Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVM0_LEIMU

TriTrypDb:

LmxM.22.0360

Length:

343

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVM0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVM0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	39	43	PF00656	0.629
CLV_NRD_NRD_1	145	147	PF00675	0.569
CLV_NRD_NRD_1	157	159	PF00675	0.411
CLV_NRD_NRD_1	187	189	PF00675	0.491
CLV_NRD_NRD_1	293	295	PF00675	0.715
CLV_NRD_NRD_1	93	95	PF00675	0.485
CLV_PCSK_KEX2_1	144	146	PF00082	0.624
CLV_PCSK_KEX2_1	157	159	PF00082	0.472
CLV_PCSK_KEX2_1	187	189	PF00082	0.491
CLV_PCSK_KEX2_1	269	271	PF00082	0.665
CLV_PCSK_KEX2_1	293	295	PF00082	0.715
CLV_PCSK_KEX2_1	64	66	PF00082	0.373
CLV_PCSK_KEX2_1	93	95	PF00082	0.485
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.541
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.665
CLV_PCSK_PC1ET2_1	64	66	PF00082	0.344
CLV_PCSK_PC7_1	265	271	PF00082	0.639
CLV_PCSK_PC7_1	289	295	PF00082	0.492
CLV_PCSK_SKI1_1	174	178	PF00082	0.548
CLV_PCSK_SKI1_1	188	192	PF00082	0.448
CLV_PCSK_SKI1_1	77	81	PF00082	0.582
CLV_Separin_Metazoa	53	57	PF03568	0.543
DEG_APCC_DBOX_1	156	164	PF00400	0.624
DEG_APCC_DBOX_1	55	63	PF00400	0.566
DOC_CYCLIN_RxL_1	72	83	PF00134	0.569
DOC_MAPK_DCC_7	165	173	PF00069	0.443
DOC_MAPK_gen_1	293	300	PF00069	0.543
DOC_MAPK_gen_1	306	314	PF00069	0.608
DOC_MAPK_gen_1	72	81	PF00069	0.438
DOC_MAPK_gen_1	93	101	PF00069	0.479
DOC_PP2B_LxvP_1	45	48	PF13499	0.465
DOC_USP7_MATH_1	211	215	PF00917	0.706
DOC_USP7_MATH_1	274	278	PF00917	0.564
DOC_USP7_UBL2_3	228	232	PF12436	0.703
DOC_WW_Pin1_4	293	298	PF00397	0.658
LIG_14-3-3_CanoR_1	157	161	PF00244	0.460
LIG_14-3-3_CanoR_1	16	24	PF00244	0.659
LIG_14-3-3_CanoR_1	187	191	PF00244	0.513
LIG_14-3-3_CanoR_1	282	290	PF00244	0.731
LIG_14-3-3_CanoR_1	302	309	PF00244	0.429
LIG_14-3-3_CanoR_1	56	60	PF00244	0.633
LIG_14-3-3_CanoR_1	75	80	PF00244	0.383
LIG_Actin_WH2_2	52	69	PF00022	0.527
LIG_FHA_1	24	30	PF00498	0.646
LIG_FHA_1	262	268	PF00498	0.528
LIG_FHA_1	49	55	PF00498	0.573
LIG_FHA_1	76	82	PF00498	0.575
LIG_FHA_1	87	93	PF00498	0.392
LIG_FHA_2	136	142	PF00498	0.563
LIG_FHA_2	34	40	PF00498	0.544
LIG_LIR_Gen_1	206	215	PF02991	0.635
LIG_LIR_Nem_3	175	180	PF02991	0.465
LIG_LIR_Nem_3	206	210	PF02991	0.626
LIG_PDZ_Class_2	338	343	PF00595	0.555
LIG_REV1ctd_RIR_1	175	183	PF16727	0.591
LIG_SH2_SRC	98	101	PF00017	0.481
LIG_SH2_STAT3	259	262	PF00017	0.639
LIG_SH2_STAT5	98	101	PF00017	0.481
LIG_SUMO_SIM_anti_2	239	245	PF11976	0.606
LIG_SUMO_SIM_anti_2	57	63	PF11976	0.436
LIG_SUMO_SIM_par_1	169	175	PF11976	0.529
LIG_SUMO_SIM_par_1	77	83	PF11976	0.530
LIG_TRAF2_1	140	143	PF00917	0.557
LIG_TYR_ITIM	96	101	PF00017	0.476
LIG_WRC_WIRS_1	204	209	PF05994	0.619
MOD_CK1_1	15	21	PF00069	0.666
MOD_CK1_1	206	212	PF00069	0.604
MOD_CK1_1	231	237	PF00069	0.554
MOD_CK1_1	301	307	PF00069	0.663
MOD_CK2_1	135	141	PF00069	0.605
MOD_CK2_1	46	52	PF00069	0.720
MOD_Cter_Amidation	267	270	PF01082	0.636
MOD_GlcNHglycan	213	216	PF01048	0.646
MOD_GlcNHglycan	276	279	PF01048	0.601
MOD_GlcNHglycan	331	334	PF01048	0.670
MOD_GSK3_1	12	19	PF00069	0.611
MOD_GSK3_1	152	159	PF00069	0.585
MOD_GSK3_1	20	27	PF00069	0.687
MOD_GSK3_1	274	281	PF00069	0.619
MOD_GSK3_1	284	291	PF00069	0.575
MOD_NEK2_1	108	113	PF00069	0.567
MOD_NEK2_1	135	140	PF00069	0.558
MOD_NEK2_1	24	29	PF00069	0.600
MOD_NEK2_1	261	266	PF00069	0.491
MOD_NEK2_1	40	45	PF00069	0.648
MOD_NEK2_1	66	71	PF00069	0.515
MOD_NEK2_2	152	157	PF00069	0.579
MOD_PIKK_1	301	307	PF00454	0.638
MOD_PIKK_1	66	72	PF00454	0.516
MOD_PKA_2	135	141	PF00069	0.499
MOD_PKA_2	15	21	PF00069	0.700
MOD_PKA_2	156	162	PF00069	0.556
MOD_PKA_2	186	192	PF00069	0.515
MOD_PKA_2	281	287	PF00069	0.604
MOD_PKA_2	288	294	PF00069	0.610
MOD_PKA_2	301	307	PF00069	0.431
MOD_PKA_2	55	61	PF00069	0.589
MOD_PKA_2	66	72	PF00069	0.453
MOD_Plk_1	152	158	PF00069	0.527
MOD_Plk_1	24	30	PF00069	0.653
MOD_Plk_1	41	47	PF00069	0.605
MOD_Plk_4	2	8	PF00069	0.571
MOD_Plk_4	203	209	PF00069	0.615
MOD_Plk_4	231	237	PF00069	0.556
MOD_Plk_4	24	30	PF00069	0.606
MOD_ProDKin_1	293	299	PF00069	0.658
TRG_DiLeu_LyEn_5	167	172	PF01217	0.409
TRG_ENDOCYTIC_2	98	101	PF00928	0.404
TRG_ER_diArg_1	156	158	PF00400	0.637
TRG_ER_diArg_1	186	188	PF00400	0.484
TRG_ER_diArg_1	92	94	PF00400	0.482
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	77	82	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVH6	Leptomonas seymouri	43%	98%
A0A3S7WX10	Leishmania donovani	87%	100%
A4HC85	Leishmania braziliensis	69%	100%
A4HZR4	Leishmania infantum	89%	100%
Q4QBV9	Leishmania major	87%	100%