EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AVM1_LEIMU

TriTrypDb:

LmxM.22.0370

Length:

274

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVM1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVM1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.597
CLV_C14_Caspase3-7	6	10	PF00656	0.368
CLV_NRD_NRD_1	150	152	PF00675	0.673
CLV_PCSK_FUR_1	69	73	PF00082	0.312
CLV_PCSK_KEX2_1	152	154	PF00082	0.598
CLV_PCSK_KEX2_1	71	73	PF00082	0.517
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.488
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.451
CLV_PCSK_SKI1_1	188	192	PF00082	0.438
CLV_PCSK_SKI1_1	40	44	PF00082	0.405
DEG_APCC_DBOX_1	39	47	PF00400	0.403
DEG_Nend_UBRbox_1	1	4	PF02207	0.575
DOC_CYCLIN_RxL_1	198	209	PF00134	0.275
DOC_CYCLIN_RxL_1	37	45	PF00134	0.400
DOC_CYCLIN_yCln2_LP_2	22	28	PF00134	0.414
DOC_PP1_RVXF_1	186	192	PF00149	0.417
DOC_PP1_RVXF_1	225	231	PF00149	0.402
DOC_PP2B_LxvP_1	65	68	PF13499	0.337
DOC_PP4_FxxP_1	161	164	PF00568	0.514
DOC_USP7_MATH_1	167	171	PF00917	0.576
DOC_USP7_MATH_1	73	77	PF00917	0.423
DOC_USP7_MATH_1	95	99	PF00917	0.659
DOC_WW_Pin1_4	206	211	PF00397	0.500
DOC_WW_Pin1_4	55	60	PF00397	0.521
LIG_14-3-3_CanoR_1	88	92	PF00244	0.506
LIG_BIR_III_4	166	170	PF00653	0.574
LIG_FHA_1	143	149	PF00498	0.618
LIG_FHA_1	215	221	PF00498	0.463
LIG_FHA_2	108	114	PF00498	0.390
LIG_FHA_2	124	130	PF00498	0.593
LIG_FHA_2	252	258	PF00498	0.576
LIG_FHA_2	58	64	PF00498	0.464
LIG_Integrin_isoDGR_2	31	33	PF01839	0.398
LIG_LIR_Apic_2	158	164	PF02991	0.509
LIG_LIR_Gen_1	265	274	PF02991	0.382
LIG_LIR_Nem_3	197	203	PF02991	0.363
LIG_LIR_Nem_3	265	270	PF02991	0.374
LIG_LIR_Nem_3	45	50	PF02991	0.414
LIG_MYND_1	100	104	PF01753	0.459
LIG_NBox_RRM_1	7	17	PF00076	0.359
LIG_NRBOX	244	250	PF00104	0.396
LIG_NRBOX	7	13	PF00104	0.472
LIG_SH2_CRK	200	204	PF00017	0.264
LIG_SH2_NCK_1	74	78	PF00017	0.396
LIG_SH3_3	175	181	PF00018	0.498
LIG_SH3_3	207	213	PF00018	0.472
LIG_SH3_3	78	84	PF00018	0.495
LIG_WW_3	85	89	PF00397	0.490
MOD_CK1_1	155	161	PF00069	0.689
MOD_CK1_1	49	55	PF00069	0.597
MOD_CK1_1	58	64	PF00069	0.521
MOD_CK2_1	107	113	PF00069	0.415
MOD_CK2_1	123	129	PF00069	0.536
MOD_CK2_1	206	212	PF00069	0.411
MOD_CK2_1	251	257	PF00069	0.457
MOD_GlcNHglycan	12	15	PF01048	0.284
MOD_GlcNHglycan	93	96	PF01048	0.773
MOD_GSK3_1	129	136	PF00069	0.644
MOD_GSK3_1	155	162	PF00069	0.639
MOD_GSK3_1	165	172	PF00069	0.629
MOD_GSK3_1	42	49	PF00069	0.459
MOD_GSK3_1	51	58	PF00069	0.562
MOD_GSK3_1	87	94	PF00069	0.609
MOD_NEK2_1	42	47	PF00069	0.394
MOD_PIKK_1	123	129	PF00454	0.572
MOD_PIKK_1	51	57	PF00454	0.606
MOD_PKA_1	152	158	PF00069	0.493
MOD_PKA_2	152	158	PF00069	0.721
MOD_PKA_2	87	93	PF00069	0.506
MOD_PKB_1	151	159	PF00069	0.630
MOD_Plk_1	141	147	PF00069	0.724
MOD_Plk_2-3	3	9	PF00069	0.472
MOD_Plk_4	142	148	PF00069	0.641
MOD_Plk_4	3	9	PF00069	0.614
MOD_ProDKin_1	206	212	PF00069	0.504
MOD_ProDKin_1	55	61	PF00069	0.516
TRG_DiLeu_BaLyEn_6	38	43	PF01217	0.385
TRG_ENDOCYTIC_2	193	196	PF00928	0.385
TRG_ENDOCYTIC_2	200	203	PF00928	0.338
TRG_ENDOCYTIC_2	74	77	PF00928	0.496
TRG_ER_diArg_1	151	154	PF00400	0.757
TRG_Pf-PMV_PEXEL_1	243	247	PF00026	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB35	Leptomonas seymouri	40%	99%
A0A3S7WWY3	Leishmania donovani	84%	100%
A4HC86	Leishmania braziliensis	63%	100%
A4HZR5	Leishmania infantum	85%	100%
Q4QBV8	Leishmania major	82%	100%