SEP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SEP domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AVL6_LEIMU

TriTrypDb:

LmxM.22.0320

Length:

351

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005829	cytosol	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AVL6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVL6

Function

Biological processes
Term	Name	Level	Count
GO:0000045	autophagosome assembly	6	1
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006996	organelle organization	4	1
GO:0007030	Golgi organization	5	1
GO:0007033	vacuole organization	5	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0016043	cellular component organization	3	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0022607	cellular component assembly	4	1
GO:0030163	protein catabolic process	4	1
GO:0031468	nuclear membrane reassembly	6	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0061024	membrane organization	4	1
GO:0061025	membrane fusion	5	1
GO:0070925	organelle assembly	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0071709	membrane assembly	5	1
GO:0071763	nuclear membrane organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1905037	autophagosome organization	6	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0032182	ubiquitin-like protein binding	3	1
GO:0043130	ubiquitin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	20	24	PF00656	0.585
CLV_NRD_NRD_1	286	288	PF00675	0.484
CLV_NRD_NRD_1	325	327	PF00675	0.552
CLV_NRD_NRD_1	48	50	PF00675	0.648
CLV_NRD_NRD_1	99	101	PF00675	0.588
CLV_PCSK_KEX2_1	286	288	PF00082	0.604
CLV_PCSK_KEX2_1	325	327	PF00082	0.552
CLV_PCSK_SKI1_1	25	29	PF00082	0.500
DEG_Nend_UBRbox_2	1	3	PF02207	0.624
DOC_MAPK_gen_1	13	21	PF00069	0.546
DOC_MAPK_gen_1	148	157	PF00069	0.453
DOC_MAPK_gen_1	283	291	PF00069	0.600
DOC_MAPK_gen_1	340	348	PF00069	0.498
DOC_MAPK_MEF2A_6	13	21	PF00069	0.569
DOC_MAPK_MEF2A_6	148	157	PF00069	0.452
DOC_PP2B_LxvP_1	229	232	PF13499	0.680
DOC_USP7_MATH_1	107	111	PF00917	0.721
DOC_USP7_MATH_1	149	153	PF00917	0.597
DOC_USP7_MATH_1	171	175	PF00917	0.498
DOC_USP7_MATH_1	230	234	PF00917	0.603
DOC_USP7_MATH_1	235	239	PF00917	0.616
DOC_USP7_MATH_1	245	249	PF00917	0.547
DOC_USP7_MATH_1	252	256	PF00917	0.517
DOC_WW_Pin1_4	137	142	PF00397	0.495
DOC_WW_Pin1_4	231	236	PF00397	0.580
DOC_WW_Pin1_4	254	259	PF00397	0.626
LIG_14-3-3_CanoR_1	132	142	PF00244	0.521
LIG_14-3-3_CanoR_1	295	299	PF00244	0.418
LIG_BRCT_BRCA1_1	165	169	PF00533	0.539
LIG_CaM_NSCaTE_8	33	40	PF13499	0.561
LIG_CtBP_PxDLS_1	190	194	PF00389	0.559
LIG_FHA_1	201	207	PF00498	0.530
LIG_FHA_1	272	278	PF00498	0.482
LIG_FHA_2	114	120	PF00498	0.727
LIG_FHA_2	18	24	PF00498	0.551
LIG_FHA_2	280	286	PF00498	0.530
LIG_FHA_2	295	301	PF00498	0.411
LIG_LIR_Apic_2	185	191	PF02991	0.559
LIG_LIR_Apic_2	213	217	PF02991	0.518
LIG_LIR_Gen_1	274	280	PF02991	0.486
LIG_LIR_Nem_3	14	19	PF02991	0.530
LIG_LIR_Nem_3	166	172	PF02991	0.523
LIG_LIR_Nem_3	274	279	PF02991	0.486
LIG_PCNA_yPIPBox_3	309	320	PF02747	0.511
LIG_SH2_PTP2	188	191	PF00017	0.515
LIG_SH2_PTP2	214	217	PF00017	0.515
LIG_SH2_SRC	188	191	PF00017	0.515
LIG_SH2_SRC	214	217	PF00017	0.515
LIG_SH2_STAT5	135	138	PF00017	0.553
LIG_SH2_STAT5	142	145	PF00017	0.569
LIG_SH2_STAT5	188	191	PF00017	0.512
LIG_SH2_STAT5	214	217	PF00017	0.498
LIG_SH2_STAT5	219	222	PF00017	0.512
LIG_SH2_STAT5	57	60	PF00017	0.539
LIG_SH3_3	229	235	PF00018	0.591
LIG_SH3_3	67	73	PF00018	0.625
LIG_SUMO_SIM_anti_2	274	282	PF11976	0.447
LIG_SUMO_SIM_par_1	274	282	PF11976	0.510
LIG_UBA3_1	94	101	PF00899	0.551
LIG_WW_1	216	219	PF00397	0.515
LIG_WW_3	322	326	PF00397	0.470
MOD_CK1_1	79	85	PF00069	0.704
MOD_CK1_1	8	14	PF00069	0.514
MOD_CK2_1	113	119	PF00069	0.729
MOD_CK2_1	279	285	PF00069	0.516
MOD_DYRK1A_RPxSP_1	254	258	PF00069	0.519
MOD_GlcNHglycan	109	112	PF01048	0.677
MOD_GlcNHglycan	238	241	PF01048	0.647
MOD_GlcNHglycan	254	257	PF01048	0.556
MOD_GlcNHglycan	65	68	PF01048	0.515
MOD_GlcNHglycan	73	76	PF01048	0.689
MOD_GlcNHglycan	80	84	PF01048	0.692
MOD_GlcNHglycan	86	89	PF01048	0.583
MOD_GSK3_1	133	140	PF00069	0.493
MOD_GSK3_1	149	156	PF00069	0.349
MOD_GSK3_1	231	238	PF00069	0.576
MOD_GSK3_1	267	274	PF00069	0.476
MOD_GSK3_1	328	335	PF00069	0.544
MOD_GSK3_1	4	11	PF00069	0.599
MOD_GSK3_1	86	93	PF00069	0.581
MOD_N-GLC_1	33	38	PF02516	0.485
MOD_N-GLC_1	76	81	PF02516	0.542
MOD_NEK2_1	133	138	PF00069	0.500
MOD_NEK2_1	279	284	PF00069	0.541
MOD_NEK2_1	327	332	PF00069	0.580
MOD_PK_1	5	11	PF00069	0.561
MOD_PKA_2	294	300	PF00069	0.427
MOD_Plk_1	149	155	PF00069	0.418
MOD_Plk_1	200	206	PF00069	0.497
MOD_Plk_1	271	277	PF00069	0.563
MOD_Plk_1	33	39	PF00069	0.481
MOD_Plk_2-3	267	273	PF00069	0.618
MOD_Plk_2-3	294	300	PF00069	0.573
MOD_Plk_4	153	159	PF00069	0.234
MOD_Plk_4	272	278	PF00069	0.537
MOD_Plk_4	90	96	PF00069	0.469
MOD_ProDKin_1	137	143	PF00069	0.497
MOD_ProDKin_1	231	237	PF00069	0.585
MOD_ProDKin_1	254	260	PF00069	0.611
TRG_DiLeu_BaEn_2	175	181	PF01217	0.541
TRG_DiLeu_BaEn_2	271	277	PF01217	0.552
TRG_DiLeu_BaEn_2	310	316	PF01217	0.543
TRG_ENDOCYTIC_2	219	222	PF00928	0.510
TRG_ER_diArg_1	12	15	PF00400	0.563
TRG_ER_diArg_1	324	326	PF00400	0.575
TRG_NES_CRM1_1	201	213	PF08389	0.541
TRG_NLS_MonoExtN_4	47	53	PF00514	0.385
TRG_Pf-PMV_PEXEL_1	25	29	PF00026	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P591	Leptomonas seymouri	69%	100%
A0A0S4JV00	Bodo saltans	34%	95%
A0A1X0NTT3	Trypanosomatidae	39%	100%
A0A3Q8IAL1	Leishmania donovani	92%	100%
A0A422NSS0	Trypanosoma rangeli	37%	100%
A4HC82	Leishmania braziliensis	82%	100%
A4HZR0	Leishmania infantum	93%	100%
C9ZRJ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
O35987	Rattus norvegicus	25%	95%
P0C627	Rattus norvegicus	21%	100%
Q0KL01	Mus musculus	23%	100%
Q14CS0	Homo sapiens	22%	100%
Q3SZC4	Bos taurus	25%	95%
Q4QBW3	Leishmania major	92%	100%
Q54BQ5	Dictyostelium discoideum	25%	85%
Q5RBG3	Pongo abelii	26%	95%
Q5ZK10	Gallus gallus	26%	95%
Q9CZ44	Mus musculus	25%	95%
Q9UNZ2	Homo sapiens	26%	95%
V5AVR5	Trypanosoma cruzi	39%	100%