Methylenetetrahydrofolate dehydrogenase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methylenetetrahydrofolate dehydrogenase-like protein

Species:

Leishmania mexicana

UniProt:

E9AVL8_LEIMU

TriTrypDb:

LmxM.22.0340

Length:

457

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVL8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVL8

Function

Biological processes
Term	Name	Level	Count
GO:0006730	one-carbon metabolic process	3	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0044237	cellular metabolic process	2	8
GO:0044281	small molecule metabolic process	2	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004486	methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity	5	8
GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity	6	8
GO:0016491	oxidoreductase activity	2	8
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	3	8
GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	4	8
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	50	54	PF00656	0.324
CLV_NRD_NRD_1	273	275	PF00675	0.541
CLV_NRD_NRD_1	371	373	PF00675	0.342
CLV_NRD_NRD_1	62	64	PF00675	0.278
CLV_PCSK_KEX2_1	272	274	PF00082	0.575
CLV_PCSK_KEX2_1	61	63	PF00082	0.277
CLV_PCSK_PC1ET2_1	61	63	PF00082	0.302
CLV_PCSK_SKI1_1	193	197	PF00082	0.440
CLV_PCSK_SKI1_1	205	209	PF00082	0.247
CLV_PCSK_SKI1_1	73	77	PF00082	0.179
DEG_APCC_DBOX_1	143	151	PF00400	0.554
DEG_APCC_DBOX_1	272	280	PF00400	0.290
DEG_SPOP_SBC_1	240	244	PF00917	0.472
DOC_CYCLIN_yCln2_LP_2	104	110	PF00134	0.302
DOC_MAPK_DCC_7	394	404	PF00069	0.179
DOC_MAPK_gen_1	272	281	PF00069	0.303
DOC_MAPK_gen_1	297	305	PF00069	0.179
DOC_MAPK_HePTP_8	36	48	PF00069	0.290
DOC_MAPK_MEF2A_6	39	48	PF00069	0.248
DOC_MAPK_MEF2A_6	443	451	PF00069	0.572
DOC_PP2B_LxvP_1	104	107	PF13499	0.246
DOC_PP2B_LxvP_1	449	452	PF13499	0.571
DOC_SPAK_OSR1_1	300	304	PF12202	0.179
DOC_USP7_MATH_1	152	156	PF00917	0.577
DOC_USP7_MATH_1	224	228	PF00917	0.552
DOC_USP7_MATH_1	240	244	PF00917	0.576
DOC_USP7_MATH_1	262	266	PF00917	0.674
DOC_USP7_UBL2_3	24	28	PF12436	0.179
DOC_WW_Pin1_4	251	256	PF00397	0.706
LIG_14-3-3_CanoR_1	263	271	PF00244	0.592
LIG_14-3-3_CanoR_1	300	306	PF00244	0.245
LIG_14-3-3_CanoR_1	308	313	PF00244	0.275
LIG_14-3-3_CanoR_1	31	37	PF00244	0.340
LIG_14-3-3_CanoR_1	62	70	PF00244	0.374
LIG_14-3-3_CanoR_1	9	17	PF00244	0.569
LIG_EVH1_1	106	110	PF00568	0.362
LIG_FHA_1	245	251	PF00498	0.604
LIG_FHA_1	289	295	PF00498	0.246
LIG_FHA_1	3	9	PF00498	0.539
LIG_FHA_1	32	38	PF00498	0.393
LIG_FHA_1	428	434	PF00498	0.522
LIG_FHA_2	62	68	PF00498	0.220
LIG_LIR_Gen_1	206	216	PF02991	0.445
LIG_LIR_Gen_1	422	433	PF02991	0.480
LIG_LIR_Nem_3	206	212	PF02991	0.413
LIG_LIR_Nem_3	215	221	PF02991	0.519
LIG_LIR_Nem_3	422	428	PF02991	0.510
LIG_PCNA_yPIPBox_3	164	174	PF02747	0.409
LIG_Pex14_2	335	339	PF04695	0.290
LIG_SH2_CRK	429	433	PF00017	0.565
LIG_SH2_GRB2like	57	60	PF00017	0.362
LIG_SH2_NCK_1	425	429	PF00017	0.520
LIG_SH2_SRC	57	60	PF00017	0.290
LIG_SH2_STAP1	429	433	PF00017	0.513
LIG_SH2_STAT3	359	362	PF00017	0.179
LIG_SH2_STAT5	211	214	PF00017	0.409
LIG_SH2_STAT5	429	432	PF00017	0.512
LIG_SH2_STAT5	57	60	PF00017	0.246
LIG_SH3_3	104	110	PF00018	0.414
LIG_SH3_3	230	236	PF00018	0.622
LIG_SH3_3	284	290	PF00018	0.246
LIG_SUMO_SIM_anti_2	229	234	PF11976	0.469
LIG_SUMO_SIM_par_1	400	405	PF11976	0.242
LIG_SUMO_SIM_par_1	44	50	PF11976	0.302
LIG_SxIP_EBH_1	263	274	PF03271	0.459
LIG_TYR_ITIM	423	428	PF00017	0.407
LIG_UBA3_1	118	125	PF00899	0.246
MOD_CK1_1	241	247	PF00069	0.649
MOD_CK1_1	264	270	PF00069	0.525
MOD_CK1_1	311	317	PF00069	0.290
MOD_CK1_1	35	41	PF00069	0.389
MOD_CK1_1	4	10	PF00069	0.650
MOD_CK2_1	228	234	PF00069	0.721
MOD_CK2_1	251	257	PF00069	0.606
MOD_CK2_1	61	67	PF00069	0.220
MOD_GlcNHglycan	12	15	PF01048	0.382
MOD_GlcNHglycan	154	157	PF01048	0.655
MOD_GlcNHglycan	17	20	PF01048	0.246
MOD_GlcNHglycan	183	186	PF01048	0.753
MOD_GlcNHglycan	244	247	PF01048	0.513
MOD_GlcNHglycan	264	267	PF01048	0.454
MOD_GlcNHglycan	369	372	PF01048	0.350
MOD_GlcNHglycan	385	388	PF01048	0.322
MOD_GlcNHglycan	77	80	PF01048	0.455
MOD_GSK3_1	142	149	PF00069	0.611
MOD_GSK3_1	203	210	PF00069	0.419
MOD_GSK3_1	224	231	PF00069	0.649
MOD_GSK3_1	234	241	PF00069	0.603
MOD_GSK3_1	245	252	PF00069	0.667
MOD_GSK3_1	261	268	PF00069	0.574
MOD_GSK3_1	304	311	PF00069	0.336
MOD_GSK3_1	31	38	PF00069	0.383
MOD_GSK3_1	4	11	PF00069	0.697
MOD_N-GLC_1	281	286	PF02516	0.246
MOD_N-GLC_1	31	36	PF02516	0.179
MOD_NEK2_1	1	6	PF00069	0.629
MOD_NEK2_1	207	212	PF00069	0.272
MOD_NEK2_1	301	306	PF00069	0.268
MOD_NEK2_1	335	340	PF00069	0.403
MOD_NEK2_1	402	407	PF00069	0.266
MOD_NEK2_1	77	82	PF00069	0.290
MOD_NEK2_1	8	13	PF00069	0.524
MOD_NEK2_1	86	91	PF00069	0.231
MOD_PIKK_1	111	117	PF00454	0.306
MOD_PIKK_1	265	271	PF00454	0.584
MOD_PK_1	51	57	PF00069	0.268
MOD_PKA_1	61	67	PF00069	0.179
MOD_PKA_2	181	187	PF00069	0.565
MOD_PKA_2	262	268	PF00069	0.607
MOD_PKA_2	30	36	PF00069	0.384
MOD_PKA_2	61	67	PF00069	0.244
MOD_PKA_2	8	14	PF00069	0.481
MOD_Plk_1	228	234	PF00069	0.707
MOD_Plk_1	281	287	PF00069	0.246
MOD_Plk_1	31	37	PF00069	0.250
MOD_Plk_1	335	341	PF00069	0.362
MOD_Plk_4	146	152	PF00069	0.680
MOD_Plk_4	157	163	PF00069	0.701
MOD_Plk_4	228	234	PF00069	0.468
MOD_Plk_4	32	38	PF00069	0.434
MOD_ProDKin_1	251	257	PF00069	0.707
TRG_DiLeu_BaEn_2	191	197	PF01217	0.363
TRG_ENDOCYTIC_2	425	428	PF00928	0.528
TRG_ENDOCYTIC_2	429	432	PF00928	0.514
TRG_ER_diArg_1	187	190	PF00400	0.631
TRG_ER_diArg_1	271	274	PF00400	0.589

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAR1	Leptomonas seymouri	55%	88%
A0A1X0NT48	Trypanosomatidae	43%	100%
A0A3Q8IB41	Leishmania donovani	86%	100%
A0A422NSL2	Trypanosoma rangeli	41%	100%
A4HZR2	Leishmania infantum	85%	96%
V5BK74	Trypanosoma cruzi	42%	100%