0.392
CLV_PCSK_PC1ET2_1	443	445	PF00082	0.306
CLV_PCSK_PC1ET2_1	621	623	PF00082	0.293
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.392
CLV_PCSK_SKI1_1	317	321	PF00082	0.304
CLV_PCSK_SKI1_1	341	345	PF00082	0.306
CLV_PCSK_SKI1_1	419	423	PF00082	0.306
CLV_PCSK_SKI1_1	524	528	PF00082	0.372
CLV_PCSK_SKI1_1	596	600	PF00082	0.293
CLV_PCSK_SKI1_1	621	625	PF00082	0.343
CLV_Separin_Metazoa	412	416	PF03568	0.306
DEG_Kelch_Keap1_1	267	272	PF01344	0.559
DEG_Nend_UBRbox_3	1	3	PF02207	0.557
DEG_SCF_FBW7_2	576	583	PF00400	0.343
DEG_SPOP_SBC_1	129	133	PF00917	0.640
DEG_SPOP_SBC_1	250	254	PF00917	0.592
DEG_SPOP_SBC_1	547	551	PF00917	0.309
DEG_SPOP_SBC_1	6	10	PF00917	0.550
DOC_CDC14_PxL_1	384	392	PF14671	0.306
DOC_CYCLIN_RxL_1	591	603	PF00134	0.293
DOC_MAPK_gen_1	341	350	PF00069	0.306
DOC_MAPK_gen_1	383	392	PF00069	0.306
DOC_MAPK_gen_1	482	491	PF00069	0.503
DOC_MAPK_HePTP_8	380	392	PF00069	0.306
DOC_MAPK_MEF2A_6	383	392	PF00069	0.306
DOC_MAPK_MEF2A_6	485	493	PF00069	0.484
DOC_PP1_RVXF_1	318	325	PF00149	0.349
DOC_PP1_RVXF_1	326	333	PF00149	0.269
DOC_PP2B_LxvP_1	438	441	PF13499	0.372
DOC_PP2B_LxvP_1	675	678	PF13499	0.397
DOC_USP7_MATH_1	105	109	PF00917	0.686
DOC_USP7_MATH_1	129	133	PF00917	0.668
DOC_USP7_MATH_1	14	18	PF00917	0.690
DOC_USP7_MATH_1	205	209	PF00917	0.652
DOC_USP7_MATH_1	33	37	PF00917	0.508
DOC_USP7_MATH_1	563	567	PF00917	0.232
DOC_USP7_MATH_1	6	10	PF00917	0.663
DOC_USP7_MATH_1	655	659	PF00917	0.616
DOC_USP7_UBL2_3	68	72	PF12436	0.367
DOC_WW_Pin1_4	123	128	PF00397	0.567
DOC_WW_Pin1_4	253	258	PF00397	0.708
DOC_WW_Pin1_4	278	283	PF00397	0.748
DOC_WW_Pin1_4	37	42	PF00397	0.525
DOC_WW_Pin1_4	535	540	PF00397	0.306
DOC_WW_Pin1_4	542	547	PF00397	0.306
DOC_WW_Pin1_4	561	566	PF00397	0.229
DOC_WW_Pin1_4	576	581	PF00397	0.321
DOC_WW_Pin1_4	600	605	PF00397	0.293
DOC_WW_Pin1_4	660	665	PF00397	0.636
LIG_14-3-3_CanoR_1	120	130	PF00244	0.666
LIG_14-3-3_CanoR_1	15	22	PF00244	0.662
LIG_14-3-3_CanoR_1	35	41	PF00244	0.501
LIG_14-3-3_CanoR_1	423	431	PF00244	0.306
LIG_14-3-3_CanoR_1	465	470	PF00244	0.372
LIG_14-3-3_CanoR_1	482	491	PF00244	0.372
LIG_14-3-3_CanoR_1	622	629	PF00244	0.293
LIG_14-3-3_CanoR_1	695	703	PF00244	0.431
LIG_Actin_WH2_2	331	346	PF00022	0.293
LIG_Actin_WH2_2	402	417	PF00022	0.306
LIG_Actin_WH2_2	490	508	PF00022	0.212
LIG_Actin_WH2_2	630	648	PF00022	0.364
LIG_AP2alpha_1	634	638	PF02296	0.359
LIG_deltaCOP1_diTrp_1	402	406	PF00928	0.306
LIG_eIF4E_1	385	391	PF01652	0.306
LIG_FHA_1	109	115	PF00498	0.630
LIG_FHA_1	352	358	PF00498	0.306
LIG_FHA_1	568	574	PF00498	0.343
LIG_FHA_1	645	651	PF00498	0.488
LIG_FHA_2	102	108	PF00498	0.805
LIG_FHA_2	133	139	PF00498	0.594
LIG_FHA_2	424	430	PF00498	0.306
LIG_FHA_2	570	576	PF00498	0.318
LIG_FHA_2	577	583	PF00498	0.312
LIG_FHA_2	601	607	PF00498	0.293
LIG_FHA_2	622	628	PF00498	0.343
LIG_FHA_2	652	658	PF00498	0.506
LIG_FHA_2	689	695	PF00498	0.418
LIG_Integrin_isoDGR_2	679	681	PF01839	0.407
LIG_LIR_Apic_2	382	388	PF02991	0.341
LIG_LIR_Gen_1	582	593	PF02991	0.293
LIG_LIR_Nem_3	155	160	PF02991	0.422
LIG_LIR_Nem_3	389	395	PF02991	0.324
LIG_LIR_Nem_3	40	46	PF02991	0.509
LIG_LIR_Nem_3	405	409	PF02991	0.324
LIG_LIR_Nem_3	433	438	PF02991	0.405
LIG_LIR_Nem_3	53	57	PF02991	0.420
LIG_LIR_Nem_3	579	584	PF02991	0.305
LIG_Pex14_1	595	599	PF04695	0.293
LIG_Pex14_2	634	638	PF04695	0.359
LIG_SH2_CRK	397	401	PF00017	0.212
LIG_SH2_CRK	43	47	PF00017	0.444
LIG_SH2_CRK	585	589	PF00017	0.293
LIG_SH2_NCK_1	160	164	PF00017	0.447
LIG_SH2_NCK_1	698	702	PF00017	0.427
LIG_SH2_STAP1	698	702	PF00017	0.377
LIG_SH2_STAP1	76	80	PF00017	0.510
LIG_SH2_STAT5	157	160	PF00017	0.387
LIG_SH2_STAT5	221	224	PF00017	0.340
LIG_SH2_STAT5	228	231	PF00017	0.361
LIG_SH2_STAT5	235	238	PF00017	0.278
LIG_SH2_STAT5	240	243	PF00017	0.434
LIG_SH2_STAT5	379	382	PF00017	0.306
LIG_SH2_STAT5	48	51	PF00017	0.456
LIG_SH2_STAT5	698	701	PF00017	0.388
LIG_SH3_3	279	285	PF00018	0.666
LIG_SH3_3	626	632	PF00018	0.343
LIG_SH3_3	90	96	PF00018	0.518
LIG_SUMO_SIM_anti_2	606	613	PF11976	0.286
LIG_SUMO_SIM_anti_2	84	90	PF11976	0.394
LIG_SUMO_SIM_par_1	149	155	PF11976	0.356
LIG_SUMO_SIM_par_1	55	62	PF11976	0.385
LIG_TRAF2_1	371	374	PF00917	0.372
LIG_TRAF2_1	580	583	PF00917	0.343
LIG_UBA3_1	434	443	PF00899	0.306
LIG_WRC_WIRS_1	403	408	PF05994	0.306
MOD_CDK_SPK_2	281	286	PF00069	0.691
MOD_CDK_SPxxK_3	37	44	PF00069	0.456
MOD_CK1_1	10	16	PF00069	0.666
MOD_CK1_1	108	114	PF00069	0.593
MOD_CK1_1	122	128	PF00069	0.675
MOD_CK1_1	132	138	PF00069	0.544
MOD_CK1_1	17	23	PF00069	0.612
MOD_CK1_1	199	205	PF00069	0.654
MOD_CK1_1	252	258	PF00069	0.629
MOD_CK1_1	281	287	PF00069	0.624
MOD_CK1_1	295	301	PF00069	0.739
MOD_CK1_1	302	308	PF00069	0.693
MOD_CK1_1	36	42	PF00069	0.444
MOD_CK1_1	532	538	PF00069	0.408
MOD_CK1_1	564	570	PF00069	0.219
MOD_CK1_1	658	664	PF00069	0.636
MOD_CK2_1	266	272	PF00069	0.602
MOD_CK2_1	439	445	PF00069	0.306
MOD_CK2_1	515	521	PF00069	0.285
MOD_CK2_1	576	582	PF00069	0.343
MOD_CK2_1	600	606	PF00069	0.293
MOD_CK2_1	621	627	PF00069	0.343
MOD_CK2_1	651	657	PF00069	0.620
MOD_CK2_1	688	694	PF00069	0.363
MOD_GlcNHglycan	12	15	PF01048	0.696
MOD_GlcNHglycan	127	130	PF01048	0.778
MOD_GlcNHglycan	16	19	PF01048	0.679
MOD_GlcNHglycan	198	201	PF01048	0.674
MOD_GlcNHglycan	205	208	PF01048	0.672
MOD_GlcNHglycan	212	215	PF01048	0.537
MOD_GlcNHglycan	269	272	PF01048	0.782
MOD_GlcNHglycan	305	308	PF01048	0.672
MOD_GlcNHglycan	363	366	PF01048	0.323
MOD_GlcNHglycan	416	419	PF01048	0.306
MOD_GlcNHglycan	474	477	PF01048	0.491
MOD_GlcNHglycan	507	510	PF01048	0.240
MOD_GlcNHglycan	535	538	PF01048	0.293
MOD_GlcNHglycan	561	564	PF01048	0.343
MOD_GlcNHglycan	638	641	PF01048	0.571
MOD_GlcNHglycan	657	660	PF01048	0.600
MOD_GlcNHglycan	671	674	PF01048	0.426
MOD_GSK3_1	101	108	PF00069	0.823
MOD_GSK3_1	116	123	PF00069	0.622
MOD_GSK3_1	125	132	PF00069	0.646
MOD_GSK3_1	185	192	PF00069	0.527
MOD_GSK3_1	199	206	PF00069	0.644
MOD_GSK3_1	245	252	PF00069	0.455
MOD_GSK3_1	253	260	PF00069	0.643
MOD_GSK3_1	263	270	PF00069	0.778
MOD_GSK3_1	27	34	PF00069	0.646
MOD_GSK3_1	274	281	PF00069	0.634
MOD_GSK3_1	295	302	PF00069	0.721
MOD_GSK3_1	375	382	PF00069	0.306
MOD_GSK3_1	529	536	PF00069	0.331
MOD_GSK3_1	542	549	PF00069	0.330
MOD_GSK3_1	559	566	PF00069	0.283
MOD_GSK3_1	6	13	PF00069	0.735
MOD_GSK3_1	606	613	PF00069	0.222
MOD_GSK3_1	651	658	PF00069	0.688
MOD_N-GLC_1	108	113	PF02516	0.538
MOD_N-GLC_1	292	297	PF02516	0.773
MOD_N-GLC_1	375	380	PF02516	0.330
MOD_NEK2_1	130	135	PF00069	0.630
MOD_NEK2_1	173	178	PF00069	0.495
MOD_NEK2_1	224	229	PF00069	0.341
MOD_NEK2_1	249	254	PF00069	0.629
MOD_NEK2_1	414	419	PF00069	0.306
MOD_NEK2_1	457	462	PF00069	0.306
MOD_NEK2_1	505	510	PF00069	0.212
MOD_NEK2_1	610	615	PF00069	0.343
MOD_NEK2_1	7	12	PF00069	0.735
MOD_PIKK_1	33	39	PF00454	0.647
MOD_PIKK_1	530	536	PF00454	0.372
MOD_PKA_1	621	627	PF00069	0.293
MOD_PKA_2	10	16	PF00069	0.709
MOD_PKA_2	119	125	PF00069	0.685
MOD_PKA_2	414	420	PF00069	0.315
MOD_PKA_2	50	56	PF00069	0.454
MOD_PKA_2	505	511	PF00069	0.212
MOD_PKA_2	559	565	PF00069	0.282
MOD_PKA_2	621	627	PF00069	0.342
MOD_Plk_1	109	115	PF00069	0.590
MOD_Plk_1	375	381	PF00069	0.330
MOD_Plk_4	224	230	PF00069	0.318
MOD_Plk_4	245	251	PF00069	0.374
MOD_Plk_4	375	381	PF00069	0.306
MOD_Plk_4	606	612	PF00069	0.366
MOD_Plk_4	683	689	PF00069	0.482
MOD_Plk_4	87	93	PF00069	0.426
MOD_ProDKin_1	123	129	PF00069	0.563
MOD_ProDKin_1	253	259	PF00069	0.711
MOD_ProDKin_1	278	284	PF00069	0.747
MOD_ProDKin_1	37	43	PF00069	0.506
MOD_ProDKin_1	535	541	PF00069	0.306
MOD_ProDKin_1	542	548	PF00069	0.306
MOD_ProDKin_1	561	567	PF00069	0.229
MOD_ProDKin_1	576	582	PF00069	0.321
MOD_ProDKin_1	600	606	PF00069	0.293
MOD_ProDKin_1	660	666	PF00069	0.632
MOD_SUMO_rev_2	550	559	PF00179	0.339
TRG_DiLeu_BaEn_1	606	611	PF01217	0.293
TRG_ENDOCYTIC_2	221	224	PF00928	0.349
TRG_ENDOCYTIC_2	228	231	PF00928	0.339
TRG_ENDOCYTIC_2	240	243	PF00928	0.416
TRG_ENDOCYTIC_2	43	46	PF00928	0.443
TRG_ENDOCYTIC_2	584	587	PF00928	0.293
TRG_ER_diArg_1	3	5	PF00400	0.703
TRG_ER_diArg_1	356	359	PF00400	0.212
TRG_ER_diArg_1	458	461	PF00400	0.356
TRG_ER_diArg_1	595	597	PF00400	0.343
TRG_Pf-PMV_PEXEL_1	695	700	PF00026	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU16	Leptomonas seymouri	51%	100%
A0A3Q8IC49	Leishmania donovani	90%	99%
A4HC95	Leishmania braziliensis	75%	100%
A4HZS7	Leishmania infantum	90%	86%
Q4QBU7	Leishmania major	91%	100%