Mitochondrial carrier protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial carrier protein, putative

Species:

Leishmania mexicana

UniProt:

E9AVL3_LEIMU

TriTrypDb:

LmxM.22.0290

Length:

464

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AVL3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVL3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	243	247	PF00656	0.534
CLV_C14_Caspase3-7	387	391	PF00656	0.499
CLV_NRD_NRD_1	196	198	PF00675	0.402
CLV_NRD_NRD_1	202	204	PF00675	0.455
CLV_NRD_NRD_1	217	219	PF00675	0.298
CLV_NRD_NRD_1	374	376	PF00675	0.743
CLV_NRD_NRD_1	459	461	PF00675	0.531
CLV_NRD_NRD_1	63	65	PF00675	0.423
CLV_PCSK_KEX2_1	196	198	PF00082	0.402
CLV_PCSK_KEX2_1	202	204	PF00082	0.455
CLV_PCSK_KEX2_1	217	219	PF00082	0.351
CLV_PCSK_KEX2_1	374	376	PF00082	0.759
CLV_PCSK_KEX2_1	63	65	PF00082	0.433
CLV_PCSK_KEX2_1	70	72	PF00082	0.414
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.522
CLV_PCSK_PC7_1	59	65	PF00082	0.417
CLV_PCSK_PC7_1	66	72	PF00082	0.413
CLV_PCSK_SKI1_1	154	158	PF00082	0.412
CLV_PCSK_SKI1_1	160	164	PF00082	0.379
CLV_PCSK_SKI1_1	202	206	PF00082	0.463
DEG_COP1_1	342	352	PF00400	0.661
DEG_SPOP_SBC_1	363	367	PF00917	0.729
DOC_ANK_TNKS_1	241	248	PF00023	0.534
DOC_CDC14_PxL_1	320	328	PF14671	0.464
DOC_CKS1_1	252	257	PF01111	0.445
DOC_CKS1_1	311	316	PF01111	0.504
DOC_CYCLIN_yCln2_LP_2	299	305	PF00134	0.513
DOC_MAPK_MEF2A_6	54	62	PF00069	0.418
DOC_PP1_RVXF_1	152	159	PF00149	0.449
DOC_PP1_RVXF_1	438	444	PF00149	0.458
DOC_PP1_RVXF_1	57	63	PF00149	0.435
DOC_PP4_FxxP_1	216	219	PF00568	0.567
DOC_PP4_FxxP_1	73	76	PF00568	0.415
DOC_USP7_MATH_1	129	133	PF00917	0.398
DOC_USP7_MATH_1	361	365	PF00917	0.651
DOC_WW_Pin1_4	115	120	PF00397	0.435
DOC_WW_Pin1_4	222	227	PF00397	0.591
DOC_WW_Pin1_4	251	256	PF00397	0.699
DOC_WW_Pin1_4	298	303	PF00397	0.364
DOC_WW_Pin1_4	310	315	PF00397	0.321
DOC_WW_Pin1_4	398	403	PF00397	0.639
LIG_14-3-3_CanoR_1	154	159	PF00244	0.487
LIG_14-3-3_CanoR_1	196	205	PF00244	0.501
LIG_14-3-3_CanoR_1	217	226	PF00244	0.663
LIG_14-3-3_CanoR_1	338	344	PF00244	0.576
LIG_APCC_ABBA_1	163	168	PF00400	0.396
LIG_BRCT_BRCA1_1	299	303	PF00533	0.413
LIG_BRCT_BRCA1_1	92	96	PF00533	0.380
LIG_FHA_1	178	184	PF00498	0.399
LIG_FHA_1	393	399	PF00498	0.516
LIG_FHA_1	6	12	PF00498	0.630
LIG_FHA_2	19	25	PF00498	0.449
LIG_FHA_2	254	260	PF00498	0.480
LIG_FHA_2	382	388	PF00498	0.670
LIG_GBD_Chelix_1	291	299	PF00786	0.514
LIG_LIR_Apic_2	308	314	PF02991	0.403
LIG_LIR_Gen_1	300	311	PF02991	0.444
LIG_LIR_Gen_1	328	337	PF02991	0.488
LIG_LIR_Nem_3	13	19	PF02991	0.682
LIG_LIR_Nem_3	185	191	PF02991	0.343
LIG_LIR_Nem_3	199	204	PF02991	0.424
LIG_LIR_Nem_3	300	306	PF02991	0.414
LIG_LIR_Nem_3	328	333	PF02991	0.449
LIG_LIR_Nem_3	74	80	PF02991	0.430
LIG_NRP_CendR_1	461	464	PF00754	0.443
LIG_Pex14_1	201	205	PF04695	0.545
LIG_Pex14_2	175	179	PF04695	0.456
LIG_Pex14_2	329	333	PF04695	0.490
LIG_Pex14_2	73	77	PF04695	0.418
LIG_REV1ctd_RIR_1	172	180	PF16727	0.339
LIG_SH2_CRK	311	315	PF00017	0.408
LIG_SH2_CRK	86	90	PF00017	0.378
LIG_SH2_PTP2	322	325	PF00017	0.511
LIG_SH2_PTP2	57	60	PF00017	0.398
LIG_SH2_SRC	166	169	PF00017	0.184
LIG_SH2_STAP1	330	334	PF00017	0.464
LIG_SH2_STAT3	453	456	PF00017	0.543
LIG_SH2_STAT5	305	308	PF00017	0.407
LIG_SH2_STAT5	322	325	PF00017	0.447
LIG_SH2_STAT5	330	333	PF00017	0.414
LIG_SH2_STAT5	335	338	PF00017	0.331
LIG_SH2_STAT5	343	346	PF00017	0.481
LIG_SH2_STAT5	453	456	PF00017	0.507
LIG_SH2_STAT5	458	461	PF00017	0.525
LIG_SH2_STAT5	57	60	PF00017	0.382
LIG_SH2_STAT5	94	97	PF00017	0.469
LIG_TYR_ITIM	320	325	PF00017	0.484
LIG_TYR_ITIM	84	89	PF00017	0.531
LIG_WRC_WIRS_1	326	331	PF05994	0.423
MOD_CDK_SPxxK_3	398	405	PF00069	0.626
MOD_CK1_1	220	226	PF00069	0.643
MOD_CK1_1	241	247	PF00069	0.536
MOD_CK1_1	297	303	PF00069	0.376
MOD_CK1_1	328	334	PF00069	0.465
MOD_CK1_1	362	368	PF00069	0.694
MOD_CK1_1	381	387	PF00069	0.667
MOD_CK1_1	401	407	PF00069	0.549
MOD_CK1_1	41	47	PF00069	0.444
MOD_CK1_1	5	11	PF00069	0.637
MOD_CK2_1	247	253	PF00069	0.626
MOD_CK2_1	350	356	PF00069	0.471
MOD_CK2_1	367	373	PF00069	0.761
MOD_CK2_1	381	387	PF00069	0.611
MOD_CK2_1	7	13	PF00069	0.698
MOD_GlcNHglycan	198	201	PF01048	0.571
MOD_GlcNHglycan	220	223	PF01048	0.638
MOD_GlcNHglycan	232	235	PF01048	0.610
MOD_GlcNHglycan	243	246	PF01048	0.580
MOD_GlcNHglycan	249	252	PF01048	0.518
MOD_GlcNHglycan	283	286	PF01048	0.462
MOD_GlcNHglycan	33	36	PF01048	0.561
MOD_GlcNHglycan	359	362	PF01048	0.666
MOD_GlcNHglycan	369	372	PF01048	0.678
MOD_GlcNHglycan	380	383	PF01048	0.658
MOD_GlcNHglycan	4	7	PF01048	0.656
MOD_GlcNHglycan	40	43	PF01048	0.370
MOD_GSK3_1	1	8	PF00069	0.637
MOD_GSK3_1	154	161	PF00069	0.434
MOD_GSK3_1	217	224	PF00069	0.539
MOD_GSK3_1	230	237	PF00069	0.501
MOD_GSK3_1	247	254	PF00069	0.668
MOD_GSK3_1	281	288	PF00069	0.482
MOD_GSK3_1	294	301	PF00069	0.320
MOD_GSK3_1	357	364	PF00069	0.661
MOD_GSK3_1	392	399	PF00069	0.694
MOD_GSK3_1	423	430	PF00069	0.485
MOD_LATS_1	339	345	PF00433	0.561
MOD_N-GLC_2	30	32	PF02516	0.546
MOD_NEK2_1	1	6	PF00069	0.640
MOD_NEK2_1	158	163	PF00069	0.387
MOD_NEK2_1	31	36	PF00069	0.433
MOD_NEK2_1	325	330	PF00069	0.394
MOD_NEK2_1	333	338	PF00069	0.388
MOD_NEK2_1	359	364	PF00069	0.567
MOD_NEK2_1	447	452	PF00069	0.476
MOD_NEK2_1	7	12	PF00069	0.602
MOD_NEK2_2	435	440	PF00069	0.418
MOD_NEK2_2	97	102	PF00069	0.414
MOD_NMyristoyl	1	7	PF02799	0.514
MOD_PIKK_1	328	334	PF00454	0.508
MOD_PIKK_1	41	47	PF00454	0.485
MOD_PKA_1	196	202	PF00069	0.473
MOD_PKA_1	217	223	PF00069	0.349
MOD_PKA_2	183	189	PF00069	0.360
MOD_PKA_2	196	202	PF00069	0.362
MOD_PKA_2	217	223	PF00069	0.480
MOD_PKA_2	241	247	PF00069	0.682
MOD_PKA_2	396	402	PF00069	0.624
MOD_Plk_2-3	18	24	PF00069	0.383
MOD_Plk_4	120	126	PF00069	0.449
MOD_Plk_4	154	160	PF00069	0.379
MOD_Plk_4	178	184	PF00069	0.399
MOD_Plk_4	294	300	PF00069	0.398
MOD_Plk_4	325	331	PF00069	0.437
MOD_Plk_4	447	453	PF00069	0.404
MOD_Plk_4	90	96	PF00069	0.368
MOD_ProDKin_1	115	121	PF00069	0.431
MOD_ProDKin_1	222	228	PF00069	0.595
MOD_ProDKin_1	251	257	PF00069	0.696
MOD_ProDKin_1	298	304	PF00069	0.367
MOD_ProDKin_1	310	316	PF00069	0.330
MOD_ProDKin_1	398	404	PF00069	0.629
MOD_SUMO_rev_2	253	262	PF00179	0.658
TRG_DiLeu_BaEn_1	168	173	PF01217	0.398
TRG_DiLeu_BaLyEn_6	321	326	PF01217	0.455
TRG_ENDOCYTIC_2	213	216	PF00928	0.490
TRG_ENDOCYTIC_2	322	325	PF00928	0.447
TRG_ENDOCYTIC_2	330	333	PF00928	0.399
TRG_ENDOCYTIC_2	57	60	PF00928	0.372
TRG_ENDOCYTIC_2	86	89	PF00928	0.378
TRG_ER_diArg_1	201	203	PF00400	0.352
TRG_ER_diArg_1	216	218	PF00400	0.505
TRG_ER_diArg_1	374	376	PF00400	0.735
TRG_ER_diArg_1	62	64	PF00400	0.420

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I563	Leptomonas seymouri	61%	100%
A0A0S4JRQ8	Bodo saltans	41%	100%
A0A1X0NUU2	Trypanosomatidae	46%	100%
A0A3Q8IC61	Leishmania donovani	90%	100%
A0A3R7L681	Trypanosoma rangeli	45%	100%
A4HC79	Leishmania braziliensis	76%	99%
A4HZQ7	Leishmania infantum	90%	100%
C9ZSF0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
Q4QBW6	Leishmania major	90%	100%
V5BK78	Trypanosoma cruzi	45%	100%