Carnitine palmitoyltransferase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

carnitine palmitoyltransferase-like protein

Species:

Leishmania mexicana

UniProt:

E9AVL5_LEIMU

TriTrypDb:

LmxM.22.0310

Length:

678

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AVL5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVL5

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	7
GO:0006629	lipid metabolic process	3	7
GO:0006631	fatty acid metabolic process	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0019752	carboxylic acid metabolic process	5	7
GO:0032787	monocarboxylic acid metabolic process	6	7
GO:0043436	oxoacid metabolic process	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044255	cellular lipid metabolic process	3	7
GO:0044281	small molecule metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:0006635	fatty acid beta-oxidation	6	1
GO:0009056	catabolic process	2	1
GO:0009062	fatty acid catabolic process	5	1
GO:0016042	lipid catabolic process	4	1
GO:0016054	organic acid catabolic process	4	1
GO:0019395	fatty acid oxidation	5	1
GO:0030258	lipid modification	4	1
GO:0034440	lipid oxidation	5	1
GO:0044242	cellular lipid catabolic process	4	1
GO:0044248	cellular catabolic process	3	1
GO:0044282	small molecule catabolic process	3	1
GO:0046395	carboxylic acid catabolic process	5	1
GO:0072329	monocarboxylic acid catabolic process	6	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004095	carnitine O-palmitoyltransferase activity	7	8
GO:0008374	O-acyltransferase activity	5	8
GO:0016406	carnitine O-acyltransferase activity	6	8
GO:0016409	palmitoyltransferase activity	5	8
GO:0016416	O-palmitoyltransferase activity	6	8
GO:0016740	transferase activity	2	12
GO:0016746	acyltransferase activity	3	12
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	277	281	PF00656	0.364
CLV_C14_Caspase3-7	403	407	PF00656	0.341
CLV_MEL_PAP_1	457	463	PF00089	0.267
CLV_NRD_NRD_1	114	116	PF00675	0.427
CLV_NRD_NRD_1	411	413	PF00675	0.395
CLV_NRD_NRD_1	429	431	PF00675	0.188
CLV_NRD_NRD_1	459	461	PF00675	0.337
CLV_NRD_NRD_1	518	520	PF00675	0.427
CLV_PCSK_KEX2_1	114	116	PF00082	0.427
CLV_PCSK_KEX2_1	157	159	PF00082	0.242
CLV_PCSK_KEX2_1	197	199	PF00082	0.438
CLV_PCSK_KEX2_1	411	413	PF00082	0.370
CLV_PCSK_KEX2_1	459	461	PF00082	0.364
CLV_PCSK_KEX2_1	518	520	PF00082	0.427
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.307
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.438
CLV_PCSK_SKI1_1	138	142	PF00082	0.438
CLV_PCSK_SKI1_1	158	162	PF00082	0.124
CLV_PCSK_SKI1_1	77	81	PF00082	0.291
DEG_APCC_DBOX_1	1	9	PF00400	0.555
DEG_SCF_FBW7_1	527	533	PF00400	0.243
DEG_SCF_FBW7_2	481	486	PF00400	0.451
DEG_SPOP_SBC_1	653	657	PF00917	0.556
DOC_ANK_TNKS_1	187	194	PF00023	0.453
DOC_CDC14_PxL_1	586	594	PF14671	0.410
DOC_CKS1_1	218	223	PF01111	0.427
DOC_CKS1_1	527	532	PF01111	0.247
DOC_CKS1_1	85	90	PF01111	0.366
DOC_CYCLIN_yCln2_LP_2	66	72	PF00134	0.467
DOC_MAPK_DCC_7	257	267	PF00069	0.281
DOC_MAPK_gen_1	136	143	PF00069	0.433
DOC_MAPK_gen_1	459	470	PF00069	0.404
DOC_MAPK_gen_1	518	527	PF00069	0.414
DOC_MAPK_MEF2A_6	61	68	PF00069	0.523
DOC_PP1_RVXF_1	255	262	PF00149	0.395
DOC_PP1_RVXF_1	438	445	PF00149	0.322
DOC_PP2B_LxvP_1	48	51	PF13499	0.414
DOC_PP2B_LxvP_1	66	69	PF13499	0.311
DOC_PP2B_LxvP_1	674	677	PF13499	0.473
DOC_USP7_MATH_1	121	125	PF00917	0.453
DOC_USP7_MATH_1	142	146	PF00917	0.392
DOC_USP7_MATH_1	400	404	PF00917	0.427
DOC_USP7_MATH_1	423	427	PF00917	0.427
DOC_USP7_MATH_1	653	657	PF00917	0.459
DOC_USP7_MATH_1	92	96	PF00917	0.427
DOC_USP7_UBL2_3	559	563	PF12436	0.328
DOC_WW_Pin1_4	217	222	PF00397	0.346
DOC_WW_Pin1_4	361	366	PF00397	0.444
DOC_WW_Pin1_4	369	374	PF00397	0.403
DOC_WW_Pin1_4	37	42	PF00397	0.644
DOC_WW_Pin1_4	477	482	PF00397	0.446
DOC_WW_Pin1_4	526	531	PF00397	0.388
DOC_WW_Pin1_4	80	85	PF00397	0.350
LIG_14-3-3_CanoR_1	114	121	PF00244	0.403
LIG_14-3-3_CanoR_1	144	150	PF00244	0.458
LIG_14-3-3_CanoR_1	325	329	PF00244	0.189
LIG_14-3-3_CanoR_1	42	46	PF00244	0.516
LIG_14-3-3_CanoR_1	518	527	PF00244	0.409
LIG_14-3-3_CanoR_1	540	544	PF00244	0.364
LIG_14-3-3_CanoR_1	567	573	PF00244	0.446
LIG_14-3-3_CanoR_1	579	586	PF00244	0.334
LIG_14-3-3_CanoR_1	634	640	PF00244	0.544
LIG_14-3-3_CanoR_1	77	85	PF00244	0.247
LIG_Actin_WH2_2	281	298	PF00022	0.427
LIG_BRCT_BRCA1_1	127	131	PF00533	0.427
LIG_BRCT_BRCA1_1	170	174	PF00533	0.307
LIG_BRCT_BRCA1_1	218	222	PF00533	0.404
LIG_BRCT_BRCA1_1	531	535	PF00533	0.295
LIG_BRCT_BRCA1_1	656	660	PF00533	0.505
LIG_BRCT_BRCA1_2	170	176	PF00533	0.392
LIG_CtBP_PxDLS_1	233	237	PF00389	0.307
LIG_eIF4E_1	125	131	PF01652	0.427
LIG_FHA_1	121	127	PF00498	0.296
LIG_FHA_1	146	152	PF00498	0.389
LIG_FHA_1	208	214	PF00498	0.295
LIG_FHA_1	218	224	PF00498	0.326
LIG_FHA_1	299	305	PF00498	0.165
LIG_FHA_1	324	330	PF00498	0.341
LIG_FHA_1	434	440	PF00498	0.301
LIG_FHA_1	456	462	PF00498	0.376
LIG_FHA_1	480	486	PF00498	0.384
LIG_FHA_1	531	537	PF00498	0.372
LIG_FHA_2	275	281	PF00498	0.317
LIG_FHA_2	42	48	PF00498	0.577
LIG_FHA_2	526	532	PF00498	0.391
LIG_Integrin_RGD_1	393	395	PF01839	0.453
LIG_LIR_Apic_2	591	596	PF02991	0.392
LIG_LIR_Gen_1	237	243	PF02991	0.352
LIG_LIR_Gen_1	27	38	PF02991	0.556
LIG_LIR_Gen_1	289	299	PF02991	0.299
LIG_LIR_Gen_1	311	317	PF02991	0.380
LIG_LIR_Gen_1	569	580	PF02991	0.267
LIG_LIR_Gen_1	595	606	PF02991	0.312
LIG_LIR_Nem_3	171	177	PF02991	0.377
LIG_LIR_Nem_3	237	242	PF02991	0.352
LIG_LIR_Nem_3	27	33	PF02991	0.504
LIG_LIR_Nem_3	289	295	PF02991	0.299
LIG_LIR_Nem_3	311	316	PF02991	0.359
LIG_LIR_Nem_3	569	575	PF02991	0.267
LIG_LIR_Nem_3	595	601	PF02991	0.276
LIG_MYND_1	51	55	PF01753	0.557
LIG_PCNA_yPIPBox_3	588	601	PF02747	0.329
LIG_Pex14_2	239	243	PF04695	0.405
LIG_Pex14_2	660	664	PF04695	0.473
LIG_PTB_Apo_2	412	419	PF02174	0.453
LIG_PTB_Phospho_1	412	418	PF10480	0.453
LIG_SH2_CRK	292	296	PF00017	0.307
LIG_SH2_GRB2like	413	416	PF00017	0.453
LIG_SH2_STAP1	572	576	PF00017	0.267
LIG_SH2_STAT5	125	128	PF00017	0.322
LIG_SH2_STAT5	178	181	PF00017	0.301
LIG_SH2_STAT5	217	220	PF00017	0.402
LIG_SH2_STAT5	25	28	PF00017	0.640
LIG_SH2_STAT5	413	416	PF00017	0.307
LIG_SH2_STAT5	621	624	PF00017	0.350
LIG_SH2_STAT5	78	81	PF00017	0.307
LIG_SH3_1	61	67	PF00018	0.525
LIG_SH3_3	215	221	PF00018	0.453
LIG_SH3_3	227	233	PF00018	0.255
LIG_SH3_3	300	306	PF00018	0.199
LIG_SH3_3	359	365	PF00018	0.456
LIG_SH3_3	598	604	PF00018	0.453
LIG_SH3_3	61	67	PF00018	0.525
LIG_SH3_3	640	646	PF00018	0.512
LIG_SUMO_SIM_anti_2	395	403	PF11976	0.227
LIG_SUMO_SIM_par_1	284	290	PF11976	0.409
LIG_TRAF2_1	340	343	PF00917	0.414
LIG_TRAF2_1	44	47	PF00917	0.594
LIG_TRAF2_1	667	670	PF00917	0.420
LIG_TRFH_1	621	625	PF08558	0.453
MOD_CDK_SPK_2	37	42	PF00069	0.586
MOD_CDK_SPxxK_3	369	376	PF00069	0.427
MOD_CK1_1	124	130	PF00069	0.302
MOD_CK1_1	145	151	PF00069	0.377
MOD_CK1_1	196	202	PF00069	0.377
MOD_CK1_1	311	317	PF00069	0.398
MOD_CK1_1	389	395	PF00069	0.448
MOD_CK1_1	526	532	PF00069	0.374
MOD_CK1_1	538	544	PF00069	0.428
MOD_CK1_1	566	572	PF00069	0.370
MOD_CK1_1	599	605	PF00069	0.308
MOD_CK2_1	284	290	PF00069	0.453
MOD_CK2_1	41	47	PF00069	0.594
MOD_CK2_1	525	531	PF00069	0.438
MOD_CK2_1	539	545	PF00069	0.236
MOD_GlcNHglycan	138	141	PF01048	0.391
MOD_GlcNHglycan	15	18	PF01048	0.690
MOD_GlcNHglycan	163	166	PF01048	0.466
MOD_GlcNHglycan	198	201	PF01048	0.395
MOD_GlcNHglycan	26	29	PF01048	0.660
MOD_GlcNHglycan	656	659	PF01048	0.419
MOD_GlcNHglycan	670	674	PF01048	0.452
MOD_GlcNHglycan	94	97	PF01048	0.368
MOD_GSK3_1	120	127	PF00069	0.307
MOD_GSK3_1	192	199	PF00069	0.428
MOD_GSK3_1	37	44	PF00069	0.575
MOD_GSK3_1	382	389	PF00069	0.346
MOD_GSK3_1	455	462	PF00069	0.403
MOD_GSK3_1	49	56	PF00069	0.312
MOD_GSK3_1	519	526	PF00069	0.440
MOD_GSK3_1	535	542	PF00069	0.274
MOD_GSK3_1	563	570	PF00069	0.453
MOD_GSK3_1	624	631	PF00069	0.493
MOD_GSK3_1	80	87	PF00069	0.383
MOD_GSK3_1	90	97	PF00069	0.384
MOD_N-GLC_1	243	248	PF02516	0.318
MOD_NEK2_1	131	136	PF00069	0.405
MOD_NEK2_1	161	166	PF00069	0.341
MOD_NEK2_1	168	173	PF00069	0.299
MOD_NEK2_1	207	212	PF00069	0.307
MOD_NEK2_1	234	239	PF00069	0.288
MOD_NEK2_1	242	247	PF00069	0.274
MOD_NEK2_1	274	279	PF00069	0.423
MOD_NEK2_1	386	391	PF00069	0.390
MOD_NEK2_1	399	404	PF00069	0.291
MOD_NEK2_1	535	540	PF00069	0.439
MOD_NEK2_1	630	635	PF00069	0.403
MOD_NEK2_1	71	76	PF00069	0.380
MOD_NEK2_1	91	96	PF00069	0.124
MOD_NEK2_2	619	624	PF00069	0.267
MOD_PIKK_1	234	240	PF00454	0.332
MOD_PIKK_1	543	549	PF00454	0.453
MOD_PK_1	371	377	PF00069	0.398
MOD_PK_1	384	390	PF00069	0.210
MOD_PKA_1	459	465	PF00069	0.370
MOD_PKA_2	113	119	PF00069	0.403
MOD_PKA_2	324	330	PF00069	0.189
MOD_PKA_2	41	47	PF00069	0.577
MOD_PKA_2	455	461	PF00069	0.379
MOD_PKA_2	464	470	PF00069	0.341
MOD_PKA_2	539	545	PF00069	0.422
MOD_PKA_2	566	572	PF00069	0.445
MOD_PKA_2	578	584	PF00069	0.362
MOD_Plk_1	131	137	PF00069	0.432
MOD_Plk_1	234	240	PF00069	0.302
MOD_Plk_1	243	249	PF00069	0.273
MOD_Plk_1	308	314	PF00069	0.380
MOD_Plk_1	341	347	PF00069	0.410
MOD_Plk_1	382	388	PF00069	0.333
MOD_Plk_1	400	406	PF00069	0.307
MOD_Plk_1	485	491	PF00069	0.392
MOD_Plk_1	530	536	PF00069	0.453
MOD_Plk_1	613	619	PF00069	0.466
MOD_Plk_1	669	675	PF00069	0.512
MOD_Plk_2-3	464	470	PF00069	0.350
MOD_Plk_4	121	127	PF00069	0.316
MOD_Plk_4	308	314	PF00069	0.463
MOD_Plk_4	324	330	PF00069	0.310
MOD_Plk_4	341	347	PF00069	0.416
MOD_Plk_4	49	55	PF00069	0.438
MOD_Plk_4	635	641	PF00069	0.513
MOD_ProDKin_1	217	223	PF00069	0.346
MOD_ProDKin_1	361	367	PF00069	0.444
MOD_ProDKin_1	369	375	PF00069	0.403
MOD_ProDKin_1	37	43	PF00069	0.633
MOD_ProDKin_1	477	483	PF00069	0.446
MOD_ProDKin_1	526	532	PF00069	0.388
MOD_ProDKin_1	80	86	PF00069	0.350
MOD_SUMO_for_1	102	105	PF00179	0.267
MOD_SUMO_rev_2	254	259	PF00179	0.397
TRG_DiLeu_BaEn_1	342	347	PF01217	0.440
TRG_DiLeu_BaEn_1	670	675	PF01217	0.516
TRG_DiLeu_BaEn_2	530	536	PF01217	0.453
TRG_ENDOCYTIC_2	292	295	PF00928	0.307
TRG_ENDOCYTIC_2	572	575	PF00928	0.267
TRG_ER_diArg_1	113	115	PF00400	0.427
TRG_ER_diArg_1	410	412	PF00400	0.412
TRG_ER_diArg_1	459	461	PF00400	0.339
TRG_ER_diArg_1	517	519	PF00400	0.344
TRG_ER_diArg_1	6	9	PF00400	0.619
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.281
TRG_Pf-PMV_PEXEL_1	412	416	PF00026	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK11	Leptomonas seymouri	61%	100%
A0A0S4JAG1	Bodo saltans	23%	93%
A0A0S4JRH6	Bodo saltans	38%	99%
A0A0S4JRL8	Bodo saltans	24%	84%
A0A0S4KE24	Bodo saltans	21%	82%
A0A1X0NT49	Trypanosomatidae	22%	91%
A0A1X0NT60	Trypanosomatidae	38%	100%
A0A1X0NZS6	Trypanosomatidae	23%	100%
A0A1X0P523	Trypanosomatidae	22%	89%
A0A1X0P5Y2	Trypanosomatidae	25%	86%
A0A3S5IQT1	Trypanosoma rangeli	23%	91%
A0A3S7WX31	Leishmania donovani	92%	100%
A0A422NSK2	Trypanosoma rangeli	36%	100%
A4HC81	Leishmania braziliensis	83%	100%
A4HHE2	Leishmania braziliensis	24%	100%
A4HZQ9	Leishmania infantum	92%	100%
B2ZGJ1	Danio rerio	23%	100%
C9ZL75	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
C9ZRI9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
D0A627	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	88%
F1LN46	Rattus norvegicus	23%	85%
O19094	Bos taurus	25%	100%
P07668	Drosophila melanogaster	25%	94%
P11466	Rattus norvegicus	26%	100%
P13222	Sus scrofa	25%	100%
P18886	Rattus norvegicus	30%	100%
P23786	Homo sapiens	30%	100%
P28329	Homo sapiens	26%	91%
P32198	Rattus norvegicus	24%	88%
P32738	Rattus norvegicus	25%	100%
P32756	Caenorhabditis elegans	23%	100%
P32796	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
P43155	Homo sapiens	23%	100%
P47934	Mus musculus	22%	100%
P52825	Mus musculus	30%	100%
P52826	Columba livia	25%	100%
P80235	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	99%
P97742	Mus musculus	25%	88%
Q00614	Candida tropicalis	21%	100%
Q03059	Mus musculus	26%	100%
Q2KJB7	Bos taurus	30%	100%
Q4QBW4	Leishmania major	90%	100%
Q58DK1	Bos taurus	22%	88%
Q5U3U3	Danio rerio	30%	100%
Q60HG9	Macaca fascicularis	30%	100%
Q63704	Rattus norvegicus	22%	88%
Q68Y62	Equus caballus	24%	87%
Q6P4X5	Xenopus tropicalis	27%	100%
Q704S8	Rattus norvegicus	23%	100%
Q7ZXE1	Xenopus laevis	28%	100%
Q8BGD5	Mus musculus	23%	85%
Q8HY46	Sus scrofa	23%	88%
Q8TCG5	Homo sapiens	25%	84%
Q90YJ9	Gallus gallus	25%	100%
Q924X2	Mus musculus	22%	88%
Q92523	Homo sapiens	23%	88%
Q9DC50	Mus musculus	26%	100%
Q9UKG9	Homo sapiens	25%	100%
V5BH74	Trypanosoma cruzi	25%	100%
V5BQH8	Trypanosoma cruzi	22%	85%
V5DBT5	Trypanosoma cruzi	39%	100%