N-acetyltransferase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Acetyltransferase (GNAT) family, putative

Species:

Leishmania mexicana

UniProt:

E9AVM8_LEIMU

TriTrypDb:

LmxM.22.0450

Length:

290

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031248	protein acetyltransferase complex	3	1
GO:0031414	N-terminal protein acetyltransferase complex	4	1
GO:0031417	NatC complex	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902493	acetyltransferase complex	4	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

E9AVM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVM8

Function

Biological processes
Term	Name	Level	Count
GO:0006473	protein acetylation	6	10
GO:0006474	N-terminal protein amino acid acetylation	5	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0017196	N-terminal peptidyl-methionine acetylation	6	10
GO:0018193	peptidyl-amino acid modification	5	10
GO:0018206	peptidyl-methionine modification	6	10
GO:0019538	protein metabolic process	3	10
GO:0031365	N-terminal protein amino acid modification	5	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0043543	protein acylation	5	10
GO:0044238	primary metabolic process	2	10
GO:0051604	protein maturation	4	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004596	peptide alpha-N-acetyltransferase activity	8	10
GO:0008080	N-acetyltransferase activity	6	10
GO:0016407	acetyltransferase activity	5	10
GO:0016410	N-acyltransferase activity	5	10
GO:0016740	transferase activity	2	10
GO:0016746	acyltransferase activity	3	10
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	10
GO:0034212	peptide N-acetyltransferase activity	7	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.342
CLV_C14_Caspase3-7	258	262	PF00656	0.397
CLV_NRD_NRD_1	180	182	PF00675	0.329
CLV_PCSK_KEX2_1	8	10	PF00082	0.747
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.779
CLV_PCSK_SKI1_1	68	72	PF00082	0.489
CLV_Separin_Metazoa	216	220	PF03568	0.402
DOC_CKS1_1	228	233	PF01111	0.329
DOC_CKS1_1	278	283	PF01111	0.564
DOC_MAPK_gen_1	178	188	PF00069	0.441
DOC_MAPK_gen_1	219	228	PF00069	0.329
DOC_MAPK_MEF2A_6	209	217	PF00069	0.322
DOC_MAPK_MEF2A_6	236	244	PF00069	0.325
DOC_PP4_FxxP_1	145	148	PF00568	0.374
DOC_USP7_MATH_1	11	15	PF00917	0.517
DOC_USP7_MATH_1	134	138	PF00917	0.411
DOC_USP7_MATH_1	163	167	PF00917	0.323
DOC_USP7_MATH_1	174	178	PF00917	0.350
DOC_USP7_UBL2_3	266	270	PF12436	0.476
DOC_USP7_UBL2_3	38	42	PF12436	0.653
DOC_USP7_UBL2_3	4	8	PF12436	0.655
DOC_WW_Pin1_4	227	232	PF00397	0.329
DOC_WW_Pin1_4	277	282	PF00397	0.532
LIG_14-3-3_CanoR_1	209	214	PF00244	0.373
LIG_BIR_III_2	271	275	PF00653	0.653
LIG_FHA_1	126	132	PF00498	0.429
LIG_FHA_1	212	218	PF00498	0.336
LIG_FHA_1	247	253	PF00498	0.315
LIG_FHA_2	159	165	PF00498	0.372
LIG_Integrin_isoDGR_2	57	59	PF01839	0.460
LIG_KLC1_Yacidic_2	224	229	PF13176	0.329
LIG_LIR_Gen_1	132	143	PF02991	0.394
LIG_LIR_Gen_1	82	93	PF02991	0.504
LIG_LIR_Gen_1	96	107	PF02991	0.497
LIG_LIR_Nem_3	132	138	PF02991	0.415
LIG_LIR_Nem_3	139	145	PF02991	0.368
LIG_LIR_Nem_3	82	88	PF02991	0.537
LIG_LIR_Nem_3	96	102	PF02991	0.498
LIG_PDZ_Class_3	285	290	PF00595	0.702
LIG_Pex14_2	143	147	PF04695	0.364
LIG_PTB_Apo_2	240	247	PF02174	0.372
LIG_SH2_GRB2like	241	244	PF00017	0.372
LIG_SH2_GRB2like	85	88	PF00017	0.518
LIG_SH2_PTP2	85	88	PF00017	0.542
LIG_SH2_SRC	256	259	PF00017	0.456
LIG_SH2_SRC	85	88	PF00017	0.518
LIG_SH2_STAT5	107	110	PF00017	0.365
LIG_SH2_STAT5	142	145	PF00017	0.367
LIG_SH2_STAT5	191	194	PF00017	0.329
LIG_SH2_STAT5	227	230	PF00017	0.329
LIG_SH2_STAT5	241	244	PF00017	0.280
LIG_SH2_STAT5	251	254	PF00017	0.390
LIG_SH2_STAT5	256	259	PF00017	0.384
LIG_SH2_STAT5	61	64	PF00017	0.642
LIG_SH2_STAT5	85	88	PF00017	0.518
LIG_SH3_1	275	281	PF00018	0.422
LIG_SH3_2	3	8	PF14604	0.520
LIG_SH3_3	270	276	PF00018	0.520
LIG_SH3_3	83	89	PF00018	0.544
LIG_SUMO_SIM_anti_2	214	220	PF11976	0.348
LIG_SUMO_SIM_par_1	208	214	PF11976	0.323
LIG_TRAF2_1	79	82	PF00917	0.708
LIG_TRAF2_1	93	96	PF00917	0.588
LIG_WRC_WIRS_1	135	140	PF05994	0.392
MOD_CK1_1	136	142	PF00069	0.383
MOD_CK1_1	177	183	PF00069	0.348
MOD_CK2_1	113	119	PF00069	0.532
MOD_GSK3_1	125	132	PF00069	0.406
MOD_GSK3_1	205	212	PF00069	0.400
MOD_GSK3_1	57	64	PF00069	0.627
MOD_NEK2_1	150	155	PF00069	0.436
MOD_NEK2_1	246	251	PF00069	0.392
MOD_PIKK_1	40	46	PF00454	0.665
MOD_PKA_1	37	43	PF00069	0.660
MOD_PKA_2	177	183	PF00069	0.348
MOD_Plk_1	163	169	PF00069	0.441
MOD_Plk_1	21	27	PF00069	0.570
MOD_Plk_1	49	55	PF00069	0.683
MOD_Plk_2-3	21	27	PF00069	0.526
MOD_Plk_4	163	169	PF00069	0.470
MOD_ProDKin_1	227	233	PF00069	0.329
MOD_ProDKin_1	277	283	PF00069	0.535
MOD_SUMO_rev_2	158	163	PF00179	0.410
MOD_SUMO_rev_2	43	53	PF00179	0.594
TRG_ENDOCYTIC_2	110	113	PF00928	0.393
TRG_ENDOCYTIC_2	135	138	PF00928	0.404
TRG_ENDOCYTIC_2	140	143	PF00928	0.363
TRG_ENDOCYTIC_2	191	194	PF00928	0.329
TRG_ENDOCYTIC_2	241	244	PF00928	0.329
TRG_ENDOCYTIC_2	85	88	PF00928	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2R0	Leptomonas seymouri	77%	100%
A0A1X0NT56	Trypanosomatidae	62%	99%
A0A3S7WWZ5	Leishmania donovani	94%	100%
A0A422MXL6	Trypanosoma rangeli	60%	97%
A4HZS3	Leishmania infantum	94%	100%
C9ZRK1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	94%
Q4QBV1	Leishmania major	94%	100%
V5CKM9	Trypanosoma cruzi	62%	97%