Condensin complex subunit 1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVL4_LEIMU

TriTrypDb:

LmxM.22.0300

Length:

562

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVL4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVL4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.593
CLV_NRD_NRD_1	122	124	PF00675	0.588
CLV_NRD_NRD_1	247	249	PF00675	0.602
CLV_NRD_NRD_1	4	6	PF00675	0.725
CLV_NRD_NRD_1	411	413	PF00675	0.571
CLV_NRD_NRD_1	539	541	PF00675	0.853
CLV_NRD_NRD_1	554	556	PF00675	0.779
CLV_NRD_NRD_1	557	559	PF00675	0.732
CLV_PCSK_FUR_1	555	559	PF00082	0.769
CLV_PCSK_KEX2_1	4	6	PF00082	0.725
CLV_PCSK_KEX2_1	413	415	PF00082	0.609
CLV_PCSK_KEX2_1	482	484	PF00082	0.587
CLV_PCSK_KEX2_1	504	506	PF00082	0.726
CLV_PCSK_KEX2_1	529	531	PF00082	0.753
CLV_PCSK_KEX2_1	541	543	PF00082	0.821
CLV_PCSK_KEX2_1	554	556	PF00082	0.755
CLV_PCSK_KEX2_1	557	559	PF00082	0.706
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.725
CLV_PCSK_PC1ET2_1	413	415	PF00082	0.609
CLV_PCSK_PC1ET2_1	482	484	PF00082	0.587
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.726
CLV_PCSK_PC1ET2_1	529	531	PF00082	0.753
CLV_PCSK_PC1ET2_1	541	543	PF00082	0.821
CLV_PCSK_SKI1_1	124	128	PF00082	0.450
CLV_PCSK_SKI1_1	181	185	PF00082	0.595
CLV_PCSK_SKI1_1	205	209	PF00082	0.514
CLV_PCSK_SKI1_1	356	360	PF00082	0.438
CLV_PCSK_SKI1_1	363	367	PF00082	0.438
CLV_PCSK_SKI1_1	473	477	PF00082	0.510
DEG_APCC_DBOX_1	204	212	PF00400	0.534
DEG_APCC_DBOX_1	482	490	PF00400	0.650
DEG_SPOP_SBC_1	57	61	PF00917	0.647
DOC_CDC14_PxL_1	328	336	PF14671	0.500
DOC_CKS1_1	95	100	PF01111	0.586
DOC_CYCLIN_RxL_1	479	488	PF00134	0.632
DOC_MAPK_RevD_3	398	414	PF00069	0.538
DOC_PP1_RVXF_1	100	106	PF00149	0.438
DOC_PP1_RVXF_1	208	215	PF00149	0.420
DOC_PP1_RVXF_1	441	448	PF00149	0.558
DOC_PP4_MxPP_1	514	517	PF00568	0.798
DOC_USP7_MATH_1	192	196	PF00917	0.480
DOC_USP7_MATH_1	203	207	PF00917	0.433
DOC_USP7_MATH_1	465	469	PF00917	0.597
DOC_USP7_MATH_1	91	95	PF00917	0.614
DOC_USP7_UBL2_3	6	10	PF12436	0.787
DOC_WW_Pin1_4	136	141	PF00397	0.517
DOC_WW_Pin1_4	26	31	PF00397	0.624
DOC_WW_Pin1_4	9	14	PF00397	0.830
DOC_WW_Pin1_4	94	99	PF00397	0.556
LIG_14-3-3_CanoR_1	123	133	PF00244	0.571
LIG_14-3-3_CanoR_1	248	258	PF00244	0.650
LIG_14-3-3_CanoR_1	265	271	PF00244	0.498
LIG_14-3-3_CanoR_1	280	287	PF00244	0.420
LIG_14-3-3_CanoR_1	320	330	PF00244	0.541
LIG_14-3-3_CanoR_1	379	385	PF00244	0.569
LIG_14-3-3_CanoR_1	389	398	PF00244	0.549
LIG_14-3-3_CanoR_1	412	419	PF00244	0.592
LIG_14-3-3_CanoR_1	530	538	PF00244	0.799
LIG_Actin_WH2_2	109	125	PF00022	0.568
LIG_BIR_II_1	1	5	PF00653	0.677
LIG_BIR_III_2	182	186	PF00653	0.632
LIG_BRCT_BRCA1_1	200	204	PF00533	0.546
LIG_BRCT_BRCA1_1	324	328	PF00533	0.530
LIG_Clathr_ClatBox_1	397	401	PF01394	0.530
LIG_FHA_1	125	131	PF00498	0.457
LIG_FHA_1	137	143	PF00498	0.438
LIG_FHA_1	237	243	PF00498	0.543
LIG_FHA_1	267	273	PF00498	0.485
LIG_FHA_1	27	33	PF00498	0.738
LIG_FHA_1	280	286	PF00498	0.517
LIG_FHA_1	352	358	PF00498	0.493
LIG_FHA_1	392	398	PF00498	0.593
LIG_FHA_1	42	48	PF00498	0.625
LIG_FHA_1	95	101	PF00498	0.557
LIG_FHA_2	338	344	PF00498	0.570
LIG_FHA_2	472	478	PF00498	0.542
LIG_Integrin_RGD_1	558	560	PF01839	0.565
LIG_LIR_Apic_2	255	261	PF02991	0.591
LIG_LIR_Gen_1	160	171	PF02991	0.491
LIG_LIR_Gen_1	274	281	PF02991	0.448
LIG_LIR_Gen_1	61	71	PF02991	0.463
LIG_LIR_Nem_3	160	166	PF02991	0.523
LIG_LIR_Nem_3	201	207	PF02991	0.448
LIG_LIR_Nem_3	274	278	PF02991	0.446
LIG_LIR_Nem_3	325	331	PF02991	0.544
LIG_LIR_Nem_3	440	445	PF02991	0.610
LIG_LIR_Nem_3	61	67	PF02991	0.473
LIG_LRP6_Inhibitor_1	467	473	PF00058	0.602
LIG_LYPXL_S_1	330	334	PF13949	0.472
LIG_LYPXL_S_1	373	377	PF13949	0.540
LIG_LYPXL_yS_3	331	334	PF13949	0.477
LIG_LYPXL_yS_3	374	377	PF13949	0.545
LIG_MYND_3	294	298	PF01753	0.543
LIG_NRBOX	207	213	PF00104	0.533
LIG_NRP_CendR_1	561	562	PF00754	0.817
LIG_PCNA_yPIPBox_3	117	126	PF02747	0.576
LIG_PCNA_yPIPBox_3	291	300	PF02747	0.565
LIG_RPA_C_Fungi	407	419	PF08784	0.594
LIG_SH2_CRK	378	382	PF00017	0.480
LIG_SH2_CRK	442	446	PF00017	0.616
LIG_SH2_CRK	64	68	PF00017	0.487
LIG_SH2_SRC	258	261	PF00017	0.587
LIG_SH2_STAT3	81	84	PF00017	0.562
LIG_SH2_STAT5	165	168	PF00017	0.455
LIG_SH2_STAT5	300	303	PF00017	0.550
LIG_SH2_STAT5	376	379	PF00017	0.551
LIG_SH2_STAT5	81	84	PF00017	0.562
LIG_SH3_3	29	35	PF00018	0.727
LIG_SH3_3	44	50	PF00018	0.720
LIG_SH3_3	512	518	PF00018	0.712
LIG_SH3_3	92	98	PF00018	0.493
LIG_SUMO_SIM_anti_2	313	319	PF11976	0.436
LIG_SUMO_SIM_par_1	154	160	PF11976	0.579
LIG_SUMO_SIM_par_1	268	274	PF11976	0.489
LIG_SUMO_SIM_par_1	356	362	PF11976	0.569
LIG_SUMO_SIM_par_1	380	387	PF11976	0.530
LIG_SUMO_SIM_par_1	396	401	PF11976	0.509
LIG_SUMO_SIM_par_1	53	62	PF11976	0.402
LIG_SUMO_SIM_par_1	69	74	PF11976	0.479
LIG_TRAF2_1	14	17	PF00917	0.791
LIG_TRAF2_1	365	368	PF00917	0.302
LIG_TRFH_1	328	332	PF08558	0.458
MOD_CK1_1	195	201	PF00069	0.507
MOD_CK1_1	348	354	PF00069	0.616
MOD_CK1_1	383	389	PF00069	0.609
MOD_CK1_1	531	537	PF00069	0.805
MOD_CK1_1	69	75	PF00069	0.618
MOD_CK1_1	9	15	PF00069	0.814
MOD_CK1_1	94	100	PF00069	0.603
MOD_CK2_1	321	327	PF00069	0.508
MOD_CK2_1	471	477	PF00069	0.548
MOD_CK2_1	519	525	PF00069	0.672
MOD_CK2_1	56	62	PF00069	0.560
MOD_Cter_Amidation	526	529	PF01082	0.841
MOD_GlcNHglycan	201	204	PF01048	0.536
MOD_GlcNHglycan	414	417	PF01048	0.573
MOD_GlcNHglycan	432	435	PF01048	0.360
MOD_GlcNHglycan	461	464	PF01048	0.578
MOD_GlcNHglycan	521	524	PF01048	0.636
MOD_GSK3_1	195	202	PF00069	0.473
MOD_GSK3_1	344	351	PF00069	0.646
MOD_GSK3_1	359	366	PF00069	0.456
MOD_GSK3_1	423	430	PF00069	0.559
MOD_GSK3_1	58	65	PF00069	0.579
MOD_N-GLC_1	427	432	PF02516	0.583
MOD_NEK2_1	199	204	PF00069	0.468
MOD_NEK2_1	321	326	PF00069	0.483
MOD_NEK2_1	359	364	PF00069	0.560
MOD_NEK2_1	388	393	PF00069	0.587
MOD_NEK2_1	427	432	PF00069	0.553
MOD_PIKK_1	243	249	PF00454	0.560
MOD_PIKK_1	252	258	PF00454	0.544
MOD_PIKK_1	531	537	PF00454	0.838
MOD_PIKK_1	62	68	PF00454	0.579
MOD_PKA_1	412	418	PF00069	0.587
MOD_PKA_1	528	534	PF00069	0.833
MOD_PKA_2	236	242	PF00069	0.544
MOD_PKA_2	279	285	PF00069	0.594
MOD_PKA_2	388	394	PF00069	0.588
MOD_PKA_2	529	535	PF00069	0.856
MOD_PKA_2	553	559	PF00069	0.810
MOD_Plk_1	252	258	PF00069	0.640
MOD_Plk_1	423	429	PF00069	0.559
MOD_Plk_4	125	131	PF00069	0.458
MOD_Plk_4	154	160	PF00069	0.556
MOD_Plk_4	380	386	PF00069	0.534
MOD_Plk_4	66	72	PF00069	0.535
MOD_ProDKin_1	136	142	PF00069	0.507
MOD_ProDKin_1	26	32	PF00069	0.623
MOD_ProDKin_1	9	15	PF00069	0.829
MOD_ProDKin_1	94	100	PF00069	0.559
MOD_SUMO_rev_2	533	543	PF00179	0.855
TRG_DiLeu_BaEn_1	96	101	PF01217	0.523
TRG_DiLeu_BaLyEn_6	237	242	PF01217	0.520
TRG_DiLeu_BaLyEn_6	258	263	PF01217	0.578
TRG_DiLeu_BaLyEn_6	292	297	PF01217	0.462
TRG_ENDOCYTIC_2	331	334	PF00928	0.501
TRG_ENDOCYTIC_2	374	377	PF00928	0.459
TRG_ENDOCYTIC_2	378	381	PF00928	0.463
TRG_ENDOCYTIC_2	442	445	PF00928	0.621
TRG_ENDOCYTIC_2	64	67	PF00928	0.482
TRG_ER_diArg_1	101	104	PF00400	0.424
TRG_ER_diArg_1	554	557	PF00400	0.759
TRG_NES_CRM1_1	260	274	PF08389	0.540
TRG_NES_CRM1_1	277	290	PF08389	0.520
TRG_NES_CRM1_1	62	74	PF08389	0.499
TRG_NLS_Bipartite_1	528	545	PF00514	0.820
TRG_NLS_MonoExtC_3	411	417	PF00514	0.583
TRG_NLS_MonoExtC_3	540	546	PF00514	0.799
TRG_NLS_MonoExtN_4	3	8	PF00514	0.680
TRG_NLS_MonoExtN_4	538	545	PF00514	0.787

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4V0	Leptomonas seymouri	65%	95%
A0A0S4JSH7	Bodo saltans	30%	100%
A0A1X0NTF0	Trypanosomatidae	40%	100%
A0A3Q8IC40	Leishmania donovani	94%	100%
A0A3R7NVM0	Trypanosoma rangeli	41%	100%
A4HC80	Leishmania braziliensis	83%	100%
A4HZQ8	Leishmania infantum	94%	100%
C9ZSF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
Q4QBW5	Leishmania major	94%	100%
V5BFQ6	Trypanosoma cruzi	41%	100%