Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVM4_LEIMU

TriTrypDb:

LmxM.22.0400

Length:

720

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVM4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVM4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	277	281	PF00656	0.518
CLV_NRD_NRD_1	102	104	PF00675	0.630
CLV_NRD_NRD_1	128	130	PF00675	0.618
CLV_NRD_NRD_1	187	189	PF00675	0.480
CLV_NRD_NRD_1	32	34	PF00675	0.549
CLV_NRD_NRD_1	414	416	PF00675	0.564
CLV_NRD_NRD_1	418	420	PF00675	0.505
CLV_NRD_NRD_1	429	431	PF00675	0.441
CLV_NRD_NRD_1	523	525	PF00675	0.450
CLV_NRD_NRD_1	569	571	PF00675	0.536
CLV_NRD_NRD_1	642	644	PF00675	0.446
CLV_PCSK_FUR_1	412	416	PF00082	0.642
CLV_PCSK_KEX2_1	128	130	PF00082	0.716
CLV_PCSK_KEX2_1	414	416	PF00082	0.564
CLV_PCSK_KEX2_1	418	420	PF00082	0.505
CLV_PCSK_KEX2_1	429	431	PF00082	0.441
CLV_PCSK_KEX2_1	523	525	PF00082	0.450
CLV_PCSK_KEX2_1	569	571	PF00082	0.536
CLV_PCSK_KEX2_1	642	644	PF00082	0.446
CLV_PCSK_PC7_1	414	420	PF00082	0.554
CLV_PCSK_SKI1_1	184	188	PF00082	0.507
CLV_PCSK_SKI1_1	429	433	PF00082	0.518
CLV_PCSK_SKI1_1	542	546	PF00082	0.530
CLV_PCSK_SKI1_1	625	629	PF00082	0.701
CLV_PCSK_SKI1_1	634	638	PF00082	0.530
CLV_PCSK_SKI1_1	688	692	PF00082	0.592
CLV_PCSK_SKI1_1	699	703	PF00082	0.588
DEG_APCC_DBOX_1	499	507	PF00400	0.511
DEG_COP1_1	467	476	PF00400	0.629
DEG_SCF_FBW7_1	67	72	PF00400	0.700
DEG_SCF_FBW7_2	503	508	PF00400	0.507
DEG_SPOP_SBC_1	288	292	PF00917	0.543
DEG_SPOP_SBC_1	97	101	PF00917	0.598
DOC_CKS1_1	112	117	PF01111	0.677
DOC_CYCLIN_yCln2_LP_2	134	140	PF00134	0.624
DOC_CYCLIN_yCln2_LP_2	225	228	PF00134	0.541
DOC_CYCLIN_yCln2_LP_2	74	80	PF00134	0.601
DOC_MAPK_DCC_7	482	492	PF00069	0.391
DOC_MAPK_DCC_7	71	81	PF00069	0.505
DOC_MAPK_gen_1	128	138	PF00069	0.721
DOC_MAPK_gen_1	482	492	PF00069	0.391
DOC_MAPK_HePTP_8	138	150	PF00069	0.566
DOC_MAPK_MEF2A_6	129	138	PF00069	0.679
DOC_MAPK_MEF2A_6	141	150	PF00069	0.471
DOC_MAPK_MEF2A_6	485	492	PF00069	0.491
DOC_MAPK_NFAT4_5	131	139	PF00069	0.646
DOC_MAPK_RevD_3	174	189	PF00069	0.535
DOC_PP2B_LxvP_1	134	137	PF13499	0.623
DOC_PP2B_LxvP_1	158	161	PF13499	0.610
DOC_PP2B_LxvP_1	224	227	PF13499	0.744
DOC_PP2B_LxvP_1	74	77	PF13499	0.677
DOC_PP2B_LxvP_1	93	96	PF13499	0.445
DOC_USP7_MATH_1	110	114	PF00917	0.539
DOC_USP7_MATH_1	472	476	PF00917	0.546
DOC_USP7_MATH_1	559	563	PF00917	0.521
DOC_USP7_MATH_1	635	639	PF00917	0.594
DOC_USP7_MATH_1	96	100	PF00917	0.711
DOC_USP7_UBL2_3	36	40	PF12436	0.751
DOC_WW_Pin1_4	111	116	PF00397	0.653
DOC_WW_Pin1_4	236	241	PF00397	0.535
DOC_WW_Pin1_4	300	305	PF00397	0.563
DOC_WW_Pin1_4	501	506	PF00397	0.541
DOC_WW_Pin1_4	542	547	PF00397	0.561
DOC_WW_Pin1_4	552	557	PF00397	0.533
DOC_WW_Pin1_4	57	62	PF00397	0.682
DOC_WW_Pin1_4	65	70	PF00397	0.753
LIG_14-3-3_CanoR_1	129	135	PF00244	0.627
LIG_14-3-3_CanoR_1	151	157	PF00244	0.537
LIG_14-3-3_CanoR_1	216	222	PF00244	0.775
LIG_14-3-3_CanoR_1	294	304	PF00244	0.665
LIG_14-3-3_CanoR_1	523	533	PF00244	0.474
LIG_14-3-3_CanoR_1	643	649	PF00244	0.462
LIG_Actin_WH2_2	172	190	PF00022	0.346
LIG_APCC_ABBAyCdc20_2	677	683	PF00400	0.542
LIG_APCC_ABBAyCdc20_2	699	705	PF00400	0.486
LIG_BIR_III_4	372	376	PF00653	0.515
LIG_BRCT_BRCA1_1	637	641	PF00533	0.680
LIG_Clathr_ClatBox_1	22	26	PF01394	0.651
LIG_deltaCOP1_diTrp_1	591	599	PF00928	0.585
LIG_FHA_1	171	177	PF00498	0.621
LIG_FHA_1	269	275	PF00498	0.709
LIG_FHA_1	315	321	PF00498	0.711
LIG_FHA_1	392	398	PF00498	0.533
LIG_FHA_1	492	498	PF00498	0.617
LIG_FHA_2	167	173	PF00498	0.479
LIG_FHA_2	210	216	PF00498	0.807
LIG_FHA_2	447	453	PF00498	0.651
LIG_FHA_2	465	471	PF00498	0.715
LIG_FHA_2	6	12	PF00498	0.629
LIG_GBD_Chelix_1	432	440	PF00786	0.297
LIG_Integrin_RGD_1	570	572	PF01839	0.503
LIG_LIR_Gen_1	331	339	PF02991	0.545
LIG_LIR_Gen_1	597	606	PF02991	0.402
LIG_LIR_Gen_1	654	664	PF02991	0.413
LIG_LIR_Gen_1	693	702	PF02991	0.503
LIG_LIR_LC3C_4	516	521	PF02991	0.266
LIG_LIR_Nem_3	126	130	PF02991	0.618
LIG_LIR_Nem_3	157	162	PF02991	0.530
LIG_LIR_Nem_3	331	337	PF02991	0.550
LIG_LIR_Nem_3	360	366	PF02991	0.655
LIG_LIR_Nem_3	654	660	PF02991	0.407
LIG_LIR_Nem_3	683	687	PF02991	0.502
LIG_LIR_Nem_3	693	697	PF02991	0.468
LIG_NRBOX	220	226	PF00104	0.744
LIG_Pex14_1	594	598	PF04695	0.575
LIG_SH2_CRK	687	691	PF00017	0.361
LIG_SH2_GRB2like	579	582	PF00017	0.600
LIG_SH2_PTP2	657	660	PF00017	0.459
LIG_SH2_STAP1	376	380	PF00017	0.606
LIG_SH2_STAP1	694	698	PF00017	0.471
LIG_SH2_STAT3	366	369	PF00017	0.528
LIG_SH2_STAT5	197	200	PF00017	0.513
LIG_SH2_STAT5	389	392	PF00017	0.502
LIG_SH2_STAT5	512	515	PF00017	0.443
LIG_SH2_STAT5	573	576	PF00017	0.460
LIG_SH2_STAT5	579	582	PF00017	0.499
LIG_SH2_STAT5	657	660	PF00017	0.459
LIG_SH3_3	109	115	PF00018	0.650
LIG_SH3_3	261	267	PF00018	0.664
LIG_SH3_3	550	556	PF00018	0.654
LIG_SH3_3	655	661	PF00018	0.465
LIG_SH3_3	76	82	PF00018	0.548
LIG_SUMO_SIM_anti_2	391	403	PF11976	0.643
LIG_SUMO_SIM_anti_2	475	481	PF11976	0.299
LIG_SUMO_SIM_par_1	164	173	PF11976	0.506
LIG_SUMO_SIM_par_1	217	222	PF11976	0.720
LIG_SUMO_SIM_par_1	284	292	PF11976	0.627
LIG_SUMO_SIM_par_1	391	403	PF11976	0.643
LIG_TRAF2_1	454	457	PF00917	0.742
LIG_TRFH_1	366	370	PF08558	0.628
LIG_TRFH_1	657	661	PF08558	0.461
MOD_CDC14_SPxK_1	60	63	PF00782	0.520
MOD_CDK_SPK_2	236	241	PF00069	0.535
MOD_CDK_SPK_2	57	62	PF00069	0.642
MOD_CDK_SPxK_1	57	63	PF00069	0.644
MOD_CDK_SPxK_1	65	71	PF00069	0.730
MOD_CK1_1	199	205	PF00069	0.609
MOD_CK1_1	265	271	PF00069	0.765
MOD_CK1_1	295	301	PF00069	0.619
MOD_CK1_1	392	398	PF00069	0.430
MOD_CK1_1	47	53	PF00069	0.724
MOD_CK1_1	5	11	PF00069	0.737
MOD_CK1_1	65	71	PF00069	0.638
MOD_CK2_1	166	172	PF00069	0.466
MOD_CK2_1	464	470	PF00069	0.725
MOD_CK2_1	5	11	PF00069	0.635
MOD_DYRK1A_RPxSP_1	542	546	PF00069	0.648
MOD_GlcNHglycan	100	103	PF01048	0.711
MOD_GlcNHglycan	64	67	PF01048	0.784
MOD_GSK3_1	110	117	PF00069	0.740
MOD_GSK3_1	166	173	PF00069	0.549
MOD_GSK3_1	288	295	PF00069	0.671
MOD_GSK3_1	296	303	PF00069	0.733
MOD_GSK3_1	310	317	PF00069	0.592
MOD_GSK3_1	358	365	PF00069	0.508
MOD_GSK3_1	388	395	PF00069	0.611
MOD_GSK3_1	53	60	PF00069	0.674
MOD_GSK3_1	594	601	PF00069	0.520
MOD_GSK3_1	604	611	PF00069	0.676
MOD_GSK3_1	621	628	PF00069	0.711
MOD_GSK3_1	65	72	PF00069	0.655
MOD_NEK2_1	152	157	PF00069	0.531
MOD_NEK2_1	170	175	PF00069	0.284
MOD_NEK2_1	177	182	PF00069	0.592
MOD_NEK2_1	198	203	PF00069	0.606
MOD_NEK2_1	279	284	PF00069	0.516
MOD_NEK2_1	293	298	PF00069	0.524
MOD_NEK2_1	45	50	PF00069	0.585
MOD_NEK2_1	608	613	PF00069	0.556
MOD_NEK2_2	636	641	PF00069	0.684
MOD_PIKK_1	17	23	PF00454	0.669
MOD_PIKK_1	293	299	PF00454	0.731
MOD_PIKK_1	491	497	PF00454	0.405
MOD_PIKK_1	524	530	PF00454	0.504
MOD_PIKK_1	608	614	PF00454	0.796
MOD_PIKK_1	709	715	PF00454	0.563
MOD_PKA_1	62	68	PF00069	0.534
MOD_PKA_2	130	136	PF00069	0.645
MOD_PKA_2	293	299	PF00069	0.746
MOD_PKA_2	32	38	PF00069	0.541
MOD_PKA_2	608	614	PF00069	0.796
MOD_Plk_1	324	330	PF00069	0.673
MOD_Plk_1	392	398	PF00069	0.430
MOD_Plk_2-3	166	172	PF00069	0.474
MOD_Plk_4	154	160	PF00069	0.466
MOD_Plk_4	358	364	PF00069	0.415
MOD_Plk_4	393	399	PF00069	0.353
MOD_Plk_4	493	499	PF00069	0.390
MOD_Plk_4	594	600	PF00069	0.464
MOD_Plk_4	636	642	PF00069	0.513
MOD_Plk_4	644	650	PF00069	0.415
MOD_Plk_4	652	658	PF00069	0.437
MOD_ProDKin_1	111	117	PF00069	0.651
MOD_ProDKin_1	236	242	PF00069	0.525
MOD_ProDKin_1	300	306	PF00069	0.561
MOD_ProDKin_1	501	507	PF00069	0.544
MOD_ProDKin_1	542	548	PF00069	0.569
MOD_ProDKin_1	552	558	PF00069	0.527
MOD_ProDKin_1	57	63	PF00069	0.684
MOD_ProDKin_1	65	71	PF00069	0.753
TRG_DiLeu_BaEn_1	393	398	PF01217	0.646
TRG_DiLeu_BaEn_1	536	541	PF01217	0.627
TRG_DiLeu_BaEn_4	143	149	PF01217	0.654
TRG_DiLeu_BaLyEn_6	148	153	PF01217	0.523
TRG_DiLeu_BaLyEn_6	158	163	PF01217	0.507
TRG_DiLeu_BaLyEn_6	529	534	PF01217	0.411
TRG_ENDOCYTIC_2	376	379	PF00928	0.544
TRG_ENDOCYTIC_2	512	515	PF00928	0.443
TRG_ENDOCYTIC_2	657	660	PF00928	0.459
TRG_ENDOCYTIC_2	687	690	PF00928	0.493
TRG_ENDOCYTIC_2	694	697	PF00928	0.481
TRG_ER_diArg_1	127	129	PF00400	0.726
TRG_ER_diArg_1	412	415	PF00400	0.573
TRG_ER_diArg_1	429	431	PF00400	0.399
TRG_ER_diArg_1	436	439	PF00400	0.600
TRG_ER_diArg_1	522	524	PF00400	0.437
TRG_ER_diArg_1	568	570	PF00400	0.543
TRG_ER_diArg_1	641	643	PF00400	0.522
TRG_NES_CRM1_1	165	178	PF08389	0.511
TRG_Pf-PMV_PEXEL_1	351	355	PF00026	0.654
TRG_Pf-PMV_PEXEL_1	430	435	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	532	536	PF00026	0.377
TRG_Pf-PMV_PEXEL_1	706	710	PF00026	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4U6	Leptomonas seymouri	40%	96%
A0A3Q8ILF7	Leishmania donovani	83%	99%
A4HC89	Leishmania braziliensis	64%	100%
A4HZR8	Leishmania infantum	84%	99%
Q4QBV5	Leishmania major	82%	100%