tRNA-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative tRNA binding domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AVN0_LEIMU

TriTrypDb:

LmxM.22.0470

Length:

420

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 3
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AVN0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVN0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000049	tRNA binding	5	11
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003824	catalytic activity	1	3
GO:0004812	aminoacyl-tRNA ligase activity	4	3
GO:0016874	ligase activity	2	3
GO:0016875	ligase activity, forming carbon-oxygen bonds	3	3
GO:0140098	catalytic activity, acting on RNA	3	3
GO:0140101	catalytic activity, acting on a tRNA	4	3
GO:0140640	catalytic activity, acting on a nucleic acid	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	253	257	PF00656	0.512
CLV_C14_Caspase3-7	388	392	PF00656	0.538
CLV_MEL_PAP_1	260	266	PF00089	0.326
CLV_NRD_NRD_1	211	213	PF00675	0.539
CLV_NRD_NRD_1	271	273	PF00675	0.346
CLV_NRD_NRD_1	58	60	PF00675	0.651
CLV_PCSK_KEX2_1	210	212	PF00082	0.540
CLV_PCSK_KEX2_1	271	273	PF00082	0.321
CLV_PCSK_KEX2_1	335	337	PF00082	0.308
CLV_PCSK_KEX2_1	58	60	PF00082	0.574
CLV_PCSK_PC1ET2_1	335	337	PF00082	0.308
CLV_PCSK_SKI1_1	115	119	PF00082	0.496
CLV_PCSK_SKI1_1	126	130	PF00082	0.721
CLV_PCSK_SKI1_1	354	358	PF00082	0.401
CLV_PCSK_SKI1_1	67	71	PF00082	0.616
CLV_Separin_Metazoa	207	211	PF03568	0.559
DEG_Nend_UBRbox_3	1	3	PF02207	0.492
DOC_MAPK_gen_1	318	325	PF00069	0.584
DOC_MAPK_gen_1	335	342	PF00069	0.584
DOC_MAPK_RevD_3	196	212	PF00069	0.593
DOC_PIKK_1	299	306	PF02985	0.416
DOC_PP1_RVXF_1	352	358	PF00149	0.535
DOC_PP2B_LxvP_1	118	121	PF13499	0.444
DOC_PP2B_LxvP_1	23	26	PF13499	0.578
DOC_USP7_MATH_1	173	177	PF00917	0.679
DOC_USP7_MATH_1	18	22	PF00917	0.644
DOC_USP7_MATH_1	234	238	PF00917	0.622
DOC_USP7_UBL2_3	215	219	PF12436	0.514
DOC_USP7_UBL2_3	248	252	PF12436	0.657
DOC_WW_Pin1_4	236	241	PF00397	0.716
DOC_WW_Pin1_4	60	65	PF00397	0.647
LIG_14-3-3_CanoR_1	133	137	PF00244	0.542
LIG_14-3-3_CanoR_1	58	64	PF00244	0.550
LIG_Actin_WH2_2	43	60	PF00022	0.567
LIG_FHA_1	150	156	PF00498	0.644
LIG_FHA_1	288	294	PF00498	0.529
LIG_FHA_1	307	313	PF00498	0.521
LIG_FHA_2	127	133	PF00498	0.580
LIG_FHA_2	251	257	PF00498	0.548
LIG_FHA_2	357	363	PF00498	0.369
LIG_FHA_2	386	392	PF00498	0.418
LIG_KLC1_Yacidic_2	277	282	PF13176	0.521
LIG_LIR_Apic_2	167	173	PF02991	0.578
LIG_LIR_Apic_2	199	203	PF02991	0.728
LIG_LIR_Gen_1	258	267	PF02991	0.426
LIG_LIR_LC3C_4	309	314	PF02991	0.584
LIG_LIR_Nem_3	158	164	PF02991	0.562
LIG_LIR_Nem_3	258	264	PF02991	0.505
LIG_LIR_Nem_3	46	50	PF02991	0.597
LIG_PCNA_PIPBox_1	379	388	PF02747	0.435
LIG_SH2_NCK_1	110	114	PF00017	0.573
LIG_SH2_NCK_1	142	146	PF00017	0.670
LIG_SH2_PTP2	200	203	PF00017	0.695
LIG_SH2_PTP2	261	264	PF00017	0.426
LIG_SH2_STAP1	142	146	PF00017	0.670
LIG_SH2_STAP1	361	365	PF00017	0.567
LIG_SH2_STAT5	127	130	PF00017	0.665
LIG_SH2_STAT5	170	173	PF00017	0.580
LIG_SH2_STAT5	200	203	PF00017	0.695
LIG_SH2_STAT5	261	264	PF00017	0.420
LIG_SH2_STAT5	280	283	PF00017	0.486
LIG_SUMO_SIM_anti_2	72	81	PF11976	0.673
LIG_TRAF2_1	203	206	PF00917	0.567
LIG_TRAF2_1	302	305	PF00917	0.561
MOD_CAAXbox	417	420	PF01239	0.526
MOD_CDK_SPxxK_3	236	243	PF00069	0.743
MOD_CDK_SPxxK_3	60	67	PF00069	0.649
MOD_CK1_1	149	155	PF00069	0.598
MOD_CK1_1	21	27	PF00069	0.574
MOD_CK1_1	377	383	PF00069	0.341
MOD_CK2_1	108	114	PF00069	0.716
MOD_CK2_1	126	132	PF00069	0.445
MOD_CK2_1	147	153	PF00069	0.524
MOD_CK2_1	201	207	PF00069	0.528
MOD_CK2_1	248	254	PF00069	0.645
MOD_Cter_Amidation	246	249	PF01082	0.775
MOD_GlcNHglycan	176	179	PF01048	0.672
MOD_GlcNHglycan	20	23	PF01048	0.494
MOD_GlcNHglycan	236	239	PF01048	0.713
MOD_GlcNHglycan	240	243	PF01048	0.737
MOD_GlcNHglycan	294	297	PF01048	0.290
MOD_GlcNHglycan	404	407	PF01048	0.513
MOD_GSK3_1	122	129	PF00069	0.569
MOD_GSK3_1	174	181	PF00069	0.651
MOD_GSK3_1	234	241	PF00069	0.748
MOD_GSK3_1	250	257	PF00069	0.548
MOD_GSK3_1	377	384	PF00069	0.489
MOD_N-GLC_1	146	151	PF02516	0.595
MOD_N-GLC_1	185	190	PF02516	0.597
MOD_N-GLC_1	5	10	PF02516	0.489
MOD_NEK2_1	146	151	PF00069	0.653
MOD_NEK2_1	255	260	PF00069	0.569
MOD_NEK2_1	306	311	PF00069	0.498
MOD_NEK2_1	323	328	PF00069	0.486
MOD_NEK2_1	356	361	PF00069	0.462
MOD_NEK2_1	374	379	PF00069	0.348
MOD_NEK2_1	57	62	PF00069	0.535
MOD_PIKK_1	306	312	PF00454	0.641
MOD_PIKK_1	324	330	PF00454	0.454
MOD_PKA_1	248	254	PF00069	0.637
MOD_PKA_2	132	138	PF00069	0.526
MOD_PKA_2	174	180	PF00069	0.803
MOD_PKA_2	38	44	PF00069	0.593
MOD_PKA_2	57	63	PF00069	0.551
MOD_Plk_1	255	261	PF00069	0.538
MOD_Plk_1	5	11	PF00069	0.497
MOD_Plk_2-3	132	138	PF00069	0.579
MOD_Plk_4	196	202	PF00069	0.617
MOD_Plk_4	256	262	PF00069	0.520
MOD_Plk_4	6	12	PF00069	0.592
MOD_Plk_4	75	81	PF00069	0.685
MOD_ProDKin_1	236	242	PF00069	0.717
MOD_ProDKin_1	60	66	PF00069	0.644
MOD_SUMO_for_1	179	182	PF00179	0.517
MOD_SUMO_for_1	218	221	PF00179	0.641
MOD_SUMO_rev_2	241	250	PF00179	0.788
MOD_SUMO_rev_2	337	343	PF00179	0.508
TRG_DiLeu_BaEn_1	167	172	PF01217	0.452
TRG_DiLeu_BaEn_1	75	80	PF01217	0.659
TRG_DiLeu_BaEn_2	64	70	PF01217	0.671
TRG_ENDOCYTIC_2	110	113	PF00928	0.656
TRG_ENDOCYTIC_2	261	264	PF00928	0.426
TRG_ER_diArg_1	209	212	PF00400	0.543
TRG_ER_diArg_1	270	272	PF00400	0.546
TRG_ER_diArg_1	57	59	PF00400	0.563

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P301	Leptomonas seymouri	65%	100%
A0A0S4IJF4	Bodo saltans	39%	100%
A0A1X0NUW2	Trypanosomatidae	46%	100%
A0A3R7KNR3	Trypanosoma rangeli	43%	100%
A0A3S7WX09	Leishmania donovani	87%	100%
A4HC93	Leishmania braziliensis	79%	100%
A4HZS5	Leishmania infantum	87%	100%
C9ZRK5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
Q4QBU9	Leishmania major	87%	100%